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1. 发明申请

WO2007002325A1 PYRROLO[2,3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：吡咯并[2,3-B]吡啶衍生物作为蛋白激酶抑制剂
公开(公告)号：WO2007002325A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/024361
申请日：2006-06-21
申请人： PLEXXIKON, INC. , IBRAHIM, Prahbha, N. , ARTIS, Dean, R. , BREMER, Ryan , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxiam , ZHU, Hongyao , SHI, Shenghua
发明人： IBRAHIM, Prahbha, N. , ARTIS, Dean, R. , BREMER, Ryan , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxiam , ZHU, Hongyao , SHI, Shenghua
IPC分类号： C07D471/04 , A61K31/435 , C07C49/517 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds of formula III which are active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译：描述了对蛋白激酶有活性的式III化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。

2. 发明申请

WO2007002433A1 PYRROLO [2, 3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译： PYRROLO [2,3-B]吡啶衍生物作为蛋白激酶抑制剂
公开(公告)号：WO2007002433A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/024524
申请日：2006-06-21
申请人： PLEXXIKON, INC. , IBRAHIM, Prabha, N. , ARTIS, Dean, R. , BREMER, Ryan , HABETS, Gaston , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , ZUCKERMAN, Rebecca , WEST, Brian , SUZUKI, Yoshihisa , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxian , ZHU, Hongyao , SHI, Shenghua
发明人： IBRAHIM, Prabha, N. , ARTIS, Dean, R. , BREMER, Ryan , HABETS, Gaston , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , ZUCKERMAN, Rebecca , WEST, Brian , SUZUKI, Yoshihisa , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxian , ZHU, Hongyao , SHI, Shenghua
IPC分类号： C07D471/04 , A61K31/435 , C07C49/517 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds of formula III which are active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. (Formula III).
摘要翻译：描述了对蛋白激酶有活性的式III化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。（式III）。

3. 发明申请

WO2009012283A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
标题翻译：化合物及其调节方法及其适应症
公开(公告)号：WO2009012283A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/070124
申请日：2008-07-16
申请人： PLEXXIKON INC. , WU, Guoxian , ZHANG, Jiazhong , ZHU, Yong-Liang , ZHANG, Chao , IBRAHIM, Prabha, N. , SHI, Songyuan , SPEVAK, Wayne , ARTIS, Dean, R. , TSAI, James
发明人： WU, Guoxian , ZHANG, Jiazhong , ZHU, Yong-Liang , ZHANG, Chao , IBRAHIM, Prabha, N. , SHI, Songyuan , SPEVAK, Wayne , ARTIS, Dean, R. , TSAI, James
IPC分类号： C07D213/75 , C07D215/38 , C07D231/40 , C07D261/14 , C07D285/16 , C07D401/12 , C07D407/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D285/135 , A61P35/00
CPC分类号： A61K31/44 , A61K31/415 , A61K31/42 , A61K31/433 , A61K31/437 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/82 , C07D215/12 , C07D215/14 , C07D215/20 , C07D215/38 , C07D231/40 , C07D239/48 , C07D239/49 , C07D261/14 , C07D263/48 , C07D285/135 , C07D285/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , A61K31/4427 , A61K2300/00
摘要： Compounds of formula I active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. Formula (I) wherein Ar is optionally substituted heteroaryl; R 2 is hydrogen, lower alkyl or halogen; U is selected from the group consisting of -S(O) 2 -, -C(X)-, -C(X)-N(R 10 )-, and -S(O) 2 -N(R 10 )-; R 3 is optionally substituted lower alkyl, optionally substituted C3.6 cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl or optionally substituted heteroaryl; and wherein R 1 , R 3 , R 4 , m, L 1 , X R 10 are as described herein.
摘要翻译：描述了对蛋白激酶有活性的式I化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。式（I）其中Ar是任选取代的杂芳基; R2是氢，低级烷基或卤素; U选自-S（O）2 - ， - C（X） - ， - C（X）-N（R 10） - 和-S（O）2 -N（R 10） - ; R 3是任选取代的低级烷基，任选取代的C 3-6环烷基，任选取代的杂环烷基，任选取代的芳基或任选取代的杂芳基; 并且其中R 1，R 3，R 4，m，L 1，X R 10如本文所述。

