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1. 发明申请

WO2010045370A3 METHOD OF PREPARING POLYGLUTAMATE CONJUGATES 审中-公开
公开(公告)号：WO2010045370A3
公开(公告)日：2010-04-22
申请号：PCT/US2009/060694
申请日：2009-10-14
申请人： NITTO DENKO CORPORATION , VAN, Sang , DAS, Sanjib, Kumar , ZHAO, Gang , YU, Lei
发明人： VAN, Sang , DAS, Sanjib, Kumar , ZHAO, Gang , YU, Lei
IPC分类号： A61K47/48
摘要： Methods for preparing and isolating polymer conjugates that include a recurring unit of Formulae (I) and (Ia) are described herein. The polymer conjugates can include an anti-cancer drug.

2. 发明申请

WO2008141107A8 COMPOSITIONS THAT INCLUDE A HYDROPHOBIC COMPOUND AND A POLYAMINO ACID CONJUGATE 审中-公开
公开(公告)号：WO2008141107A8
公开(公告)日：2008-11-20
申请号：PCT/US2008/063114
申请日：2008-05-08
申请人： NITTO DENKO CORPORATION , VAN, Sang , SONG, Yucheng , WANG, Xinghe , HOU, Zheng , FENG, Zhongling , ZHAO, Gang , YU, Lei
发明人： VAN, Sang , SONG, Yucheng , WANG, Xinghe , HOU, Zheng , FENG, Zhongling , ZHAO, Gang , YU, Lei
IPC分类号： A61K47/48 , A61K49/00 , A61K49/12 , A61K49/18 , A61P35/00
摘要： Various compositions that include a hydrophobic compound and a polymer conjugate are described herein. The compositions can include a polymer conjugate, a first hydrophobic drug, and a second hydrophobic drug. The polymer conjugates of the compositions described herein are capable of conjugating to a number of agents, such as imaging agents, targeting agents, stabilizing agents and/or drugs. Additionally, the polymer conjugates described herein can form nanoparticles that effectively solubilize the agent in an aqueous system by dispersing it at a molecular level, thus increasing the functionality and/or bioavailability of the agent. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications, including delivery of an agent to specific parts of the body.

3. 发明申请

WO2006101664A1 POLYMER COATING OF CELLS 审中-公开
标题翻译：聚合物涂层的细胞
公开(公告)号：WO2006101664A1
公开(公告)日：2006-09-28
申请号：PCT/US2006/006568
申请日：2006-02-23
申请人： NITTO DENKO CORPORATION , VAN, Sang , TANAKA, Yasunobu , YU, Lei
发明人： VAN, Sang , TANAKA, Yasunobu , YU, Lei
IPC分类号： C08G69/10
CPC分类号： C08G69/10 , A61K31/765 , A61K35/36 , A61K35/44 , A61K35/545 , A61K47/59 , A61K47/595 , A61K47/6901 , A61L27/18 , A61L27/34 , A61L27/3834 , A61L27/54 , A61L2300/64 , C08G69/02 , C08G69/08 , C08G73/028 , C12N5/0068 , C12N2533/30 , Y10T70/437 , C08L77/00
摘要： Polymers and methods of making them are described. The polymers may be used to coat living cells. The polymer-coated cells are useful in cell therapy applications.
摘要翻译：描述了聚合物及其制备方法。聚合物可用于包衣活细胞。聚合物涂覆的细胞可用于细胞治疗应用。

