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1. 发明申请

WO2005097791A1 INHIBITORS OF IAP 审中-公开
标题翻译： IAP的抑制剂
公开(公告)号：WO2005097791A1
公开(公告)日：2005-10-20
申请号：PCT/EP2005/003619
申请日：2005-04-06
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , PALERMO, Mark, G. , SHARMA, Sushil, Kumar , STRAUB, Christopher , WANG, Run-Ming , ZAWEL, Leigh , ZHANG, Yanlin , CHEN, Zhuoliang , WANG, Yaping , YANG, Fan , WRONA, Wojciech , LIU, Gang , CHAREST, Mark, G. , HE, Feng
发明人： PALERMO, Mark, G. , SHARMA, Sushil, Kumar , STRAUB, Christopher , WANG, Run-Ming , ZAWEL, Leigh , ZHANG, Yanlin , CHEN, Zhuoliang , WANG, Yaping , YANG, Fan , WRONA, Wojciech , LIU, Gang , CHAREST, Mark, G. , HE, Feng
IPC分类号： C07D471/04
CPC分类号： C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
摘要翻译：抑制Smac蛋白与式（I）的凋亡蛋白抑制剂（IAP）结合的新型化合物。

2. 发明申请

WO2008016893A1 SMAC PEPTIDOMIMETICS USEFUL AS IAP INHIBITORS 审中-公开
标题翻译： SMAC PEPTIDOMIMETICS作为IAP抑制剂有用
公开(公告)号：WO2008016893A1
公开(公告)日：2008-02-07
申请号：PCT/US2007/074790
申请日：2007-07-31
申请人： NOVARTIS AG , NOVARTIS PHARMA GmbH , CHAREST, Mark G. , CHEN, Christine Hiu-Tung , CHEN, Zhuoliang , DAI, Miao , HE, Feng , LEI, Huangshu , PHAM, Ly Luu , SHARMA, Sushil Kumar , STRAUB, Christopher Sean , WANG, Run-Ming David , YANG, Fan , ZAWEL, Leigh
发明人： CHAREST, Mark G. , CHEN, Christine Hiu-Tung , CHEN, Zhuoliang , DAI, Miao , HE, Feng , LEI, Huangshu , PHAM, Ly Luu , SHARMA, Sushil Kumar , STRAUB, Christopher Sean , WANG, Run-Ming David , YANG, Fan , ZAWEL, Leigh
IPC分类号： C07K5/06 , A61P35/00 , A61K31/4439 , A61K31/427
CPC分类号： C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
摘要： The present invention is directed to a compound of the formula (I); or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
摘要翻译：本发明涉及式（I）的化合物; 或其药学上可接受的盐，以及这些化合物在哺乳动物中用于治疗增殖性疾病如癌症的用途。

3. 发明申请

WO2013046136A1 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH 审中-公开
标题翻译： 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES作为突变体IDH的抑制剂
公开(公告)号：WO2013046136A1
公开(公告)日：2013-04-04
申请号：PCT/IB2012/055133
申请日：2012-09-26
申请人： NOVARTIS AG , CHO, Young Shin , LEVELL, Julian Roy , TOURE, Bakary-Barry , YANG, Fan , CAFERRO, Thomas , LEI, Huangshu , LENOIR, Francois , LIU, Gang , PALERMO, Mark G. , SHULTZ, Michael David , SMITH, Troy , COSTALES, Abran Q. , PFISTER, Keith Bruce , SENDZIK, Martin , SHAFER, Cynthia , SUTTON, James , ZHAO, Qian
发明人： CHO, Young Shin , LEVELL, Julian Roy , TOURE, Bakary-Barry , YANG, Fan , CAFERRO, Thomas , LEI, Huangshu , LENOIR, Francois , LIU, Gang , PALERMO, Mark G. , SHULTZ, Michael David , SMITH, Troy , COSTALES, Abran Q. , PFISTER, Keith Bruce , SENDZIK, Martin , SHAFER, Cynthia , SUTTON, James , ZHAO, Qian
IPC分类号： C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/10 , C07D513/04 , A61K31/506 , A61P35/00
CPC分类号： C07D413/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D498/10 , C07D513/04
摘要： The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 -R 6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formual (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1 -R 6在本文中定义。本发明还涉及含有式（I）化合物的组合物以及这些化合物在抑制具有新形态活性的突变体IDH蛋白质中的用途。本发明进一步涉及式（I）化合物在治疗与这种突变体IDH蛋白相关的疾病或病症的用途，包括但不限于细胞增殖病症如癌症。

