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1. 发明申请

WO2013188469A3 PATHWAYS CHARACTERIZATION OF CELLS 审中-公开
标题翻译：细胞的途径特征
公开(公告)号：WO2013188469A3
公开(公告)日：2015-04-02
申请号：PCT/US2013045273
申请日：2013-06-11
申请人： NODALITY INC , CESANO ALESSANDRA , ROSEN DAVID , FANTL WENDY J , HAWTIN RACHAEL
发明人： CESANO ALESSANDRA , ROSEN DAVID , FANTL WENDY J , HAWTIN RACHAEL
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： G01N33/57415 , C12N15/1137 , C12N2310/14 , C12N2320/31 , C12Y301/02015 , G01N33/5011 , G01N33/505 , G01N33/57449 , G01N33/6875 , G01N33/6893 , G01N2333/9108 , G01N2510/00 , G01N2800/52
摘要： The present invention provides methods, compositions and kits for the characterization of cellular pathways in cells containing genetic alterations.
摘要翻译：本发明提供用于在含有遗传改变的细胞中表征细胞途径的方法，组合物和试剂盒。

2. 发明申请

WO2013055751A3 SYSTEMS AND METHODS FOR HEALTH CARE CREDIT TRANSACTIONS 审中-公开
标题翻译：卫生保健信托交易系统与方法
公开(公告)号：WO2013055751A3
公开(公告)日：2014-05-30
申请号：PCT/US2012059486
申请日：2012-10-10
申请人： STAGE 5 INNOVATION LLC , SAIDEL ANDREW M , ROSEN DAVID K
发明人： SAIDEL ANDREW M , ROSEN DAVID K
IPC分类号： G06Q50/00
CPC分类号： G06Q40/08 , G06F19/328 , G06Q10/10 , G06Q20/24 , G06Q30/0207 , G06Q40/04 , G06Q40/06 , G06Q50/22
摘要： Systems, methods, and computer program media for creating, managing, backing, and transferring health care credits are described. Health care credits may be implemented as freely transferrable financial instruments whose initial value is based on costs or savings generated by an individual, or by a health care provider, that are associated with a health-related metric or a health benefitting behavior(s).
摘要翻译：描述了用于创建，管理，支持和转移医疗保健积分的系统，方法和计算机程序媒体。医疗保健贷款可以实施为可自由转让的金融工具，其初始价值取决于与健康相关的指标或健康受益行为相关的个人或医疗保健提供者产生的成本或储蓄。

3. 发明申请

WO2013055605A1 SYSTEMS AND METHODS FOR PROVIDING HEALTH CARE CREDITS TO SUBSCRIBERS 审中-公开
标题翻译：向用户提供健康照护信用证的系统和方法
公开(公告)号：WO2013055605A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/059143
申请日：2012-10-05
申请人： STAGE 5 INNOVATION, LLC , SAIDEL, Andrew, M. , ROSEN, David, K.
发明人： SAIDEL, Andrew, M. , ROSEN, David, K.
IPC分类号： G06Q10/00
CPC分类号： G06Q10/10 , G06F19/00 , G06Q30/0207 , G06Q40/08 , G06Q50/22
摘要： Systems and methods to manage health insurance are described. An individual can submit a request to enroll in a health insurance plan of an insurance provider. The individual can complete a health assessment with a health care provider associated with the insurance provider, and the insurance provider can review results of the health assessment to determine an amount of health care credits to award to the individual An account servicer can manage a health care credits account associated with the individual. In implementations, the individual can be rewarded with additional health care credits on a periodic or event-driven basis, based on a health of the individual and other factors.
摘要翻译：描述了管理健康保险的系统和方法。个人可以提交参加保险提供者健康保险计划的请求。个人可以与与保险提供者相关的保健提供者完成健康评估，保险提供者可以检查健康评估的结果，以确定向个人授予的医疗保健金额的数量帐户服务人员可以管理保健与个人相关的信用账户。在实施中，个人可以根据个人的健康和其他因素在定期或事件驱动的基础上奖励额外的医疗保健积分。

