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1. 发明申请

WO2012109075A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
标题翻译：化合物及其调节方法及其适应症
公开(公告)号：WO2012109075A1
公开(公告)日：2012-08-16
申请号：PCT/US2012/023543
申请日：2012-02-01
申请人： PLEXXIKON INC. , IBRAHIM, Prabha N. , ZHANG, Chao , SPEVAK, Wayne , ZHANG, Jiazhong , WU, Guoxian , LIN, Jack , CHO, Hanna , NESPI, Marika , SHI, Songyuan , EWING, Todd , ZHANG, Ying
发明人： IBRAHIM, Prabha N. , ZHANG, Chao , SPEVAK, Wayne , ZHANG, Jiazhong , WU, Guoxian , LIN, Jack , CHO, Hanna , NESPI, Marika , SHI, Songyuan , EWING, Todd , ZHANG, Ying
IPC分类号： A61K31/407
CPC分类号： A61K31/506 , A61K31/437 , A61K31/5377 , C07D471/04
摘要： Compounds active on protein kinases are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译：描述了对蛋白激酶有活性的化合物，以及制备和使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。

2. 发明申请

WO2007002433A1 PYRROLO [2, 3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译： PYRROLO [2,3-B]吡啶衍生物作为蛋白激酶抑制剂
公开(公告)号：WO2007002433A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/024524
申请日：2006-06-21
申请人： PLEXXIKON, INC. , IBRAHIM, Prabha, N. , ARTIS, Dean, R. , BREMER, Ryan , HABETS, Gaston , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , ZUCKERMAN, Rebecca , WEST, Brian , SUZUKI, Yoshihisa , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxian , ZHU, Hongyao , SHI, Shenghua
发明人： IBRAHIM, Prabha, N. , ARTIS, Dean, R. , BREMER, Ryan , HABETS, Gaston , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , ZUCKERMAN, Rebecca , WEST, Brian , SUZUKI, Yoshihisa , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxian , ZHU, Hongyao , SHI, Shenghua
IPC分类号： C07D471/04 , A61K31/435 , C07C49/517 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds of formula III which are active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. (Formula III).
摘要翻译：描述了对蛋白激酶有活性的式III化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。（式III）。

3. 发明申请

WO2008064265A2 COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR 审中-公开
公开(公告)号：WO2008064265A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/085299
申请日：2007-11-20
申请人： PLEXXIKON, INC. , ZHANG, Chao , ZHANG, Jiazhong , IBRAHIM, Prabha, N. , ARTIS, Dean, R. , BREMER, Ryan , WU, Guoxian , ZHU, Hongyao , NESPI, Marika
发明人： ZHANG, Chao , ZHANG, Jiazhong , IBRAHIM, Prabha, N. , ARTIS, Dean, R. , BREMER, Ryan , WU, Guoxian , ZHU, Hongyao , NESPI, Marika
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.

4. 发明申请

WO2008063888A3 COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR 审中-公开
公开(公告)号：WO2008063888A3
公开(公告)日：2008-05-29
申请号：PCT/US2007/083910
申请日：2007-11-07
申请人： PLEXXIKON, INC. , ZHANG, Chao , ZHANG, Jiazhong , IBRAHIM, Prabha N. , ARTIS, Dean R. , BREMER, Ryan , WU, Guoxian , ZHU, Hongyao , NESPI, Marika
发明人： ZHANG, Chao , ZHANG, Jiazhong , IBRAHIM, Prabha N. , ARTIS, Dean R. , BREMER, Ryan , WU, Guoxian , ZHU, Hongyao , NESPI, Marika
IPC分类号： C07D471/04 , A61K31/437
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.

5. 发明申请

WO2008064255A2 COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR 审中-公开
标题翻译：调节C-FMS和/或C-KIT活性的化合物及其用途
公开(公告)号：WO2008064255A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/085289
申请日：2007-11-20
申请人： PLEXXIKON, INC. , ZHANG, Chao , ZHANG, Jiazhong , IBRAHIM, Prabha N. , ARTIS, Dean R. , BREMER, Ryan , WU, Guoxian , ZHU, Hongyao , NESPI, Marika
发明人： ZHANG, Chao , ZHANG, Jiazhong , IBRAHIM, Prabha N. , ARTIS, Dean R. , BREMER, Ryan , WU, Guoxian , ZHU, Hongyao , NESPI, Marika
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
摘要翻译：本文提供了对受体蛋白酪氨酸激酶c-kit和/或c-fms具有活性的化合物。本文还提供了用于治疗c-kit介导的疾病或病症和/或c-fms介导的疾病或病症的组合物，以及使用它们的方法。

6. 发明申请

WO2007002325A1 PYRROLO[2,3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：吡咯并[2,3-B]吡啶衍生物作为蛋白激酶抑制剂
公开(公告)号：WO2007002325A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/024361
申请日：2006-06-21
申请人： PLEXXIKON, INC. , IBRAHIM, Prahbha, N. , ARTIS, Dean, R. , BREMER, Ryan , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxiam , ZHU, Hongyao , SHI, Shenghua
发明人： IBRAHIM, Prahbha, N. , ARTIS, Dean, R. , BREMER, Ryan , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxiam , ZHU, Hongyao , SHI, Shenghua
IPC分类号： C07D471/04 , A61K31/435 , C07C49/517 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds of formula III which are active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译：描述了对蛋白激酶有活性的式III化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。

