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1. 发明申请

WO2019068876A1 CHIMERIC FLAVIVIRUS VACCINES 审中-公开
公开(公告)号：WO2019068876A1
公开(公告)日：2019-04-11
申请号：PCT/EP2018/077156
申请日：2018-10-05
申请人： KATHOLIEKE UNIVERSITEIT LEUVEN
发明人： BOUDEWIJNS, Robbert , DALLMEIER, Kai , KUM, Dieudonné, Buh , MISHRA, Niraj , NEYTS, Johan , SCHMID, Michael, Alexander
IPC分类号： A61K39/12 , A61P31/14 , C07K14/18
CPC分类号： A61K39/12 , A61P31/14 , C07K14/1825 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134
摘要： The invention relates to chimeric live infectious attenuated flavivirusese of a first and a second flavivirus for use in the prevention of an infection by the first flavivirus, wherein at least one of the structural proteins of the first flavivirus is replaced by the 5 corresponding at least one of the structural proteins of the second flavivirus.

2. 发明申请

WO2016012800A1 ANTI-DENGUE VACCINES AND ANTIBODIES 审中-公开
标题翻译：抗真菌疫苗和抗体
公开(公告)号：WO2016012800A1
公开(公告)日：2016-01-28
申请号：PCT/GB2015/052139
申请日：2015-07-23
申请人： IMPERIAL INNOVATIONS LIMITED , INSTITUT PASTEUR , CNRS- CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE PARIS-SUD
发明人： SCREATON, Gavin , MONGKOLSAPAYA, Juthathip , ROUVINSKI, Alexander , GUARDADO-CALVO, Pablo , BARBA-SPAETH, Giovanna , DUQUERROY, Stéphane , VANEY, Marie-Christine , REY, Felix Augusto
IPC分类号： C07K16/10 , A61K39/12 , A61P31/14
CPC分类号： C07K14/005 , A61K39/12 , A61K47/6841 , A61K2039/5258 , A61K2039/545 , C07K14/1825 , C07K16/1081 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C12N2770/24122 , C12N2770/24134 , Y02A50/386
摘要： A Dengue virus Envelope Dimer Epitope (EDE) wherein the EDE: c) spans the polypeptides of a Dengue virus Envelope polypeptide dimer; and/or d) is presented on a dimer of Envelope proteins; and/or c) is formed from consecutive or non-consecutive residues of the envelope polypeptide dimer, wherein the dimer is a homodimer or heterodimer of native and/or mutant envelope polypeptides, from any one or two of DENV-1, DENV-2, DENV-3 and DENV-4. The EDE may be a stabilized recombinant dengue virus envelope glycoprotein E ectodomain (sE) dimer, wherein the dimer is: covalently stabilized with at least one disulphide inter-chain bond between the two sE monomers, and/or covalently stabilized with at least one sulfhydryl-reactive crosslinker between the two sE monomers, and/or covalently stabilized by linking the two sE monomers through modified sugars; and/or, covalently stabilised by being formed as a single polypeptide chain, optionally with a linker region, optionally a Glycine Serine rich linker region, separating the sE sequences, and/or non-covalently stabilized by substituting at least one amino acid residue in the amino acid sequence of at least one sE monomer with at least one bulky side chain amino acid, at the dimer interface or in domain 1 (D1) / domain 3 (D3) linker of each monomer. A compound, for example an antibody or antibody fragment that can neutralise more than one Dengue virus serotype, for example an antibody that can bind to an EDE of the invention.
摘要翻译：登革热病毒包膜二聚体表位（EDE），其中EDE：c）跨越登革病毒包膜多肽二聚体的多肽; 和/或d）呈现在信封蛋白的二聚体上; 和/或c）由包膜多肽二聚体的连续或非连续残基形成，其中二聚体是天然和/或突变包膜多肽的同二聚体或异源二聚体，来自DENV-1，DENV-2 ，DENV-3和DENV-4。 EDE可以是稳定的重组登革热病毒包膜糖蛋白E胞外域（sE）二聚体，其中所述二聚体：通过两个sE单体之间的至少一个二硫键互链键共价稳定，和/或与至少一个巯基共价稳定两个sE单体之间的 - 反应性交联剂和/或通过将两种sE单体通过改性糖连接而共价稳定; 通过形成单个多肽链和/或共价稳定化，任选地具有接头区域，任选地富含甘氨酸丝氨酸的接头区域，分离sE序列，和/或通过将至少一个氨基酸残基取代而非共价稳定化至少一种具有至少一个大的侧链氨基酸的sE单体的氨基酸序列，在每个单体的二聚体界面处或在结构域1（D1）/结构域3（D3）接头中。化合物，例如可以中和多于一种登革热病毒血清型的抗体或抗体片段，例如可结合本发明EDE的抗体。

