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1. 发明申请

WO1997045367A1 DISSOLVABLE OXIDES FOR BIOLOGICAL APPLICATIONS 审中-公开
标题翻译：用于生物应用的不溶性氧化物
公开(公告)号：WO1997045367A1
公开(公告)日：1997-12-04
申请号：PCT/FI1997000330
申请日：1997-05-29
申请人： ORION-YHTYMÄ OY , BIOXID OY , AHOLA, Manja , FAGERHOLM, Heidi , KANGASNIEMI, Ilkka , KIESVAARA, Juha , KORTESUO, Pirjo , KURKELA, Kauko , SAARINEN, Niilo , YLI-URPO, Antti
发明人： ORION-YHTYMÄ OY , BIOXID OY
IPC分类号： C01B33/16
CPC分类号： A61K9/0019 , A61K9/06 , A61K9/1676 , A61K47/02 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/02 , A61L27/10 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/30 , A61L2300/416 , A61L2300/43 , A61L2300/602 , A61L2300/64 , C01B33/163
摘要： The present invention is concerned with controllably dissolvable silica-xerogels prepared via sol-gel process and their use. Specifically, the invention is concerned with a delivery device comprising controllably dissolvable silica-xerogel into which structure a biologically active agent is incorporated. The invention is further concerned with pharmaceutical preparations comprising said delivery device. Further, the invention is directed to medical devices for orthopedic and surgical purposes comprising controllably dissolvable silica-xerogels, which may further comprise a biologically active agent.
摘要翻译：本发明涉及通过溶胶 - 凝胶法制备的可控地溶解的二氧化硅干凝胶及其用途。具体地，本发明涉及包含可控制地溶解的二氧化硅干凝胶的输送装置，其中结合有生物活性剂。本发明还涉及包含所述递送装置的药物制剂。此外，本发明涉及用于矫形和外科用途的医疗装置，其包括可控制地溶解的二氧化硅干凝胶，其可以进一步包含生物活性剂。

2. 发明申请

WO1992000109A1 BIOCERAMIC SYSTEM FOR DELIVERY OF BIOACTIVE COMPOUNDS 审中-公开
标题翻译：用于输送生物化合物的生物体系
公开(公告)号：WO1992000109A1
公开(公告)日：1992-01-09
申请号：PCT/FI1991000196
申请日：1991-06-24
申请人： ORION-YHTYMÄ OY , YLI-URPO, Antti, Uuno, Uolevi , JALONEN, Harry, Gösta , KURKELA, Kauko, Oiva, Antero
发明人： ORION-YHTYMÄ OY
IPC分类号： A61L25/00
CPC分类号： A61K9/0024 , A61K9/2009 , C03C4/0007
摘要： A bioceramic system for delivery of a bioactive compound, which comprises a combination of bioactive glass, bioactive glass ceramic or bioactive ceramic, hydroxyapatite, optionally one or more other calcium phosphate compound and optionally a matrix, may incorporate in the bioceramic system a bioactive compound. The timing of the release of the bioactive compound or compounds can be regulated as desired, and depends on the conditions of the surrounding, the composition of the bioceramic system and the method of preparation of the bioceramic system.

