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1. 发明申请

WO2008062429A3 PARTICLES FOR DELIVERY OF ACTIVE INGREDIENTS, PROCESS OF MAKING AND COMPOSITIONS THEREOF 审中-公开
标题翻译：用于递送活性成分的颗粒，其制备方法和组合物
公开(公告)号：WO2008062429A3
公开(公告)日：2008-11-13
申请号：PCT/IN2007000340
申请日：2007-08-10
申请人： PANACEA BIOTEC LTD , SINGH AMARJIT , SINGH SARABJIT , SINGH PARAMJIT , JAIN RAJESH
发明人： SINGH AMARJIT , SINGH SARABJIT , SINGH PARAMJIT , JAIN RAJESH
IPC分类号： B82B3/00 , A61K9/00 , A61K9/51 , A61K47/30
CPC分类号： A61K9/19 , A61K9/5115 , A61K9/5161 , A61K9/5192 , B82Y5/00
摘要： The present invention discloses compositions having particles comprising, inorganic element; one or more active ingredient and optionally a release rate modulating agent, suitable for the delivery of active ingredients to human and animal tissues. The particles are nanoparticles or microparticles or mixtures thereof, made preferably by sol-gel method. The compositions are useful for application to the topical or mucosal surfaces preferably in the form of creams, gels, lotions, dry powders, spray, foam and other suitable forms.
摘要翻译：本发明公开了具有包含无机元素的颗粒的组合物; 一种或多种活性成分和任选的释放速度调节剂，其适用于将活性成分递送至人和动物组织。颗粒是纳米颗粒或微颗粒或其混合物，优选通过溶胶 - 凝胶方法制备。该组合物可用于局部或粘膜表面，优选以霜剂，凝胶剂，洗剂，干粉剂，喷雾剂，泡沫剂和其它合适的形式施用。

2. 发明申请

WO2010106557A3 STABLE PHARMACEUTICAL FORMULATIONS COMPRISING ANHYDROUS LANTHANUM CARBONATE AND PROCESS FOR PREPARATION THEREOF 审中-公开
标题翻译：包含无机碳酸锰的稳定药物制剂及其制备方法
公开(公告)号：WO2010106557A3
公开(公告)日：2011-03-10
申请号：PCT/IN2010000163
申请日：2010-03-19
申请人： PANACEA BIOTEC LTD , JAIN RAJESH , SINGH SARABJIT , SINGH PARAMJIT , SINGH PIRTHI PAL
发明人： JAIN RAJESH , SINGH SARABJIT , SINGH PARAMJIT , SINGH PIRTHI PAL
IPC分类号： A01N59/16 , A61K33/24
CPC分类号： A61K33/24 , A61K9/0056 , A61K9/2054
摘要： The present invention discloses the premix pharmaceutical formulation comprising anhydrous lanthanum carbonate. The present invention further relates to a stable pharmaceutical formulation comprising a therapeutically effective amount of anhydrous lanthanum carbonate and pharmaceutically acceptable carrier and/or excipients, with the proviso that the said formulation is substantially free of monosaccharides or disaccharides. Further the said formulation is substantially free of amino acids and/or stabilizers. The process of preparing such formulations is also described.
摘要翻译：本发明公开了包含无水碳酸镧的预混药物制剂。本发明还涉及包含治疗有效量的无水碳酸镧和药学上可接受的载体和/或赋形剂的稳定药物制剂，条件是所述制剂基本上不含单糖或二糖。此外，所述制剂基本上不含氨基酸和/或稳定剂。还描述了制备这种制剂的方法。

