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1. 发明申请

WO2016081622A1 ACTIVE WATER PHANTOM FOR THREE-DIMENSIONAL ION BEAM THERAPY QUALITY ASSURANCE 审中-公开
标题翻译：主要用于三维离子束治疗质量保证的水质
公开(公告)号：WO2016081622A1
公开(公告)日：2016-05-26
申请号：PCT/US2015/061376
申请日：2015-11-18
申请人： PHENIX MEDICAL LLC , BROOKHAVEN SCIENCE ASSOCIATES, LLC , VIGDOR, Steven E. , YEH, Minfang , JAFFE, David E.
发明人： VIGDOR, Steven E. , YEH, Minfang , JAFFE, David E.
IPC分类号： A61N5/00 , G01T1/16
CPC分类号： A61B6/4258 , A61B6/583 , A61N5/1075 , A61N2005/1076 , A61N2005/1087 , G01T1/169
摘要： An Active Water Phantom is designed to provide fast, accurate, high resolution, complete Quality Assurance of patient-specific treatment plans utilizing intensity-modulated Ion Beam Therapy, prior to their delivery to the patient. The detection medium is a tissue-equivalent water-based liquid scintillator material. A three-dimensional pattern of scintillation light, emitted upon ion beam irradiation, is reconstructed from three orthogonal two-dimensional light yield profiles, which are read out for each individual beam energy layer. The 3-D information has dose measurement accuracy 1-2% and spatial resolution 1-2 millimeters. The measurement sequence provides up to four orders of magnitude more data characterizing the treatment plan than currently commercially available alternatives, all in a time period no greater than that needed for actual delivery of the dose fraction to a patient. The system provides sophisticated control and readout of the cameras or photo-detectors, data archiving and analysis, simulation capabilities, and 3-D dose image reconstruction and visualization.
摘要翻译： Active Water Phantom旨在提供快速，准确，高分辨率，完整的质量保证，在使用强度调制离子束治疗之前，将患者特异性治疗计划交付给患者。检测介质是组织等效的水基液体闪烁体材料。从三个正交的二维光产生曲线重建离子束照射时发射的闪烁光的三维图案，其对于每个单独的光束能量层读出。 3-D信息的剂量测量精度为1-2％，空间分辨率为1-2毫米。测量序列提供比目前商业上可获得的替代物多达四个数量级的表征治疗计划的数据，所有这些数据在不大于向患者实际递送剂量分数所需的时间内。该系统提供复杂的摄像机或光电检测器的控制和读出，数据归档和分析，仿真功能和3-D剂量图像重建和可视化。

2. 发明申请

WO2016168076A1 POSITRON-EMISSION TOMOGRAPHY DETECTOR SYSTEMS BASED ON LOW-DENSITY LIQUID SCINTILLATORS AND PRECISE TIME-RESOLVING PHOTODETECTORS 审中-公开
标题翻译：基于低密度液体扫描仪和精确时间分辨率光电子的位置发射测量系统
公开(公告)号：WO2016168076A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/026640
申请日：2016-04-08
申请人： THE UNIVERSITY OF CHICAGO , BROOKHAVEN SCIENCE ASSOCIATES, LLC
发明人： FRISCH, Henry J. , OBERLA, Eric J. , KIM, Hee-Jong , YEH, Minfang
IPC分类号： G01T1/204 , G01T1/29
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/2018 , G01T1/204
摘要： TOF-PET detector systems, and methods for imaging photon-emitting samples using the detector systems, are provided. The TOF-PET detector systems use large-area photodetectors with extremely high time-resolution and an approach to data collection and analysis that allows for the use of inexpensive low-density scintillator materials. The TOF-PET detector systems are characterized by their ability to identify, on a statistical basis, the transverse and depth location of the first of the series of energy deposition events that are generated when a gamma photon enters the low-density scintillator material.
摘要翻译： TOF-PET检测器系统以及使用检测器系统对光子发射样品成像的方法。 TOF-PET检测器系统使用具有非常高的时间分辨率的大面积光电探测器以及数据采集和分析方法，允许使用廉价的低密度闪烁体材料。 TOF-PET检测器系统的特征在于它们能够在统计的基础上识别当γ光子进入低密度闪烁体材料时产生的一系列能量沉积事件中的第一个能量沉积事件的横向和深度位置。

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