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1. 发明申请

WO2009101479A3 FC RECEPTOR-BINDING POLYPEPTIDES WITH MODIFIED EFFECTOR FUNCTIONS 审中-公开
公开(公告)号：WO2009101479A3
公开(公告)日：2009-08-20
申请号：PCT/IB2008/003978
申请日：2008-05-14
申请人： NOVIMMUNE SA , ELSON, Greg , LEGER, Olivier
发明人： ELSON, Greg , LEGER, Olivier
IPC分类号： A61K39/395 , A61P29/00
摘要： Disclosed are processes for producing a variant polypeptide (e.g. antibodies) having modified binding characteristics for human Fc gamma receptor IIA (CD32A) leading to increased inhibition of proinflammatory mediators while retaining binding to a target antigen via its Fv portion, which processes comprise altering the polypeptides by substitution of at least two amino acid residues at EU position 325, 326 or 328 of a human IgG CH2 region for a sequence selected from SAAF, SKAF, NAAF and NKAF. Also disclosed are molecules, particularly polypeptides, more particularly immunoglobulins (e.g. antibodies) that include a variant CDR3 region, wherein the variant CDR3 region includes at least one amino acid modified relative to a wild-type CDR3 region. The polypeptides that can be generated according to the methods of the invention are highly variable, and they can include antibodies and fusion proteins that contain an Fc region or a biologically active portion thereof.

2. 发明申请

WO2010041145A3 IL-17-MEDIATED TRANSFECTION METHODS 审中-公开
公开(公告)号：WO2010041145A3
公开(公告)日：2010-04-15
申请号：PCT/IB2009/007235
申请日：2009-10-07
申请人： NOVIMMUNE SA , ELSON, Greg , CONTIE, Mathias , FOUQUE, Nicolas , LEGER, Olivier , POITEVIN, Yves
发明人： ELSON, Greg , CONTIE, Mathias , FOUQUE, Nicolas , LEGER, Olivier , POITEVIN, Yves
IPC分类号： C07K14/54 , C12N15/00
摘要： The invention comprises compositions and methods for IL-17-mediated transfection that results in superior and enhanced properties of cell survival and protein production.

3. 发明申请

WO2009140348A2 ANTI-IL-6/IL-6R ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗IL-6 / IL-6R抗体及其使用方法
公开(公告)号：WO2009140348A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/043734
申请日：2009-05-13
申请人： NOVIMMUNE SA , FERLIN, Walter , KOSCO-VILBOIS, Marie , ELSON, Greg , LEGER, Olivier , GUILHOT, Florence
发明人： FERLIN, Walter , KOSCO-VILBOIS, Marie , ELSON, Greg , LEGER, Olivier , GUILHOT, Florence
IPC分类号： A23G3/44
CPC分类号： C07K16/2866 , C07K16/248 , C07K2317/21 , C07K2317/32 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： This invention provides fully human monoclonal antibodies that recognize the IL- 6/IL-6R complex. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic.
摘要翻译：本发明提供了识别IL-6 / IL-6R复合物的完全人单克隆抗体。本发明还提供使用这样的单克隆抗体作为治疗，诊断和预防的方法。

4. 发明申请

WO2006109191A2 ANTI-INTERFERON GAMMA ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗干扰素抗体及其使用方法
公开(公告)号：WO2006109191A2
公开(公告)日：2006-10-19
申请号：PCT/IB2006/001514
申请日：2006-01-27
申请人： NOVIMMUNE S.A. , FERLIN, Walter , FISCHER, Nicolas , ELSON, Greg , LEGER, Olivier
发明人： FERLIN, Walter , FISCHER, Nicolas , ELSON, Greg , LEGER, Olivier
CPC分类号： C07K16/249 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/54 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The invention relates to fully human antibodies, and fragments thereof, that bind to human interferon gamma (hlFNγ), thereby modulating the interaction between IFNγ and its receptor, IFNγ-R, and/or modulating the biological activities of IFNγ. The invention also relates to the use of such anti-IFNγ antibodies in the prevention or treatment of immune- related disorders and in the amelioration of a symptom associated with an immune-related disorder.
摘要翻译：本发明涉及与人类干扰素γ（hIFN1β）结合的完全人抗体及其片段，从而调节IFNα 和其受体IFNγ-R，和/或调节IFNα的生物学活性。本发明还涉及使用这种抗-IFN？抗体在预防或治疗免疫相关疾病和改善与免疫相关病症相关的症状中。

