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1. 发明申请

WO2013185116A1 LIPIDS FOR THERAPEUTIC AGENT DELIVERY FORMULATIONS 审中-公开
标题翻译：用于治疗药物递送配方的药物
公开(公告)号：WO2013185116A1
公开(公告)日：2013-12-12
申请号：PCT/US2013/044849
申请日：2013-06-07
申请人： PAYNE, Joseph, E. , GAUDETTE, John, A. , HOU, Zheng , AHMADIAN, Mohammad , YU, Lei , KNOPOV, Victor , AKOPIAN, Violetta , KARMALI, Priya , WITTE, Richard, P. , SAFARZADEH, Neda , YING, Wenbin , ZHANG, Jun
发明人： PAYNE, Joseph, E. , GAUDETTE, John, A. , HOU, Zheng , AHMADIAN, Mohammad , YU, Lei , KNOPOV, Victor , AKOPIAN, Violetta , KARMALI, Priya , WITTE, Richard, P. , SAFARZADEH, Neda , YING, Wenbin , ZHANG, Jun
IPC分类号： C07C271/16 , C07D333/40 , C07C317/44 , C07C321/14 , C07C333/04 , C07C235/08 , C07C237/08 , C07D207/16 , A61K47/16 , A61K47/18 , A61K47/22
CPC分类号： A61K47/20 , A61K9/1272 , A61K47/14 , A61K47/18 , A61K47/22 , C07C235/08 , C07C237/08 , C07C237/16 , C07C271/16 , C07C317/44 , C07C323/60 , C07C333/04 , C07D207/16 , C07D333/38 , C07D333/40 , Y10T428/2998
摘要： The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.
摘要翻译：该描述针对可用于增强脂质体中治疗剂递送的可离子化脂质。

2. 发明申请

WO2012150923A1 ENERGY DISSIPATION DEVICE FOR CONTROLLING FLOW OF A FUEL CELL FLUID 审中-公开
标题翻译：用于控制燃料池流量的能量消耗装置
公开(公告)号：WO2012150923A1
公开(公告)日：2012-11-08
申请号：PCT/US2011/034716
申请日：2011-05-02
申请人： UTC POWER CORPORATION , LAKE, Jeffrey G. , GUO, Yu , DENG, Xiangyang , SHI, Ying , YU, Lei , HIRKO, George S. , ZHANG, Vicky , GUTHRIE, Robin J. , BHADANGE, Sushant S. , MELOUGH, Andrew Joseph
发明人： LAKE, Jeffrey G. , GUO, Yu , DENG, Xiangyang , SHI, Ying , YU, Lei , HIRKO, George S. , ZHANG, Vicky , GUTHRIE, Robin J. , BHADANGE, Sushant S. , MELOUGH, Andrew Joseph
IPC分类号： H01M8/04 , H01M8/24 , H01M8/02
CPC分类号： H01M8/04029 , H01M8/026 , H01M8/0267 , H01M8/0271 , H01M8/04074 , H01M8/04768 , H01M8/086 , H01M8/2465 , Y02E60/50
摘要： An example energy dissipation device for controlling a fuel cell fluid includes a conduit extending in longitudinal direction between a first opening and a second opening. A flow control insert is configured to be received within the conduit. The flow control insert is configured to cause a fuel cell fluid to flow helically relative to the longitudinal direction.
摘要翻译：用于控制燃料电池流体的示例性能量消耗装置包括在第一开口和第二开口之间沿纵向方向延伸的导管。流量控制插入件构造成被容纳在导管内。流量控制插入件构造成使得燃料电池流体相对于纵向方向螺旋地流动。

