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1. 发明申请

WO2010006291A1 METHODS FOR DIAGNOSIS, PROGNOSIS AND TREATMENT 审中-公开
标题翻译：诊断，预防和治疗方法
公开(公告)号：WO2010006291A1
公开(公告)日：2010-01-14
申请号：PCT/US2009/050295
申请日：2009-07-10
申请人： NODALITY, INC. , FANTL, Wendy, J. , ROSEN, David, B. , CESANO, Alessandra , PUTTA, Santosh, K. , NOLAN, Garry, P. , COHEN, Aileen, C. , EVENSON, Erik
发明人： FANTL, Wendy, J. , ROSEN, David, B. , CESANO, Alessandra , PUTTA, Santosh, K. , NOLAN, Garry, P. , COHEN, Aileen, C. , EVENSON, Erik
IPC分类号： G01N33/50
CPC分类号： G01N33/57426 , G01N33/5041 , G01N33/5044 , G01N33/5055 , G01N33/5073 , G01N33/6893 , G01N2333/70589 , G01N2800/22 , G01N2800/52
摘要： The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
摘要翻译：本发明提供了用于确定单细胞中多种蛋白质的活化状态的方法。这种方法允许基于活化状态，表达标志物和其他标准快速检测复杂细胞群体中的异质性，以及在细胞群体内表现出相关的激活变化的细胞亚群的鉴定。此外，这种方法允许细胞活动或性质的相关性。此外，使用细胞激活的调节剂允许表征途径和细胞群体。可以使用本发明分析的几种示例性疾病包括AML，MDS和MPN。

2. 发明申请

WO2013188469A2 PATHWAYS CHARACTERIZATION OF CELLS 审中-公开
标题翻译：细胞的途径特征
公开(公告)号：WO2013188469A2
公开(公告)日：2013-12-19
申请号：PCT/US2013/045273
申请日：2013-06-11
申请人： NODALITY, INC. , CESANO, Alessandra , ROSEN, David , FANTL, Wendy, J. , HAWTIN, Rachael
发明人： CESANO, Alessandra , ROSEN, David , FANTL, Wendy, J. , HAWTIN, Rachael
IPC分类号： G01N33/68
CPC分类号： G01N33/57415 , C12N15/1137 , C12N2310/14 , C12N2320/31 , C12Y301/02015 , G01N33/5011 , G01N33/505 , G01N33/57449 , G01N33/6875 , G01N33/6893 , G01N2333/9108 , G01N2510/00 , G01N2800/52
摘要： The present invention provides methods, compositions and kits for the characterization of cellular pathways in cells containing genetic alterations.
摘要翻译：本发明提供用于在含有遗传改变的细胞中表征细胞途径的方法，组合物和试剂盒。

3. 发明申请

WO2012083274A2 METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT 审中-公开
标题翻译：诊断，预防和治疗方法的方法
公开(公告)号：WO2012083274A2
公开(公告)日：2012-06-21
申请号：PCT/US2011/065675
申请日：2011-12-16
申请人： NODALITY, INC. , COHEN, Aileen , CESANO, Alessandra , FANTL, Wendy, J. , HUANG, Ying-wen , SOPER, David , ROSEN, David , HOTSON, Drew
发明人： COHEN, Aileen , CESANO, Alessandra , FANTL, Wendy, J. , HUANG, Ying-wen , SOPER, David , ROSEN, David , HOTSON, Drew
CPC分类号： G01N33/57426 , G01N33/5044 , G01N2800/52
摘要： The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. The process is effective at characterizing MDS.
摘要翻译：本发明提供了用于确定单细胞中多种蛋白质的活化状态的方法。这种方法允许基于活化状态，表达标志物和其他标准快速检测复杂细胞群体中的异质性，以及在细胞群体内表现出相关的激活变化的细胞亚群的鉴定。此外，这种方法允许细胞活动或性质的相关性。此外，使用细胞激活的调节剂允许表征途径和细胞群体。该过程在表征MDS方面是有效的。