3. 发明申请

WO2009022354A3 MODIFIED DOSAGE FORMS OF TACROLIMUS 审中-公开
标题翻译：改良剂量剂型
公开(公告)号：WO2009022354A3
公开(公告)日：2009-04-09
申请号：PCT/IN2008000179
申请日：2008-03-25
申请人： PANACEA BIOTEC LTD , SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND , JAIN RAJESH
发明人： SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND , JAIN RAJESH
IPC分类号： A61K31/4745 , A61K9/22
CPC分类号： A61K9/146 , A61K9/1676 , A61K9/5078 , A61K9/5084 , A61K31/436
摘要： The present invention provides a modified release dosage form of tacrolimus that releases two or more amount of tacrolimus upon oral administration, the first amount of tacrolimus releases from the immediate release dosage unit substantially immediately within 0-2 hours followed by a time interval ranging from about 1-10 hours during which substantially no amount of tacrolimus is released from the dosage form, after which a second amount of tacrolimus is released wherein said second amount is released from the delayed release dosage unit either immediately e.g. within 0-2 hours or over a period of time ranging from about 2-12 hours from its initial release from the delayed release dosage unit. The dosage form may further comprise additional amount of tacrolimus to provide additional pulse of tacrolimus. The dosage forms of tacrolimus exhibit improved bioavailability and reduced flux or fluctuation over existing composition of tacrolimus. A method of preparing the dosage forms is also described.
摘要翻译：本发明提供了他克莫司的释放剂型，其口服给药释放两种或更多量的他克莫司，第一批量的他克莫司基本上立即在0-2小时内立即从立即释放剂量单位释放，之后是从约 1-10小时，其中基本上没有量的他克莫司从剂型中释放出来，之后第二量的他克莫司被释放，其中所述第二量从延迟释放剂量单位释放，在0-2小时内或超过延迟释放剂量单位从其初始释放约2-12小时的时间段内。剂型还可包含额外量的他克莫司以提供他克莫司的额外脉冲。他克莫司的剂型表现出改善的生物利用度和减少通量或波动超过现有组合的他克莫司。还描述了制备剂型的方法。

4. 发明申请

WO2009050726A3 COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF BUPROPION 审中-公开
标题翻译：用于改进交付运输的组合物和方法
公开(公告)号：WO2009050726A3
公开(公告)日：2009-06-25
申请号：PCT/IN2008000337
申请日：2008-05-28
申请人： PANACEA BIOTEC LTD , SINGH AMARJIT , SINGH SARABJIT , PRASAD KORLAKUNTE , JAIN RAJESH
发明人： SINGH AMARJIT , SINGH SARABJIT , PRASAD KORLAKUNTE , JAIN RAJESH
IPC分类号： A61K9/50 , A61K9/16 , A61K31/137
CPC分类号： A61K31/137 , A61K9/0043 , A61K9/141 , A61K9/48 , A61K9/5021
摘要： The present invention provides a pharmaceutical composition comprising micronized bupropion having controlled particle size in the range between 1-60 µm. The pharmaceutical composition of the present invention comprises micronized bupropion having median particle size less than 40 micron, which exhibits outstanding bioavailability via nasal and pulmonary route even without any need for blending the micronized bupropion with large carrier particles. The composition of the present invention comprises micronized bupropion -and one or more pharmaceutically acceptable carriers, surfactants, a dispersing agents, or dispersants, which can be administered in an aerosol formulation as a dry powder for nasal and pulmonary inhalation. Particularly, the composition of the present invention for nasal delivery comprises bioadhesive microparticles of bupropion and carbohydrates like pullulan to prevent and treat diseases such as depression, premenstrual syndrome, premature ejaculation and as an aid to smoking cessation. The invention also provides a process of preparing the compositions of the present invention.
摘要翻译：本发明提供一种药物组合物，其包含微粒化的安非他酮，其控制粒度在1-60μm之间。本发明的药物组合物包含中值粒度小于40微米的微粉化安非他酮，即使不需要将微粉化的安非他酮与大载体颗粒混合，也可以通过鼻和肺途径表现出优异的生物利用度。本发明的组合物包含微粉化的安非他酮和一种或多种药学上可接受的载体，表面活性剂，分散剂或分散剂，其可以作为用于鼻吸入和肺部吸入的干粉在气溶胶制剂中施用。特别地，用于鼻腔输送的本发明的组合物包括安非他酮的生物粘附微粒和诸如支链淀粉的碳水化合物，以预防和治疗诸如抑郁症，经前期综合征，早泄以及作为戒烟的辅助之类的疾病。本发明还提供了制备本发明组合物的方法。

