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1. 发明申请

WO2009050726A3 COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF BUPROPION 审中-公开
标题翻译：用于改进交付运输的组合物和方法
公开(公告)号：WO2009050726A3
公开(公告)日：2009-06-25
申请号：PCT/IN2008000337
申请日：2008-05-28
申请人： PANACEA BIOTEC LTD , SINGH AMARJIT , SINGH SARABJIT , PRASAD KORLAKUNTE , JAIN RAJESH
发明人： SINGH AMARJIT , SINGH SARABJIT , PRASAD KORLAKUNTE , JAIN RAJESH
IPC分类号： A61K9/50 , A61K9/16 , A61K31/137
CPC分类号： A61K31/137 , A61K9/0043 , A61K9/141 , A61K9/48 , A61K9/5021
摘要： The present invention provides a pharmaceutical composition comprising micronized bupropion having controlled particle size in the range between 1-60 µm. The pharmaceutical composition of the present invention comprises micronized bupropion having median particle size less than 40 micron, which exhibits outstanding bioavailability via nasal and pulmonary route even without any need for blending the micronized bupropion with large carrier particles. The composition of the present invention comprises micronized bupropion -and one or more pharmaceutically acceptable carriers, surfactants, a dispersing agents, or dispersants, which can be administered in an aerosol formulation as a dry powder for nasal and pulmonary inhalation. Particularly, the composition of the present invention for nasal delivery comprises bioadhesive microparticles of bupropion and carbohydrates like pullulan to prevent and treat diseases such as depression, premenstrual syndrome, premature ejaculation and as an aid to smoking cessation. The invention also provides a process of preparing the compositions of the present invention.
摘要翻译：本发明提供一种药物组合物，其包含微粒化的安非他酮，其控制粒度在1-60μm之间。本发明的药物组合物包含中值粒度小于40微米的微粉化安非他酮，即使不需要将微粉化的安非他酮与大载体颗粒混合，也可以通过鼻和肺途径表现出优异的生物利用度。本发明的组合物包含微粉化的安非他酮和一种或多种药学上可接受的载体，表面活性剂，分散剂或分散剂，其可以作为用于鼻吸入和肺部吸入的干粉在气溶胶制剂中施用。特别地，用于鼻腔输送的本发明的组合物包括安非他酮的生物粘附微粒和诸如支链淀粉的碳水化合物，以预防和治疗诸如抑郁症，经前期综合征，早泄以及作为戒烟的辅助之类的疾病。本发明还提供了制备本发明组合物的方法。

2. 发明申请

WO2009022354A3 MODIFIED DOSAGE FORMS OF TACROLIMUS 审中-公开
标题翻译：改良剂量剂型
公开(公告)号：WO2009022354A3
公开(公告)日：2009-04-09
申请号：PCT/IN2008000179
申请日：2008-03-25
申请人： PANACEA BIOTEC LTD , SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND , JAIN RAJESH
发明人： SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND , JAIN RAJESH
IPC分类号： A61K31/4745 , A61K9/22
CPC分类号： A61K9/146 , A61K9/1676 , A61K9/5078 , A61K9/5084 , A61K31/436
摘要： The present invention provides a modified release dosage form of tacrolimus that releases two or more amount of tacrolimus upon oral administration, the first amount of tacrolimus releases from the immediate release dosage unit substantially immediately within 0-2 hours followed by a time interval ranging from about 1-10 hours during which substantially no amount of tacrolimus is released from the dosage form, after which a second amount of tacrolimus is released wherein said second amount is released from the delayed release dosage unit either immediately e.g. within 0-2 hours or over a period of time ranging from about 2-12 hours from its initial release from the delayed release dosage unit. The dosage form may further comprise additional amount of tacrolimus to provide additional pulse of tacrolimus. The dosage forms of tacrolimus exhibit improved bioavailability and reduced flux or fluctuation over existing composition of tacrolimus. A method of preparing the dosage forms is also described.
摘要翻译：本发明提供了他克莫司的释放剂型，其口服给药释放两种或更多量的他克莫司，第一批量的他克莫司基本上立即在0-2小时内立即从立即释放剂量单位释放，之后是从约 1-10小时，其中基本上没有量的他克莫司从剂型中释放出来，之后第二量的他克莫司被释放，其中所述第二量从延迟释放剂量单位释放，在0-2小时内或超过延迟释放剂量单位从其初始释放约2-12小时的时间段内。剂型还可包含额外量的他克莫司以提供他克莫司的额外脉冲。他克莫司的剂型表现出改善的生物利用度和减少通量或波动超过现有组合的他克莫司。还描述了制备剂型的方法。

