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1. 发明申请

WO2019215510A8 COMPOSITIONS AND METHODS RELATED TO ANTI-CD19 ANTIBODY DRUG CONJUGATES 审中-公开
公开(公告)号：WO2019215510A8
公开(公告)日：2019-11-14
申请号：PCT/IB2019/000577
申请日：2019-05-09
申请人： LEGOCHEM BIOSCIENCES, INC. , NOVIMMUNE, SA
发明人： SONG, Ho Young , PARK, Yun Hee , KIM, Sung Min , KIM, Hyoung Rae , OH, Ji Hye , RYU, Hyun Min , CHAE, Jeiwook , OH, Yeong Soo , KIM, Yong Zu , DEEHAN, Maureen , FISCHER, Nicolas
IPC分类号： A61K47/68 , A61K31/5517 , A61K31/7052 , A61K45/06 , A61P35/00 , A61P37/00 , C07K16/28
摘要： The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-CD 19 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind CD 19, as well as methods of making and using these anti-CD 19 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.

2. 发明申请

WO2019215510A3 COMPOSITIONS AND METHODS RELATED TO ANTI-CD19 ANTIBODY DRUG CONJUGATES 审中-公开
公开(公告)号：WO2019215510A3
公开(公告)日：2019-11-14
申请号：PCT/IB2019/000577
申请日：2019-05-09
申请人： LEGOCHEM BIOSCIENCES, INC. , NOVIMMUNE, Sa
发明人： SONG, Ho, Young , PARK, Yun, Hee , KIM, Sung, Min , KIM, Hyoung, Rae , OH, Ji, Hye , RYU, Hyun, Min , CHAE, Jeiwook , OH, Yeong, Soo , KIM, Yong, Zu , DEEHAN, Maureen , FISCHER, Nicolas
IPC分类号： A61K47/68 , A61K31/5517 , A61K31/7052 , A61K45/06 , A61P35/00 , A61P37/00 , C07K16/28
摘要： The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-CD 19 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind CD 19, as well as methods of making and using these anti-CD 19 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.

3. 发明申请

WO2019215510A2 COMPOSITIONS AND METHODS RELATED TO ANTI-CD19 ANTIBODY DRUG CONJUGATES 审中-公开
公开(公告)号：WO2019215510A2
公开(公告)日：2019-11-14
申请号：PCT/IB2019/000577
申请日：2019-05-09
申请人： LEGOCHEM BIOSCIENCES, INC. , NOVIMMUNE, Sa
发明人： SONG, Ho, Young , PARK, Yun, Hee , KIM, Sung, Min , KIM, Hyoung, Rae , OH, Ji, Hye , RYU, Hyun, Min , CHAE, Jeiwook , OH, Yeong, Soo , KIM, Yong, Zu , DEEHAN, Maureen , FISCHER, Nicolas
IPC分类号： A61K47/68
摘要： The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-CD 19 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind CD 19, as well as methods of making and using these anti-CD 19 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.

4. 发明申请

WO2015033223A3 READILY ISOLATED BISPECIFIC BINDING MOLECULES WITH NATIVE FORMAT HAVING MUTATED CONSTANT REGIONS 审中-公开
标题翻译：准备隔离的双特异性结合分子与本地格式具有变异的恒定区域
公开(公告)号：WO2015033223A3
公开(公告)日：2015-10-29
申请号：PCT/IB2014002388
申请日：2014-09-03
申请人： NOVIMMUNE SA
发明人： FISCHER NICOLAS , MAGISTRELLI GIOVANNI , ROUSSEAU FRANÇOIS , MASTERNAK KRZYSZTOF , MALINGE PAULINE
IPC分类号： C07K16/24 , C07K1/00 , C07K16/28 , C07K16/46
CPC分类号： C07K16/468 , C07K16/244 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/522 , C07K2317/526 , C07K2317/622 , C07K2317/94
摘要： The invention provides heterodimer bispecific antigen-binding molecules that include a first polypeptide thai does not include an IgG CH1 domain and a second polypeptide having an immunoglobulin constant region where there is at least one mutation in the IgG CH3 domain that abolishes the ability of the second polypeptide to bind CH3- specific affinity media such that the first and second polypeptides have different affinities with respect to CH1 and CH3 specific affinity reagents that allows rapid isolation by differential binding of the first and second polypeptides to these affinity reagents. The invention also provides bispeeific antibodies that have IgG CH1 and CH3 regions with different affinities with respect to affinity reagents that allows rapid isolation by differential binding of the IgG regions to these affinity reagents. The invention also concerns bispeeific antibodies which are heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least two amino acids that allowr for the isolation of the bispeeific antibody based on a differential affinity of one mutated immunoglobulin heavy chain and a second mutated immunoglobulin heavy chain toward two different affinity reagents.
摘要翻译：本发明提供了异二聚体双特异性抗原结合分子，其包括不包含IgG CH1结构域的第一多肽和具有免疫球蛋白恒定区的第二多肽，其中IgG CH3结构域中存在至少一个突变，其消除了第二多肽结合CH3特异性亲和介质，使得第一和第二多肽对于CH1和CH3特异性亲和试剂具有不同的亲和力，其允许通过第一和第二多肽与这些亲和试剂的差异结合来快速分离。本发明还提供具有对于亲和试剂具有不同亲和力的IgG CH1和CH3区的双特异性抗体，其允许通过IgG区与这些亲和试剂的差异结合来快速分离。本发明还涉及作为重链异二聚体的双特异性抗体，即两条免疫球蛋白重链相差至少两个氨基酸，允许基于一种突变的免疫球蛋白重链与第二种突变的免疫球蛋白重链的差异亲和力分离双特异性抗体突变的免疫球蛋白重链朝向两种不同的亲和试剂。