3. 发明申请

WO2011146933A2 UNIVERSAL DENGUE VIRUS SEQUENCES AND METHODS OF USE 审中-公开
标题翻译：通用登革病毒序列和使用方法
公开(公告)号：WO2011146933A2
公开(公告)日：2011-11-24
申请号：PCT/US2011/037598
申请日：2011-05-23
申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , ROSS, Ted, M. , VASILAKIS, Nikolaos
发明人： ROSS, Ted, M. , VASILAKIS, Nikolaos
CPC分类号： A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/55516 , A61K2039/70 , C07K14/005 , C07K14/1825 , C07K19/00 , C07K2319/00 , C12N2770/24122 , C12N2770/24123 , C12N2770/24134 , C12N2770/24171 , Y02A50/386
摘要： Disclosed herein are computationally optimized broadly reactive dengue virus E polypeptide sequences for DENV-1, DENV-2, DENV-3 and DENV-4. Also disclosed are dengue virus E protein fragments (such as the E protein ectodomain and Dili domain) fused to the molecular adjuvant P28. The disclosed nucleic acid and polypeptide sequences can be used as vaccines for immunization against dengue virus infection. In some cases, the vaccine includes a virus-like particle containing the universal dengue virus E protein, or fragment thereof, or the vaccine is a DNA molecule encoding the VLP.
摘要翻译：本文公开了用于DENV-1，DENV-2，DENV-3和DENV-4的计算上优化的广泛反应性登革病毒E多肽序列。还公开了与分子佐剂P28融合的登革病毒E蛋白片段（例如E蛋白胞外域和Dili结构域）。所公开的核酸和多肽序列可用作免疫登革病毒感染的疫苗。在一些情况下，疫苗包括含有通用登革病毒E蛋白或其片段的病毒样颗粒，或者疫苗是编码VLP的DNA分子。

4. 发明申请

WO2016091836A1 LENTIVIRAL VECTOR-BASED JAPANESE ENCEPHALITIS IMMUNOGENIC COMPOSITION 审中-公开
标题翻译：基于活性载体的日本ENCEPHALITIS免疫组化
公开(公告)号：WO2016091836A1
公开(公告)日：2016-06-16
申请号：PCT/EP2015/078891
申请日：2015-12-07
申请人： INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： CHARNEAU, Pierre , DESPRES, Philippe , DE WISPELAERE, Melissanne , SOUQUE, Philippe , FRENKIEL, Marie-Pascale
IPC分类号： C12N15/86 , C07K14/18 , A61K35/76 , A61K39/00
CPC分类号： A61K39/12 , A61K9/19 , A61K47/26 , A61K2039/5256 , A61K2039/5258 , A61K2039/54 , A61K2039/552 , A61K2039/575 , C07K14/005 , C07K14/1825 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2740/15043 , C12N2740/16043 , C12N2770/24122 , C12N2770/24123 , C12N2770/24134 , C12N2770/24171 , Y02A50/39
摘要： The present invention relates to a lentiviral vector-based Japanese encephalitis (JE) immunogenic composition. The present invention is directed to a recombinant lentiviral vector expressing the precursor of membrane (prM) and the envelope (E) protein, in particular glycoprotein of a Japanese encephalitis virus (JEV) or immunogenic fragments thereof. The present invention also provides cells expressing the lentiviral vector, uses and methods to prevent a JEV infection in a mammalian host, especially in a human or an animal host, in particular a pig or a piglet, preferably a domestic pig or a domestic piglet.
摘要翻译：本发明涉及一种基于慢病毒载体的日本脑炎（JE）免疫原性组合物。本发明涉及表达膜（prM）和包膜（E）蛋白的前体，特别是日本脑炎病毒（JEV）的糖蛋白或其免疫原性片段的重组慢病毒载体。本发明还提供表达慢病毒载体的细胞，用于和预防哺乳动物宿主，特别是人或动物宿主，特别是猪或小猪，优选家猪或家养仔猪中的JEV感染的用途和方法。