3. 发明申请

WO2008062429A3 PARTICLES FOR DELIVERY OF ACTIVE INGREDIENTS, PROCESS OF MAKING AND COMPOSITIONS THEREOF 审中-公开
标题翻译：用于递送活性成分的颗粒，其制备方法和组合物
公开(公告)号：WO2008062429A3
公开(公告)日：2008-11-13
申请号：PCT/IN2007000340
申请日：2007-08-10
申请人： PANACEA BIOTEC LTD , SINGH AMARJIT , SINGH SARABJIT , SINGH PARAMJIT , JAIN RAJESH
发明人： SINGH AMARJIT , SINGH SARABJIT , SINGH PARAMJIT , JAIN RAJESH
IPC分类号： B82B3/00 , A61K9/00 , A61K9/51 , A61K47/30
CPC分类号： A61K9/19 , A61K9/5115 , A61K9/5161 , A61K9/5192 , B82Y5/00
摘要： The present invention discloses compositions having particles comprising, inorganic element; one or more active ingredient and optionally a release rate modulating agent, suitable for the delivery of active ingredients to human and animal tissues. The particles are nanoparticles or microparticles or mixtures thereof, made preferably by sol-gel method. The compositions are useful for application to the topical or mucosal surfaces preferably in the form of creams, gels, lotions, dry powders, spray, foam and other suitable forms.
摘要翻译：本发明公开了具有包含无机元素的颗粒的组合物; 一种或多种活性成分和任选的释放速度调节剂，其适用于将活性成分递送至人和动物组织。颗粒是纳米颗粒或微颗粒或其混合物，优选通过溶胶 - 凝胶方法制备。该组合物可用于局部或粘膜表面，优选以霜剂，凝胶剂，洗剂，干粉剂，喷雾剂，泡沫剂和其它合适的形式施用。

4. 发明申请

WO2008068770A3 PHARMACEUTICAL COMPOSITION CONTAINING BICALUTAMIDE AND A METHOD FOR ITS USE 审中-公开
标题翻译：含有贝他丁胺的药物组合物及其使用方法
公开(公告)号：WO2008068770A3
公开(公告)日：2008-10-16
申请号：PCT/IN2007000274
申请日：2007-07-05
申请人： PANACEA BIOTEC LTD , SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND
发明人： SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND
IPC分类号： A61K31/277 , A61K31/10 , A61K31/167
CPC分类号： A61K31/10 , A61K9/2018 , A61K9/2846 , A61K9/2886 , A61K31/167
摘要： The invention refers to an oral bicalutamide-containing formulation with a modified release pattern. The composition is suitable for being administered in a twice-a-week, twice-a-week and once-a-week dosing schedule. The composition is used for producing an anti-androgenic effect.
摘要翻译：本发明涉及具有改良释放模式的口服比卡鲁胺制剂。该组合物适于以每周两次，每周两次和一周一次的给药方案施用。该组合物用于产生抗雄激素作用。

5. 发明申请

WO2008062440A3 PROGRAMMABLE BUOYANT DELIVERY TECHNOLOGY 审中-公开
标题翻译：可编程交付技术
公开(公告)号：WO2008062440A3
公开(公告)日：2008-07-31
申请号：PCT/IN2007000392
申请日：2007-09-03
申请人： PANACEA BIOTEC LTD , SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND , TANDALE RAJENDRA
发明人： SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND , TANDALE RAJENDRA
IPC分类号： A61K9/24 , A61K47/30
CPC分类号： A61K9/0065 , A61K9/2072 , A61K9/2086 , A61K9/209 , A61K9/2095 , A61K9/2886
摘要： The present invention is concerned with a system for spatially and temporally programmable delivery of an active agent. When administered orally, the System can be retained in the gastric region for a prolonged period of time. It comprises of a core (I), one or more layers (II, IV, V) coated over the core and a preformed hollow space (III). The invention also concerns with a process for preparation of the System and a method for treating/preventing diseases, by administering to a subject in need thereof, the System of the invention.
摘要翻译：本发明涉及用于活性剂的空间和时间可编程递送的系统。口服给药时，可以将系统长时间保留在胃区。它包括芯（I），涂覆在芯上的一层或多层（II，IV，V）和预成型的中空空间（III）。本发明还涉及通过向有需要的受试者施用本发明的系统来制备该系统的方法和一种治疗/预防疾病的方法。