5. 发明申请

WO2014087248A3 ANTI-CD47 ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗CD47抗体及其使用方法
公开(公告)号：WO2014087248A3
公开(公告)日：2014-11-06
申请号：PCT/IB2013003164
申请日：2013-12-03
申请人： NOVIMMUNE SA
发明人： MASTERNAK KRZYSZTOF , FISCHER NICOLAS , ROUSSEAU FRANCOIS , DHEILLY ELIE , KOSCO-VILBOIS MARIE
IPC分类号： C07K16/28 , A61K39/00
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/2803 , C07K16/2896 , C07K16/461 , C07K2317/30 , C07K2317/31 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The invention relates to monoclonal and/or monovalent antibodies that bind CD47. The invention relates to monoclonal and/or monovalent antibodies that bind CD19. The invention also relates to novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD47. The invention also relates to novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD19.
摘要翻译：本发明涉及结合CD47的单克隆和/或单价抗体。本发明涉及结合CD19的单克隆和/或单价抗体。本发明还涉及对免疫球蛋白分子的每个结合位点具有不同特异性的新的双特异性单克隆抗体，其中结合位点之一对CD47是特异性的。本发明还涉及对免疫球蛋白分子的每个结合位点具有不同特异性的新的双特异性单克隆抗体，其中一个结合位点对CD19是特异性的。

6. 发明申请

WO2009101479A3 FC RECEPTOR-BINDING POLYPEPTIDES WITH MODIFIED EFFECTOR FUNCTIONS 审中-公开
公开(公告)号：WO2009101479A3
公开(公告)日：2009-08-20
申请号：PCT/IB2008/003978
申请日：2008-05-14
申请人： NOVIMMUNE SA , ELSON, Greg , LEGER, Olivier
发明人： ELSON, Greg , LEGER, Olivier
IPC分类号： A61K39/395 , A61P29/00
摘要： Disclosed are processes for producing a variant polypeptide (e.g. antibodies) having modified binding characteristics for human Fc gamma receptor IIA (CD32A) leading to increased inhibition of proinflammatory mediators while retaining binding to a target antigen via its Fv portion, which processes comprise altering the polypeptides by substitution of at least two amino acid residues at EU position 325, 326 or 328 of a human IgG CH2 region for a sequence selected from SAAF, SKAF, NAAF and NKAF. Also disclosed are molecules, particularly polypeptides, more particularly immunoglobulins (e.g. antibodies) that include a variant CDR3 region, wherein the variant CDR3 region includes at least one amino acid modified relative to a wild-type CDR3 region. The polypeptides that can be generated according to the methods of the invention are highly variable, and they can include antibodies and fusion proteins that contain an Fc region or a biologically active portion thereof.

7. 发明申请

WO0024766A3 NEW TRANSCRIPTION FACTOR OF MHC CLASS II GENES, SUBSTANCES CAPABLE OF INHIBITING THIS NEW TRANSCRIPTION FACTOR AND MEDICAL USES OF THESE SUBSTANCES 审中-公开
标题翻译： MHC II类基因新的转录因子，能够抑制这种新的转录因子的物质以及这些物质的医学用途
公开(公告)号：WO0024766A3
公开(公告)日：2000-08-17
申请号：PCT/EP9908026
申请日：1999-10-22
申请人： NOVIMMUNE SA , MASTERNAK KRZYSZTOF , REITH WALTER , MACH BERNARD
发明人： MASTERNAK KRZYSZTOF , REITH WALTER , MACH BERNARD
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P37/06 , C07K14/47 , C07K16/18 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention relates to a novel transcription factor of MHC class II genes and its derivatives, inhibitors down-regulating the expression of MHC class II molecules, process to identify these inhibitors and medical uses of these inhibitors.
摘要翻译：本发明涉及MHC II类基因及其衍生物的新转录因子，下调MHC II类分子表达的抑制剂，鉴定这些抑制剂的方法以及这些抑制剂的医学用途。