3. 发明申请

WO2010014117A1 DRUG CARRIERS 审中-公开
标题翻译：药物承运人
公开(公告)号：WO2010014117A1
公开(公告)日：2010-02-04
申请号：PCT/US2008/076295
申请日：2008-09-12
申请人： NITTO DENKO CORPORATION , YU, Lei , ZHAO, Gang , VAN, Sang , ZHAO, Xin , CHEN, Fu
发明人： YU, Lei , ZHAO, Gang , VAN, Sang , ZHAO, Xin , CHEN, Fu
IPC分类号： A61K47/48 , A61K31/337
CPC分类号： A61K47/34 , A61K9/127 , A61K31/00 , A61K31/337 , A61K31/7088 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/36 , A61K47/64
摘要： Compositions that can include a carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.
摘要翻译：可以包括载体，靶向剂和治疗剂的组合物在本文中公开。治疗剂可以具有治疗活性，例如抑制靶器官或组织内的纤维化或抑制癌细胞的生长。

4. 发明申请

WO2008151150A3 PEG-PEI COPOLYMERS FOR NUCLEIC ACID DELIVERY 审中-公开
标题翻译：用于核酸交付的PEG-PEI共聚物
公开(公告)号：WO2008151150A3
公开(公告)日：2009-07-30
申请号：PCT/US2008065564
申请日：2008-06-02
申请人： NITTO DENKO CORP , YU LEI , ZHAO GANG , MA NIANCHUN , ZHAO XIN , LU JIAN , TANAKA YASUNOBU
发明人： YU LEI , ZHAO GANG , MA NIANCHUN , ZHAO XIN , LU JIAN , TANAKA YASUNOBU
IPC分类号： A61K47/48 , C12N15/11
CPC分类号： C12M35/02 , A61K47/59 , A61K47/60 , C12M23/12 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32
摘要： Compositions for siRNA delivery are described which include water soluble degradable crosslinked cationic polymers having a water soluble polyethylene glycol component, a cationic polyethyleneimine component and a degradable unit component. The composition may be used to deliver siRNA to cells, particularly cancer cells. The composition may be applied to a solid surface such as a multiwell plate so that the delivery of siRNA may be carried out on the solid surface.
摘要翻译：描述了用于siRNA递送的组合物，其包括具有水溶性聚乙二醇组分的水溶性可降解交联阳离子聚合物，阳离子聚乙烯亚胺组分和可降解单元组分。该组合物可用于将siRNA递送至细胞，特别是癌细胞。可以将组合物施用于固体表面，例如多孔板，使得可以在固体表面上进行siRNA的递送。

5. 发明申请

WO2008124735A3 MULTI-FUNCTIONAL POLYGLUTAMATE DRUG CARRIERS 审中-公开
标题翻译：多官能聚氨基甲酸酯药物载体
公开(公告)号：WO2008124735A3
公开(公告)日：2009-05-14
申请号：PCT/US2008059677
申请日：2008-04-08
申请人： NITTO DENKO CORP , YU LEI , ZHAO GANG , VAN SANG
发明人： YU LEI , ZHAO GANG , VAN SANG
IPC分类号： A61K47/48 , A61K49/00 , A61K49/08 , A61K49/14 , A61P35/00
CPC分类号： A61K49/146 , A61K47/60 , A61K47/62 , A61K47/645 , A61K49/0002 , A61K49/085
摘要： Various biodegradable polyglutamate polymer conjugates that can include recurring units of the general formulae (I) and (II) are described herein. Such polymer conjugates are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译：本文描述了可包含通式（I）和（II）的重复单元的各种可生物降解的聚谷氨酸酯聚合物缀合物。这种聚合物缀合物可用于多种药物，靶向，稳定和/或成像剂递送应用。

6. 发明申请

WO2008124735A2 MULTI-FUNCTIONAL POLYGLUTAMATE DRUG CARRIERS 审中-公开
标题翻译：多官能聚氨基甲酸酯药物载体
公开(公告)号：WO2008124735A2
公开(公告)日：2008-10-16
申请号：PCT/US2008/059677
申请日：2008-04-08
申请人： NITTO DENKO CORPORATION , YU, Lei , ZHAO, Gang , VAN, Sang
发明人： YU, Lei , ZHAO, Gang , VAN, Sang
IPC分类号： A61K47/48 , A61K49/08 , A61P35/00
CPC分类号： A61K49/146 , A61K47/60 , A61K47/62 , A61K47/645 , A61K49/0002 , A61K49/085
摘要： Various biodegradable polyglutamate polymer conjugates that can include recurring units of the general formulae (I) and (II) are described herein. Such polymer conjugates are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译：本文描述了可包含通式（I）和（II）的重复单元的各种可生物降解的聚谷氨酸酯聚合物缀合物。这种聚合物缀合物可用于多种药物，靶向，稳定和/或成像剂递送应用。

