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1. 发明申请

WO1989007139A1 A METHOD FOR IMMOBILIZING A POLYPEPTIDE IN A POLYMER AND A MEMBRANE PRODUCED THEREBY 审中-公开
标题翻译：一种在聚合物中固定多肽的方法及其制备的薄膜
公开(公告)号：WO1989007139A1
公开(公告)日：1989-08-10
申请号：PCT/DK1989000019
申请日：1989-02-03
申请人： NOVO INDUSTRI A/S , EGE, Henrik
发明人： NOVO INDUSTRI A/S
IPC分类号： C12N11/08
CPC分类号： C12Q1/003 , C12N11/04 , Y10S435/817
摘要： The present invention relates generally to the immobilization or incorporation of polypeptides, especially enzymes or other bioactive polypeptides into polymeric matrixes, especially polyurethane, membranes produced by said polymers, and the utilization of such membranes in biosensors. A preferred type of biosensor is the needle sensor designed for in vivo monitoring of glucose which comprises a core platinum anode (2) coated with an insulating lacquer (3), the anode (2) is situated inside a stainless steel reference cathode (4) which is insulated from the anode (2) by a layer of epoxy resin (5). At one end, the tip, the electrode (1) has a detection surface (6), which is in an acute angle to the general direction of the electrode (1). At the other end, the base, the electrode (2) is provided with terminals (7) and (8) for the anode (2) and cathode (4), respectively. The terminals (7) and (8) are soldered to leads (9) and (10), respectively, which are connected to instrumentation used when performing measurements.
摘要翻译：本发明一般涉及将多肽，特别是酶或其他生物活性多肽固定或并入聚合物基质，特别是由所述聚合物制备的聚氨酯膜，以及在生物传感器中利用这种膜。优选的生物传感器类型是设计用于体内监测葡萄糖的针传感器，其包括涂覆有绝缘漆（3）的核心铂阳极（2），阳极（2）位于不锈钢参考阴极（4）内部，其通过一层环氧树脂（5）与阳极（2）绝缘。在一端，电极（1）具有与电极（1）的大致方向成锐角的检测面（6）。在另一端，电极（2）分别设有用于阳极（2）和阴极（4）的端子（7）和（8）。端子（7）和（8）分别焊接到引线（9）和（10），引线（9）和（10）连接到进行测量时使用的仪器。

2. 发明申请

WO1989006279A1 MUTATED SUBTILISIN GENES 审中-公开
标题翻译： MUTATED SUBTILISIN基因
公开(公告)号：WO1989006279A1
公开(公告)日：1989-07-13
申请号：PCT/DK1989000002
申请日：1989-01-06
申请人： NOVO INDUSTRI A/S
发明人： NOVO INDUSTRI A/S , HASTRUP, Sven , BRANNER, Sven , NORRIS, Fanny , PETERSEN, Steffen, B. , NORSKOV-LAURIDSEN, Leif , JENSEN, Villy, Johannes , AASLYNG, Dorrit
IPC分类号： C12N09/50
CPC分类号： C11D3/386 , C12N9/54
摘要： The present invention relates to mutations of the subtilisin gene, some of which result in changes in the chemical characteristics of subtilisin enzyme. Mutations are created at specific nucleic acids of the subtilisin gene and, in various specific embodiments, the mutant enzymes possess altered chemical properties including, but not limited to, increased stability to oxidation, augmented proteolytic activity, and improved washability. The present invention also relates, but is not limited to, the amino acid and DNA sequences for two proteases derived from Bacillus lentus variants, subtilisin 147 and subtilisin 309, as well as mutations of these genes and the corresponding mutant enzymes.
摘要翻译：本发明涉及枯草杆菌蛋白酶基因的突变，其中一些导致枯草杆菌蛋白酶的化学特性的变化。在枯草杆菌蛋白酶基因的特定核酸上产生突变，并且在各种具体实施方案中，突变酶具有改变的化学性质，包括但不限于氧化增强的稳定性，增强的蛋白水解活性和改善的可洗性。本发明还涉及但不限于来自迟缓芽孢杆菌变体，枯草杆菌蛋白酶147和枯草杆菌蛋白酶309的两种蛋白酶的氨基酸和DNA序列，以及这些基因和相应的突变酶的突变。

3. 发明申请

WO1989005342A1 PROCESS FOR THE PRODUCTION OF HUMAN FACTOR VIII BY CULTURING A HUMAN HEPATOMA CELL LINE 审中-公开
标题翻译：通过培养人类HEPATOMA细胞系生产人因子VIII的方法
公开(公告)号：WO1989005342A1
公开(公告)日：1989-06-15
申请号：PCT/DK1988000195
申请日：1988-11-30
申请人： NOVO INDUSTRI A/S , INGERSLEV, Jorgen, Mogens , PETERSEN, Jens, Claus, Munck
发明人： NOVO INDUSTRI A/S
IPC分类号： C12N05/00
CPC分类号： C07K14/755 , A61K38/00
摘要： Factor VIII is produced by culturing a human hepatoma cell line in a suitable culture medium whereupon factor VIII is isolated from the culture medium. A suitable cell line is HepG2 ATCC No. 8065.
摘要翻译：因子VIII是通过在合适的培养基中培养人肝癌细胞系而产生的，由此从培养基中分离因子VIII。合适的细胞系是HepG2 ATCC No.8065。

