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1. 发明申请

WO2006064392A2 METHOD OF DETERMINING A SPATIAL DISTRIBUTION OF MAGNETIC PARTICLES 审中-公开
标题翻译：确定磁性颗粒空间分布的方法
公开(公告)号：WO2006064392A2
公开(公告)日：2006-06-22
申请号：PCT/IB2005/054042
申请日：2005-12-05
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , NIELSEN, Tim , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： NIELSEN, Tim , GLEICH, Bernhard , WEIZENECKER, Jürgen
CPC分类号： A61B5/05 , A61B5/0515 , A61B5/7257
摘要： The invention relates to a method of determining a spatial distribution of magnetic particles in an examination area, in which a magnetic field is generated which has a first part-region having a relatively low magnetic field strength and a second part-region having a relatively high magnetic field strength. The position of the two part-regions is changed, as a result of which the magnetization in the examination area changes, and real measured values which depend on the change in magnetization are recorded. A dependence distribution which depends on a spatial distribution of magnetic particles is then determined such that a sum which comprises as summands a) the difference of the real measured values from fictitious measured values which are determined by applying a transfer function to the dependence distribution, and b) the product of a regularization parameter and of a regularization value which is determined by applying the regularization functional to the dependence distribution, is minimized. Finally, the spatial distribution of magnetic particles is determined by means of the determined dependence distribution.
摘要翻译：本发明涉及一种确定检测区域中的磁性颗粒的空间分布的方法，其中产生磁场，其具有磁场强度较低的第一部分区域和具有较高磁场强度的第二部分区域磁场强度。两部分区域的位置发生变化，其结果是检查区域的磁化改变，并且记录取决于磁化变化的实测值。然后确定依赖于磁性颗粒的空间分布的依赖性分布，使得包括作为求和的和a）通过将依赖分布应用传递函数确定的实际测量值与虚构测量值的差异，以及 b）将正则化参数和通过对依赖分布应用正则化函数确定的正则化值的乘积最小化。最后，通过确定的依赖分布来确定磁性颗粒的空间分布。

2. 发明申请

WO2006064405A1 METHOD OF DETERMINING A SPATIAL DISTRIBUTION OF MAGNETIC PARTICLES 审中-公开
标题翻译：确定磁性颗粒空间分布的方法
公开(公告)号：WO2006064405A1
公开(公告)日：2006-06-22
申请号：PCT/IB2005/054073
申请日：2005-12-06
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , GLEICH, Bernhard , WEIZENECKER, Jürgen , NIELSEN, Tim
发明人： GLEICH, Bernhard , WEIZENECKER, Jürgen , NIELSEN, Tim
IPC分类号： A61B5/05
CPC分类号： A61B5/0515 , A61B5/05 , A61B5/7257
摘要： The invention relates to a method of determining a spatial distribution of magnetic particles in an examination zone, in which a magnetic field is generated that has a first sub-zone of lower magnetic field strength and a second sub-zone of higher magnetic field strength. The positions of the two sub-zones are changed, as a result of which the magnetization in the examination zone changes. Measured values that depend on the change in magnetization are acquired. A reference response function by means of which measured values can be determined mathematically from a spatial distribution of magnetic particles is then determined by means of at least extensive magnetic specimen distribution. Finally, the spatial distribution of magnetic particles is reconstructed from the measured values by means of the reference response function.
摘要翻译：本发明涉及一种确定检测区中的磁性颗粒的空间分布的方法，其中产生具有较低磁场强度的第一子区和较高磁场强度的第二子区的磁场。两个子区域的位置改变，结果是检查区域的磁化改变。取决于磁化变化的测量值。然后可以借助于至少广泛的磁性样本分布来确定参考响应函数，通过该参考响应函数可以从磁性粒子的空间分布以数学方式确定测量值。最后，通过参考响应函数从测量值重建磁性粒子的空间分布。

3. 发明申请

WO2008075287A3 METHOD AND ARRANGEMENT FOR SEPARATING MAGNETIC PARTICLES, MAGNETIC PARTICLES AND USE MAGNETIC PARTICLES 审中-公开
公开(公告)号：WO2008075287A3
公开(公告)日：2008-06-26
申请号：PCT/IB2007/055204
申请日：2007-12-18
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： B03C1/01
摘要： A method and an arrangement for separating magnetic particles, magnetic particles and the use of magnetic particles are disclosed wherein the method comprises the steps of: - subjecting the magnetic particles to a first magnetic field such that the particle direction of easy magnetization is oriented parallel to the magnetic field vector of the first magnetic field, - subjecting the magnetic particles to a second magnetic field having an orientation rotated about an angle relative to the magnetic field vector of the first magnetic field, - applying a separating force on the magnetic particles.