7. 发明申请

WO2007038172A2 GUANIDIUM DELIVERY CARRIERS 审中-公开
标题翻译： GUANIDIUM交付运输公司
公开(公告)号：WO2007038172A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/036746
申请日：2006-09-21
申请人： NITTO DENKO CORPORATION , ZHAO, Gang , YU, Lei , LIU, Jian , KITAURA, Chieko , WANG, Xinghe , SONG, Yucheng , CASTELLO, Chris
发明人： ZHAO, Gang , YU, Lei , LIU, Jian , KITAURA, Chieko , WANG, Xinghe , SONG, Yucheng , CASTELLO, Chris
IPC分类号： C07K7/06 , C07K7/02 , A61K47/48
CPC分类号： C07K5/0215 , A61K31/555 , A61K47/641 , A61K47/645 , A61K49/085 , A61K49/146 , C07K7/02
摘要： Disclosed herein are transmembrane transporter compounds containing guanidinium groups. Also disclosed herein are methods for transporting a biologically active moiety across a biological membrane using the transmembrane transporter compounds. Particularly, this invention provides a method for the delivery of a biologically active moiety across the biological membranes of such membranes as endothelial tissues.
摘要翻译：本文公开了含有胍基的跨膜转运体化合物。本文还公开了使用跨膜转运体化合物在生物膜上输送生物活性部分的方法。特别地，本发明提供了一种在诸如内皮组织之类的膜的生物膜上递送生物活性部分的方法。

8. 发明申请

WO2006124205A3 HYDROPHILIC POLYMERS WITH PENDANT FUNCTIONAL GROUPS AND METHOD THEREOF 审中-公开
公开(公告)号：WO2006124205A3
公开(公告)日：2006-11-23
申请号：PCT/US2006/015447
申请日：2006-04-24
申请人： NITTO DENKO CORPORATION , VAN, Sang , YU, Lei
发明人： VAN, Sang , YU, Lei
IPC分类号： C08G69/40 , C08G69/48 , A61K47/48
摘要： A polymer comprising a recurring unit of the formula (I) as defined herein is described. In the formula (I), X is selected from the group consisting of -(CH2CH2O)m-CH2CH2- and -CH2CH2CH2O-(CH2CH2O)m-CH2CH2CH2-, wherein m is an integer in the range of 1 to 100; Y is selected from the group consisting of -C*HCH2-, -C*HCH2CH2-, -C*H-NHC(=O)-CH2CH2-, -C*H-NHC(=O)-CH2CH2CH2-, -CH2CH2N*CH2CH2-, -CH2CH2CH2N* CH2CH2CH2-, C2 to C20 alkyl, and C6 to C20 aryl, wherein C* and N* represent atoms to which Z is bonded; and Z is selected from the group consisting of -NHR1, -NH-C(=O)-(CH2)nC(=O)NR1R2, -NH-C(=O)-(CH2)nC(=O)OR1, -(CH2)nC(=O)NR1R2, -(CH2)nC(=O)OR1, -(CH2)nC(=O)SR1, and -(CH2)nNR1R2, wherein n is an integer in the range of 1 to 3, wherein R1 and R2 are each independently selected from the group consisting of hydrogen, C1 to C20 alkyl, C6 to C20 aryl, anticancer drugs, peptides, antibody fragment, lactose, galactose, mannose, transferrin, magnetic resonance imaging agents, succinimyl, and alkali metal.