4. 发明申请

WO1988009811A1 PROTEINS AND DERIVATIVES THEREOF 审中-公开
标题翻译：蛋白质及其衍生物
公开(公告)号：WO1988009811A1
公开(公告)日：1988-12-15
申请号：PCT/DK1988000089
申请日：1988-06-09
申请人： NOVO INDUSTRI A/S , NEXO, Bjorn, Andersen , ESPER, Boel
发明人： NOVO INDUSTRI A/S
IPC分类号： C12N15/00
CPC分类号： C12N9/6459 , C07K14/7455 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C07K2319/33 , C12Y304/21069
摘要： Authentic and modified human thrombomodulin produced by recombinant DNA techniques, DNA sequences coding for these molecules, pharmaceutical preparations containing such molecules and their use in human therapy and prophylaxis for the treatment and prevention of thrombic episodes.
摘要翻译：通过重组DNA技术产生的正确和修饰的人血栓调节蛋白，编码这些分子的DNA序列，含有这些分子的药物制剂及其在人类治疗中的用途以及用于治疗和预防血栓发作的用途。

5. 发明申请

WO1988003537A1 NOVEL PEPTIDES 审中-公开
标题翻译：新款PEPTIDES
公开(公告)号：WO1988003537A1
公开(公告)日：1988-05-19
申请号：PCT/DK1987000138
申请日：1987-11-06
申请人： NOVO INDUSTRI A/S , FAARUP, Peter , JOHANSEN, Nils, Langeland , THOGERSEN, Henning , LUNDT, Behrend, Friedrich , WEIS, Jan
发明人： NOVO INDUSTRI A/S
IPC分类号： C07K07/10
CPC分类号： C07K14/58 , A61K38/00
摘要： Derivatives of atrial natriuretic peptides (ANP) wherein at least two of the amino acid residues in the ring structure (positions 7-23) are exchanged with other amino acid residues and/or which in the C terminal end (position 28) are elongated with Pro, Trp, Phe or N-MePhe or a polypeptide moiety having one of the last mentioned 4 amino acid residues in the N terminal end, have improved pharmacological properties.
摘要翻译：心房利钠肽（ANP）的衍生物，其中环结构中的至少两个氨基酸残基（位置7-23）与其它氨基酸残基交换，和/或在C末端（位置28）中的氨基酸残基被延长， Pro，Trp，Phe或N-MePhe或在N末端具有最后提到的4个氨基酸残基之一的多肽部分具有改善的药理学性质。

6. 发明申请

WO1988002775A1 POSITIONALLY NON-SPECIFIC LIPASE FROM CANDIDA SP, A METHOD FOR PRODUCING IT, ITS USE AND A RECOMBINANT DNA PROCESS FOR PRODUCING IT 审中-公开
标题翻译：来自CANDIDA SP的非特异性脂质体，其生产方法，使用方法和用于生产IT的重组DNA方法
公开(公告)号：WO1988002775A1
公开(公告)日：1988-04-21
申请号：PCT/DK1987000127
申请日：1987-10-16
申请人： NOVO INDUSTRI A/S , MICHIYO, Ishii
发明人： NOVO INDUSTRI A/S
IPC分类号： C12N09/20
CPC分类号： C12N9/20 , C12N11/02
摘要： Novel lipase from Candida sp. is positionally non-specific and more thermostable than those previously known. It is useful in soluble or immobilized form for interesterification, ester hydrolysis and ester synthesis at 60 DEG C or above.
摘要翻译：来自念珠菌的新型脂肪酶在位置上是非特异性的，比先前已知的更具有热稳定性。在60℃以上的酯交换，酯水解和酯合成中，可溶或固定形式是有用的。

7. 发明申请

WO1989009813A1 A DETERGENT ADDITIVE FOR BLEACHING FABRIC 审中-公开
标题翻译：用于漂白织物的洗涤剂添加剂
公开(公告)号：WO1989009813A1
公开(公告)日：1989-10-19
申请号：PCT/DK1989000088
申请日：1989-04-14
申请人： NOVO INDUSTRI A/S , KIRK, Ole , DAMHUS, Ture , GOTFREDSEN, Sven, Erik
发明人： NOVO INDUSTRI A/S
IPC分类号： C11D03/395
CPC分类号： C11D3/395 , C11D3/38654 , C11D3/39
摘要： A detergent additive for use in a process for bleaching stained fabric comprises an enzyme exhibiting peroxidase activity and optionally also hydrogen peroxide or a precursor thereof, e.g. a perborate or percarbonate. The detergent additive may further comprise an enzyme capable of generating hydrogen peroxide, e.g. an oxidase, and a substrate therefor.
摘要翻译：用于漂白染色织物的方法中的洗涤剂添加剂包括显示过氧化物酶活性的酶，并且任选地还包括过氧化氢或其前体，例如，过硼酸盐或过碳酸盐。洗涤剂添加剂可以进一步包含能够产生过氧化氢的酶，例如，氧化酶，及其底物。