5. 发明申请

WO2012098562A3 LIQUID ORAL COMPOSITIONS OF LANTHANUM SALTS 审中-公开
标题翻译：镧盐的液体口服组合物
公开(公告)号：WO2012098562A3
公开(公告)日：2012-11-29
申请号：PCT/IN2012000041
申请日：2012-01-17
申请人： PANACEA BIOTEC LTD , JAIN RAJESH , SINGH SARABJIT , SINGH PARAMJIT , SINGH PIRTHI PAL
发明人： JAIN RAJESH , SINGH SARABJIT , SINGH PARAMJIT , SINGH PIRTHI PAL
IPC分类号： A61K33/24 , A61K9/00 , A61K47/02 , A61K47/14 , A61K47/26 , A61K47/38 , A61P3/12
CPC分类号： A61K9/0053 , A61K9/0095 , A61K33/24 , A61K47/02 , A61K47/14 , A61K47/26 , A61K47/38
摘要： The present invention relates to liquid oral pharmaceutical compositions of lanthanum and its pharmaceutically acceptable salts thereof. The present invention further relates to preparation of liquid oral pharmaceutical compositions of lanthanum and its salts and also provides use of such compositions in treating hyperphosphatemia in patients.
摘要翻译：本发明涉及镧及其药学上可接受的盐的液体口服药物组合物。本发明进一步涉及制备镧及其盐的液体口服药物组合物，并且还提供了这种组合物在治疗患者中的高磷酸盐血症中的用途。

6. 发明申请

WO2012053006A8 IMPROVED ORAL FAST DISSOLVING FILMS COMPRISING COMBINATION OF POLYMERS AND METHOD OF PREPARATION THEREOF 审中-公开
标题翻译：改进的口服快速溶解膜包含聚合物的组合及其制备方法
公开(公告)号：WO2012053006A8
公开(公告)日：2012-05-24
申请号：PCT/IN2011000715
申请日：2011-10-17
申请人： PANACEA BIOTEC LTD , JAIN RAJESH , SINGH SARABJIT , SINGH PARAMJIT , SAILDESAI MANSI
发明人： JAIN RAJESH , SINGH SARABJIT , SINGH PARAMJIT , SAILDESAI MANSI
IPC分类号： A61K9/70
CPC分类号： A61K9/0056 , A61K47/38
摘要： The invention relates to an oral film having reduced adherence to oral cavity comprising water-soluble polymer as an essential polymer base in combination with film former, wherein the ratio of water-soluble polymer to the film former is about 25: 1 to about 250: 1 that is suitable for delivering drugs from various pharmacological categories ranging from conventional small molecules to proteins or peptides. In particular the invention relates to oral films which are bioequivalent to conventional immediate release oral dosage forms and exhibiting one or more favorable properties such as fast dissolution time, improved drug loading, improved mechanical properties (burst strength, tensile strength, modules of elongation).
摘要翻译：本发明涉及具有降低的口腔粘附性的口腔膜，其包含与成膜剂组合的作为必需聚合物基质的水溶性聚合物，其中水溶性聚合物与成膜剂的比例为约25:1至约250:1。 1适用于从常规小分子到蛋白质或肽的各种药理学类别递送药物。特别地，本发明涉及与常规立即释放口服剂型生物等效的口腔膜，并且具有一种或多种有利的性质，例如快速溶解时间，改进的药物负载，改进的机械性能（爆裂强度，拉伸强度，伸长模量）。

7. 发明申请

WO2012053006A2 IMPROVED ORAL FAST DISSOLVING FILMS COMPRISING COMBINATION OF POLYMERS AND METHOD OF PREPARATION THEREOF 审中-公开
标题翻译：改进的包含聚合物组合的口腔快速溶解膜及其制备方法
公开(公告)号：WO2012053006A2
公开(公告)日：2012-04-26
申请号：PCT/IN2011000715
申请日：2011-10-17
申请人： PANACEA BIOTEC LTD , JAIN RAJESH , SINGH SARABJIT , SINGH PARAMJIT , SAILDESAI MANSI
发明人： JAIN RAJESH , SINGH SARABJIT , SINGH PARAMJIT , SAILDESAI MANSI
IPC分类号： A61K9/70
CPC分类号： A61K9/0056 , A61K47/38
摘要： The invention relates to an oral film having reduced adherence to oral cavity comprising water-soluble polymer as an essential polymer base in combination with film former, wherein the ratio of water-soluble polymer to the film former is about 25: 1 to about 250: 1 that is suitable for delivering drugs from various pharmacological categories ranging from conventional small molecules to proteins or peptides. In particular the invention relates to oral films which are bioequivalent to conventional immediate release oral dosage forms and exhibiting one or more favorable properties such as fast dissolution time, improved drug loading, improved mechanical properties (burst strength, tensile strength, modules of elongation).
摘要翻译：本发明涉及一种口腔膜，其对口腔粘附性降低，其包含水溶性聚合物作为与成膜剂结合的基本聚合物基质，其中水溶性聚合物与成膜剂的比例为约25:1至约250:1。 1，适用于从常规小分子到蛋白质或多肽的各种药理学类别递送药物。具体地说，本发明涉及与常规立即释放口服剂型生物等效并表现出一种或多种有利特性如快速溶解时间，改善药物负载，改进机械特性（爆裂强度，拉伸强度，伸长模块）的口服薄膜。