4. 发明申请

WO2011101409A1 PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 审中-公开
标题翻译：作为CDK4 / 6的抑制剂的吡咯烷酮化合物
公开(公告)号：WO2011101409A1
公开(公告)日：2011-08-25
申请号：PCT/EP2011/052353
申请日：2011-02-17
申请人： NOVARTIS AG , BRAIN, Christopher, Thomas , CHO, Young Shin , GIRALDES, John, William , LAGU, Bharat , LEVELL, Julian , LUZZIO, Michael , PEREZ, Lawrence, Blas , WANG, Yaping , YANG, Fan
发明人： BRAIN, Christopher, Thomas , CHO, Young Shin , GIRALDES, John, William , LAGU, Bharat , LEVELL, Julian , LUZZIO, Michael , PEREZ, Lawrence, Blas , WANG, Yaping , YANG, Fan
IPC分类号： C07D487/04 , C07B59/00 , A61K31/519 , A61P35/00 , C07D519/00
CPC分类号： C07D487/04 , C07D471/08 , C07D471/10 , C07D487/08 , C07D487/10 , C07D498/08 , C07D498/10 , C07D498/20 , C07D519/00
摘要： The invention is directed to novel pyrrolopyrimidine compounds of formula (I) wherein R 1 , R 2Y , R 4 , R 8 - R 11 , A and L are defined herein and to salts, including pharmaceutically acceptable salts thereof. The compounds of the present invention are CDK4/6 inhibitors and could be useful in the treatment of diseases and disorders mediated by CDK4/6, such as cancer, including mantle cell lymphoma, liposarcoma, non small cell lung cancer, melanoma, squamous cell esophageal cancer and breast cancer. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CDK4/6 activity and to the treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
摘要翻译：本发明涉及式（I）的新颖吡咯并嘧啶化合物，其中R 1，R 2 Y，R 4，R 8 -R 11，A和L在本文中定义，并包括其盐，包括其药学上可接受的盐。本发明的化合物是CDK4 / 6抑制剂，可用于治疗由CDK4 / 6介导的疾病和病症，如癌症，包括外套细胞淋巴瘤，脂肪肉瘤，非小细胞肺癌，黑素瘤，鳞状细胞食管癌癌症和乳腺癌。本发明还涉及包含本发明化合物的药物组合物。本发明还涉及抑制CDK4 / 6活性的方法以及使用本发明化合物或包含本发明化合物的药物组合物治疗与之相关的病症。