6. 发明申请

WO2007125545A3 TRANSMUCOSAL COMPOSITION 审中-公开
标题翻译：转运组合物
公开(公告)号：WO2007125545A3
公开(公告)日：2008-02-21
申请号：PCT/IN2007000164
申请日：2007-04-25
申请人： PANACEA BIOTEC LTD , SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND
发明人： SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND
IPC分类号： A61K47/38 , A61K9/70 , A61K47/32 , A61M37/00
CPC分类号： A61K9/0056 , A61K9/006 , A61K9/2072 , A61K9/2086
摘要： The invention provides a composition for delivering active agents through transmucosal administration, more particularly through the buccal mucosa. The composition is a unique transmucosal disk (10) which has two compartments (14) and (18); the compartments consist of at least one active agent and at least one mucoadhesive agent and both the compartments are adapted to be in contact with the mucosal membrane. The invention also provides for transmucosal administration of an active agent and method of treatment of diseases in a subject in need of such treatment.
摘要翻译：本发明提供了一种用于通过经粘膜给药递送活性剂的组合物，更具体地通过颊粘膜递送。该组合物是独特的经粘膜盘（10），其具有两个隔间（14）和（18）; 隔室由至少一种活性剂和至少一种粘膜粘附剂组成，并且两个隔室都适于与粘膜接触。本发明还提供活性剂的经粘膜给药和治疗需要这种治疗的受试者的疾病的方法。

7. 发明申请

WO2007083323A3 MODIFIED RELEASE ORAL DOSAGE FORM COMPRISING DESMOPRESSIN 审中-公开
标题翻译：改进的释放口服剂型包含DESMOPRESSIN
公开(公告)号：WO2007083323A3
公开(公告)日：2007-10-18
申请号：PCT/IN2007000022
申请日：2007-01-19
申请人： PANACEA BIOTEC LTD , SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND
发明人： SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND
IPC分类号： A61K38/08 , A61K9/22 , A61K9/48
CPC分类号： A61K9/4808 , A61K9/1617 , A61K9/2853 , A61K9/2866 , A61K9/5084 , A61K38/11
摘要： The invention describes a modified release oral dosage form of desmopressin which upon administration releases two or more amounts of desmopressin. The dosage form comprises of individual dosage units, such as an immediate release dosage unit and one or more delayed release dosage units, each comprising of a suitable amount of desmopressin, released after a predetermined time interval. The dosage form of the invention provides a release profile, adapted such that the dosage form exhibits improved efficacy for a prolonged duration of action and provides for an overall superior management of antidiuretic therapy. The invention also provides for method of manufacture of the dosage form of the invention and also method of treatment of diseases such as diabetes insipidus, nocturnal enuresis, nocturia and urinary incontinence in a mammal in need of such treatment.
摘要翻译：本发明描述了去氨加压素的改良释放口服剂型，其在施用时释放出两种或更多量的去氨加压素。剂型包括单个剂量单位，例如立即释放剂量单位和一个或多个缓释剂量单位，每个剂量单位包含在预定时间间隔后释放的合适量的去氨加压素。本发明的剂型提供释放曲线，适于使得剂型在延长的作用时间内表现出改进的功效，并且提供抗利尿治疗的总体优越的管理。本发明还提供了在需要这种治疗的哺乳动物中制备本发明的剂型的方法以及治疗诸如尿崩症，夜间遗尿，夜尿和尿失禁的疾病的方法。