8. 发明申请

WO1989008695A1 STABILIZED PARTICULATE COMPOSITION 审中-公开
标题翻译：稳定的颗粒组合物
公开(公告)号：WO1989008695A1
公开(公告)日：1989-09-21
申请号：PCT/DK1989000056
申请日：1989-03-13
申请人： NOVO INDUSTRI A/S , MARKUSSEN, Erik, Kjaer , FALHOLT, Per , GOODMAN, Howard
发明人： NOVO INDUSTRI A/S
IPC分类号： C11D03/386
CPC分类号： C11D3/0084 , C11D3/126 , C11D3/38672 , C11D3/3937 , C11D3/42 , C11D17/0039
摘要： Particles containing enzyme or optical brightener in a mixture with particles containing peroxy bleach, surfactant or builder are stabilized during storage by coating the former and/or the latter particles with clay, e.g. bentonite.
摘要翻译：在含有过氧漂白剂，表面活性剂或助洗剂的颗粒的混合物中含有酶或荧光增白剂的颗粒在储存期间通过用粘土例如涂覆前者和/或后者颗粒来稳定。膨润土。

9. 发明申请

WO1989004862A1 DETERGENT COMPOSITIONS CONTAINING CELLULASE GRANULATES 审中-公开
标题翻译：含有纤维素酶颗粒的洗涤剂组合物
公开(公告)号：WO1989004862A1
公开(公告)日：1989-06-01
申请号：PCT/DK1988000189
申请日：1988-11-18
申请人： NOVO INDUSTRI A/S , THE PROCTER & GAMBLE COMPANY , JENSEN, Poul, Erik , DE MARTELAERE, Dirk
发明人： NOVO INDUSTRI A/S , THE PROCTER & GAMBLE COMPANY
IPC分类号： C11D03/386
CPC分类号： C11D3/38645 , C11D3/126
摘要： Detergent compositions for the cleaning and softening of fabrics are claimed, in which cellulase granulates containing a water-insoluble calcium salt, preferably calcium carbonate, are incorporated. Softness and fabric-appearance benefits are excellent. The cellulase granulates per-se are also claimed.
摘要翻译：要求保护织物清洁和软化的洗涤剂组合物，其中掺入含有不溶于水的钙盐，优选碳酸钙的纤维素酶颗粒。柔软度和面料外观效果非常好。还要求纤维素酶颗粒本身。

10. 发明申请

WO1989001969A1 PROCESS FOR THE PRODUCTION OF PROTEIN PRODUCTS IN ASPERGILLUS AND PROMOTERS FOR USE IN ASPERGILLUS 审中-公开
标题翻译：用于生产ASPERGILLUS中蛋白质产品的方法和用于ASPERGILLUS的促销剂
公开(公告)号：WO1989001969A1
公开(公告)日：1989-03-09
申请号：PCT/DK1988000145
申请日：1988-09-02
申请人： NOVO INDUSTRI A/S , WÖLDIKE, Helle, Fabricius
发明人： NOVO INDUSTRI A/S
IPC分类号： C12N15/00
CPC分类号： C12N9/242 , C07K2319/00 , C07K2319/02 , C12N9/62 , C12N15/80
摘要： A process for expression of a protein product in Aspergillus is disclosed. The process comprises transforming an Aspergillus strain with a vector system comprising DNA-sequences encoding a promoter including upstream activating sequences derived from an A. niger amylase, a suitable marker for selection of transformants, and a DNA-sequence encoding the desired protein product. The process enables industrial production of many different polypeptides and proteins in Aspergillus, preferably A. niger. Examples of such products are chymosin or prochymosin and other rennets, proteases, lipases and amylases. Also disclosed is an effective promoter for expression of a protein in Aspergillus, preferably Aspergillus niger being derived from a gene encoding an A. niger amylase. The A. niger amylases are the neutral and acid stable alpha -amylases and a new amylase not so far described and designated XA amylase. Also disclosed is the novel amylase from A. niger XA amylase.
摘要翻译：公开了在曲霉中表达蛋白质产物的方法。该方法包括用包含编码启动子的DNA序列的载体系统转化曲霉菌菌株，所述启动子包括来自黑曲霉淀粉酶的上游活化序列，用于选择转化体的合适标记物和编码所需蛋白质产物的DNA序列。该方法使得能够在曲霉属中产生许多不同的多肽和蛋白质，优选黑曲霉。这些产品的实例是凝乳酶或凝乳酶原和其他雷诺丝，蛋白酶，脂肪酶和淀粉酶。还公开了用于在曲霉中表达蛋白质的有效启动子，优选来自编码黑曲霉淀粉酶的基因的黑曲霉（Aspergillus niger）。黑曲霉淀粉酶是中性和酸稳定的α-淀粉酶和不是迄今描述的新的淀粉酶，并且被称为XA淀粉酶。还公开了来自黑曲霉XA淀粉酶的新型淀粉酶。

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