4. 发明申请

WO2011156654A2 PATHWAYS CHARACTERIZATION OF CELLS 审中-公开
标题翻译：细胞的途径特征
公开(公告)号：WO2011156654A2
公开(公告)日：2011-12-15
申请号：PCT/US2011/039871
申请日：2011-06-09
申请人： NODALITY, INC. , CESANO, Alessandra , FANTL, Wendy, J. , ROSEN, David
发明人： CESANO, Alessandra , FANTL, Wendy, J. , ROSEN, David
IPC分类号： C12Q1/68
CPC分类号： G01N33/5041 , C12Q1/6886 , C12Q2600/112 , G01N2800/52 , G01N2800/7028
摘要： The present invention provides methods, compositions and kits for the characterization of cellular pathways in cells containing genetic alterations.
摘要翻译：本发明提供用于在含有遗传改变的细胞中表征细胞途径的方法，组合物和试剂盒。

5. 发明申请

WO2010135608A1 METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT 审中-公开
标题翻译：诊断，预防和治疗方法的方法
公开(公告)号：WO2010135608A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/035690
申请日：2010-05-20
申请人： NODALITY, INC. , FANTL, Wendy, J. , CESANO, Alessandra , EVENSEN, Erik , PALAZZO, Adam
发明人： FANTL, Wendy, J. , CESANO, Alessandra , EVENSEN, Erik , PALAZZO, Adam
IPC分类号： C12N5/00
CPC分类号： G01N33/56966 , C12Q1/42 , G01N33/5023 , G01N33/5052 , G01N33/564 , G01N33/57426 , G01N2333/705 , G01N2800/101 , G01N2800/52 , G01N2800/56
摘要： This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of a cell present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g. Chronic Lymphocytic Leukemia), in patient selection for therapy, to monitor treatment and to modify or optimize therapeutic regimens.
摘要翻译：本发明涉及用于诊断，预后和用于确定治疗方法的方法和组合物。存在于样品（例如临床样品）中的细胞的生理状态可用于患者选择治疗的病症（例如慢性淋巴细胞性白血病）的诊断或预后，以监测治疗和修饰或优化治疗方案。

6. 发明申请

WO2010045651A1 METHODS FOR ANALYZING DRUG RESPONSE 审中-公开
标题翻译：分析药物反应的方法
公开(公告)号：WO2010045651A1
公开(公告)日：2010-04-22
申请号：PCT/US2009/061195
申请日：2009-10-19
申请人： NODALITY, INC. , FANTL, Wendy, J. , ROSEN, David
发明人： FANTL, Wendy, J. , ROSEN, David
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/537 , G01N33/58
CPC分类号： G01N33/5091 , G01N33/5041 , G01N33/574
摘要： The present invention provides methods, instruments, reagents, kits and the biology involved in analyzing drug response. An embodiment of the present invention provides an approach for the characterization a plurality of pathways in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states of cellular molecules such as proteins, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Some of these categories include redox potential, ITIM phosphorylation, intracellular pH and other categories allows for characterization of such pathways and cell populations. Also, the present analysis is useful for the analysis of the effect of compounds on potential target cells.
摘要翻译：本发明提供了分析药物反应的方法，仪器，试剂，试剂盒和生物学。本发明的实施例提供了用于表征单个细胞中的多个途径的方法。这种方法允许基于诸如蛋白质，表达标志物和其他标准的细胞分子的活化状态，以及在细胞群体内表现出相关的激活变化的细胞亚群的鉴定来快速检测复杂细胞群体中的异质性。这些类别中的一些包括氧化还原电位，ITIM磷酸化，细胞内pH和其他类别允许表征这些途径和细胞群体。此外，本分析对于化合物对潜在靶细胞的影响的分析是有用的。