8. 发明申请

WO2008068770A3 PHARMACEUTICAL COMPOSITION CONTAINING BICALUTAMIDE AND A METHOD FOR ITS USE 审中-公开
标题翻译：含有贝他丁胺的药物组合物及其使用方法
公开(公告)号：WO2008068770A3
公开(公告)日：2008-10-16
申请号：PCT/IN2007000274
申请日：2007-07-05
申请人： PANACEA BIOTEC LTD , SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND
发明人： SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND
IPC分类号： A61K31/277 , A61K31/10 , A61K31/167
CPC分类号： A61K31/10 , A61K9/2018 , A61K9/2846 , A61K9/2886 , A61K31/167
摘要： The invention refers to an oral bicalutamide-containing formulation with a modified release pattern. The composition is suitable for being administered in a twice-a-week, twice-a-week and once-a-week dosing schedule. The composition is used for producing an anti-androgenic effect.
摘要翻译：本发明涉及具有改良释放模式的口服比卡鲁胺制剂。该组合物适于以每周两次，每周两次和一周一次的给药方案施用。该组合物用于产生抗雄激素作用。

9. 发明申请

WO2008062440A3 PROGRAMMABLE BUOYANT DELIVERY TECHNOLOGY 审中-公开
标题翻译：可编程交付技术
公开(公告)号：WO2008062440A3
公开(公告)日：2008-07-31
申请号：PCT/IN2007000392
申请日：2007-09-03
申请人： PANACEA BIOTEC LTD , SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND , TANDALE RAJENDRA
发明人： SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND , TANDALE RAJENDRA
IPC分类号： A61K9/24 , A61K47/30
CPC分类号： A61K9/0065 , A61K9/2072 , A61K9/2086 , A61K9/209 , A61K9/2095 , A61K9/2886
摘要： The present invention is concerned with a system for spatially and temporally programmable delivery of an active agent. When administered orally, the System can be retained in the gastric region for a prolonged period of time. It comprises of a core (I), one or more layers (II, IV, V) coated over the core and a preformed hollow space (III). The invention also concerns with a process for preparation of the System and a method for treating/preventing diseases, by administering to a subject in need thereof, the System of the invention.
摘要翻译：本发明涉及用于活性剂的空间和时间可编程递送的系统。口服给药时，可以将系统长时间保留在胃区。它包括芯（I），涂覆在芯上的一层或多层（II，IV，V）和预成型的中空空间（III）。本发明还涉及通过向有需要的受试者施用本发明的系统来制备该系统的方法和一种治疗/预防疾病的方法。

10. 发明申请

WO2007125545A3 TRANSMUCOSAL COMPOSITION 审中-公开
标题翻译：转运组合物
公开(公告)号：WO2007125545A3
公开(公告)日：2008-02-21
申请号：PCT/IN2007000164
申请日：2007-04-25
申请人： PANACEA BIOTEC LTD , SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND
发明人： SINGH AMARJIT , SINGH SARABJIT , PUTHLI SHIVANAND
IPC分类号： A61K47/38 , A61K9/70 , A61K47/32 , A61M37/00
CPC分类号： A61K9/0056 , A61K9/006 , A61K9/2072 , A61K9/2086
摘要： The invention provides a composition for delivering active agents through transmucosal administration, more particularly through the buccal mucosa. The composition is a unique transmucosal disk (10) which has two compartments (14) and (18); the compartments consist of at least one active agent and at least one mucoadhesive agent and both the compartments are adapted to be in contact with the mucosal membrane. The invention also provides for transmucosal administration of an active agent and method of treatment of diseases in a subject in need of such treatment.
摘要翻译：本发明提供了一种用于通过经粘膜给药递送活性剂的组合物，更具体地通过颊粘膜递送。该组合物是独特的经粘膜盘（10），其具有两个隔间（14）和（18）; 隔室由至少一种活性剂和至少一种粘膜粘附剂组成，并且两个隔室都适于与粘膜接触。本发明还提供活性剂的经粘膜给药和治疗需要这种治疗的受试者的疾病的方法。

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