4. 发明申请

WO2004091721A1 METHOD AND APPARATUS FOR INFLUENCING MAGNETIC PARTICLES 审中-公开
标题翻译：影响磁性颗粒的方法和装置
公开(公告)号：WO2004091721A1
公开(公告)日：2004-10-28
申请号：PCT/IB2004/050442
申请日：2004-04-15
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： A61N2/02
CPC分类号： A61N2/06 , A61B5/0515 , A61N1/406 , A61N2/02
摘要： The invention relates to a method and an apparatus for influencing magnetic particles in a region of action. With the help of an arrangement that has means for generating magnetic fields, a spatially inhomogeneous magnetic field is generated that has at least one zone (301) in which the magnetization of the particles is in a state of non-saturation, whereas it is in a state of saturation in the remaining zone. By displacing the said zone within the region of action, a change in magnetization is produced that can be detected from outside and that gives information on the spatial distribution of the magnetic particles in the region of action. Alternatively, the displacement may also be repeated so frequently that the region of action heats up. To improve the accessibility of the region of action, the said region is situated outside the arrangement having means for generating magnetic fields.
摘要翻译：本发明涉及用于影响动作区域中的磁性颗粒的方法和装置。在具有产生磁场的装置的帮助下，产生空间不均匀的磁场，其具有至少一个区域（301），其中颗粒的磁化处于不饱和状态，而在剩余区域的饱和状态。通过在动作区域内移动所述区域，产生可以从外部检测到的磁化变化，并且提供关于磁性颗粒在作用区域中的空间分布的信息。或者，也可以如此频繁地重复位移，使得作用区域加热。为了提高作用区域的可达性，所述区域位于具有用于产生磁场的装置的布置之外。

5. 发明申请

WO2004091394A2 METHOD TO DETERMINE THE SPATIAL DISTRIBUTION OF MAGNETIC PARTICLES AND MAGNETIC PARTICLE ADMINISTERING COMPOSITIONS 审中-公开
标题翻译：确定磁性颗粒和磁性粒子管理组合物空间分布的方法
公开(公告)号：WO2004091394A2
公开(公告)日：2004-10-28
申请号：PCT/IB2004/050444
申请日：2004-04-15
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： A61B5/06
CPC分类号： A61B5/05 , A61B5/0515 , A61B5/416 , A61K49/1818
摘要： The invention relates to a method to determine the spatial distribution of magnetic particles in an examination area of an object of examination with the following steps: a) Generation of a magnetic field with a spatial distribution of the magnetic field strength such that the examination area consists of a first sub-area with lower magnetic field strength and a second sub-area with a higher magnetic field strength, b) Change of the particularly relative spatial position of the two subareas in the area of examination or change of the magnetic field strength in the first sub-area so that the magnetization of the particles changes locally, c) Acquisition of signals that depend on the magnetization in the area of examination influenced by this change, and d) Evaluation of signals to obtain information about the change in spatial distribution and/or the movement of the magnetic particles in the area of examination, where the magnetic particles are introduced into and/or are present in the area of examination in a suspension, aerosol, in the form of a powder, especially diluted, with a casing or, more particularly a thin coating, present in at least one capsule, or coupled to cells, particularly white or red blood corpuscles, immune cells, tumor cells or stem cells, or to ingredients, medication, antibodies, transplants or living organisms, or in the preliminary stage form, especially liquid. The invention further relates to a magnetic particle composition having improved imaging properties, to various different administering compositions for administering magnetic particles into an examination area and to methods for the administering of magnetic particles.
摘要翻译：本发明涉及一种用于确定检查对象的检查区域中的磁性颗粒的空间分布的方法，具有以下步骤：a）产生具有磁场强度空间分布的磁场，使得检查区域由具有较低磁场强度的第一子区域和具有较高磁场强度的第二子区域，b）两个子区域在磁场强度检查或改变区域中的特别相对空间位置的变化第一子区域，使得颗粒的磁化在局部变化，c）获取依赖于由该变化影响的检查区域中的磁化的信号，以及d）评估信号以获得关于空间分布变化的信息和/或磁性颗粒在检查区域中的运动，其中磁性颗粒被引入和/或存在于其中 e悬浮液中的检查区域，以特别稀释的粉末形式的气溶胶，具有外壳或更特别是薄涂层存在于至少一个胶囊中，或偶联至细胞，特别是白色或红色血小粒，免疫细胞，肿瘤细胞或干细胞，或成分，药物，抗体，移植物或生物体，或初步形式，特别是液体。本发明还涉及具有改进的成像性质的磁性颗粒组合物，用于向检查区域中施用磁性颗粒的各种不同的施用组合物和用于施用磁性颗粒的方法。

