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1. 发明申请

WO1991017244A1 AN ENZYME CAPABLE OF DEGRADING CELLULOSE OR HEMICELLULOSE 审中-公开
标题翻译：可降解纤维素或细胞纤维素的酶
公开(公告)号：WO1991017244A1
公开(公告)日：1991-11-14
申请号：PCT/DK1991000124
申请日：1991-05-08
申请人： NOVO NORDISK A/S , WÖLDIKE, Helle, Fabricius , HAGEN, Fred , HJORT, Carsten, Mailand , HASTRUP, Sven
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/42
CPC分类号： C12N9/2437 , C12Y302/01004 , C12Y302/01091
摘要： A cellulose- or hemicellulose-degrading enzyme which is derivable from a fungus other than Trichoderma or Phanerochaete, and which comprises a carbohydrate binding domain homologous to a terminal A region of Trichoderma reesei cellulases, which carbohydrate binding domain comprises amino acid sequence ( alpha ) or a subsequence thereof capable of effecting binding of the enzyme to an insoluble cellulosic or hemicellulosic substrate.
摘要翻译：可衍生自木霉属或Phanerochaete以外的真菌的纤维素或半纤维素降解酶，其包含与里氏木霉纤维素酶的末端A区同源的碳水化合物结合结构域，所述碳水化合物结合结构域包含氨基酸序列（α）或其能够实现酶与不溶性纤维素或半纤维素基质的结合的亚序列。

2. 发明申请

WO1991017243A1 A CELLULASE PREPARATION COMPRISING AN ENDOGLUCANASE ENZYME 审中-公开
标题翻译：包含内切葡聚糖酶的细胞培养基制备
公开(公告)号：WO1991017243A1
公开(公告)日：1991-11-14
申请号：PCT/DK1991000123
申请日：1991-05-08
申请人： NOVO NORDISK A/S , RASMUSSEN, Grethe , MIKKELSEN, Jan, Moller , SCHÜLEIN, Martin , PATKAR, Shamkant, Anant , HAGEN, Fred , HJORT, Carsten, Mailand , HASTRUP, Sven
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/42
CPC分类号： C12Q1/6895 , C11D3/38645 , C12N9/2437 , C12N15/80 , C12Y302/01004 , C12Y302/01039 , C12Y302/01091 , D06M16/003 , D06P5/137 , D06P5/158 , D21H17/005 , D21H21/10
摘要： A cellulase preparation consisting essentially of a homogeneous endoglucanase component which is immunoreactive with an antibody raised against a highly purified SIMILAR 43kD endoglucanase derived from Humicola insolens, DSM 1800, or which is homogeneous to said SIMILAR 43kD endoglucanase, may be employed in the treatment cellulose-containing fabrics for harshness reduction or colour clarification or to provide a localized variation in the colour of such fabrics, or it may be employed in the treatment of paper pulp.
摘要翻译：基本上由均匀内切葡聚糖酶组分组成的纤维素酶制剂可用于处理纤维素酶，其与针对来自Humicola insolens DSM 1800的高度纯化的SIMILAR 43kD内切葡聚糖抗体产生免疫反应，或与所述SIMILAR 43kD内切葡聚糖酶相同的抗体，包含用于粗糙度降低或颜色澄清的织物或提供这种织物的颜色的局部变化，或者它可以用于纸浆的处理。

3. 发明申请

WO1996006861A1 TREFOIL PEPTIDE DIMER 审中-公开
公开(公告)号：WO1996006861A1
公开(公告)日：1996-03-07
申请号：PCT/DK1995000343
申请日：1995-08-25
申请人： NOVO NORDISK A/S , THIM, Lars , WÖLDIKE, Helle, Fabricius , NIELSEN, Per, Franklin
发明人： NOVO NORDISK A/S
IPC分类号： C07K14/575
CPC分类号： C07K14/575 , A61K38/00
摘要： A trefoil peptide containing a single trefoil domain characterized by being in dimer form.
摘要翻译：含有单三叶形结构域的三叶肽，其特征在于二聚体形式。

4. 发明申请

WO1997000316A1 A PROCESS FOR PRODUCING TRYPSIN (TRYPSINOGEN) 审中-公开
标题翻译：生产TRYPSIN（TRYPSINOGEN）的方法
公开(公告)号：WO1997000316A1
公开(公告)日：1997-01-03
申请号：PCT/DK1996000253
申请日：1996-06-10
申请人： NOVO NORDISK A/S , WÖLDIKE, Helle, Fabricius , KJELDSEN, Thomas, Borglum
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/76
CPC分类号： C12N9/6427 , C12N15/80
摘要： Trypsin (trypsinogen) may be produced in a filamentous fungus by transforming a filamentous fungus with a vector comprising a DNA sequence encoding protrypsin or a derivative thereof N-terminally fused to a DNA sequence encoding a signal peptide, culturing the transformed filamentous fungus in a suitable culture medium to produce trypsinogen and recovering trypsinogen and/or trypsin from the medium.
摘要翻译：胰蛋白酶（胰蛋白酶原）可以通过用包含编码早胰蛋白酶的DNA序列或其衍生物的载体转化丝状真菌来生产丝状真菌，N-末端融合到编码信号肽的DNA序列上，以合适的方式培养转化的丝状真菌培养基以产生胰蛋白酶原并从培养基中回收胰蛋白酶原和/或胰蛋白酶。