5. 发明申请

WO2014210358A1 METHODS AND COMPOSITIONS FOR DENGUE VIRUS VACCINES 审中-公开
标题翻译：登革热疫苗的方法和组合
公开(公告)号：WO2014210358A1
公开(公告)日：2014-12-31
申请号：PCT/US2014/044410
申请日：2014-06-26
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： MESSER, William , BARIC, Ralph , DESILVA, Aravinda , YOUNT, Boyd
IPC分类号： C07K14/005 , C12N15/62 , A61K38/16 , A61P31/12
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , C07K14/1825 , C07K16/1081 , C07K2317/76 , C07K2319/00 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , Y02A50/386
摘要： The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
摘要翻译：本发明提供了包含登革热病毒E糖蛋白主链的嵌合登革热病毒E糖蛋白的组合物和使用方法，其包含导入抗体所识别的表位的氨基酸取代，所述抗原来自登革热病毒血清型不同于登革热病毒血清型登革病毒E糖蛋白骨架。

6. 发明申请

WO2011062625A2 PHYSICOCHEMICAL (PCP) BASED CONSENSUS SEQUENCES AND USES THEREOF 审中-公开
标题翻译：基于物理化学（PCP）的共识序列及其用途
公开(公告)号：WO2011062625A2
公开(公告)日：2011-05-26
申请号：PCT/US2010/003001
申请日：2010-11-18
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , SCHEIN, Catherine, H. , DANECEK, Petr
发明人： SCHEIN, Catherine, H. , DANECEK, Petr
IPC分类号： G01N33/68 , G01N33/53 , G06F17/00 , G06F19/00
CPC分类号： C07K14/1825 , C07K14/005 , C07K16/1081 , C07K2317/33 , C12N2770/24122 , G01N33/56983 , G01N2333/185 , G01N2469/20 , G06F19/16 , G06F19/22 , Y02A50/51 , Y02A50/53 , Y02A90/26
摘要： Provided herein is a computational method for designing a PCP-consensus protein for a family of related proteins. The method uses a consensus alignment of a protein domain common to all the related proteins, which may or may not be substantially biased, from which an average value of p, e.g., 5, physicochemical properties are calculated for each amino acid in the alignment. The PCP-consensus protein has a sequence derived from an alignment of protein domains from a family of related proteins, said sequence containing one or more motifs common to all of the proteins. Also provided are the PCP-consensus proteins, kits comprising the same, datasets of aligned consensus sequences used to derive the PCP-consensus proteins and methods of eliciting an immune response, diagnosing or treating an infectious disease using the same.
摘要翻译：本文提供了一种用于设计相关蛋白家族的PCP-共有蛋白的计算方法。该方法使用所有相关蛋白质共有的蛋白质结构域的共有序列，所述蛋白质结构域可能或可能不是基本上偏倚的，对于每个对齐中的每个氨基酸，其平均值p，例如5，物理化学性质被计算。 PCP-共有蛋白具有衍生自相关蛋白家族的蛋白质结构域的序列的序列，所述序列含有所有蛋白质共有的一个或多个基序。还提供了PCP-共有蛋白质，包含其的试剂盒，用于衍生PCP-共有蛋白质的对准共有序列的数据集和引发免疫应答的方法，使用该PCP共有蛋白诊断或治疗感染性疾病。