6. 发明申请

WO2004091392A1 METHOD AND ARRANGEMENT FOR INFLUENCING MAGNETIC PARTICLES AND DETECTING INTERFERING MATERIAL 审中-公开
标题翻译：影响磁性颗粒和检测干燥材料的方法和装置
公开(公告)号：WO2004091392A1
公开(公告)日：2004-10-28
申请号：PCT/IB2004/001119
申请日：2004-04-05
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： A61B5/06
CPC分类号： A61N2/02 , A61B5/0515 , A61N1/406
摘要： The invention relates to a method and an arrangement for influencing magnetic particles in a region of action. Methods and arrangements of this kind can be used to determine the spatial distribution of magnetic particles in the region of action or to heat up the magnetic particles locally. If, in addition to the magnetic particles, there is also interfering material in the region of action then this material may heat up in an unwanted way. To avoid unwanted heating-up of this kind, any interfering material that may be present is detected beforehand. If there is interfering material present, then an examination or investigation, or treatment, can be carried out with changed system parameters.
摘要翻译：本发明涉及用于影响动作区域中的磁性颗粒的方法和装置。这种方法和布置可用于确定磁性颗粒在作用区域中的空间分布或局部加热磁性颗粒。如果除了磁性颗粒之外，还存在作用区域中的干扰材料，则该材料可能以不希望的方式加热。为了避免不必要的这种加热，可以预先检测可能存在的任何干扰物质。如果存在干扰物质，则可以用系统参数进行检查或调查或处理。

7. 发明申请

WO2004091408A2 ELASTOGRAPHY DEVICE AND METHOD FOR DETERMINING AND IMAGING OF MECHANICAL AND ELASTIC PARAMETERS OF AN EXAMINATION OBJECT 审中-公开
标题翻译：用于确定和成像检查对象的机械和弹性参数的ELASTOGRAPHY设备和方法
公开(公告)号：WO2004091408A2
公开(公告)日：2004-10-28
申请号：PCT/IB2004/050445
申请日：2004-04-15
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： A61B8/08
CPC分类号： A61B5/0048 , A61B5/0051 , A61B5/04005 , A61B5/05 , A61B5/0515 , A61B5/055 , A61B8/485 , A61B8/5223 , A61N1/406 , A61N2/02
摘要： The present invention relates to a device for determining mechanical, particularly elastic, parameters of an examination object, comprising a) at least one arrangement for determining the spatial distribution of magnetic particles in at least one examination area of the examination object, comprising a means for generating a magnetic field with a spatial profile of the magnetic field strength such that there is produced in at least one examination area a first part-area having a low magnetic field strength and a second part-area having a higher magnetic field strength, a means for detecting signals which depend on the magnetization in the examination object, particularly in the examination area, that is influenced by a spatial change in the particles, and a means for evaluating the signals so as to obtain information about the, in particular temporally changing, spatial distribution of the magnetic particles in the examination area; and b) at least one means for generating mechanical displacements, in particular oscillations, at least in and/or adjacent to the examination area of the examination object. The invention furthermore relates to a method for determining mechanical and/or physical parameters of an examination object, in particular using a device according to the invention. The invention further relates to magnetic particle compositions that can be used in that method according to the invention.
摘要翻译：本发明涉及一种用于确定检查对象的机械，特别是弹性的参数的装置，包括：a）至少一个用于确定检查对象的至少一个检查区域中的磁性颗粒的空间分布的装置，包括：产生具有磁场强度的空间分布的磁场，使得在至少一个检查区域中产生具有低磁场强度的第一部分区域和具有较高磁场强度的第二部分区域，用于检测依赖于检查对象中的磁化的信号，特别是在检查区域中受到颗粒的空间变化影响的信号，以及用于评估信号以获得关于特别是时间上变化的信息的装置，磁性颗粒在检查区域的空间分布; 和b）至少一个用于产生至少在检查对象的检查区域中和/或邻近检查对象的机械位移，特别是振荡的装置。本发明还涉及一种用于确定检查对象的机械和/或物理参数的方法，特别是使用根据本发明的装置。本发明还涉及可用于根据本发明的方法的磁性颗粒组合物。

8. 发明申请

WO2004091395A3 METHOD FOR SPATIALLY RESOLVED DETERMINATION OF MAGNETIC PARTICLE DISTRIBUTION IN AN AREA OF EXAMINATION 审中-公开
公开(公告)号：WO2004091395A3
公开(公告)日：2004-10-28
申请号：PCT/IB2004/050446
申请日：2004-04-15
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： A61B5/06
摘要： The present invention relates to a method for improved spatially resolved determination of magnetic particle distribution in an area of examination, where the changes in spatial distribution, the concentration and/or the anisotropy of these magnetic particles in the area of examination are monitored. The invention further also relates to magnetic particle compositions having improved magnetic imaging properties for use in the method according to the invention. The present invention further also relates to a method and an apparatus having improved spatial resolution in the method according to the invention by application of a high frequency field to increase the spin temperature of the spin systems of the magnetic particles.