4. 发明申请

WO2010045651A1 METHODS FOR ANALYZING DRUG RESPONSE 审中-公开
标题翻译：分析药物反应的方法
公开(公告)号：WO2010045651A1
公开(公告)日：2010-04-22
申请号：PCT/US2009/061195
申请日：2009-10-19
申请人： NODALITY, INC. , FANTL, Wendy, J. , ROSEN, David
发明人： FANTL, Wendy, J. , ROSEN, David
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/537 , G01N33/58
CPC分类号： G01N33/5091 , G01N33/5041 , G01N33/574
摘要： The present invention provides methods, instruments, reagents, kits and the biology involved in analyzing drug response. An embodiment of the present invention provides an approach for the characterization a plurality of pathways in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states of cellular molecules such as proteins, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Some of these categories include redox potential, ITIM phosphorylation, intracellular pH and other categories allows for characterization of such pathways and cell populations. Also, the present analysis is useful for the analysis of the effect of compounds on potential target cells.
摘要翻译：本发明提供了分析药物反应的方法，仪器，试剂，试剂盒和生物学。本发明的实施例提供了用于表征单个细胞中的多个途径的方法。这种方法允许基于诸如蛋白质，表达标志物和其他标准的细胞分子的活化状态，以及在细胞群体内表现出相关的激活变化的细胞亚群的鉴定来快速检测复杂细胞群体中的异质性。这些类别中的一些包括氧化还原电位，ITIM磷酸化，细胞内pH和其他类别允许表征这些途径和细胞群体。此外，本分析对于化合物对潜在靶细胞的影响的分析是有用的。

5. 发明申请

WO2007011610A3 PROTEIN FORMULATION FOR PROMOTING HARD TISSUE FORMATION 审中-公开
标题翻译：用于促进硬组织形成的蛋白质制剂
公开(公告)号：WO2007011610A3
公开(公告)日：2008-10-16
申请号：PCT/US2006027075
申请日：2006-07-12
申请人： ACOLOGIX INC , LAZAROV MIRELLA , MIDDLETON-HARDIE CATHERINE , ROSEN DAVID
发明人： LAZAROV MIRELLA , MIDDLETON-HARDIE CATHERINE , ROSEN DAVID
IPC分类号： A61K38/00 , A61K38/02 , A61K38/03 , A61K38/04 , A61K38/08 , A61K38/10 , A61K38/16 , A61K38/18
CPC分类号： A61K38/1709 , A61K38/1875 , A61K2300/00
摘要： Formulations and kits used to promote biological processes to form or regenerate new hard tissues such as bones, cartilage, and/or dental tissues are disclosed. The formulation comprises a carrier and two or more proteins and enhances biological activities of a hard tissue growth and differentiation factor characterized by specific and selective upregulation and/or extension of the retention time of the intracellular enzymes and signaling molecules that play important roles to proliferate, differentiate, maturate, and/or mineralize the hard tissue forming cells.
摘要翻译：公开了用于促进生物过程以形成或再生新的硬组织例如骨，软骨和/或牙科组织的制剂和试剂盒。该制剂包含载体和两种或更多种蛋白质，并增强硬组织生长和分化因子的生物学活性，其特征在于特异性和选择性上调和/或延长细胞内酶和信号分子的保留时间，其起到重要作用以增殖，分化，成熟和/或矿化硬组织形成细胞。