7. 发明申请

WO2009025847A2 METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT 审中-公开
标题翻译：诊断方法，预后和治疗方法
公开(公告)号：WO2009025847A2
公开(公告)日：2009-02-26
申请号：PCT/US2008/009975
申请日：2008-08-21
申请人： NODALITY, INC. , FANTL, Wendy, J. , PUTTA, Santosh, K. , PEREZ, Omar, D. , FRANCIS-LANG, Helen, L. , COHEN, Aileen, C.
发明人： FANTL, Wendy, J. , PUTTA, Santosh, K. , PEREZ, Omar, D. , FRANCIS-LANG, Helen, L. , COHEN, Aileen, C.
IPC分类号： C12Q1/02
CPC分类号： G01N33/57426 , G01N33/5041 , G01N33/5047 , G01N2333/4703 , G01N2333/7051 , G01N2333/70514 , G01N2333/70517 , G01N2333/70596 , G01N2333/912
摘要： This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of cells present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g. Chronic Lymphocytic Leukemia), in patient selection for therapy, to monitor treatment and to modify or optimize therapeutic regimens. The physiological status of a cell can be determined by comparing the intracellular status of one or more activation elements (e.g. the phosphorylation status of a signaling molecule) in a cell (e.g. a cancer cell) to that of another cell (e.g. a normal cell). The physiological status of a cell can be further classified by adding one or more modulators (e.g. an inhibitor or activator) to the cell in question. In some embodiments, the invention is directed to methods of determining a phenotypic profile of a population of cells.
摘要翻译：本发明涉及用于诊断，预后和确定治疗方法的方法和组合物。存在于样品（例如临床样品）中的细胞的生理状态可以用于病症（例如慢性淋巴细胞性白血病）的诊断或预后，用于治疗的患者选择，监测治疗以及修改或优化治疗方案。细胞的生理状态可以通过比较细胞（例如癌细胞）中一种或多种活化元件的细胞内状态（例如信号分子的磷酸化状态）与另一种细胞（例如正常细胞）的细胞内状态来确定，。细胞的生理状态可以通过将一种或多种调节剂（例如抑制剂或激活剂）添加到所讨论的细胞中进一步分类。在一些实施方案中，本发明涉及确定细胞群体的表型谱的方法。

8. 发明申请

WO2009134944A2 METHODS OF DETERMINING THE HEALTH STATUS OF AN INDIVIDUAL 审中-公开
标题翻译：确定个体健康状况的方法
公开(公告)号：WO2009134944A2
公开(公告)日：2009-11-05
申请号：PCT/US2009/042187
申请日：2009-04-29
申请人： NODALITY, INC. , FANTL, Wendy, J. , FRANCIS-LANG, Helen, L. , COHEN, Aileen, C. , NOLAN, Garry, P.
发明人： FANTL, Wendy, J. , FRANCIS-LANG, Helen, L. , COHEN, Aileen, C. , NOLAN, Garry, P.
IPC分类号： G01N33/50 , G01N33/574
CPC分类号： G01N33/56966 , G01N33/5091 , G01N33/57426
摘要： Methods of determining health status based on analysis of single cells in a sample or set of samples from an individual are described.
摘要翻译：描述了基于来自个体的样本或一组样本中的单个细胞的分析来确定健康状况的方法。

9. 发明申请

WO2004003152A2 SOS1 INHIBITORS 审中-公开
标题翻译： SOS1抑制剂
公开(公告)号：WO2004003152A2
公开(公告)日：2004-01-08
申请号：PCT/US2003/020293
申请日：2003-06-25
申请人： CHIRON CORPORATION , FANTL, Wendy, J. , JAITNER, Birgit, K.
发明人： FANTL, Wendy, J. , JAITNER, Birgit, K.
IPC分类号： C12N
CPC分类号： C12N15/1136 , C07K14/4705
摘要： Inhibitors of human Sos1, including antisense oligonucleotides, methods, and compositions specific for human Sos1, are provided. Methods of using the compositions for modulating Sos1 expression and for regulating cell growth, particularly tumor cell growth, are also provided.
摘要翻译：提供人Sos1的抑制剂，包括反义寡核苷酸，方法和人Sos1特异性的组合物。还提供了使用该组合物调节Sos1表达和调节细胞生长，特别是肿瘤细胞生长的方法。

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