8. 发明申请

WO2007069272A3 PHARMACEUTICAL COMPOSITION COMPRISING AT LEAST ONE ANTICANCER DRUG AND AT LEAST ONE POLYMER 审中-公开
标题翻译：至少包含一种抗生素药物和至少一种聚合物的药物组合物
公开(公告)号：WO2007069272A3
公开(公告)日：2007-08-23
申请号：PCT/IN2006000427
申请日：2006-10-19
申请人： PANACEA BIOTEC LTD , SINGH AMARJIT , SINGH SARABJIT , GUPTA AJAY K , KULKARNI MANGESH M
发明人： SINGH AMARJIT , SINGH SARABJIT , GUPTA AJAY K , KULKARNI MANGESH M
IPC分类号： A61K45/08 , A61P35/00
CPC分类号： A61K9/5138 , A61K9/5153 , A61K9/5169
摘要： The present invention relates to novel and improved compositions of anticancer drugs, preferably taxanes, such as paclitaxel and docetaxel, their derivatives or their analogues, methods of manufacturing these compositions and methods of fractionating the particles in particular size range and methods of treating cancer patients with these compositions, which provide reduced chemotherapy-induced side-effects especially reduced chemotherapy-induced- alopecia. The composition is such that there is substantially no free drug in the said composition.
摘要翻译：本发明涉及抗癌药物，优选紫杉烷类，例如紫杉醇和多西紫杉醇，其衍生物或其类似物的新颖和改进的组合物，制备这些组合物的方法和将颗粒分级在特定尺寸范围内的方法以及治疗癌症患者的方法这些组合物提供降低的化学疗法诱导的副作用，特别是降低化学疗法诱发的脱发。所述组合物使得所述组合物中基本上不含游离药物。

9. 发明申请

WO0122917A3 EFFERVESCENT COMPOSITIONS COMPRISING NIMESULIDE 审中-公开
标题翻译：含有NIMESULIDE的高效组合物
公开(公告)号：WO0122917A3
公开(公告)日：2001-12-27
申请号：PCT/IN0000093
申请日：2000-09-27
申请人： PANACEA BIOTEC LTD , SINGH AMARJIT , JAIN RAJESH
发明人： SINGH AMARJIT , JAIN RAJESH
IPC分类号： A61K9/32 , A61K9/36 , A61K9/46 , A61K31/18 , A61K9/20 , A61K9/28
CPC分类号： A61K31/18 , A61K9/0007
摘要： An effervescent Pharmaceutical composition comprising the drug Nimesulide, one or more acids and one or more carbonate source wherein the ratio between Nimesulide and the total carbonate source is between 1:17 to 1:2 w/w.
摘要翻译：泡腾药物组合物，其包含药物尼美舒利，一种或多种酸和一种或多种碳酸酯源，其中尼美舒利与总碳酸酯源之比为1:17至1:2w / w。

10. 发明申请

WO0042987A3 TARGETED VESICULAR CONSTRUCTS FOR CYTOPROTECTION AND TREATMENT OF H. PYLORI INFECTIONS 审中-公开
标题翻译：靶向幽门螺杆菌感染的细胞构建及治疗
公开(公告)号：WO0042987A3
公开(公告)日：2000-11-02
申请号：PCT/IN0000004
申请日：2000-01-24
申请人： PANACEA BIOTEC LTD , SINGH AMARJIT , JAIN RAJESH
发明人： SINGH AMARJIT , JAIN RAJESH
IPC分类号： A61K47/44 , A61K9/127 , A61K31/341 , A61K31/4164 , A61K31/43 , A61K31/4439 , A61K31/65 , A61K31/7048 , A61K33/24 , A61K45/00 , A61K47/28 , A61K47/42 , A61P1/04 , A61P31/04
CPC分类号： A61K9/1271
摘要： A novel composition for targeted vesicular constructs for treatment of H. pylori infections and for protection of the cell is disclosed. The composition comprises lectins, phospholipids sterols and one or more drugs. The composition is useful since not only it treats h. pylori infections and other diseases associated therewith but also helps in protection of the cell walls.
摘要翻译：公开了用于治疗幽门螺杆菌感染和保护细胞的靶向泡状构建体的新型组合物。该组合物包含凝集素，磷脂甾醇和一种或多种药物。该组合物是有用的，因为它不仅处理h。幽门感染和与之相关的其他疾病，但也有助于保护细胞壁。

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