4. 发明申请

WO2010129467A1 COMPOUNDS AND METHODS FOR INHIBITION OF RENIN, AND INDICATIONS THEREFOR 审中-公开
标题翻译：化合物和方法，用于抑制RENIN及其适应症
公开(公告)号：WO2010129467A1
公开(公告)日：2010-11-11
申请号：PCT/US2010/033385
申请日：2010-05-03
申请人： PLEXXIKON, INC. , WU, Guoxian , IBRAHIM, Prabha N. , ZHOU, Yong , MAMO, Shumeye , GILLETTE, Samuel J. , ZHU, Yong-Liang , LIU, Jinyu , ZHANG, Chao , ZHANG, Kam , ARTIS, Dean R.
发明人： WU, Guoxian , IBRAHIM, Prabha N. , ZHOU, Yong , MAMO, Shumeye , GILLETTE, Samuel J. , ZHU, Yong-Liang , LIU, Jinyu , ZHANG, Chao , ZHANG, Kam , ARTIS, Dean R.
IPC分类号： C07D215/06 , C07D401/06 , C07D407/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D215/227 , A61K31/47 , A61P9/12
CPC分类号： C07D215/06 , C07D215/227 , C07D401/06 , C07D407/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： Compounds active as inhibitors of renin are described, as well as methods of using such compounds to treat diseases and conditions associated with the renin-angiotensin system. Formula (I)
摘要翻译：描述了作为肾素抑制剂活性的化合物，以及使用这些化合物治疗与肾素 - 血管紧张素系统相关的疾病和病症的方法。式（I）

5. 发明申请

WO2013023145A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS 审中-公开
标题翻译：某些化学实验，组合物和方法
公开(公告)号：WO2013023145A1
公开(公告)日：2013-02-14
申请号：PCT/US2012/050346
申请日：2012-08-10
申请人： NEUPHARMA, INC. , QIAN, Xiangping , ZHU, Yong-Liang
发明人： QIAN, Xiangping , ZHU, Yong-Liang
IPC分类号： A61K31/535
CPC分类号： C07D307/33 , C07D405/12
摘要： Chemical entities that are arctigenin derivatives, pharmaceutical compositions and methods of treatment of cancer are described. Treatment encompasses administration of at least one compound of Formula I, or a pharmaceutically acceptable salt thereof, to a mammalian subject, particularly a human subject, in need of such an administration and includes (i) arresting the development of clinical symptoms of the disease, such as cancer, (ii) bringing about a regression in the clinical symptoms of the disease, such as cancer, and/or (iii) prophylactic treatment for preventing the onset of the disease, such as cancer. Cancer refers to all types of cancer o neoplasm or malignant tumors found in mammals, including carcinomas and sarcomas. Examples of cancer are cancer of the brain, breast, cervix, colon, head & neck, kidney, lung, non-small cell lung, melanoma, mesothelioma, ovary, sarcoma, stomach, uterus and Medulloblastoma.
摘要翻译：描述了作为癌基因的衍生物，药物组合物和癌症治疗方法的化学实体。治疗包括向需要这种施用的哺乳动物受试者，特别是人类受试者施用至少一种式I化合物或其药学上可接受的盐，并且包括（i）阻止疾病的临床症状的发展，例如癌症，（ii）使疾病如癌症的临床症状消退，和/或（iii）预防疾病发病例如癌症的预防性治疗。癌症是指哺乳动物中发现的肿瘤或恶性肿瘤的所有类型的肿瘤，包括癌和肉瘤。癌症的例子是脑，乳腺，子宫颈，结肠，头颈部，肾，肺，非小细胞肺，黑素瘤，间皮瘤，卵巢，肉瘤，胃，子宫和成神经管细胞瘤的癌症。

