专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006136697A3 CHIMERIC POLY PEPTIDES AND THE THERAPEUTIC USE THEREOF AGAINST A FLAVIVIRIDAE INFECTION 审中-公开
标题翻译： CHICERIC POLY PEPTIDES及其对FLAVIVIRIDIDA感染的治疗用途
公开(公告)号：WO2006136697A3
公开(公告)日：2007-03-08
申请号：PCT/FR2006001396
申请日：2006-06-20
申请人： PASTEUR INSTITUT , CENTRE NAT RECH SCIENT , TANGY FREDERIC , LUCAS-HOURANI MARIANNE , NAVARRO-SANCHEZ ERIKA , FRENKIEL MARIE-PASCALE , BEDOUELLE HUGUES , COMBREDET CHANTAL , DESPRES PHILIPPE
发明人： TANGY FREDERIC , LUCAS-HOURANI MARIANNE , NAVARRO-SANCHEZ ERIKA , FRENKIEL MARIE-PASCALE , BEDOUELLE HUGUES , COMBREDET CHANTAL , DESPRES PHILIPPE
IPC分类号： A61K38/16 , C07K14/18 , C07K16/10 , C12N15/09 , C12N15/62 , C12N15/86
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/165 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , C07K2319/00 , C07K2319/04 , C12N7/00 , C12N15/86 , C12N2760/18434 , C12N2760/18443 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171
摘要： The invention relates to building a chimeric polypeptide used for preventing or treating a Flaviviridae infection. The use of the inventive chimeric polypeptide for producing recombinant viral vectors such as a measles living viral vector is also disclosed.
摘要翻译：本发明涉及构建用于预防或治疗黄病毒科感染的嵌合多肽。还公开了本发明的嵌合多肽用于产生重组病毒载体如麻疹活病毒载体的用途。

2. 发明申请

WO2004076619A3 NEW DENGUE AND WEST NILE VIRUSES PROTEINS AND GENES CODING THE FOREGOING, AND THEIR USE IN VACCINAL, THERAPEUTIC AND DIAGNOSTIC APPLICATIONS 审中-公开
标题翻译：新登革热和西兰病毒蛋白质和基因编码前体及其在疫苗，治疗和诊断应用中的应用
公开(公告)号：WO2004076619A3
公开(公告)日：2005-03-17
申请号：PCT/IB2004001027
申请日：2004-02-26
申请人： PASTEUR INSTITUT , CENTRE NAT RECH SCIENT , TANGY FREDERIC , DESPRES PHILIPPE , COMBREDET CHANTAL , FRENKIEL MARIE PASCALE
发明人： TANGY FREDERIC , DESPRES PHILIPPE , COMBREDET CHANTAL , FRENKIEL MARIE PASCALE
IPC分类号： A61K38/00 , A61K39/00 , A61P31/12 , A61P31/14 , C07K14/18 , C12N7/01 , C12N15/40 , C12N15/86 , C12Q1/70 , A61K39/12
CPC分类号： A61K39/12 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C07K14/1825 , C12N15/86 , C12N2760/18443 , C12N2770/24122 , C12Q1/701
摘要： The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective humoral and cellular immune responses against WNV or Dengue virus infections. More specifically, the present invention relates to three (3) antigens from WNV (the secreted envelope glycoprotein (E), the heterodimer glycoproteins (pre-M-E) and the NSI protein) and from Dengue virus (the secreted envelope glycoprotein (e), the heterodimer glycoproteins (pre- m-e) and the nsl protein) and their use in vaccinal, therapeutic and diagnostic applications.
摘要翻译：本发明涉及表达来自西尼罗河脑炎病毒（WNV）或登革热病毒的不同免疫原的病毒载体的开发，其能够诱导针对WNV或登革热病毒感染的保护性体液和细胞免疫应答。更具体地，本发明涉及来自WNV（分泌的包膜糖蛋白（E），异二聚体糖蛋白（pre-ME）和NSI蛋白）和登革病毒（分泌的包膜糖蛋白（e））的三（3）个抗原，异二聚体糖蛋白（pre me）和nsl蛋白）及其在疫苗，治疗和诊断应用中的应用。