3. 发明申请

WO1993011757A1 DRUG FORMULATIONS FOR PARENTERAL USE 审中-公开
标题翻译：用于家庭用药的药物制剂
公开(公告)号：WO1993011757A1
公开(公告)日：1993-06-24
申请号：PCT/FI1992000339
申请日：1992-12-10
申请人： ORION-YHTYMÄ OY , JALONEN, Harry, Gösta , HEIKKILÄ, Terttu, Marita , JALONEN, Hannu, Uolevi , KANGAS, Lauri, Veikko, Matti , LAMMINTAUSTA, Risto, Arvo, Sakari , KURKELA, Kauko, Oiva, Antero
发明人： ORION-YHTYMÄ OY
IPC分类号： A61K31/135
CPC分类号： A61K9/1075 , A61K9/127 , A61K31/135 , A61K47/6951 , B82Y5/00
摘要： This invention relates to parenteral preparations of antiestrogens such as toremifene, desmethyl toremifene, tamoxifen or desmethyltamoxifen. The preparations can be emulsions, liposomes or aqueous solutions of cyclodextrin-drug complexes. Particularly the invention relates to a parenteral drug formulation comprising a complex having a 2-hydroxypropyl cyclodextrin component and including an active drug substance selected from the group consisting of toremifene, desmethyl toremifene, tamoxifen and desmethyltamoxifen or a pharmaceutically acceptable non-toxic salt thereof, said complex being present either in an aqueous solution or emulsion or loaded into a liposome.
摘要翻译：本发明涉及抗雌激素如托瑞米芬，去甲基托瑞米芬，他莫昔芬或去甲基他莫昔芬的肠胃外制剂。制剂可以是乳糖，脂质体或环糊精 - 药物复合物的水溶液。特别地，本发明涉及包含具有2-羟丙基环糊精组分并且包括选自托瑞米芬，去甲基托瑞米芬，他莫昔芬和去甲基他莫昔芬或其药学上可接受的无毒盐的活性药物的肠胃外药物制剂，所述复合物以水溶液或乳液存在或加载到脂质体中。

4. 发明申请

WO1993019746A1 TOPICAL ADMINISTRATION OF TOREMIFENE AND ITS METABOLITES 审中-公开
标题翻译：。E。。。。。。。。。。。。。。。。
公开(公告)号：WO1993019746A1
公开(公告)日：1993-10-14
申请号：PCT/FI1993000119
申请日：1993-03-25
申请人： ORION-YHTYMÄ OY , DEGREGORIO, Michael, William , KURKELA, Kauko, Oiva, Antero
发明人： ORION-YHTYMÄ OY
IPC分类号： A61K31/135
CPC分类号： B82Y5/00 , A61K31/135 , A61K47/6951 , Y10S514/937 , Y10S514/944 , Y10S514/969
摘要： Topical preparations containing as active ingredient toremifene or one of its metabolites N-demethyltoremifene or 4-hydroxy-toremifene or their pharmaceutically acceptable non-toxic salts are useful for the treatment of cancers localized in the skin or on a short distance from the skin such as metastatic lesions of breast cancer. They may also be used in adjuvant therapy of breast cancer and in the reversal of multidrug resistance of cancer cells to cytotoxic drugs. Such topical preparations are of particular interest in the treatment of melanoma, lymphoma, Kaposi's sarcoma and fungoides mycosis.
摘要翻译：含有作为活性成分托瑞米芬或其一种代谢物N-去甲基托美芬或4-羟基托瑞米芬或其药学上可接受的无毒盐的局部制剂可用于治疗局部在皮肤中或距皮肤短距离的癌症，例如乳腺癌转移性病变。它们也可用于乳腺癌的辅助治疗和癌细胞对细胞毒性药物的多重耐药性的逆转。这种局部制剂在治疗黑素瘤，淋巴瘤，卡波西氏肉瘤和fungoides真菌病方面特别有意义。