5. 发明申请

WO1994007998A1 CELLULASE VARIANTS 审中-公开
标题翻译：纤维素酶变体
公开(公告)号：WO1994007998A1
公开(公告)日：1994-04-14
申请号：PCT/DK1993000327
申请日：1993-10-06
申请人： NOVO NORDISK A/S , SCHÜLEIN, Martin , FREDHOLM, Henrik , HJORT, Carsten, Mailand , RASMUSSEN, Grethe , NIELSEN, Egon , ROSHOLM, Peter
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/42
CPC分类号： C12N9/2437 , C11D3/38645 , C12Y302/01004 , D06M16/003 , D06P5/02 , D06P5/137 , D06P5/158
摘要： A cellulase variant of a parent cellulase, e.g. a cellulase classified in family 45 such as a Humicola insolens 43 kD endoglucanase, comprising a cellulose binding domain (CBD), a catalytically active domain (CAD) and a region linking the cellulose binding domain and catalytically active domain (the linking region), wherein one more amino acid residues of the CBD, CAD or linking region is deleted or substituted by one or more amino acid residues and/or one or more amino acids are added to the linking region and/or another CBD is added at the opposite end of the catalytically active domain, has improved properties as regards e.g. alkaline activity, compatibility with detergent composition ingredients, particulate soil removal, colour clarification, defuzzing, depilling, harshness reduction, and sensitivity to anionic surfactants and peroxidase bleaching systems and is useful e.g. in detergent compositions, for textile treatment, in paper pulp processing, for animal feed and for stone washing of jeans.
摘要翻译：亲本纤维素酶的纤维素酶变体，例如例如分类在家族45中的纤维素酶，例如包含纤维素结合结构域（CBD），催化活性结构域（CAD）和连接纤维素结合结构域和催化活性结构域（连接区域）的区域的腐质霉43kD内切葡聚糖酶，其中 CBD，CAD或连接区的一个氨基酸残基被一个或多个氨基酸残基缺失或取代，和/或一个或多个氨基酸被添加到连接区和/或另一个CBD被加入到催化活性域，具有改进的性能，例如碱性活性，与洗涤剂组合物成分的相容性，颗粒污垢去除，颜色澄清，去污，去毛刺，粗糙度降低以及对阴离子表面活性剂和过氧化物酶漂白体系的敏感性。在洗涤剂组合物中，用于纺织品处理，纸浆加工，动物饲料和牛仔裤的石洗。

6. 发明申请

WO1997033984A1 NOVEL ACHROMOBACTER LYTICUS PROTEASE VARIANTS 审中-公开
标题翻译：新型ACHROMOBACTER LYTICUS PROTEASE VARIANTS
公开(公告)号：WO1997033984A1
公开(公告)日：1997-09-18
申请号：PCT/DK1997000100
申请日：1997-03-07
申请人： NOVO NORDISK A/S , ANDERSEN, Asser , BALSCHMIDT, Per , BRANNER, Sven , HASTRUP, Sven
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/52
CPC分类号： C12N9/52
摘要： The invention relates to novel Achromobacter lyticus protease I variants wherein one or more of the lysine residues in positions 30, 49, 106, 155 and 203 have been replaced by another amino acid residue which can be encoded by nucleic acid constructs, or wherein one or more of the lysine residues in the above-mentioned positions or other amino acid residues introduced into the above-mentioned positions have been chemically modified. The invention furthermore relates to nucleic acid constructs encoding said protease variants, and vectors and host cells comprising said constructs. The protease variants are useful for cleaving Lys-X peptide bonds in polypeptides, such as preproinsulins.
摘要翻译：本发明涉及新型无色杆菌溶酶体蛋白酶I变体，其中位置30,49,106,155和203中的一个或多个赖氨酸残基已经被可由核酸构建体编码的另一氨基酸残基取代，或其中一个或多个引入上述位置的上述位置中的更多赖氨酸残基或其他氨基酸残基已被化学修饰。本发明还涉及编码所述蛋白酶变体的核酸构建体，以及包含所述构建体的载体和宿主细胞。蛋白酶变体可用于切割多肽中的Lys-X肽键，如前胰岛素原。

7. 发明申请

WO1994025583A1 A RECOMBINANT TRYPSIN-LIKE PROTEASE 审中-公开
标题翻译：重组类似TRYPSIN样样品
公开(公告)号：WO1994025583A1
公开(公告)日：1994-11-10
申请号：PCT/DK1994000177
申请日：1994-05-04
申请人： NOVO NORDISK A/S , BRANNER, Sven , HASTRUP, Sven
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/76
CPC分类号： C12N9/58 , C11D3/386
摘要： An active recombinant trypsin-like protease enzyme comprising the amino acid residues 25-224 of the amino acid sequence shown in the appended SEQ ID No. 2 as well as a DNA construct encoding said enzyme. The enzyme may be used as a detergent enzyme.
摘要翻译：包含所附SEQ ID No.2所示氨基酸序列的氨基酸残基25-224的活性重组胰蛋白酶样蛋白酶以及编码所述酶的DNA构建体。酶可以用作洗涤剂酶。

