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    • 3. 发明申请
    • METHODS FOR THE GENERATION OF MULTISPECIFIC AND MULTIVALENT ANTIBODIES
    • 产生多种特异性和多种抗体的方法
    • WO2012023053A2
    • 2012-02-23
    • PCT/IB2011/002664
    • 2011-08-16
    • NOVIMMUNE S.A.FISCHER, NicolasMAGISTRELLI, GiovanniGUENEAU, FranckRAVN, UllaELSON, Greg
    • FISCHER, NicolasMAGISTRELLI, GiovanniGUENEAU, FranckRAVN, UllaELSON, Greg
    • C07K16/468C07K16/005C07K16/248C07K16/249C07K16/2866C07K2317/31C07K2317/32C07K2317/622C07K2317/92C12N15/1037C12N15/1075
    • The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other of a Lambda constant domain. The invention provides methods for the isolation of antibodies of different specificities but sharing a common heavy chain. The invention also provides methods for the controlled co-expression of two light chains and a single heavy chain leading to the assembly of monospecific and bispecific antibodies. The invention provides a mean of producing a fully human bispecific and bivalent antibody that is unaltered in sequence and does not involve the use of linkers or other non-human sequences, as well as antibody mixtures of two monospecific antibodies and one bispecific antibody. The invention also provides the means of efficiently purifying the bispecific antibody.
    • 本发明提供了对免疫球蛋白分子的每个结合位点具有不同特异性的新型双特异性单克隆抗体,以及生产对免疫球蛋白分子的每个结合位点具有不同特异性的新型双特异性单克隆抗体的方法。 抗体由单一重链和两条不同轻链组成,一条轻链包含κ恒定结构域和另一个λ恒定结构域。 本发明提供了用于分离不同特异性但共享共同重链的抗体的方法。 本发明还提供了用于受控共表达两条轻链和单条重链的方法,导致组装单特异性和双特异性抗体。 本发明提供了产生完全人源双特异性和二价抗体的平均值,其序列未改变,并且不涉及使用接头或其他非人序列,以及两种单特异性抗体和一种双特异性抗体的抗体混合物。 本发明还提供了有效纯化双特异性抗体的方法。
    • 5. 发明申请
    • METHODS FOR THE GENERATION OF MULTISPECIFIC AND MULTIVALENT ANTIBODIES
    • 用于产生多重和多重抗体的方法
    • WO2012023053A3
    • 2012-05-24
    • PCT/IB2011002664
    • 2011-08-16
    • NOVIMMUNE SAFISCHER NICOLASMAGISTRELLI GIOVANNIGUENEAU FRANCKRAVN ULLAELSON GREG
    • FISCHER NICOLASMAGISTRELLI GIOVANNIGUENEAU FRANCKRAVN ULLAELSON GREG
    • C07K16/00C07K16/46
    • C07K16/468C07K16/005C07K16/248C07K16/249C07K16/2866C07K2317/31C07K2317/32C07K2317/622C07K2317/92C12N15/1037C12N15/1075
    • The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other of a Lambda constant domain. The invention provides methods for the isolation of antibodies of different specificities but sharing a common heavy chain. The invention also provides methods for the controlled co-expression of two light chains and a single heavy chain leading to the assembly of monospecific and bispecific antibodies. The invention provides a mean of producing a fully human bispecific and bivalent antibody that is unaltered in sequence and does not involve the use of linkers or other non-human sequences, as well as antibody mixtures of two monospecific antibodies and one bispecific antibody. The invention also provides the means of efficiently purifying the bispecific antibody.
    • 本发明提供对免疫球蛋白分子的每个结合位点携带不同特异性的新型双特异性单克隆抗体以及用于产生对免疫球蛋白分子的每个结合位点具有不同特异性的新型双特异性单克隆抗体的方法。 抗体由单个重链和两个不同的轻链组成,一个含有κ恒定结构域,另一个是λ恒定结构域。 本发明提供了分离不同特异性但共享共同重链的抗体的方法。 本发明还提供了两个轻链和单个重链的受控共表达的方法,导致单特异性和双特异性抗体的组装。 本发明提供了产生完全人双特异性和二价抗体的平均值,其依次不变,不涉及使用接头或其它非人序列,以及两种单特异性抗体和一种双特异性抗体的抗体混合物。 本发明还提供有效纯化双特异性抗体的方法。