5. 发明申请

WO2010125402A1 IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES 审中-公开
标题翻译：咪唑衍生物及其作为细胞周期调节因子的调节剂
公开(公告)号：WO2010125402A1
公开(公告)日：2010-11-04
申请号：PCT/GB2010/050725
申请日：2010-04-30
申请人： NOVARTIS AG , ASTEX THERAPEUTICS LIMITED , HOWARD, Steven , MORTENSON, Paul Neil , HISCOCK, Steven Douglas , WOOLFORD, Alison Jo-Anne , WOODHEAD, Andrew James , CHESSARI, Gianni , O'REILLY, Marc , CONGREVE, Miles Stuart , DAGOSTIN, Claudio , CHO, Young Shin , YANG, Fan , CHEN, Christine Hiu-Tung , BRAIN, Christopher Thomas , LAGU, Bharat , WANG, Yaping , KIM, Sunkyu , GRIALDES, John , LUZZIO, Michael Joseph , PEREZ, Lawrence Blas
发明人： HOWARD, Steven , MORTENSON, Paul Neil , HISCOCK, Steven Douglas , WOOLFORD, Alison Jo-Anne , WOODHEAD, Andrew James , CHESSARI, Gianni , O'REILLY, Marc , CONGREVE, Miles Stuart , DAGOSTIN, Claudio , CHO, Young Shin , YANG, Fan , CHEN, Christine Hiu-Tung , BRAIN, Christopher Thomas , LAGU, Bharat , WANG, Yaping , KIM, Sunkyu , GRIALDES, John , LUZZIO, Michael Joseph , PEREZ, Lawrence Blas
IPC分类号： C07D233/22 , C07D235/12 , C07D401/06 , C07D401/10 , C07D401/14 , C07D409/10 , C07D409/14 , C07D413/14 , C07D417/10 , A61K31/4164 , A61K31/4178 , A61P35/00
CPC分类号： C07D471/04 , C07D233/22 , C07D233/24 , C07D235/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/14 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D487/04 , C07D519/00
摘要： The invention provides compounds of the formula (I): and salts, tautomers, solvates and N-oxides thereof; wherein Q is CH or N; X is N, N + -O - or CR 3 ; Y is N, N + -O - or CR 3a ; R 1 and R 2 are independently selected from hydrogen and various substituents as defined in the claims; or R 1 and R 2 together with the atoms to which they are attached, link to form an optionally substituted carbocyclic or heterocyclic aromatic or non-aromatic ring of 4 to 7 members; R 3 is selected from hydrogen and various substituents; and R 3a is selected from hydrogen and various substituents as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds. The compounds of formula (I) have activity as inhibitors of CDK kinases and are useful in the treatment of inter alia proliferative diseases such as cancers.
摘要翻译：本发明提供式（I）化合物及其盐，互变异构体，溶剂化物和N-氧化物; 其中Q是CH或N; X是N，N + -O-或CR 3; Y是N，N + -O-或CR3a; R 1和R 2独立地选自氢和权利要求中定义的各种取代基; 或R 1和R 2与它们所连接的原子一起连接以形成任选取代的4至7个成员的碳环或杂环芳族或非芳族环; R3选自氢和各种取代基; 并且R 3a选自氢和权利要求中定义的各种取代基。还提供含有式（I）化合物，制备化合物的方法和化合物的医疗用途的药物组合物。式（I）化合物具有作为CDK激酶抑制剂的活性，并且可用于治疗尤其是增殖性疾病如癌症。

6. 发明申请

WO2019241509A9 FAST CHARGE FEOF CATHODE FOR LITHIUM ION BATTERIES 审中-公开
公开(公告)号：WO2019241509A9
公开(公告)日：2019-12-19
申请号：PCT/US2019/036954
申请日：2019-06-13
申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION , LIU, Yadong , YANG, Fan
发明人： LIU, Yadong , YANG, Fan , XIE, Jian
IPC分类号： C23C14/24 , H01M4/04 , H01M4/52
摘要： A cathode material including a nanostructured graphene-incorporated iron oxyfluoride-based (FeOF) composite material (FeOF/G). The FeOF/G composite cathode material may have superfast charging rates, high specific capacity/energy, and enhanced cycle life.