6. 发明申请

WO2007027510A3 REGULATION OF MINERAL AND SKELETAL METABOLISM 审中-公开
标题翻译：矿物和骨骼代谢调控
公开(公告)号：WO2007027510A3
公开(公告)日：2008-01-10
申请号：PCT/US2006033133
申请日：2006-08-23
申请人： ACOLOGIX INC , HABERBERGER THOMAS , ROSEN DAVID , KUMAGAI YOSHINARI
发明人： HABERBERGER THOMAS , ROSEN DAVID , KUMAGAI YOSHINARI
IPC分类号： A01N37/18
CPC分类号： A61K38/1703
摘要： A method is disclosed whereby levels of calcium, phosphate and parathyroid hormone are measured in a patient. The patient is treated with a formulation comprising a compound having phosphotonin activity and thereafter measurements are made again. Dosing of the formulation is adjusted based on measurements with measuring, administering and adjusting dosing continually repeated as needed.
摘要翻译：公开了一种在患者体内测量钙，磷酸盐和甲状旁腺激素水平的方法。用包含具有磷酸肌醇蛋白活性的化合物的制剂治疗患者，然后再次进行测量。基于测量，根据需要，连续重复测量，施用和调整剂量来调节配方的剂量。

7. 发明申请

WO2007011844A1 SIDE VIEW IMAGING MICROWELL ARRAY 审中-公开
标题翻译：侧视图成像MICROWELL阵列
公开(公告)号：WO2007011844A1
公开(公告)日：2007-01-25
申请号：PCT/US2006/027616
申请日：2006-07-18
申请人： PHYSICAL SCIENCES, INC. , FERRANTE, Anthony, A. , ROSEN, David, I. , FERGUSON, R., Daniel
发明人： FERRANTE, Anthony, A. , ROSEN, David, I. , FERGUSON, R., Daniel
IPC分类号： G01N21/25 , B01L3/00
CPC分类号： G01N21/253 , B01L3/5085 , B01L9/523 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , G01N21/0303 , G01N21/55 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N2021/0382 , G01N2201/0634
摘要： Methods and apparatus for imaging a sample using a microwell array are provided. The methods and apparatus allow side view imaging of a sample to acquire fluorescence or bright field images.
摘要翻译：提供了使用微孔阵列成像样品的方法和装置。所述方法和装置允许样品的侧视图成像以获取荧光或明场图像。

8. 发明申请

WO2006078464A2 FORMULATIONS OF PEPTIDES FOR PERIODONTAL AND DENTAL TREATMENTS 审中-公开
标题翻译：用于周期和牙科治疗的肽的制剂
公开(公告)号：WO2006078464A2
公开(公告)日：2006-07-27
申请号：PCT/US2006/000347
申请日：2006-01-05
申请人： ACOLOGIX, INC. , LAZAROVA, Mirella , ROSEN, David , KUMAGAI, Yoshinari
发明人： LAZAROVA, Mirella , ROSEN, David , KUMAGAI, Yoshinari
IPC分类号： A01N59/26
CPC分类号： A61K38/1841 , A61K9/0063 , A61K31/728 , A61K33/42 , A61K38/10 , A61K2300/00
摘要： Methods to treat the defects in skeletal tissues characterized by protecting the marrow cells adjacent to the defects from apoptotic and/or necrotic cell death are disclosed. The methods provide additional benefits which are to reduce inflammation and irritation in the marrow tissues and assist promoting new skeletal tissue formation to an application of a simple skeletal formation or regeneration activity such as a bone growth factor. The methods may involve application of pharmacologically active peptidic compounds comprising about 15 to about 28 amino acids in their sequences characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan attachment motif, and/or a calcium binding motif. The sequence may be a 23 amino acid sequence formulated for injection, topical application, or dispersed in a matrix such as collagen or a tooth filling composition or gum patch and administered to enhance bone/tooth growth or prevent loss.
摘要翻译：公开了治疗骨缺损的方法，其特征在于保护与缺陷相邻的骨髓细胞凋亡和/或坏死细胞死亡。所述方法提供额外的益处，其是减少骨髓组织中的炎症和刺激，并且有助于促进新的骨骼组织形成以应用简单的骨骼形成或再生活性，例如骨生长因子。所述方法可以包括在其序列中应用包含约15至约28个氨基酸的药理学活性肽化合物，其特征在于含有整联蛋白结合基序如RGD序列，糖胺聚糖附着基序和/或钙结合基序。该序列可以是配制用于注射，局部施用或分散在诸如胶原或牙齿填充组合物或牙龈贴剂的基质中的23个氨基酸序列，并且用于增强骨/牙齿生长或防止损失。

