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1. 发明申请

WO2010006291A1 METHODS FOR DIAGNOSIS, PROGNOSIS AND TREATMENT 审中-公开
标题翻译：诊断，预防和治疗方法
公开(公告)号：WO2010006291A1
公开(公告)日：2010-01-14
申请号：PCT/US2009/050295
申请日：2009-07-10
申请人： NODALITY, INC. , FANTL, Wendy, J. , ROSEN, David, B. , CESANO, Alessandra , PUTTA, Santosh, K. , NOLAN, Garry, P. , COHEN, Aileen, C. , EVENSON, Erik
发明人： FANTL, Wendy, J. , ROSEN, David, B. , CESANO, Alessandra , PUTTA, Santosh, K. , NOLAN, Garry, P. , COHEN, Aileen, C. , EVENSON, Erik
IPC分类号： G01N33/50
CPC分类号： G01N33/57426 , G01N33/5041 , G01N33/5044 , G01N33/5055 , G01N33/5073 , G01N33/6893 , G01N2333/70589 , G01N2800/22 , G01N2800/52
摘要： The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
摘要翻译：本发明提供了用于确定单细胞中多种蛋白质的活化状态的方法。这种方法允许基于活化状态，表达标志物和其他标准快速检测复杂细胞群体中的异质性，以及在细胞群体内表现出相关的激活变化的细胞亚群的鉴定。此外，这种方法允许细胞活动或性质的相关性。此外，使用细胞激活的调节剂允许表征途径和细胞群体。可以使用本发明分析的几种示例性疾病包括AML，MDS和MPN。

2. 发明申请

WO2016138182A1 METHODS AND COMPOSITIONS FOR IMMUNOMODULATION 审中-公开
标题翻译：免疫调节的方法和组合物
公开(公告)号：WO2016138182A1
公开(公告)日：2016-09-01
申请号：PCT/US2016/019423
申请日：2016-02-24
申请人： NODALITY, INC. , HOTSON, Drew , CONROY, Andy , LE SCOLAN, Erwan
发明人： HOTSON, Drew , CONROY, Andy , LE SCOLAN, Erwan , HAWTIN, Rachael
IPC分类号： G06F7/00
CPC分类号： G01N33/5091 , G01N33/56972 , G01N33/57407 , G01N2800/52
摘要： The invention relates to immunomodulation of cells and the detection and use thereof, for example, in drug screening, including methods, compositions and systems therefor, or in an aspect of healthcare, such as prognosis, diagnosis, an aspect of treatment, monitoring, and the like, and methods, compositions, and systems thereof.
摘要翻译：本发明涉及细胞的免疫调节及其检测和使用，例如在药物筛选中，包括其方法，组合物和系统，或在保健方面，例如预后，诊断，治疗方面，监测和类似物，及其方法，组合物和系统。

3. 发明申请

WO2016036878A1 METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT 审中-公开
标题翻译：诊断，预防和治疗方法的方法
公开(公告)号：WO2016036878A1
公开(公告)日：2016-03-10
申请号：PCT/US2015/048184
申请日：2015-09-02
申请人： NODALITY, INC.
发明人： CESANO, Alessandra , HAWTIN, Rachael , PUTTA, Santosh
IPC分类号： C12Q1/68 , C12Q1/37 , G01N33/574 , G01N33/53
CPC分类号： G01N33/57426 , G01N2510/00
摘要： The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations.
摘要翻译：本发明提供了确定单细胞中多种蛋白质的活化状态的方法。这种方法允许基于激活状态，表达标志物和其他标准快速检测复杂细胞群体中的异质性，以及鉴定细胞群体内活化相关变化的细胞亚群。此外，该方法允许细胞活性或性质的相关性。此外，使用细胞激活的调节剂允许表征途径和细胞群体。