9. 发明申请

WO2006124205A2 HYDROPHILIC POLYMERS WITH PENDANT FUNCTIONAL GROUPS AND METHOD THEREOF 审中-公开
标题翻译：具有辅助功能组的亲水聚合物及其方法
公开(公告)号：WO2006124205A2
公开(公告)日：2006-11-23
申请号：PCT/US2006015447
申请日：2006-04-24
申请人： NITTO DENKO CORP , VAN SANG , YU LEI
发明人： VAN SANG , YU LEI
CPC分类号： C08G69/26 , A61K47/595 , A61K47/60 , C08G69/02
摘要： A polymer comprising a recurring unit of the formula (I) as defined herein is described. In the formula (I), X is selected from the group consisting of -(CH2CH2O)m-CH2CH2- and -CH2CH2CH2O-(CH2CH2O)m-CH2CH2CH2-, wherein m is an integer in the range of 1 to 100; Y is selected from the group consisting of -C*HCH2-, -C*HCH2CH2-, -C*H-NHC(=O)-CH2CH2-, -C*H-NHC(=O)-CH2CH2CH2-, -CH2CH2N*CH2CH2-, -CH2CH2CH2N* CH2CH2CH2-, C2 to C20 alkyl, and C6 to C20 aryl, wherein C* and N* represent atoms to which Z is bonded; and Z is selected from the group consisting of -NHR1, -NH-C(=O)-(CH2)nC(=O)NR1R2, -NH-C(=O)-(CH2)nC(=O)OR1, -(CH2)nC(=O)NR1R2, -(CH2)nC(=O)OR1, -(CH2)nC(=O)SR1, and -(CH2)nNR1R2, wherein n is an integer in the range of 1 to 3, wherein R1 and R2 are each independently selected from the group consisting of hydrogen, C1 to C20 alkyl, C6 to C20 aryl, anticancer drugs, peptides, antibody fragment, lactose, galactose, mannose, transferrin, magnetic resonance imaging agents, succinimyl, and alkali metal.
摘要翻译：描述了包含如本文所定义的式（I）的重复单元的聚合物。在式（I）中，X选自 - （CH 2 CH 2 O）m -CH 2 CH 2 - 和-CH 2 CH 2 CH 2 O-（CH 2 CH 2 O）m -CH 2 CH 2 CH 2 - ，其中m是1至100的整数; Y选自-C * HCH 2 - ， - C * HCH 2 CH 2 - ， - C * H-NHC（= O）-CH 2 CH 2 - ， - C * H-NHC（= O）-CH 2 CH 2 CH 2 - ， - CH 2 CH 2 N * CH 2 CH 2 - ， - CH 2 CH 2 CH 2 N * CH 2 CH 2 CH 2 - ，C 2至C 20烷基和C 6至C 20芳基，其中C *和N *表示与Z键合的原子; 并且Z选自-NHR1，-NH-C（= O） - （CH2）nC（= O）NR1R2，-NH-C（= O） - （CH2）nC（= O）OR1， - （CH2）nC（= O）NR1R2， - （CH2）nC（= O）OR1， - （CH2）nC（= O）SR1和 - （CH2）nNR1R2，其中n是1 3，其中R1和R2各自独立地选自氢，C1至C20烷基，C6至C20芳基，抗癌药物，肽，抗体片段，乳糖，半乳糖，甘露糖，转铁蛋白，磁共振成像剂，琥珀酰基，和碱金属。

10. 发明申请

WO2006121535A1 BIODEGRADABLE POLYACETALS AND METHODS 审中-公开
标题翻译：生物可降解聚合物和方法
公开(公告)号：WO2006121535A1
公开(公告)日：2006-11-16
申请号：PCT/US2006/012420
申请日：2006-04-03
申请人： NITTO DENKO CORPORATION , VAN, Sang , CHAE, Hyun, Sik , YU, Lei
发明人： VAN, Sang , CHAE, Hyun, Sik , YU, Lei
IPC分类号： C08G2/00 , C08G2/30 , A61K31/74
CPC分类号： A61K31/74 , C08G2/30
摘要： Condensation polymerization methods are used to prepare various biodegradable polyacetals of the general formula (I). Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.
摘要翻译：缩合聚合法用于制备通式（I）的各种可生物降解的聚缩醛。这些聚合物可用于各种药物，生物分子和成像剂递送应用。

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