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    • 4. 发明申请
    • INK-JET PRINTING OF TISSUES
    • INK-JET打印组织
    • WO2007124023A3
    • 2008-01-03
    • PCT/US2007009612
    • 2007-04-20
    • UNIV WAKE FOREST HEALTH SCIENCESYOO JAMESXU TAOATALA ANTHONY
    • YOO JAMESXU TAOATALA ANTHONY
    • A61L33/00C12N5/00C12N5/08G01N33/48
    • C12N5/0062B01L3/0268B29C70/76B33Y10/00B33Y80/00C12N2533/54C12N2533/74
    • A method of forming an array of viable cells is carried out by ink-jet printing a cellular composition containing said cells on a substrate. At least two different types of viable mammalian cells are printed on the substrate, the at least two different types of viable mammalian cells selected to together form a tissue. In some embodiments at least three or four different viable mammalian cells are printed on the substrate, the cells selected to together form a tissue. In some embodiments one of the viable mammalian cell types is a stem cell. In some embodiments the method further comprises printing at least one support compound on the substrate, the support compound selected to form a tissue together with said cells. In some embodiments the method further comprises printing at least one growth factor on the substrate, the growth factor selected to cause the cells to form a tissue.
    • 形成活细胞阵列的方法通过在基底上喷墨印刷含有所述细胞的细胞组合物来进行。 将至少两种不同类型的活的哺乳动物细胞印刷在底物上,所选择的至少两种不同类型的活的哺乳动物细胞一起形成组织。 在一些实施方案中,至少三个或四个不同的可行的哺乳动物细胞印刷在底物上,选择一起形成组织的细胞。 在一些实施方案中,活的哺乳动物细胞类型之一是干细胞。 在一些实施方案中,所述方法还包括在所述底物上印刷至少一种载体化合物,所述载体化合物选择为与所述细胞一起形成组织。 在一些实施方案中,所述方法还包括在所述底物上印刷至少一种生长因子,所述生长因子被选择以引起细胞形成组织。