7. 发明申请

WO2017058106A1 A SELF-ADAPTIVE VEHICLE MOVEMENT NETWORK SERVICE FOR SMART TRAFFIC DATA COLLECTION 审中-公开
标题翻译：用于智能交通数据收集的自适应车辆运动网络服务
公开(公告)号：WO2017058106A1
公开(公告)日：2017-04-06
申请号：PCT/SG2016/050440
申请日：2016-09-08
申请人： ST ELECTRONICS (INFO-COMM SYSTEMS) PTE LTD , NEO, Aik Chian , YAP, Jiunn Ter, Nicholas , ADI, Robertus Wahendro , NG, Kim Chwee, Albert , YANG, Fan
发明人： NEO, Aik Chian , YAP, Jiunn Ter, Nicholas , ADI, Robertus Wahendro , NG, Kim Chwee, Albert , YANG, Fan
IPC分类号： H04W84/20 , H04W84/22 , G08G1/01
CPC分类号： H04W84/20 , G08G1/0112 , G08G1/0133 , G08G1/0141 , G08G1/052 , G08G1/056 , H04W84/22
摘要： A vehicular communication system comprising one or more vehicle groups or clusters, wherein each group has at least one vehicle comprising a communication module, wherein the or each communication module is configured for communication via a local channel (eg. 802.1 1/WLAN) with other communication modules and via a wide-area channel (eg. LTE/Cellular) with a traffic monitoring server, wherein each vehicle group has at most one vehicle configured as a master or cluster head and optionally one or more additional vehicles configured as slaves or cluster members, wherein the master aggregates vehicle telemetry data from the slave nodes in the group and transmits this information as group telemetry data to the traffic monitoring server via the wide area channel.
摘要翻译：一种包括一个或多个车辆组或集群的车辆通信系统，其中每个组具有包括通信模块的至少一个车辆，其中所述或每个通信模块被配置用于经由本地信道（例如，802.11 / WLAN）与其他通信通信模块和经由具有业务监控服务器的广域信道（例如，LTE /蜂窝）），其中每个车辆组具有至多一个配置为主机或集群头部的车辆，以及可选地一个或多个被配置为从站或集群的车辆成员，其中主人聚集来自组中的从节点的车辆遥测数据，并且经由广域信道将该信息作为组遥测数据发送到交通监控服务器。

8. 发明申请

WO2013149381A1 PLATFORM FOR CONTINUOUS GRAPH UPDATE AND COMPUTATION 审中-公开
标题翻译：连续图表更新和计算的平台
公开(公告)号：WO2013149381A1
公开(公告)日：2013-10-10
申请号：PCT/CN2012/073529
申请日：2012-04-05
申请人： MICROSOFT CORPORATION , YANG, Fan , ZHOU, Lidong , WU, Ming , KYROLA, Aapo , CHENG, Raymond , MIAO, Youshan , WENG, Xuetian , HONG, Ji
发明人： YANG, Fan , ZHOU, Lidong , WU, Ming , KYROLA, Aapo , CHENG, Raymond , MIAO, Youshan , WENG, Xuetian , HONG, Ji
IPC分类号： G06F17/30
CPC分类号： G06F17/30958 , G06F11/1451 , G06F17/30368 , G06F17/30516 , G06F17/30578 , G06F2201/84
摘要： A continuous stream data (e.g., messages, tweets) is received by ingest nodes of a platform. The ingest nodes may analyze the data to create a transaction of graph updates, assign a sequence number to the transaction, and distribute the graph updates with the sequence number to graph nodes of the platform. The graph nodes may store graph updates from ingest nodes, and then the ingest nodes may report graph update progresses in a progress table. A snapshot may be taken based on the progress table, and then graph- mining computation may be implemented. Tolerate failures and decaying may be supported and incremental expansion may be allowed to cope with increasing update rates and computation needs.
摘要翻译：通过平台的摄取节点接收连续流数据（例如，消息，推文）。摄取节点可以分析数据以创建图更新的事务，为事务分配序列号，并将具有序列号的图更新分发到平台的图形节点。图形节点可以存储来自摄取节点的图更新，然后摄取节点可以在进度表中报告图更新进度。可以基于进度表进行快照，然后可以实现图形挖掘计算。可以支持容忍故障和衰减，并且可以允许增量扩展来应对增加的更新速率和计算需求。