3. 发明申请

WO2008152528A2 METHOD FOR THE DIAGNOSIS OR THE SCREENING OF AN ARBOVIRUS INFECTION, REAGENTS USEFUL IN SAID METHOD AND THEIR APPLICATIONS 审中-公开
标题翻译：用于诊断或筛查ARBOVIRUS感染的方法，有用的方法及其应用的试剂
公开(公告)号：WO2008152528A2
公开(公告)日：2008-12-18
申请号：PCT/IB2008002614
申请日：2008-06-13
申请人： PASTEUR INSTITUT , CENTRE NAT RECH SCIENT , BEDOUELLE HUGUES , BRIENT-LITZLER ELODIE , DUSSART PHILIPPE , DESPRES PHILIPPE , BREMAND LAETITIA
发明人： BEDOUELLE HUGUES , BRIENT-LITZLER ELODIE , DUSSART PHILIPPE , DESPRES PHILIPPE , BREMAND LAETITIA
IPC分类号： C07K14/18 , C12N15/62 , G01N33/535 , G01N33/543
CPC分类号： G01N33/56983 , C07K2319/61 , C12N2770/24011 , G01N33/581 , G01N2333/185 , G01N2469/20
摘要： Method for the diagnosis or the screening of an arbovirus infection and preferably a flaviviridae infection and more preferably a flavivirus infection, reagents useful in said method and their applications. Said method comprises: (i) contacting a sample from the subject or animal with a solid support sensitized with an Ig binding protein which is directed against a specific class of Ig molecules of the subject or animal species under consideration and (ii) incubating the immunocomplex formed in (i) with a detector molecule consisting of a hybrid protein comprising at least an arboviral ED3 domain and an alkaline phosphatase (PhoA), the detection of said immunocomplex being the sign of the presence of an arbovirus in said sample.
摘要翻译：用于诊断或筛选病毒感染，优选黄病毒科感染，更优选黄病毒感染的方法，可用于所述方法及其应用的试剂。所述方法包括：（i）使来自受试者或动物的样品与用Ig结合蛋白致敏的固体支持物接触，所述固定支持物针对正在考虑的受试者或动物物种的特定类别的Ig分子，以及（ii）孵育免疫复合物由（i）由包含至少包含Arboviral ED3结构域和碱性磷酸酶（PhoA）的杂交蛋白组成的检测器分子形成，所述免疫复合物的检测是所述样品中存在弓形病毒的征兆。

4. 发明申请

WO2009031045A3 ANTI-CHIKUNGUNYA MONOCLONAL ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗青春单抗单克隆抗体及其用途
公开(公告)号：WO2009031045A3
公开(公告)日：2009-04-23
申请号：PCT/IB2008003092
申请日：2008-09-04
申请人： PASTEUR INSTITUT , BREHIN ANNE-CLAIRE , SALL AMADOU ALPHA , DESPRES PHILIPPE
发明人： BREHIN ANNE-CLAIRE , SALL AMADOU ALPHA , DESPRES PHILIPPE
IPC分类号： C07K16/10 , G01N33/569
CPC分类号： C07K16/1081 , G01N33/56983 , G01N2333/18 , G01N2469/10
摘要： The present invention relates to the field of arbovirosis caused by Chikungunya virus (CHIK). The present invention specifically concerns anti-CHIK monoclonal antibodies (MAbs), and more specifically anti-CHIK.E2 MAbs and their use as diagnostic products in methods for detecting the presence or absence of a CHIK strain.
摘要翻译：本发明涉及由基孔肯雅病毒（CHIK）引起的阿波病的领域。本发明具体涉及抗CHIK单克隆抗体（MAb），更具体地涉及抗CHIK.E2 MAb及其在检测CHIK株存在或不存在的方法中作为诊断产品的用途。

5. 发明申请

WO0196376A9 PRO-APOPTOTIC FRAGMENTS OF THE DENGUE VIRUS ENVELOPE GLYCOPROTEINS 审中-公开
标题翻译：登革病毒包膜糖蛋白的PRO-APOPTOTIC片段
公开(公告)号：WO0196376A9
公开(公告)日：2003-10-23
申请号：PCT/IB0101570
申请日：2001-06-18
申请人： PASTEUR INSTITUT , DESPRES PHILIPPE , COURAGEOT MARIE-PIERRE , DEUBEL VINCENT , CATTEAU ADELINE
发明人： DESPRES PHILIPPE , COURAGEOT MARIE-PIERRE , DEUBEL VINCENT , CATTEAU ADELINE
IPC分类号： G01N33/50 , A61K38/00 , A61K39/00 , A61K48/00 , A61P31/14 , A61P35/00 , A61P43/00 , C07K14/18 , C07K16/10 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/02 , G01N33/15 , G01N33/577
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , C12N2770/24122
摘要： The present invention relates to pro-apoptotic fragments of the Dengue virus pRM and E glycoproteins, methods of screening for molecules capable of inducing apoptosis and methods of inducing apoptosis in a cell.
摘要翻译：本发明涉及登革热病毒pRM和E糖蛋白的促凋亡片段，筛选能够诱导凋亡的分子的方法和诱导细胞凋亡的方法。