8. 发明申请

WO2018050871A1 BISPECIFIC ANTIBODY DISPLAY ON PHAGE SURFACE 审中-公开
标题翻译：双特异性抗体在噬菌体表面展示
公开(公告)号：WO2018050871A1
公开(公告)日：2018-03-22
申请号：PCT/EP2017/073369
申请日：2017-09-15
申请人： NOVIMMUNE SA
发明人： FAGÈTE, Séverine , HARTLEY, Oliver , FISCHER, Nicolas
IPC分类号： C07K16/00 , G01N33/53
摘要： Provided herein are display systems for simultaneously displaying two different ligand binding polypeptides at the surface of a phage. The two different polypeptides are joined through a protein dimerization domain such as a leucine zipper. Also provided are kits, methods of using such display systems and methods of discovering novel bispecific antibodies.
摘要翻译：本文提供了用于在噬菌体表面同时展示两种不同的配体结合多肽的展示系统。两种不同的多肽通过蛋白质二聚化结构域例如亮氨酸拉链连接。还提供了试剂盒，使用这种显示系统的方法和发现新型双特异性抗体的方法。

9. 发明申请

WO2016177913A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF DISORDERS IN PATIENTS WITH ELEVATED LEVELS OF CXCL9 AND OTHER BIOMARKERS 审中-公开
标题翻译：用于诊断和治疗患有CXCL9和其他生物标志物高水平患者的疾病的方法和组合
公开(公告)号：WO2016177913A1
公开(公告)日：2016-11-10
申请号：PCT/EP2016/060360
申请日：2016-05-09
申请人： NOVIMMUNE SA
发明人： DE MIN, Cristina , FERLIN, Walter , DE BENEDETTI, Fabrizio
IPC分类号： C07K16/24 , A61K39/395 , G01N33/50
CPC分类号： C07K16/249 , A61K9/0019 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/565 , C07K2317/76 , G01N33/6863 , G01N2333/521 , G01N2800/24 , G01N2800/7095
摘要： Methods and compositions for treating hemophagocytic lymphohistiocytosis (HLH) are provided. The disclosure also relates generally to methods and compositions for diagnosing and treating disorders associated with elevated levels of CXCL9, elevated levels of total IFNγ, and other biomarkers. The disclosure also relates to methods of treating, delaying the progression of, or otherwise ameliorating a symptom of a disorder in patients with elevated levels of CXCL9 elevated levels of total IFNγ, and other biomarkers using agents that interfere with or otherwise antagonize interferon gamma (IFNγ) signaling, including neutralizing anti-IFNγ antibodies.
摘要翻译：提供了治疗嗜血细胞淋巴组织细胞增多症（HLH）的方法和组合物。本公开还涉及用于诊断和治疗与升高的CXCL9水平，总IFNγ水平升高和其它生物标志物相关的疾病的方法和组合物。本公开还涉及治疗，延缓进展或以其他方式改善患有CXCL9水平升高的总IFNγ水平的患者的症状的方法，以及使用干扰或以其它方式拮抗干扰素γ（IFNγ）的试剂的其他生物标志物）信号，包括中和抗IFNγ抗体。

10. 发明申请

WO2013136186A3 READILY ISOLATED BISPECIFIC ANTIBODIES WITH NATIVE IMMUNOGLOBULIN FORMAT 审中-公开
标题翻译：具有本身免疫球蛋白形式的自分离分离抗体
公开(公告)号：WO2013136186A3
公开(公告)日：2014-01-23
申请号：PCT/IB2013000902
申请日：2013-03-13
申请人： NOVIMMUNE SA , FISCHER NICOLAS , MAGISTRELLI GIOVANNI , ROUSSEAU FRANCOIS , MASTERNAK KRZYSZTOF , MALINGE PAULINE
发明人： FISCHER NICOLAS , MAGISTRELLI GIOVANNI , ROUSSEAU FRANCOIS , MASTERNAK KRZYSZTOF , MALINGE PAULINE
IPC分类号： C07K16/24 , C07K16/28
CPC分类号： C07K16/468 , C07K16/244 , C07K16/2809 , C07K2317/31
摘要： The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH1 regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).
摘要翻译：本发明涉及具有重链异源二聚体的抗原结合蛋白或抗体，即两条免疫球蛋白重链之间有差异的至少一个或两个氨基酸，其允许基于差异亲和力分离抗原结合蛋白的免疫球蛋白重链和修饰/突变的免疫球蛋白重链朝向亲和试剂。本发明还涉及包含双特异性抗体的抗原结合蛋白，其具有相对于亲和试剂具有不同亲和力的IgG CH1区域，其允许通过IgG区域与亲和试剂的差异结合快速分离。

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