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1. 发明申请

WO2011084255A2 SYNTHETIC POLYPEPTIDE LIBRARIES AND METHODS FOR GENERATING NATURALLY DIVERSIFIED POLYPEPTIDE VARIANTS 审中-公开
标题翻译：合成多肽图书馆和产生自然多样性多肽变体的方法
公开(公告)号：WO2011084255A2
公开(公告)日：2011-07-14
申请号：PCT/US2010/057780
申请日：2010-11-23
申请人： NOVIMMUNE S.A. , FISCHER, Nicolas , KOSCO-VILBOIS, Marie , RAVN, Ulla , GUENEAU, Franck , VENET-BONNOT, Sophie
发明人： FISCHER, Nicolas , KOSCO-VILBOIS, Marie , RAVN, Ulla , GUENEAU, Franck , VENET-BONNOT, Sophie
IPC分类号： C12N15/13 , C12N15/70 , C07K16/18
CPC分类号： C12N15/70 , C07K16/005 , C07K16/249 , C07K16/42 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N15/1034
摘要： The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence.
摘要翻译：本发明提供了用于产生编码同源多肽的DNA序列文库的组合物和方法，以及文库鉴定天然多样化多肽变体的用途。本发明还提供用于产生合成抗体片段的组合物的组合物和方法，其中一个或几个互补决定区域（CDR）由从天然来源捕获的相应CDR的集合代替。本发明还提供了通过插入合成或天然来源的多样化序列来多样化多肽的组合物和方法，而不需要修饰原始多肽编码序列。

2. 发明申请

WO2010135558A1 SYSTHETIC POLYPEPTIDE LIBRARIES AND METHODS FOR GENERATING NATURALLY DIVERSIFIED POLYPEPTIDE VARIANTS 审中-公开
公开(公告)号：WO2010135558A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/035619
申请日：2010-05-20
申请人： NOVIMMUNE S.A. , FISCHER, Nicolas , KOSCO-VILBOIS, Marie , RAVN, Ulla , GUENEAU, Franck , VENET-BONNOT, Sophie
发明人： FISCHER, Nicolas , KOSCO-VILBOIS, Marie , RAVN, Ulla , GUENEAU, Franck , VENET-BONNOT, Sophie
IPC分类号： C12N15/10
CPC分类号： C12N15/1037 , C07K16/005 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C12N15/66 , C40B40/08 , C40B50/06
摘要： The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence.
摘要翻译：本发明提供用于产生编码同源多肽的DNA序列文库的组合物和方法，以及文库用于鉴定天然多样化多肽变体的用途。本发明还提供用于产生合成抗体片段的组合物的组合物和方法，其中一个或几个互补决定区域（CDR）被从天然来源捕获的相应CDR的集合代替。本发明还提供了通过插入合成或天然来源的多样化序列多样化多肽的组合物和方法，而不需要修饰原始多肽编码序列。

3. 发明申请

WO2012023053A2 METHODS FOR THE GENERATION OF MULTISPECIFIC AND MULTIVALENT ANTIBODIES 审中-公开
标题翻译：产生多种特异性和多种抗体的方法
公开(公告)号：WO2012023053A2
公开(公告)日：2012-02-23
申请号：PCT/IB2011/002664
申请日：2011-08-16
申请人： NOVIMMUNE S.A. , FISCHER, Nicolas , MAGISTRELLI, Giovanni , GUENEAU, Franck , RAVN, Ulla , ELSON, Greg
发明人： FISCHER, Nicolas , MAGISTRELLI, Giovanni , GUENEAU, Franck , RAVN, Ulla , ELSON, Greg
CPC分类号： C07K16/468 , C07K16/005 , C07K16/248 , C07K16/249 , C07K16/2866 , C07K2317/31 , C07K2317/32 , C07K2317/622 , C07K2317/92 , C12N15/1037 , C12N15/1075
摘要： The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other of a Lambda constant domain. The invention provides methods for the isolation of antibodies of different specificities but sharing a common heavy chain. The invention also provides methods for the controlled co-expression of two light chains and a single heavy chain leading to the assembly of monospecific and bispecific antibodies. The invention provides a mean of producing a fully human bispecific and bivalent antibody that is unaltered in sequence and does not involve the use of linkers or other non-human sequences, as well as antibody mixtures of two monospecific antibodies and one bispecific antibody. The invention also provides the means of efficiently purifying the bispecific antibody.
摘要翻译：本发明提供了对免疫球蛋白分子的每个结合位点具有不同特异性的新型双特异性单克隆抗体，以及生产对免疫球蛋白分子的每个结合位点具有不同特异性的新型双特异性单克隆抗体的方法。抗体由单一重链和两条不同轻链组成，一条轻链包含κ恒定结构域和另一个λ恒定结构域。本发明提供了用于分离不同特异性但共享共同重链的抗体的方法。本发明还提供了用于受控共表达两条轻链和单条重链的方法，导致组装单特异性和双特异性抗体。本发明提供了产生完全人源双特异性和二价抗体的平均值，其序列未改变，并且不涉及使用接头或其他非人序列，以及两种单特异性抗体和一种双特异性抗体的抗体混合物。本发明还提供了有效纯化双特异性抗体的方法。