6. 发明申请

WO2007052165A3 A LENTIVIRAL VECTOR-BASED VACCINE 审中-公开
标题翻译：基于烟草载体的疫苗
公开(公告)号：WO2007052165A3
公开(公告)日：2007-10-25
申请号：PCT/IB2006003931
申请日：2006-10-17
申请人： PASTEUR INSTITUT , CHARNEAU PIERRE , DESPRES PHILIPPE
发明人： CHARNEAU PIERRE , DESPRES PHILIPPE
IPC分类号： A61K39/00 , C07K14/18
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5256 , C12N2740/15043 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171
摘要： Methods of eliciting humoral responses, methods of immunization, and methods of vaccination using lentiviral vector are disclosed. Additionally, immunogenic compositions and vaccines for West Nile Virus are disclosed.
摘要翻译：公开了引起体液应答的方法，免疫方法和使用慢病毒载体的疫苗接种方法。另外，公开了用于西尼罗河病毒的免疫原性组合物和疫苗。

7. 发明申请

WO0196376A2 PRO-APOPTOTIC FRAGMENTS OF THE DENGUE VIRUS ENVELOPE GLYCOPROTEINS 审中-公开
标题翻译：登革热病毒糖皮质激素的抗病毒片段（PRO-APOPTOTIC FRAGMENTS OF THE DENGUE VIRUS ENVELOPE GLYCOPROTEINS）
公开(公告)号：WO0196376A2
公开(公告)日：2001-12-20
申请号：PCT/IB0101570
申请日：2001-06-18
申请人： PASTEUR INSTITUT , DESPRES PHILIPPE , COURAGEOT MARIE PIERRE , DEUBEL VINCENT , CATTEAU ADELINE
发明人： DESPRES PHILIPPE , COURAGEOT MARIE-PIERRE , DEUBEL VINCENT , CATTEAU ADELINE
IPC分类号： G01N33/50 , A61K38/00 , A61K39/00 , A61K48/00 , A61P31/14 , A61P35/00 , A61P43/00 , C07K14/18 , C07K16/10 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/02 , G01N33/15 , G01N33/577 , C07K14/005
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , C12N2770/24122
摘要： The present invention relates to pro-apoptotic fragments of the Dengue virus pRM and E glycoproteins, methods of screening for molecules capable of inducing apoptosis and methods of inducing apoptosis in a cell.
摘要翻译：本发明涉及登革病毒pRM和E糖蛋白的促凋亡片段，筛选能够诱导细胞凋亡的分子的方法和诱导细胞凋亡的方法。

8. 发明申请

WO2009141731A2 THE LARGE FORM OF HUMAN 2', 5'-OLIGOADENYLATE SYNTHETASE OAS3 FOR PREVENTING OR TREATING INFECTION WITH POSITIVE-SENSE SINGLE-STRANDED RNA VIRUSES 审中-公开
标题翻译：人类2'，5'-二氨基酸合成酶OAS3的大型形式，用于预防或治疗具有阳性感染单链RNA病毒的感染
公开(公告)号：WO2009141731A2
公开(公告)日：2009-11-26
申请号：PCT/IB2009005956
申请日：2009-05-20
申请人： PASTEUR INSTITUT , BREHIN ANNE-CLAIRE , SAKUNTABHAI ANAVAJ , DESPRES PHILIPPE , CASADEMONT ISABELLE , JULIER CECILE , CHUANSUMRIT AMPAIWAN , MALASIT PRIDA , PAULOUS SYLVIE
发明人： BREHIN ANNE-CLAIRE , SAKUNTABHAI ANAVAJ , DESPRES PHILIPPE , CASADEMONT ISABELLE , JULIER CECILE , CHUANSUMRIT AMPAIWAN , MALASIT PRIDA , PAULOUS SYLVIE
IPC分类号： C12N9/12 , A61K38/45 , C12Q1/68
CPC分类号： A61K38/45 , C12N9/1241 , C12Q1/6883 , C12Q1/701 , C12Q2600/156 , C12Q2600/158
摘要： Use of the large form of human 2',5'-Oligoadenylate Synthetase (OAS3) for diagnosis, prevention and treatment of infection with positive-sense single-stranded RNA viruses and for prediction of human genetic susceptibility to positive-sense single-stranded RNA virus-related diseases.
摘要翻译：大量形式的人2'，5'-寡腺苷酸合成酶（OAS3）用于诊断，预防和治疗阳性单链RNA病毒感染，并用于预测正义单链RNA的人类遗传易感性病毒相关疾病