4. 发明申请

WO2014036040A2 METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT 审中-公开
标题翻译：诊断，预防和治疗方法的方法
公开(公告)号：WO2014036040A2
公开(公告)日：2014-03-06
申请号：PCT/US2013056914
申请日：2013-08-27
申请人： NODALITY INC , PTACEK JASON , EVENSEN ERIK , HAWTIN RACHAEL
发明人： PTACEK JASON , EVENSEN ERIK , HAWTIN RACHAEL
IPC分类号： G01N33/50
CPC分类号： G01N33/5091 , G01N33/50 , G01N33/5017 , G01N33/502 , G01N33/5041 , G01N33/5094 , G01N2800/24 , G01N2800/50 , G01N2800/52 , G01N2800/60 , G01N2800/7028
摘要： The invention provides methods, compositions, and systems for diagnosis, evaluation of status, and/or determination of treatment for pathological conditions.
摘要翻译：本发明提供用于诊断，评估状态和/或病理状态治疗的确定的方法，组合物和系统。

5. 发明申请

WO2010006303A3 METHODS AND APPARATUS RELATED TO MANAGEMENT OF EXPERIMENTS 审中-公开
标题翻译：与实验管理相关的方法和装置
公开(公告)号：WO2010006303A3
公开(公告)日：2010-04-22
申请号：PCT/US2009050307
申请日：2009-07-10
申请人： NODALITY INC , PUTTA SANTOSH K
发明人： PUTTA SANTOSH K
IPC分类号： G01N15/14 , G01N35/00
CPC分类号： G01N35/00663 , G01N15/1404 , G01N35/00712
摘要： In one embodiment, a method includes sending an indicator of an availability of a sample from a sample pool stored in a physical inventory. The sample is included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool. An indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites is received. A rule is retrieved from a rule database based on an experimental parameter value associated with the first test site. At least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site is modified based on a condition within the rule being satisfied.
摘要翻译：在一个实施例中，一种方法包括从存储在物理库存中的样本池发送样本的可用性的指示符。基于满足与样本池相关联的条件的样本的属性，将样本包含在样本池中。收到样本已经从样本池中选择用于在包含在测试点阵列中的第一测试位点进行分析的指示符。基于与第一测试站点相关联的实验参数值从规则数据库检索规则。基于满足规则内的条件，修改与第一测试站点相关联的实验参数值中的至少一个或与第二测试站点相关联的实验参数值。

6. 发明申请

WO2009134944A3 METHODS OF DETERMINING THE HEALTH STATUS OF AN INDIVIDUAL 审中-公开
标题翻译：确定个体健康状况的方法
公开(公告)号：WO2009134944A3
公开(公告)日：2010-02-25
申请号：PCT/US2009042187
申请日：2009-04-29
申请人： NODALITY INC , FANTL WENDY J , FRANCIS-LANG HELEN L , COHEN AILEEN C , NOLAN GARRY P
发明人： FANTL WENDY J , FRANCIS-LANG HELEN L , COHEN AILEEN C , NOLAN GARRY P
IPC分类号： G01N33/50 , G01N33/574
CPC分类号： G01N33/56966 , G01N33/5091 , G01N33/57426
摘要： Methods of determining health status based on analysis of single cells in a sample or set of samples from an individual are described.
摘要翻译：描述了基于来自个体的样本或一组样本中的单个细胞的分析来确定健康状况的方法。

7. 发明申请

WO2010006303A2 METHODS AND APPARATUS RELATED TO MANAGEMENT OF EXPERIMENTS 审中-公开
标题翻译：与实验管理相关的方法和装置
公开(公告)号：WO2010006303A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/050307
申请日：2009-07-10
申请人： NODALITY, INC. , PUTTA, Santosh, K.
发明人： PUTTA, Santosh, K.
IPC分类号： G01N15/14 , G01N35/00
CPC分类号： G01N35/00663 , G01N15/1404 , G01N35/00712
摘要： In one embodiment, a method includes sending an indicator of an availability of a sample from a sample pool stored in a physical inventory. The sample being included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool. An indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites is received. A rule is retrieved from a rule database based on an experimental parameter value associated with the first test site. At least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site is modified based on a condition within the rule being satisfied.
摘要翻译：在一个实施例中，一种方法包括从存储在物理库存中的样本池发送样本的可用性的指示符。基于满足与样本池相关联的条件的样本的属性，将样本包含在样本池中。收到样本已经从样本池中选择用于在包含在测试点阵列中的第一测试位点进行分析的指示符。基于与第一测试站点相关联的实验参数值从规则数据库检索规则。基于满足规则内的条件，修改与第一测试站点相关联的实验参数值中的至少一个或与第二测试站点相关联的实验参数值。