4. 发明申请

WO2011084255A3 SYNTHETIC POLYPEPTIDE LIBRARIES AND METHODS FOR GENERATING NATURALLY DIVERSIFIED POLYPEPTIDE VARIANTS 审中-公开
标题翻译：合成多肽文库和产生自然多样化多肽变体的方法
公开(公告)号：WO2011084255A3
公开(公告)日：2011-10-06
申请号：PCT/US2010057780
申请日：2010-11-23
申请人： NOVIMMUNE SA , FISCHER NICOLAS , KOSCO-VILBOIS MARIE , RAVN ULLA , GUENEAU FRANCK , VENET-BONNOT SOPHIE
发明人： FISCHER NICOLAS , KOSCO-VILBOIS MARIE , RAVN ULLA , GUENEAU FRANCK , VENET-BONNOT SOPHIE
IPC分类号： C12N15/13 , C07K16/18 , C12N15/70
CPC分类号： C12N15/70 , C07K16/005 , C07K16/249 , C07K16/42 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N15/1034
摘要： The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide variants. The invention also provides compositions and methods for generating collections of synthetic antibody fragments in which one or several complementary determining regions (CDR) are replaced by a collection of the corresponding CDR captured from a natural source. The invention further provides compositions and methods for diversifying a portion of a polypeptide by inserting a diversified sequence of synthetic or natural origin without the need for modification of the original polypeptide coding sequence.
摘要翻译：本发明提供了用于产生编码同源多肽的DNA序列文库的组合物和方法，以及文库用于鉴定天然多样化的多肽变体的用途。本发明还提供了用于产生合成抗体片段集合的组合物和方法，其中一个或多个互补决定区（CDR）被从天然来源捕获的相应CDR的集合所取代。本发明进一步提供了通过插入多样化的合成或天然来源序列而不需要修饰原始多肽编码序列来使多肽的一部分多样化的组合物和方法。

5. 发明申请

WO2012023053A3 METHODS FOR THE GENERATION OF MULTISPECIFIC AND MULTIVALENT ANTIBODIES 审中-公开
标题翻译：用于产生多重和多重抗体的方法
公开(公告)号：WO2012023053A3
公开(公告)日：2012-05-24
申请号：PCT/IB2011002664
申请日：2011-08-16
申请人： NOVIMMUNE SA , FISCHER NICOLAS , MAGISTRELLI GIOVANNI , GUENEAU FRANCK , RAVN ULLA , ELSON GREG
发明人： FISCHER NICOLAS , MAGISTRELLI GIOVANNI , GUENEAU FRANCK , RAVN ULLA , ELSON GREG
IPC分类号： C07K16/00 , C07K16/46
CPC分类号： C07K16/468 , C07K16/005 , C07K16/248 , C07K16/249 , C07K16/2866 , C07K2317/31 , C07K2317/32 , C07K2317/622 , C07K2317/92 , C12N15/1037 , C12N15/1075
摘要： The invention provides novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule and methods for producing novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule. The antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other of a Lambda constant domain. The invention provides methods for the isolation of antibodies of different specificities but sharing a common heavy chain. The invention also provides methods for the controlled co-expression of two light chains and a single heavy chain leading to the assembly of monospecific and bispecific antibodies. The invention provides a mean of producing a fully human bispecific and bivalent antibody that is unaltered in sequence and does not involve the use of linkers or other non-human sequences, as well as antibody mixtures of two monospecific antibodies and one bispecific antibody. The invention also provides the means of efficiently purifying the bispecific antibody.
摘要翻译：本发明提供对免疫球蛋白分子的每个结合位点携带不同特异性的新型双特异性单克隆抗体以及用于产生对免疫球蛋白分子的每个结合位点具有不同特异性的新型双特异性单克隆抗体的方法。抗体由单个重链和两个不同的轻链组成，一个含有κ恒定结构域，另一个是λ恒定结构域。本发明提供了分离不同特异性但共享共同重链的抗体的方法。本发明还提供了两个轻链和单个重链的受控共表达的方法，导致单特异性和双特异性抗体的组装。本发明提供了产生完全人双特异性和二价抗体的平均值，其依次不变，不涉及使用接头或其它非人序列，以及两种单特异性抗体和一种双特异性抗体的抗体混合物。本发明还提供有效纯化双特异性抗体的方法。

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