4. 发明申请

WO2004076557A1 BIODEGRADABLE POLYACETALS 审中-公开
标题翻译：生物可降解聚酯
公开(公告)号：WO2004076557A1
公开(公告)日：2004-09-10
申请号：PCT/US2004/005363
申请日：2004-02-24
申请人： NITTO DENKO CORPORATION , YU, Lei , VAN, Sang , JI, Shouping , MATSUMOTO, Kenji
发明人： YU, Lei , VAN, Sang , JI, Shouping , MATSUMOTO, Kenji
IPC分类号： C08L59/00
CPC分类号： C08G73/0213 , A61K47/59 , C08G65/002
摘要： A polymer comprising recurring units represented by formula (I); wherein X is selected from the group consisting of C(O)OR 1 , C(O)SR 1 , C(O)NR 1 R 2 , and VZ, where R 1 and R 2 are each individually selected from the group consisting of hydrogen, C 1 to C 10 alkyl, and C 6 to C 10 aryl, where V is a labile linker group, and where Z is selected from the group consisting of poly(ethyleneimine), poly(propyleneimine), poly(lysine), PAMAM dendrimer, octaamine dendrimer, and hexadecaamine dendrimer; and wherein Y is selected from the group consisting of -(CH 2 ) 2 -, -(CH 2 ) 2 -O-(CH 2 ) 2 -, -(CH 2 ) 2 -O-(CH 2 ) 2 -O-(CH 2 ) 2 -, and -(CH 2 ) 3 -NHC(O)-(CH 2 ) 6 -C(O)NH-(CH 2 ) 3 - is useful in nucleic acid delivery applications. Polyacetals of the formula (I) are preferably made by reacting appropriate diols and divinyl ethers. In preferred embodiments, complexes formed between polyacetals of the formula (I) and polynucleotides are useful as transfection reagents.
摘要翻译：一种包含由式（I）表示的重复单元的聚合物; 其中X选自C（O）OR 1，C（O）SR 1，C（O）NR 1 R 2和V Z，其中R 1和R 各自独立地选自氢，C1至C10烷基和C6至C10芳基，其中V是不稳定的连接基团，其中Z选自聚（乙烯亚胺），聚（乙烯亚胺）丙烯亚胺），聚（赖氨酸），PAMAM树枝状聚合物，八胺树枝状聚合物和十六胺树枝状聚合物; 并且其中Y选自 - （CH 2）2 - ， - （CH 2）2 -O-（CH 2）2 - ， - （CH 2）2 -O - （CH 2）2 -O - （CH 2）2 - 和 - （CH 2）3 -NHC（O） - （CH 2）6 -C（O）NH-（CH 2）3 - 可用于核酸递送应用。式（I）的聚缩醛优选通过使适当的二醇和二乙烯基醚反应来制备。在优选的实施方案中，在式（I）的聚缩醛和多核苷酸之间形成的络合物可用作转染试剂。

5. 发明申请

WO2010014117A1 DRUG CARRIERS 审中-公开
标题翻译：药物承运人
公开(公告)号：WO2010014117A1
公开(公告)日：2010-02-04
申请号：PCT/US2008/076295
申请日：2008-09-12
申请人： NITTO DENKO CORPORATION , YU, Lei , ZHAO, Gang , VAN, Sang , ZHAO, Xin , CHEN, Fu
发明人： YU, Lei , ZHAO, Gang , VAN, Sang , ZHAO, Xin , CHEN, Fu
IPC分类号： A61K47/48 , A61K31/337
CPC分类号： A61K47/34 , A61K9/127 , A61K31/00 , A61K31/337 , A61K31/7088 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/36 , A61K47/64
摘要： Compositions that can include a carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.
摘要翻译：可以包括载体，靶向剂和治疗剂的组合物在本文中公开。治疗剂可以具有治疗活性，例如抑制靶器官或组织内的纤维化或抑制癌细胞的生长。

6. 发明申请

WO2008124735A2 MULTI-FUNCTIONAL POLYGLUTAMATE DRUG CARRIERS 审中-公开
标题翻译：多官能聚氨基甲酸酯药物载体
公开(公告)号：WO2008124735A2
公开(公告)日：2008-10-16
申请号：PCT/US2008/059677
申请日：2008-04-08
申请人： NITTO DENKO CORPORATION , YU, Lei , ZHAO, Gang , VAN, Sang
发明人： YU, Lei , ZHAO, Gang , VAN, Sang
IPC分类号： A61K47/48 , A61K49/08 , A61P35/00
CPC分类号： A61K49/146 , A61K47/60 , A61K47/62 , A61K47/645 , A61K49/0002 , A61K49/085
摘要： Various biodegradable polyglutamate polymer conjugates that can include recurring units of the general formulae (I) and (II) are described herein. Such polymer conjugates are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译：本文描述了可包含通式（I）和（II）的重复单元的各种可生物降解的聚谷氨酸酯聚合物缀合物。这种聚合物缀合物可用于多种药物，靶向，稳定和/或成像剂递送应用。