6. 发明申请

WO2012024893A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS 审中-公开
标题翻译：某些化学实验，组合物和方法
公开(公告)号：WO2012024893A1
公开(公告)日：2012-03-01
申请号：PCT/CN2011/001391
申请日：2011-08-22
申请人： SUZHOU NEUPHARMA CO., LTD. , QIAN, Xiangping , ZHU, Yong-Liang
发明人： QIAN, Xiangping , ZHU, Yong-Liang
IPC分类号： C07J63/00 , A61K31/573 , A61K36/77 , A61P35/00 , A61P35/02 , A61P29/00 , A61P19/02 , A61P25/28 , A61P25/14 , A61P25/16
CPC分类号： C07J63/008
摘要： Chemical entities which are triterpenoid derivatives, pharmaceutical compositions and methods of treatment of inflammatory, neurodegenerative, neoplastic and autoimmune diseases are described.
摘要翻译：描述了三萜衍生物的化学实体，药物组合物和治疗炎性，神经变性，肿瘤和自身免疫性疾病的方法。

7. 发明申请

WO2011079118A1 PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE 审中-公开
标题翻译：作为激素类激酶抑制剂的西酞菁酮
公开(公告)号：WO2011079118A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/061551
申请日：2010-12-21
申请人： ELAN PHARMACEUTICALS, INC , GALEMMO, Robert, A., Jr. , ARTIS, Dean Richard , YE, Xiaocong Michael , AUBELE, Danielle, L. , TRUONG, Anh, P. , BOWERS, Simeon , HOM, Roy, K. , ZHU, Yong-Liang , NEITZ, R., Jeffrey , SEALY, Jennifer , ADLER, Marc , BEROZA, Paul , ANDERSON, John, P.
发明人： GALEMMO, Robert, A., Jr. , ARTIS, Dean Richard , YE, Xiaocong Michael , AUBELE, Danielle, L. , TRUONG, Anh, P. , BOWERS, Simeon , HOM, Roy, K. , ZHU, Yong-Liang , NEITZ, R., Jeffrey , SEALY, Jennifer , ADLER, Marc , BEROZA, Paul , ANDERSON, John, P.
IPC分类号： C07D475/04 , C07D475/12 , A61K31/4985 , A61P25/00
CPC分类号： C07D475/00 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D475/04 , C07D475/12 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, E 1 , E 2 , R 1 , R 2 , R 3 and R 4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译：本发明提供具有式（I）结构的化合物或其盐或溶剂化物，其中环A，E1，E2，R 1，R 2，R 3和R 4在本文中定义。本发明进一步提供包含本发明化合物的药物组合物，以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。

8. 发明申请

WO2011079114A1 PTERIDINONES AS INHIBITORS OF POLO - LIKE KINASE 审中-公开
标题翻译：作为类似激素的抑制剂的PTERIDONONES
公开(公告)号：WO2011079114A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/061535
申请日：2010-12-21
申请人： ELAN PHARMACEUTICALS, INC. , GALEMMO, Robert, A., Jr. , ARTIS, Dean, Richard , YE, Xiaocong, Michael , AUBELE, Danielle, L. , TRUONG, Anh, P. , BOWERS, Simeon , HOM, Roy, K. , ZHU, Yong-Liang , NEITZ, R., Jeffrey , SEALY, Jennifer , ADLER, Marc , BEROZA, Paul , ANDERSON, John, P.
发明人： GALEMMO, Robert, A., Jr. , ARTIS, Dean, Richard , YE, Xiaocong, Michael , AUBELE, Danielle, L. , TRUONG, Anh, P. , BOWERS, Simeon , HOM, Roy, K. , ZHU, Yong-Liang , NEITZ, R., Jeffrey , SEALY, Jennifer , ADLER, Marc , BEROZA, Paul , ANDERSON, John, P.
IPC分类号： C07D475/04 , C07D475/12 , A61K31/4985 , A61P25/00
CPC分类号： C07D475/00 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D475/04 , C07D475/12 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention provides compounds having a structure according to Formula (I) or a salt or solvate thereof, wherein ring A, X, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 , are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
摘要翻译：本发明提供具有式（I）结构或其盐或溶剂合物的化合物，其中环A，X，R 1，R 2，R 3，R 4，R 5和R 6在本文中定义。本发明进一步提供包含本发明化合物的药物组合物以及制备和使用本发明化合物和组合物的方法，例如治疗和预防各种疾病如帕金森病。

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