7. 发明申请

WO2004076619A3 NEW DENGUE AND WEST NILE VIRUSES PROTEINS AND GENES CODING THE FOREGOING, AND THEIR USE IN VACCINAL, THERAPEUTIC AND DIAGNOSTIC APPLICATIONS 审中-公开
标题翻译：新登革热和西兰病毒蛋白质和基因编码前体及其在疫苗，治疗和诊断应用中的应用
公开(公告)号：WO2004076619A3
公开(公告)日：2005-03-17
申请号：PCT/IB2004001027
申请日：2004-02-26
申请人： PASTEUR INSTITUT , CENTRE NAT RECH SCIENT , TANGY FREDERIC , DESPRES PHILIPPE , COMBREDET CHANTAL , FRENKIEL MARIE PASCALE
发明人： TANGY FREDERIC , DESPRES PHILIPPE , COMBREDET CHANTAL , FRENKIEL MARIE PASCALE
IPC分类号： A61K38/00 , A61K39/00 , A61P31/12 , A61P31/14 , C07K14/18 , C12N7/01 , C12N15/40 , C12N15/86 , C12Q1/70 , A61K39/12
CPC分类号： A61K39/12 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C07K14/1825 , C12N15/86 , C12N2760/18443 , C12N2770/24122 , C12Q1/701
摘要： The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective humoral and cellular immune responses against WNV or Dengue virus infections. More specifically, the present invention relates to three (3) antigens from WNV (the secreted envelope glycoprotein (E), the heterodimer glycoproteins (pre-M-E) and the NSI protein) and from Dengue virus (the secreted envelope glycoprotein (e), the heterodimer glycoproteins (pre- m-e) and the nsl protein) and their use in vaccinal, therapeutic and diagnostic applications.
摘要翻译：本发明涉及表达来自西尼罗河脑炎病毒（WNV）或登革热病毒的不同免疫原的病毒载体的开发，其能够诱导针对WNV或登革热病毒感染的保护性体液和细胞免疫应答。更具体地，本发明涉及来自WNV（分泌的包膜糖蛋白（E），异二聚体糖蛋白（pre-ME）和NSI蛋白）和登革病毒（分泌的包膜糖蛋白（e））的三（3）个抗原，异二聚体糖蛋白（pre me）和nsl蛋白）及其在疫苗，治疗和诊断应用中的应用。

8. 发明申请

WO2017005652A1 CONCOMITANT DENGUE AND YELLOW FEVER VACCINATION 审中-公开
标题翻译：可持续登山和黄烧鱼疫苗
公开(公告)号：WO2017005652A1
公开(公告)日：2017-01-12
申请号：PCT/EP2016/065580
申请日：2016-07-01
申请人： SANOFI PASTEUR
发明人： NORIEGA, Fernando , ZAMBRANO, Betzana , TORNIEPORTH, Nadia , SAVILLE, Mélanie , PLENNEVAUX, Eric , BOAZ, Mark , PAPA, Thomas
IPC分类号： A61K39/12 , C07K14/18
CPC分类号： A61K39/12 , A61K2039/522 , A61K2039/5254 , A61K2039/545 , A61K2039/70 , C07K14/1825 , C12N2770/24134 , C12N2770/24141 , C12N2770/24171 , Y02A50/386 , Y02A50/388
摘要： The present invention relates to a yellow fever (YF) vaccine for use in a method for inducing a protective immune response against yellow fever, wherein said method comprises concomitantly administering said yellow fever vaccine to a human subject together with a tetravalent dengue vaccine which comprises a live attenuated dengue virus of each of serotypes 1 to 4. This invention also pertains to a tetravalent dengue vaccine which comprises a live attenuated dengue virus of each of serotypes 1 to 4 for use in a method of inducing a protective immune response against yellow fever, wherein said method comprises concomitantly administering said tetravalent dengue vaccine to a human subject together with a yellow fever (YF) vaccine.
摘要翻译：本发明涉及一种用于诱导针对黄热病的保护性免疫应答的方法中的黄热病（YF）疫苗，其中所述方法包括与四价登革热疫苗一起向人受试者连同施用所述黄热病疫苗，所述四价登革热疫苗包含本发明还涉及四价登革热疫苗，其包含用于诱导针对黄热病的保护性免疫应答的方法中的每种血清型1至4的活减毒登革热病毒，其中所述方法包括与黄热病（YF）疫苗一起将所述四价登革热疫苗同时施用于人受试者。