7. 发明申请

WO2009143018A2 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
标题翻译：化合物及其调节方法及其适应症
公开(公告)号：WO2009143018A2
公开(公告)日：2009-11-26
申请号：PCT/US2009/044151
申请日：2009-05-15
申请人： PLEXXIKON, INC. , IBRAHIM, Prabha, N. , BREMER, Ryan , ZHANG, Jiazhong , NESPI, Marika , CHO, Hanna
发明人： IBRAHIM, Prabha, N. , BREMER, Ryan , ZHANG, Jiazhong , NESPI, Marika , CHO, Hanna
IPC分类号： C07D487/04 , A61K31/519 , A61P19/00 , A61P29/00 , A61P35/00 , A61P31/12
CPC分类号： C07D487/04 , A61K31/519
摘要： Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one of Fms protein kinase or Kit protein kinase. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of Fms protein kinases and/or Kit protein kinases, including rheumatoid arthiritis, osteoarthritis, osteoporosis, peri-prosthetic osteolysis, systemic sclerosis, demyelinating disorders, multiple sclerosis, Charcot Marie Tooth syndrome, amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, ulcerative colitis, Crohn's disease, immune thrombocytopenic purpura, myelopreparation for autologous transplantation, transplant rejection, nephritis, nephropathy, type I diabetes, acute pain, inflammatory pain, neuropathic pain, breast cancer, prostate cancer, pancreatic cancer, lung cancer, ovarian cancer, gliomas, glioblastomas, neurofibromatosis, osteolytic bone metastases, and giant cell tumors.
摘要翻译：其化合物及其盐，其制剂，其缀合物，其衍生物，其形式及用途。在某些方面和实施方案中，所述的化合物或其盐，其制剂，其缀合物，其衍生物，其形式在Fms蛋白激酶或Kit蛋白激酶中的至少一种上是有活性的。还描述了其用于治疗疾病和病症的方法，包括与Fms蛋白激酶和/或Kit蛋白激酶（包括类风湿性关节炎，骨关节炎，骨质疏松症，骨质疏松症，系统性硬化症，脱髓鞘疾病，多发性硬化症，Charcot玛丽牙综合征，肌萎缩性侧索硬化，阿尔茨海默病，帕金森病，溃疡性结肠炎，克罗恩病，免疫性血小板减少性紫癜，自体移植用骨髓制剂，移植排斥，肾炎，肾病，I型糖尿病，急性疼痛，神经性疼痛，乳腺癌，前列腺癌，胰腺癌，肺癌，卵巢癌，神经胶质瘤，成胶质细胞瘤，神经纤维瘤病，溶骨性骨转移和巨细胞肿瘤。

8. 发明申请

WO2006026754A2 PDE4B INHIBITORS 审中-公开
标题翻译： PDE4B抑制剂
公开(公告)号：WO2006026754A2
公开(公告)日：2006-03-09
申请号：PCT/US2005/031322
申请日：2005-09-02
申请人： PLEXXIKON, INC. , IBRAHIM, Prabham, L. , BREMER, Ryan, E. , GILLETTE, Samuel, J. , CHO, Hanna , NESPI, Marika , MAMO, Shumeye , ZHANG, Chao , ARTIS, Dean R. , LEE, Byunghun , ZUCKERMAN, Rebecca, L.
发明人： IBRAHIM, Prabham, L. , BREMER, Ryan, E. , GILLETTE, Samuel, J. , CHO, Hanna , NESPI, Marika , MAMO, Shumeye , ZHANG, Chao , ARTIS, Dean R. , LEE, Byunghun , ZUCKERMAN, Rebecca, L.
CPC分类号： C07D471/04 , C07D209/12 , C07D401/12 , C07D405/04 , G06F19/16 , G06F19/706
摘要： Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and strucural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.
摘要翻译：描述了在PDE4上有活性的化合物。还描述了使用X射线晶体学测定的PDE4B的晶体结构，使用PDE4B晶体和结构信息来鉴定分子支架，用于开发结合和调节PDE4B的配体，以及基于已知配体鉴定改进的配体。

9. 发明申请

WO2014194127A1 COMPOUNDS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
标题翻译：用于激酶调节的化合物及其适应症
公开(公告)号：WO2014194127A1
公开(公告)日：2014-12-04
申请号：PCT/US2014/040076
申请日：2014-05-29
申请人： PLEXXIKON INC.
发明人： ZHANG, Chao , HIRTH, Klaus-Peter , IBRAHIM, Prabha N. , NESPI, Marika , SHI, Songyuan , SPEVAK, Wayne , HABETS, Gaston G. , BURTON, Betsy
IPC分类号： C07D213/75 , C07D417/04 , C07D471/04 , C07D487/04 , A61K31/519
CPC分类号： C07D487/04 , A61K31/437 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D213/75 , C07D417/04 , C07D471/04
摘要： Compounds active on protein kinases and methods for regulating protein kinase pathways are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译：描述了对蛋白激酶有活性的化合物和调节蛋白激酶途径的方法，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。

10. 发明申请

WO2014100620A2 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
标题翻译：化合物及其调节方法及其适应症
公开(公告)号：WO2014100620A2
公开(公告)日：2014-06-26
申请号：PCT/US2013/076995
申请日：2013-12-20
申请人： PLEXXIKON INC.
发明人： WU, Guoxian , CHAN, Katrina , EWING, Todd , IBRAHIM, Prabha, N. , LIN, Jack , NESPI, Marika , SPEVAK, Wayne , ZHANG, Ying
IPC分类号： C07D403/12
CPC分类号： C07D401/12 , A61K31/437 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/675 , C07D403/12 , C07D471/04 , C07D487/04 , C07D513/04 , C07F5/025 , C07F9/65616
摘要： Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.
摘要翻译：描述了对具有任何突变的c-kit蛋白激酶或突变c-kit蛋白激酶有活性的化合物，以及制备和使用这些化合物治疗与c-kit蛋白激酶异常活性相关的疾病和病症的方法和/或突变c-kit蛋白激酶。

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