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    • 10. 发明申请
    • PHARMACEUTICAL COMPOSITION CONTAINING WATER SOLUBLE DRUG
    • 含有水溶性药物的药物组合物
    • WO2005013939A1
    • 2005-02-17
    • PCT/US2004/025445
    • 2004-08-06
    • MULYE, Nirmal
    • MULYE, Nirmal
    • A61K9/24
    • A61K9/5078A61K9/1676A61K9/5047
    • The present invention is directed to a process of preparing beads coated with a water soluble drug for incorporation into a pharmaceutical composition comprising: (a) preparing a supersaturated drug solution containing a desired amount of drug, which is completely saturated at a first temperature but which is supersaturated at a second temperature which is below the first temperature; and (b) coating inert beads with the drug solution, said drug solution being maintained at or below the first temperature but above the second temperature, and said beads maintained at a second temperature, wherein the second temperature is less than the first temperature and wherein the solution containing the drug is supersaturated at the second temperature, as well as to the pharmaceutical compositions containing same.
    • 本发明涉及一种制备涂覆有水溶性药物的珠粒以掺入药物组合物的方法,该方法包括:(a)制备含有所需量药物的过饱和药物溶液,其在第一温度下完全饱和, 在低于第一温度的第二温度下过饱和; 并且(b)用药物溶液涂覆惰性珠粒,所述药物溶液保持在或低于第一温度但低于第二温度,并且所述珠子保持在第二温度,其中第二温度小于第一温度,其中 含有药物的溶液在第二温度下过饱和,以及含有该药物的药物组合物。