9. 发明申请

WO2007105111A3 NOVEL ISOLATED AND PURIFIED STRAINS OF CHIKUNGUNYA VIRUS AND POLYNUCLEOTIDES AND POLYPEPTIDES SEQUENCES, DIAGNOSTIC AND IMMUNOGENICAL USES THEREOF 审中-公开
标题翻译： CH UN A A US OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF
公开(公告)号：WO2007105111A3
公开(公告)日：2008-03-27
申请号：PCT/IB2007001716
申请日：2007-03-15
申请人： PASTEUR INSTITUT , DESPRES PHILIPPE , BREHIN ANNE-CLAIRE , MARECHAL VALERIE , CHARNEAU PIERRE , SOUQUE PHILIPPE
发明人： DESPRES PHILIPPE , BREHIN ANNE-CLAIRE , MARECHAL VALERIE , CHARNEAU PIERRE , SOUQUE PHILIPPE
IPC分类号： C07K14/18
CPC分类号： G01N33/56983 , A61K38/00 , A61K39/00 , C07K14/005 , C07K16/1081 , C12N7/00 , C12N2770/36121 , C12N2770/36122 , C12N2770/36131 , G01N2333/181 , G01N2800/32
摘要： The present invention concerns wild-strains of Chikungunya virus isolated from patients exhibiting severe forms of infection and stemming from a human arbovirosis epidemy. The present invention also concerns polypeptide sequences and fragment thereof derived from their genome, the polynucleotide encoding same and their use as diagnostic products, as vaccine and/or as immunogenic compositions.
摘要翻译：本发明涉及从表现出严重感染形式的患者和从人类阿博病病毒流行中产生的患者分离的基孔肯雅病毒的野生菌株。本发明还涉及衍生自其基因组的多肽序列及其片段，编码它们的多核苷酸及其作为诊断产品的用途，作为疫苗和/或免疫原性组合物。

10. 发明申请

WO2013083847A3 MULTIPLEX IMMUNO SCREENING ASSAY 审中-公开
标题翻译：多重免疫屏蔽测定
公开(公告)号：WO2013083847A3
公开(公告)日：2013-08-01
申请号：PCT/EP2012074986
申请日：2012-12-10
申请人： PASTEUR INSTITUT
发明人： MANUGUERRA JEAN-CLAUDE , VANHOMWEGEN JESSICA , DESPRES PHILIPPE , PAULOUS SYLVIE
IPC分类号： C12N9/10 , C12N15/62 , G01N33/543 , G01N33/564
CPC分类号： G01N33/54306 , G01N33/54313 , G01N33/54353 , G01N33/564 , G01N33/56983 , G01N33/6845 , G01N2333/18 , G01N2333/185 , G01N2469/20
摘要： The present invention provides kits and assay methods for the early detection of pathogens, precise identification of the etiologic agent, and improved disease surveillance. More specifically, the present invention discloses an immunoassay leading to the rapid and simultaneous detection of antibodies to a wide range of infectious pathogens in biological fluids of infected patients. This immunoassay involves the covalent and oriented coupling of fusion proteins comprising an AGT enzyme and a viral antigen on an identifiable solid support (e.g. fluorescent microspheres), said support being previously coated with an AGT substrate. This coupling is mediated by the irreversible reaction of the AGT enzyme on its substrate. The thus obtained antigen-coupled microspheres show enhanced capture of specific antibodies as compared to antigen-coupled microspheres produced by standard amine coupling procedures. The methods of the invention possess the ability to multiplex, minimize the amount of biological sample, and have enhanced sensitivity and specificity toward target antibodies as compared with classical ELISA or Radio-Immunoprecipitation assays.
摘要翻译：本发明提供用于病原体的早期检测，病原体的精确鉴定和改进的疾病监测的试剂盒和测定方法。更具体地，本发明公开了一种免疫测定，其导致快速和同时检测感染患者生物流体中广泛感染性病原体的抗体。该免疫测定涉及包含AGT酶和病毒抗原的融合蛋白在可识别的固体支持物（例如荧光微球）上的共价和取向偶联，所述载体预先用AGT底物涂覆。该偶联由AGT酶在其底物上的不可逆反应介导。与通过标准胺偶联方法制备的抗原偶联微球相比，由此获得的抗原偶联微球显示出特异性抗体的增强捕获。与传统的ELISA或放射免疫沉淀测定相比，本发明的方法具有复用多样化，最小化生物样品的量并且对靶抗体具有增强的敏感性和特异性的能力。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式