5. 发明申请

WO2007110678A2 NEUTRALIZING ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：中和抗体及其使用方法
公开(公告)号：WO2007110678A2
公开(公告)日：2007-10-04
申请号：PCT/IB2005/004206
申请日：2005-06-14
申请人： NOVIMMUNE S.A. , ELSON, Greg , LEGER, Olivier
发明人： ELSON, Greg , LEGER, Olivier
IPC分类号： C07K16/00
CPC分类号： C07K16/2896 , A61K38/00 , A61K38/1709 , A61K38/177 , A61K39/0005 , A61K2039/505 , A61K2039/575 , C07K14/47 , C07K14/70596 , C07K16/18 , C07K2317/24 , C07K2317/32 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2319/00
摘要： This invention provides monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, and monoclonal antibodies that recognize the TLR4/MD2 complex as well as TLR4 when not complexed with MD-2. The invention further provides methods of using the humanized monoclonal antibodies as therapeutics. This invention also provides soluble chimeric proteins, methods of expressing and purifying soluble chimeric proteins, and methods of using soluble chimeric proteins as therapeutics, in screening assays and in the production of antibodies.
摘要翻译：本发明提供识别Toll样受体4 / MD-2受体复合物的单克隆抗体，以及当与MD-2不复合时识别TLR4 / MD2复合物以及TLR4的单克隆抗体。本发明还提供使用人源化单克隆抗体作为治疗剂的方法。本发明还提供可溶性嵌合蛋白，表达和纯化可溶性嵌合蛋白的方法，以及在筛选测定和抗体生成中使用可溶性嵌合蛋白作为治疗剂的方法。

6. 发明申请

WO2006077471A3 COMBINING THERAPIES TARGETING MULTIPLE TOLL-LIKE RECEPTORS AND USE THEREOF 审中-公开
公开(公告)号：WO2006077471A3
公开(公告)日：2006-07-27
申请号：PCT/IB2005/004174
申请日：2005-12-12
申请人： NOVIMMUNE S.A. , ELSON, Greg , LEGER, Olivier
发明人： ELSON, Greg , LEGER, Olivier
IPC分类号： A61K39/395 , A61P37/06 , A61P1/00 , A61P19/02 , A61P11/06 , A61P11/00 , A61P37/00 , C07K16/28 , C07K16/18
摘要： The invention relates generally to compositions that contain multiple antibodies, e.g., multiple neutralizing antibodies, that immunospecifically bind to one or more toll-like receptors, e.g., two or more toll-like receptors, and methods of using these compositions in the treatment of inflammatory disorders.

7. 发明申请

WO2013088259A2 METHODS OF PURIFYING ANTIBODIES 审中-公开
标题翻译：纯化抗体的方法
公开(公告)号：WO2013088259A2
公开(公告)日：2013-06-20
申请号：PCT/IB2012/003028
申请日：2012-10-19
申请人： NOVIMMUNE S.A. , ELSON, Greg , FOUQUE, Nicolas , DEPOISIER, Jean-François , FISCHER, Nicolas , MAGISTRELLI, Giovanni
发明人： ELSON, Greg , FOUQUE, Nicolas , DEPOISIER, Jean-François , FISCHER, Nicolas , MAGISTRELLI, Giovanni
IPC分类号： A61K39/00
CPC分类号： C07K16/00 , C07K16/248 , C07K16/249 , C07K16/2866 , C07K16/468 , C07K2317/32 , C07K2317/52
摘要： The invention provides methods of purifying antibodies using various antibody- specific purification media to rapidly and efficiently separate mixtures of antibodies, antibody fragments and/or antibody components to isolate a desired antibody product from the mixture. The invention relates to the purification of bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, e.g., antibodies composed of a single heavy chain and two different light chains, one containing Kappa constant domain and the other a Lambda constant domain, including antibodies of different specificities that share a common heavy chain. The invention also provides the methods of efficiently purifying intact antibodies by separating the intact antibody from non-intact antibodies including free light chains.
摘要翻译：本发明提供使用各种抗体特异性纯化介质纯化抗体的方法，以快速且有效地分离抗体，抗体片段和/或抗体组分的混合物，以从混合物中分离所需的抗体产物。本发明涉及对免疫球蛋白分子的每个结合位点具有不同特异性的双特异性单克隆抗体的纯化，例如由单个重链和两个不同轻链组成的抗体，一个含有κ恒定结构域，另一个包含λ恒定结构域，包括具有共同重链的不同特异性的抗体。本发明还提供了通过将完整抗体与包括游离轻链在内的不完整抗体分离来有效纯化完整抗体的方法。