8. 发明申请

WO2009025847A2 METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT 审中-公开
标题翻译：诊断方法，预后和治疗方法
公开(公告)号：WO2009025847A2
公开(公告)日：2009-02-26
申请号：PCT/US2008/009975
申请日：2008-08-21
申请人： NODALITY, INC. , FANTL, Wendy, J. , PUTTA, Santosh, K. , PEREZ, Omar, D. , FRANCIS-LANG, Helen, L. , COHEN, Aileen, C.
发明人： FANTL, Wendy, J. , PUTTA, Santosh, K. , PEREZ, Omar, D. , FRANCIS-LANG, Helen, L. , COHEN, Aileen, C.
IPC分类号： C12Q1/02
CPC分类号： G01N33/57426 , G01N33/5041 , G01N33/5047 , G01N2333/4703 , G01N2333/7051 , G01N2333/70514 , G01N2333/70517 , G01N2333/70596 , G01N2333/912
摘要： This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of cells present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g. Chronic Lymphocytic Leukemia), in patient selection for therapy, to monitor treatment and to modify or optimize therapeutic regimens. The physiological status of a cell can be determined by comparing the intracellular status of one or more activation elements (e.g. the phosphorylation status of a signaling molecule) in a cell (e.g. a cancer cell) to that of another cell (e.g. a normal cell). The physiological status of a cell can be further classified by adding one or more modulators (e.g. an inhibitor or activator) to the cell in question. In some embodiments, the invention is directed to methods of determining a phenotypic profile of a population of cells.
摘要翻译：本发明涉及用于诊断，预后和确定治疗方法的方法和组合物。存在于样品（例如临床样品）中的细胞的生理状态可以用于病症（例如慢性淋巴细胞性白血病）的诊断或预后，用于治疗的患者选择，监测治疗以及修改或优化治疗方案。细胞的生理状态可以通过比较细胞（例如癌细胞）中一种或多种活化元件的细胞内状态（例如信号分子的磷酸化状态）与另一种细胞（例如正常细胞）的细胞内状态来确定，。细胞的生理状态可以通过将一种或多种调节剂（例如抑制剂或激活剂）添加到所讨论的细胞中进一步分类。在一些实施方案中，本发明涉及确定细胞群体的表型谱的方法。

9. 发明申请

WO2012083274A3 METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT 审中-公开
标题翻译：诊断，预防和治疗方法的方法
公开(公告)号：WO2012083274A3
公开(公告)日：2014-04-10
申请号：PCT/US2011065675
申请日：2011-12-16
申请人： NODALITY INC , COHEN AILEEN , CESANO ALESSANDRA , FANTL WENDY J , HUANG YING-WEN , SOPER DAVID , ROSEN DAVID , HOTSON DREW
发明人： COHEN AILEEN , CESANO ALESSANDRA , FANTL WENDY J , HUANG YING-WEN , SOPER DAVID , ROSEN DAVID , HOTSON DREW
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57426 , G01N33/5044 , G01N2800/52
摘要： The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. The process is effective at characterizing MDS.
摘要翻译：本发明提供了确定单细胞中多种蛋白质的活化状态的方法。这种方法允许基于激活状态，表达标志物和其他标准快速检测复杂细胞群体中的异质性，以及鉴定细胞群体内活化相关变化的细胞亚群。此外，该方法允许细胞活性或性质的相关性。此外，使用细胞激活的调节剂允许表征途径和细胞群体。该过程在表征MDS方面是有效的。

10. 发明申请

WO2014036040A3 METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT 审中-公开
公开(公告)号：WO2014036040A3
公开(公告)日：2014-03-06
申请号：PCT/US2013/056914
申请日：2013-08-27
申请人： NODALITY INC. , PTACEK, Jason , EVENSEN, Erik , HAWTIN, Rachael
发明人： PTACEK, Jason , EVENSEN, Erik , HAWTIN, Rachael
IPC分类号： C12Q1/02 , G01N33/53
摘要： The invention provides methods, compositions, and systems for diagnosis, evaluation of status, and/or determination of treatment for pathological conditions.

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