9. 发明申请

WO2006031674A1 PROCESS FOR PREPARING N-(SUBSTITUTED ARYLMETHYL)-4-SUBSTITUTED-4- (DISUBSTITUTED METHYL) PIPERIDINES AND INTERMEDIATES 审中-公开
标题翻译：制备N-（取代的芳基甲基）-4-取代的4-（取代的甲基）哌嗪和中间体的方法
公开(公告)号：WO2006031674A1
公开(公告)日：2006-03-23
申请号：PCT/US2005/032279
申请日：2005-09-12
申请人： FMC CORPORATION , GOUDAR, Jaidev , ROSEN, David, S. , YEAGER, Walter, H. , WANG, Guozhi , ZHANG, Qun , PATERA, Russell
发明人： GOUDAR, Jaidev , ROSEN, David, S. , YEAGER, Walter, H. , WANG, Guozhi , ZHANG, Qun , PATERA, Russell
IPC分类号： C07D401/10 , C07D211/40 , A61K31/4747
CPC分类号： C07D211/46 , C07D401/12
摘要： An improved process is described for preparing a N-(substituted arylmethyl)4-substituted-4-(disubstituted methyl)piperidine of formula (I): wherein R l and R 2 are independently selected from the group consisting of halogen, CF 3 , OCF 3 , OCHF 2 , OCF 2 CHF 2 and SF 5 ; and Z and B are independently selected from the group consisting of CH and N; as well as processes for preparing intermediates useful in the overall process.
摘要翻译：描述了制备式（I）的N-（取代的芳基甲基）-4-取代的-4-（二取代的甲基）哌啶的改进方法：其中R

10. 发明申请

WO2005036961A2 N-SUBSTITUTED AZACYCLES 审中-公开
标题翻译： N-取代的缩合物
公开(公告)号：WO2005036961A2
公开(公告)日：2005-04-28
申请号：PCT/US2004/032720
申请日：2004-10-04
申请人： FMC CORPORATION , THEODORIDIS, George , ROSEN, David , ZHANG, Shunxiang , YEAGER, Walter, H. , HENRIE II, Robert, N. , AHMED, Syed, Z. , MEN, Hongbin , DONOVAN, Stephen, F.
发明人： THEODORIDIS, George , ROSEN, David , ZHANG, Shunxiang , YEAGER, Walter, H. , HENRIE II, Robert, N. , AHMED, Syed, Z. , MEN, Hongbin , DONOVAN, Stephen, F.
IPC分类号： A01N
CPC分类号： C07D211/48 , A01N43/40 , A01N43/54 , A01N43/58 , A01N43/713 , A01N43/90 , A01N47/06 , A01N47/20 , A01N47/22 , C07D211/94 , C07D401/10 , C07D401/12 , C07D451/02 , C07D471/10
摘要： N-substituted azacycle derivative compounds represented by formula (I): wherein m, q, r, t and u are independently selected from 0 or 1; and p is 0, 1, 2, or 3; and A, B, D, X, Y, R, R', R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 are fully described herein. The compounds being particularly useful in compositions comprising an insecticidally effective amount of at least one compound of formula I, and an insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.
摘要翻译：由式（I）表示的N-取代的azacycle衍生物化合物：其中m，q，r，t和u独立地选自0或1; 且p为0,1,2或3; 和A，B，D，X，Y，R，R'，R 2，R 3，R 4，R 5，R 6，R 7，R 8， R 9，R 10和R 11在此完全描述。还公开了特别可用于包含杀虫有效量的至少一种式I化合物和杀虫相容载体的化合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。

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