5. 发明申请

WO1997048492A1 STOPPER HAVING A CAVITY FOR REAGENTS AND AN ASSAY METHOD USING SAID STOPPER 审中-公开
标题翻译：具有试剂盒的停止剂和使用停止剂的测定方法
公开(公告)号：WO1997048492A1
公开(公告)日：1997-12-24
申请号：PCT/FI1997000388
申请日：1997-06-18
申请人： ORION-YHTYMÄ OY , LUOTOLA, Juhani , BACKMAN, Henry , HELLMAN, Tapani , KAHMA, Kauko , KAPLAS, Antti
发明人： ORION-YHTYMÄ OY
IPC分类号： B01L03/14
CPC分类号： B65D51/2871 , B01L3/50825
摘要： The invention relates to a closure device and a method for performing an assay of a sample using the closure device. The closure device, mountable on the mouth of a test vessel, comprises a body part (1) with an axially passing cylindrical bore. The bore is covered at one end with an openable lid (7). The closure device further includes a plunger (3), slidably mounted in the bore for the formation of a sealed reagent storage chamber (9) in the space remaining between the closed lid and the plunger. The inner wall of the bore (2) is provided with at least one groove (4), whose depth is so deep as not to be within the reach of the outer diameter of the plunger (3). The groove extends from exterior end of the bore, over such a length as to maintain a gas flow communication between said reagent storage chamber (9) and the exterior end of the cylindrical bore when the plunger (3) is in a partially inserted position. In the assay method according to the invention, the reagent is added from the closure into the test vessel containing the sample.
摘要翻译：本发明涉及一种闭合装置和使用封闭装置进行样品测定的方法。可安装在测试容器的口部上的封闭装置包括具有轴向通过的圆柱形孔的主体部分（1）。孔的一端用可打开的盖（7）覆盖。闭合装置还包括可滑动地安装在孔中的柱塞（3），用于在保持在闭合盖和柱塞之间的空间中形成密封的试剂储存室（9）。孔（2）的内壁设置有至少一个凹槽（4），其深度非常深，不会在柱塞（3）的外径范围内。所述槽从所述孔的外端延伸超过所述长度，以便当所述柱塞（3）处于部分插入位置时，保持所述试剂储存室（9）与所述圆柱形孔的外端之间的气流连通。在根据本发明的测定方法中，将试剂从封闭物加入到含有样品的测试容器中。

6. 发明申请

WO1997015302A1 PHARMACEUTICAL COMPOSITIONS OF LEVO-ENANTIOMERS OF MEDETOMIDINE DERIVATIVES AND THEIR USE 审中-公开
标题翻译：药物衍生物精神病药物的药物组合物及其用途
公开(公告)号：WO1997015302A1
公开(公告)日：1997-05-01
申请号：PCT/FI1996000560
申请日：1996-10-23
申请人： ORION-YHTYMÄ OY , ÅKERMAN, Karl, E., O. , JANSSON, Christian , KUKKONEN, Jyrki , SAVOLA, Juha-Matti , WURSTER, Siegfried , COCKCROFT, Victor
发明人： ORION-YHTYMÄ OY
IPC分类号： A61K31/415
CPC分类号： A61K31/4164
摘要： The levo-isomers of certain imidazole derivatives, particularly medetomidine, have been found to be inverse agonists of adrenergic alpha -2 receptors and are therefore useful in the prevention or treatment of conditions associated with overexpression or hypersensitization of adrenergic alpha -2 receptors such as obesity, a withdrawal symptom to an adrenergic alpha -2 receptor agonist, a neurological disorder, multiple system atrophy, diabetes mellitus, benign prostatic hyperplasia and drug-induced sensitization of adrenergic alpha -2 receptors. The pharmaceutical composition is preferably transdermal.
摘要翻译：已经发现某些咪唑衍生物，特别是美托咪定的左旋异构体是肾上腺素α-2受体的反向激动剂，因此可用于预防或治疗与肾上腺素α-2受体例如肥胖的过度表达或过敏相关的病症，肾上腺素α2受体激动剂，神经系统疾病，多系统萎缩，糖尿病，良性前列腺增生和药物诱导的肾上腺素α-2受体致敏的戒断症状。药物组合物优选为透皮的。