9. 发明申请

WO2015197565A1 A DENGUE VIRUS CHIMERIC POLYEPITOPE COMPOSED OF FRAGMENTS OF NON-STRUCTURAL PROTEINS AND ITS USE IN AN IMMUNOGENIC COMPOSITION AGAINST DENGUE VIRUS INFECTION 审中-公开
标题翻译：由非结构蛋白质片段组成的登革病毒半乳聚糖及其在免疫组织化学反应中的用途
公开(公告)号：WO2015197565A1
公开(公告)日：2015-12-30
申请号：PCT/EP2015/064010
申请日：2015-06-22
申请人： INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： TANGY, Frédéric , SHAKUNTABAI, Anavaj , SIMON-LORIERE, Etienne , ROTH, Claude , BUCHY, Philippe
IPC分类号： A61K39/12 , C07K14/18
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/525 , A61K2039/5254 , A61K2039/54 , A61K2039/70 , C07K14/1825 , C07K2319/00 , C12N7/00 , C12N2760/18441 , C12N2760/18443 , C12N2770/24134 , Y02A50/386
摘要： The present invention is directed to a dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection. The present invention provides means, in particular polynucleotides, vectors, cells and methods to produce vectors expressing said chimeric polyepitopes, in particular vectors consisting of recombinant measles virus (MV) particles. The present invention also relates to the use of the recombinant MV particles, in particular under the form of a composition or of a vaccine, for the prevention and/or treatment of a dengue virus infection.
摘要翻译：本发明涉及由非结构蛋白的片段组成的登革病毒嵌合多表位及其在针对登革热病毒感染的免疫原性组合物中的用途。本发明提供了特别是多核苷酸，载体，细胞和产生表达所述嵌合多表位的载体的方法，特别是由重组麻疹病毒（MV）颗粒组成的载体。本发明还涉及重组MV颗粒，特别是组合物或疫苗形式用于预防和/或治疗登革热病毒感染的用途。

10. 发明申请

WO2011062625A3 PHYSICOCHEMICAL (PCP) BASED CONSENSUS SEQUENCES AND USES THEREOF 审中-公开
标题翻译：基于物理化学（PCP）的共识序列及其用途
公开(公告)号：WO2011062625A3
公开(公告)日：2012-04-12
申请号：PCT/US2010003001
申请日：2010-11-18
申请人： UNIV TEXAS , SCHEIN CATHERINE H , DANECEK PETR
发明人： SCHEIN CATHERINE H , DANECEK PETR
IPC分类号： G01N33/68 , G01N33/53 , G06F17/00 , G06F19/00
CPC分类号： C07K14/1825 , C07K14/005 , C07K16/1081 , C07K2317/33 , C12N2770/24122 , G01N33/56983 , G01N2333/185 , G01N2469/20 , G06F19/16 , G06F19/22 , Y02A90/26
摘要： Provided herein is a computational method for designing a PCP-consensus protein for a family of related proteins. The method uses a consensus alignment of a protein domain common to all the related proteins, which may or may not be substantially biased, from which an average value of p, e.g., 5, physicochemical properties are calculated for each amino acid in the alignment. The PCP-consensus protein has a sequence derived from an alignment of protein domains from a family of related proteins, said sequence containing one or more motifs common to all of the proteins. Also provided are the PCP-consensus proteins, kits comprising the same, datasets of aligned consensus sequences used to derive the PCP-consensus proteins and methods of eliciting an immune response, diagnosing or treating an infectious disease using the same.
摘要翻译：本文提供了一种用于设计相关蛋白家族的PCP-共有蛋白的计算方法。该方法使用所有相关蛋白质共有的蛋白质结构域的共有序列，所述蛋白质结构域可能或可能不是基本上偏倚的，对于每个对齐中的每个氨基酸，其平均值p，例如5，物理化学性质被计算。 PCP-共有蛋白具有衍生自相关蛋白家族的蛋白质结构域的序列的序列，所述序列含有所有蛋白质共有的一个或多个基序。还提供了PCP-共有蛋白质，包含其的试剂盒，用于衍生PCP-共有蛋白质的对准共有序列的数据集和引发免疫应答的方法，使用该PCP共有蛋白诊断或治疗感染性疾病。

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