9. 发明申请

WO2008078276A1 ARRANGEMENT AND METHOD FOR DETECTING AND/OR LOCATING A MAGNETIC MATERIAL IN A REGION OF ACTION, USE OF AN ARRANGEMENT IN THE EXAMINATION OF BUILDINGS 审中-公开
标题翻译：在行动区域检测和/或定位磁性材料的安排和方法，在检查建筑物时使用安排
公开(公告)号：WO2008078276A1
公开(公告)日：2008-07-03
申请号：PCT/IB2007/055178
申请日：2007-12-17
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： G01V3/08 , G01R33/60
CPC分类号： G01R33/12
摘要： An arrangement and a method for detecting and/or locating magnetic material, and the use of an arrangement in the examination of buildings is disclosed, which arrangement comprises: selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic material changes locally, receiving means for acquiring detection signals, which detection signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein the magnetic selection field comprises at least a time-variable field component varying at a frequency of at least about 100 Hz.
摘要翻译：公开了一种用于检测和/或定位磁性材料的装置和方法，以及在建筑物检查中使用一种装置，该装置包括：用于产生具有其磁场强度空间中的图案的磁选择场的选择装置使得具有低磁场强度的第一子区域和具有较高磁场强度的第二子区域形成在作用区域中，用于改变该区域中两个子区域的空间位置的驱动装置通过磁驱动场的作用，使得磁性材料的磁化在局部变化，用于获取检测信号的接收装置，该检测信号取决于作用区域中的磁化强度，该磁化受位置变化的影响在所述第一和第二子区域的空间中，其中所述磁选择场包括至少一个随时间变化的场分量至少约100Hz。

10. 发明申请

WO2010070575A1 PERMANENT MAGNETIC ASSEMBLY FOR MAGNETIC PARTICLE IMAGING 审中-公开
标题翻译：用于磁颗粒成像的永久磁性组件
公开(公告)号：WO2010070575A1
公开(公告)日：2010-06-24
申请号：PCT/IB2009/055741
申请日：2009-12-14
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , TIMINGER, Holger , WEIZENECKER, Jürgen , GLEICH, Bernhard
发明人： TIMINGER, Holger , WEIZENECKER, Jürgen , GLEICH, Bernhard
IPC分类号： G01R33/383 , A61B5/05
CPC分类号： A61B5/055 , A61B5/0515 , G01R33/022 , G01R33/14 , G01R33/3802 , G01R33/383
摘要： The present invention relates to an arrangement (10) for influencing and/or detecting magnetic particles in a region of action (300). The arrangement (10) comprises selection means (210) for generating a magnetic selection field (211) having a pattern in space of its magnetic field strength such that a first sub-zone (301) having a low magnetic field strength and a second sub-zone (302) having a higher magnetic field strength are formed in the region of action (300), drive means (220) for changing the position in space of the two sub- zones (301, 302) in the region of action (300) by means of a magnetic drive field (221) so that the magnetization of the magnetic material changes locally, and receiving means (230) for acquiring detection signals, which detection signals depend on the magnetization in the region of action (300), which magnetization is influenced by the change in the position in space of the first and second sub-zone (301, 302). The selection means (210) comprises a permanent magnetic assembly having at least one permanent magnetic unit (213) comprising a plurality of magnetic sub-elements (214) wherein the magnetic sub-elements (214) have individually fixed magnetization orientation, and are bonded together to form said at least one permanent magnetic unit (213).
摘要翻译：本发明涉及用于在动作区域（300）中影响和/或检测磁性颗粒的装置（10）。该装置（10）包括选择装置（210），用于产生具有其磁场强度空间中的图案的磁选择场（211），使得具有低磁场强度的第一子区（301）和第二子在动作区域（300）中形成具有较高磁场强度的区域（302），用于改变动作区域中的两个子区域（301,302）的空间位置的驱动装置（220） 300），借助磁驱动场（221）使得磁性材料的磁化在局部变化，以及用于获取检测信号的接收装置（230），该检测信号取决于作用区域（300）中的磁化，该磁化受到第一和第二子区（301,302）的空间位置变化的影响。所述选择装置（210）包括具有至少一个包括多个磁性子元件（214）的永久磁性单元（213）的永久磁性组件，其中所述磁性子元件（214）具有单独固定的磁化取向，一起形成所述至少一个永磁单元（213）。

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