7. 发明申请

WO1996023545A1 CONNECTING ELEMENT 审中-公开
标题翻译：连接元件
公开(公告)号：WO1996023545A1
公开(公告)日：1996-08-08
申请号：PCT/FI1996000064
申请日：1996-02-02
申请人： ORION-YHTYMÄ OY , HÄMÄLÄINEN, Risto , NIEMI, Jukka , RANTALA, Mauri
发明人： ORION-YHTYMÄ OY
IPC分类号： A61M39/12
CPC分类号： A61J1/10
摘要： The invention relates to a port assembly intended for being secured to the wall membrane of an infusion fluid bag, the assembly having a base section (1) securable to the wall membrane; an administration port (2) and a medicament-adding port (3), which adjoin the base section; and a fold (4) of the base section, which divides the base section into two halves and allows the halves to fold against each other. When secured to an infusion fluid bag, the port assembly will follow the flattening shape of the emptying bag, and the bag will empty to maximal completion.
摘要翻译：本发明涉及一种用于固定到输注液体袋的壁膜的端口组件，该组件具有可固定在壁膜上的基部（1）; 管理端口（2）和与基部相邻的药物添加口（3）; 以及基部的折叠部分（4），其将基部分成两半，并允许一半彼此折叠。当固定到输液袋时，端口组件将遵循排空袋的扁平形状，并且袋将空出以最大化完成。

8. 发明申请

WO1996009274A1 NEW METHOD FOR THE PREPARATION OF 3,4-DIHYDROXY-5-NITROBENZALDEHYDE 审中-公开
标题翻译：制备3,4-二羟基-5-硝基苯甲醛的新方法
公开(公告)号：WO1996009274A1
公开(公告)日：1996-03-28
申请号：PCT/FI1995000513
申请日：1995-09-20
申请人： ORION-YHTYMÄ OY , BÄCKSTRÖM, Reijo, Johannes
发明人： ORION-YHTYMÄ OY
IPC分类号： C07C205/44
CPC分类号： C07C201/12 , C07C201/16 , C07C205/44
摘要： The invention provides a method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde by reacting 3-ethoxy-4-hydroxy-5-nitrobenzaldehyde with a reagent comprising zinc chloride, water and hydrogen chloride.
摘要翻译：本发明提供通过使3-乙氧基-4-羟基-5-硝基苯甲醛与包含氯化锌，水和氯化氢的试剂反应来制备3,4-二羟基-5-硝基苯甲醛的方法。

9. 发明申请

WO1995031237A1 POWDER INHALER 审中-公开
标题翻译：粉末吸入器
公开(公告)号：WO1995031237A1
公开(公告)日：1995-11-23
申请号：PCT/FI1995000247
申请日：1995-05-10
申请人： ORION-YHTYMÄ OY , HYPPÖLÄ, Jukka
发明人： ORION-YHTYMÄ OY
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M2202/064
摘要： This device is intended for the dispensing of a powdered medication by inhalation. The device includes a powder container (1), an air channel (2), and a metering strip (4) equipped with a dosing recess (3). The metering strip (4) can be moved along a flat surface (5) from a filling position, in which the dosing recess (3) is filled with powder coming from the container (1), to an inhalation position, in which the dosing recess (3) is in the air channel (2).
摘要翻译：该装置用于通过吸入分配粉末状药物。该装置包括粉末容器（1），空气通道（2）和配备有计量凹槽（3）的计量带（4）。计量带（4）可以从填充位置沿着平坦表面（5）移动，其中计量凹槽（3）被填充有来自容器（1）的粉末到达吸入位置，其中给药凹槽（3）在空气通道（2）中。

10. 发明申请

WO1993021921A1 ANTI-ISCHEMIC MEDICAMENT 审中-公开
标题翻译：抗化学药物
公开(公告)号：WO1993021921A1
公开(公告)日：1993-11-11
申请号：PCT/FI1993000191
申请日：1993-05-05
申请人： ORION-YHTYMÄ OY , HAIKALA, Heimo, Olavi , LEVIJOKI, Jouko, Michael , BÄCKSTRÖM, Reijo, Johannes , NORE, Pentti, Tapio , HONKANEN, Erkki, Juhani
发明人： ORION-YHTYMÄ OY
IPC分类号： A61K31/50
CPC分类号： A61K31/50
摘要： [[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile which has been previously suggested for the treatment of congestive heart failure is useful in the treatment of myocardial ischemia.

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