8. 发明申请

WO2007033230A3 ANTI-CD3 ANTIBODY FORMULATIONS 审中-公开
公开(公告)号：WO2007033230A3
公开(公告)日：2007-03-22
申请号：PCT/US2006/035615
申请日：2006-09-12
申请人： NOVIMMUNE S.A. , ELSON, Greg , DEAN, Yann , KOSCO-VILBOIS, Marie
发明人： ELSON, Greg , DEAN, Yann , KOSCO-VILBOIS, Marie
IPC分类号： A61K39/395 , C07K16/28 , A61P37/06
摘要： This invention relates to therapeutic, diagnostic and/or prophylactic formulations and dosages of anti-CD3 antibodies, as well as to methods for using such formulations and dosages.

9. 发明申请

WO2013149111A2 ANTI-TLR4 ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗TLR4抗体及其用途
公开(公告)号：WO2013149111A2
公开(公告)日：2013-10-03
申请号：PCT/US2013/034543
申请日：2013-03-29
申请人： NOVIMMUNE S.A. , ROUSSEAU, Francois , LOYAU, Jérémy , FISCHER, Nicolas , ELSON, Greg , KOSCO-VILBOIS, Marie
发明人： ROUSSEAU, Francois , LOYAU, Jérémy , FISCHER, Nicolas , ELSON, Greg , KOSCO-VILBOIS, Marie
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , C07K16/2866 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： Disclosed are antibodies that specifically bind Toll-like Receptor 4 (TLR-4), and to methods of using the anti-TLR4 antibodies as therapeutics and diagnostic agents.
摘要翻译：公开了特异性结合Toll样受体4（TLR-4）的抗体，以及使用抗TLR4抗体作为治疗剂和诊断剂的方法。

10. 发明申请

WO2012023053A2 METHODS FOR THE GENERATION OF MULTISPECIFIC AND MULTIVALENT ANTIBODIES 审中-公开
标题翻译：产生多种特异性和多种抗体的方法
公开(公告)号：WO2012023053A2
公开(公告)日：2012-02-23
申请号：PCT/IB2011/002664
申请日：2011-08-16
申请人： NOVIMMUNE S.A. , FISCHER, Nicolas , MAGISTRELLI, Giovanni , GUENEAU, Franck , RAVN, Ulla , ELSON, Greg
发明人： FISCHER, Nicolas , MAGISTRELLI, Giovanni , GUENEAU, Franck , RAVN, Ulla , ELSON, Greg
CPC分类号： C07K16/468 , C07K16/005 , C07K16/248 , C07K16/249 , C07K16/2866 , C07K2317/31 , C07K2317/32 , C07K2317/622 , C07K2317/92 , C12N15/1037 , C12N15/1075
摘要： The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other of a Lambda constant domain. The invention provides methods for the isolation of antibodies of different specificities but sharing a common heavy chain. The invention also provides methods for the controlled co-expression of two light chains and a single heavy chain leading to the assembly of monospecific and bispecific antibodies. The invention provides a mean of producing a fully human bispecific and bivalent antibody that is unaltered in sequence and does not involve the use of linkers or other non-human sequences, as well as antibody mixtures of two monospecific antibodies and one bispecific antibody. The invention also provides the means of efficiently purifying the bispecific antibody.
摘要翻译：本发明提供了对免疫球蛋白分子的每个结合位点具有不同特异性的新型双特异性单克隆抗体，以及生产对免疫球蛋白分子的每个结合位点具有不同特异性的新型双特异性单克隆抗体的方法。抗体由单一重链和两条不同轻链组成，一条轻链包含κ恒定结构域和另一个λ恒定结构域。本发明提供了用于分离不同特异性但共享共同重链的抗体的方法。本发明还提供了用于受控共表达两条轻链和单条重链的方法，导致组装单特异性和双特异性抗体。本发明提供了产生完全人源双特异性和二价抗体的平均值，其序列未改变，并且不涉及使用接头或其他非人序列，以及两种单特异性抗体和一种双特异性抗体的抗体混合物。本发明还提供了有效纯化双特异性抗体的方法。

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