9. 发明申请

WO2011011301A2 A MIXED SILICON PHASE FILM FOR HIGH EFFICIENCY THIN FILM SILICON SOLAR CELLS 审中-公开
标题翻译：用于高效薄膜硅太阳电池的混合硅相薄膜
公开(公告)号：WO2011011301A2
公开(公告)日：2011-01-27
申请号：PCT/US2010/042392
申请日：2010-07-19
申请人： APPLIED MATERIALS, INC. , YANG, Fan , ZHANG, Lin , ZHENG, Yi , SCHMITT, Francimar , YUAN, Zheng
发明人： YANG, Fan , ZHANG, Lin , ZHENG, Yi , SCHMITT, Francimar , YUAN, Zheng
IPC分类号： H01L31/075
CPC分类号： H01L31/03685 , H01L31/03762 , H01L31/075 , H01L31/076 , H01L31/1824 , H01L31/202 , Y02E10/545 , Y02E10/548 , Y02P70/521
摘要： A method and apparatus for forming solar cells is provided. In one embodiment, a photovoltaic device includes a first p-i-n junction cell formed on a substrate, wherein the p-i-n junction cell comprises a p-type silicon containing layer, an intrinsic type silicon containing layer formed over the p-type silicon containing layer, and a n-type silicon containing layer formed over the intrinsic type silicon containing layer, wherein the intrinsic type silicon containing layer comprises a first pair of microcrystalline layer and amorphous silicon layer.
摘要翻译：提供了一种用于形成太阳能电池的方法和设备。在一个实施例中，光伏器件包括形成在衬底上的第一pin结电池，其中pin结电池包括p型含硅层，形成在p型含硅层上的本征型含硅层和在本征型含硅层上形成的n型含硅层，其中本征型含硅层包含第一对微晶层和非晶硅层。

10. 发明申请

WO2008097258A2 CONTROLLED GROWTH OF LARGER HETEROJUNCTION INTERFACE AREA FOR ORGANIC PHOTOSENSITIVE DEVICES 审中-公开
标题翻译：用于有机感光装置的大型异步接口界面的控制生长
公开(公告)号：WO2008097258A2
公开(公告)日：2008-08-14
申请号：PCT/US2007/015809
申请日：2007-07-10
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , YANG, Fan , FORREST, Stephen, R.
发明人： YANG, Fan , FORREST, Stephen, R.
IPC分类号： H01L51/42
CPC分类号： H01L51/4246 , H01L51/0008 , H01L51/4253 , Y02E10/549 , Y02P70/521
摘要： An optoelectronic device and a method of fabricating a photosensitive optoelectronic device includes depositing a first organic semiconductor material on a first electrode to form a continuous first layer having protrusions, a side of the first layer opposite the first electrode having a surface area at least three times greater than an underlying lateral cross-sectional area; depositing a second organic semiconductor material directly on the first layer to form a discontinuous second layer, portions of the first layer remaining exposed; depositing a third organic semiconductor material directly on the second layer to form a discontinuous third layer, portions of at least the second layer remaining exposed; depositing a fourth organic semiconductor material on the third layer to form a continuous fourth layer, filling any exposed gaps and recesses in the first, second, and third layers; and depositing a second electrode on the fourth layer, wherein at least one of the first electrode and the second electrode is transparent, and the first and third organic semiconductor materials are both of a donor-type or an acceptor-type relative to second and fourth organic semiconductor materials, which are of the other material type.
摘要翻译：光电子器件和制造光敏光电子器件的方法包括在第一电极上沉积第一有机半导体材料以形成具有突起的连续的第一层，与第一电极相对的第一层的一侧的表面积至少为三倍大于下面的横截面积; 将第二有机半导体材料直接沉积在第一层上以形成不连续的第二层，第一层的部分保持暴露; 将第三有机半导体材料直接沉积在第二层上以形成不连续的第三层，至少第二层的部分保持暴露; 在第三层上沉积第四有机半导体材料以形成连续的第四层，填充第一层，第二层和第三层中任何露出的间隙和凹陷; 以及在所述第四层上沉积第二电极，其中所述第一电极和所述第二电极中的至少一个是透明的，并且所述第一和第三有机半导体材料相对于第二和第四电极都是供体型或受体型有机半导体材料，其它材料类型。

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