8. 发明申请

WO1996017943A1 A PROCESS OF PRODUCING EXTRACELLULAR PROTEINS IN BACTERIA 审中-公开
标题翻译：在细菌中生产细胞外蛋白的过程
公开(公告)号：WO1996017943A1
公开(公告)日：1996-06-13
申请号：PCT/DK1995000498
申请日：1995-12-08
申请人： NOVO NORDISK A/S , FABRICIUS WÖLDIKE, Helle , HASTRUP, Sven
发明人： NOVO NORDISK A/S
IPC分类号： C12N15/70
CPC分类号： C12N9/54 , C07K14/605 , C07K2319/00 , C07K2319/02 , C07K2319/75 , C12N9/20 , C12N9/52 , C12N15/62 , Y10S435/824
摘要： The invention relates to a method of producing an extracellular protein in a bacterium provided with an inner and an outer cell membrane, the method comprising: (a) providing a recombinant vector including a DNA construct comprising a DNA sequence encoding the prepropeptide or part of the prepropeptide of a bacterial extracellular protease selected from the group consisting of Achromobacter lyticus protease I, Bacillus metalloproteases and Bacillus serine proteases preceding and operably connected to a DNA sequence encoding a desired protein, (b) transforming cells of a microorganism provided with an inner and outer cell membrane with the recombinant vector of step (a), (c) culturing the transformed cells of step (b) under conditions permitting expression of said DNA insert and leakage of the bacterial extracellular protease propeptide fused to the desired protein into the culture medium, and (d) recovering the resulting protein from the medium.
摘要翻译：本发明涉及在具有内细胞膜和外细胞膜的细菌中产生细胞外蛋白质的方法，所述方法包括：（a）提供包含DNA构建体的重组载体，所述DNA构建体包含编码前肽的DNA序列或部分选自下组的细菌细胞外蛋白酶的前肽，所述细菌细胞外蛋白酶选自无菌杆菌蛋白酶I，芽孢杆菌金属蛋白酶和芽孢杆菌丝氨酸蛋白酶，之前和可操作地连接到编码所需蛋白质的DNA序列，（b）转化具有内部和外部的微生物的细胞细胞膜与步骤（a）的重组载体，（c）在允许所述DNA插入片段表达的条件下培养步骤（b）的转化细胞，并将融合到所需蛋白质的细菌细胞外蛋白酶前体的渗漏渗入培养基中，和（d）从培养基中回收得到的蛋白质。

9. 发明申请

WO1998028409A1 PHYTASE POLYPEPTIDES 审中-公开
公开(公告)号：WO1998028409A1
公开(公告)日：1998-07-02
申请号：PCT/DK1997000568
申请日：1997-12-15
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , LASSEN, Soren, Flensted , BECH, Lisbeth , OHMANN, Anders , BREINHOLT, Jens , FUGLSANG, Claus, Crone
IPC分类号： C12N09/16
CPC分类号： C12Y301/03026 , A23K20/189 , A23L5/25 , A23L29/06 , C12N9/16
摘要： The present invention relates to isolated polypeptides having phytase activity, the corresponding cloned DNA sequences, a process for preparing such polypeptides, and the use thereof for a number of industrial applications. In particular, the invention relates to phytases derived from the phyllum Basidiomycota, phytases of certain consensus sequences and fungal 6-phytases.
摘要翻译：本发明涉及具有植酸酶活性的分离的多肽，相应的克隆的DNA序列，制备该多肽的方法及其在许多工业应用中的应用。特别地，本发明涉及源自担子菌的植酸酶，某些共有序列的植酸酶和真菌6-肌醇六磷酸酶。

10. 发明申请

WO1998020895A1 USE OF GLP-1 PEPTIDES 审中-公开
标题翻译：使用GLP-1肽
公开(公告)号：WO1998020895A1
公开(公告)日：1998-05-22
申请号：PCT/DK1997000509
申请日：1997-11-07
申请人： NOVO NORDISK A/S , KNUDSEN, Liselotte, Bjerre , THIM, Lars , JUDGE, Martin, Edward , HOLST, Jens, Juul , ASTRUP, Arne, Vernon , WULFF, Brigitte, Schjellerup
发明人： NOVO NORDISK A/S
IPC分类号： A61K38/26
CPC分类号： A61K38/26
摘要： GLP-1(1-45) or a fragment or an analogue thereof can be used in the preparation of a medicament for peripheral administration in the suppression of appetite or induction of satiety.
摘要翻译： GLP-1（1-45）或其片段或类似物可用于制备用于抑制食欲或诱导饱腹感的外周施用的药物。

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