7. 发明申请

WO2006124205A3 HYDROPHILIC POLYMERS WITH PENDANT FUNCTIONAL GROUPS AND METHOD THEREOF 审中-公开
公开(公告)号：WO2006124205A3
公开(公告)日：2006-11-23
申请号：PCT/US2006/015447
申请日：2006-04-24
申请人： NITTO DENKO CORPORATION , VAN, Sang , YU, Lei
发明人： VAN, Sang , YU, Lei
IPC分类号： C08G69/40 , C08G69/48 , A61K47/48
摘要： A polymer comprising a recurring unit of the formula (I) as defined herein is described. In the formula (I), X is selected from the group consisting of -(CH2CH2O)m-CH2CH2- and -CH2CH2CH2O-(CH2CH2O)m-CH2CH2CH2-, wherein m is an integer in the range of 1 to 100; Y is selected from the group consisting of -C*HCH2-, -C*HCH2CH2-, -C*H-NHC(=O)-CH2CH2-, -C*H-NHC(=O)-CH2CH2CH2-, -CH2CH2N*CH2CH2-, -CH2CH2CH2N* CH2CH2CH2-, C2 to C20 alkyl, and C6 to C20 aryl, wherein C* and N* represent atoms to which Z is bonded; and Z is selected from the group consisting of -NHR1, -NH-C(=O)-(CH2)nC(=O)NR1R2, -NH-C(=O)-(CH2)nC(=O)OR1, -(CH2)nC(=O)NR1R2, -(CH2)nC(=O)OR1, -(CH2)nC(=O)SR1, and -(CH2)nNR1R2, wherein n is an integer in the range of 1 to 3, wherein R1 and R2 are each independently selected from the group consisting of hydrogen, C1 to C20 alkyl, C6 to C20 aryl, anticancer drugs, peptides, antibody fragment, lactose, galactose, mannose, transferrin, magnetic resonance imaging agents, succinimyl, and alkali metal.

8. 发明申请

WO2006121535A1 BIODEGRADABLE POLYACETALS AND METHODS 审中-公开
标题翻译：生物可降解聚合物和方法
公开(公告)号：WO2006121535A1
公开(公告)日：2006-11-16
申请号：PCT/US2006/012420
申请日：2006-04-03
申请人： NITTO DENKO CORPORATION , VAN, Sang , CHAE, Hyun, Sik , YU, Lei
发明人： VAN, Sang , CHAE, Hyun, Sik , YU, Lei
IPC分类号： C08G2/00 , C08G2/30 , A61K31/74
CPC分类号： A61K31/74 , C08G2/30
摘要： Condensation polymerization methods are used to prepare various biodegradable polyacetals of the general formula (I). Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.
摘要翻译：缩合聚合法用于制备通式（I）的各种可生物降解的聚缩醛。这些聚合物可用于各种药物，生物分子和成像剂递送应用。

9. 发明申请

WO2005032597A1 BIODEGRADABLE POLYACETALS FOR IN VIVO POLYNUCLEOTIDE DELIVERY 审中-公开
标题翻译：生物可降解的聚四氢呋喃交联聚合物
公开(公告)号：WO2005032597A1
公开(公告)日：2005-04-14
申请号：PCT/US2004/030323
申请日：2004-09-16
申请人： NITTO DENKO CORPORATION , VAN, Sang , ZHOU, Jiadong , FU, Xiaoli , YU, Lei
发明人： VAN, Sang , ZHOU, Jiadong , FU, Xiaoli , YU, Lei
IPC分类号： A61K48/00
CPC分类号： C08L59/00 , A61K47/59 , A61K47/593 , A61K47/595 , A61K48/0008 , A61K48/0041 , C12N15/87
摘要： Degradable complexes comprising a polycation, a polyanion and a polynucleotide are useful for in vivo polynucleotide delivery applications.
摘要翻译：包含聚阳离子，聚阴离子和多核苷酸的可降解络合物可用于体内多核苷酸递送应用。

10. 发明申请

WO2012027204A1 END-CAPPED POLYMERS 审中-公开
标题翻译：封端聚合物
公开(公告)号：WO2012027204A1
公开(公告)日：2012-03-01
申请号：PCT/US2011/048313
申请日：2011-08-18
申请人： NITTO DENKO CORPORATION , YU, Lei , WANG, Hai , YIN, Tsang, Kwok , JIN, Yi , VAN, Sang
发明人： YU, Lei , WANG, Hai , YIN, Tsang, Kwok , JIN, Yi , VAN, Sang
IPC分类号： A61K47/48 , A61K49/08 , C08G69/00 , A61K47/30 , A61P35/00
CPC分类号： A61K49/146 , A61K47/645 , C08G69/48
摘要： Polymers that can include an end-cap selected from Formula (I) and/or Formula (II and a recurring unit of the Formulae (IIΙ), and/or (IV). The polymers can include various substituents such as drug, targeting agents, stabilizing agents, imaging agent and polydentate ligands. Such polymer can be useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译：可以包括选自式（I）和/或式（II）的端帽的聚合物和式（II'）和/或（IV）的重复单元。聚合物可以包括各种取代基，例如药物，靶向药剂，稳定剂，成像剂和多齿配体。这种聚合物可用于多种药物，靶向，稳定和/或成像剂递送应用。

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