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1. 发明申请

WO2010042882A2 INVENTORY SPARING CATHETER SYSTEM 审中-公开
标题翻译：存货空调导管系统
公开(公告)号：WO2010042882A2
公开(公告)日：2010-04-15
申请号：PCT/US2009060259
申请日：2009-10-09
申请人： NEXEON MEDSYSTEMS INC , STALKER KENT C B , WHITFIELD JOHN D , BATES MARK C , D AQUANNI PETER J , HABEGER JASON ANDREW
发明人： STALKER KENT C B , WHITFIELD JOHN D , BATES MARK C , D AQUANNI PETER J , HABEGER JASON ANDREW
IPC分类号： A61M25/01 , A61F2/84 , A61M25/00 , A61M25/10 , A61M29/02
CPC分类号： A61M25/01 , A61F2/958 , A61M25/0041 , A61M25/10 , A61M25/104 , A61M2025/0008 , A61M2025/0063 , A61M2025/0175 , A61M2025/0183 , A61M2025/0681 , A61M2025/107
摘要： Some embodiments relate to a catheter system having a changeable or adjustable working length. The catheter system can comprise a proximal end, a distal end, and a first axial lumen configured to receive a guidewire formed through at least a portion of the catheter body. A first opening can be formed through a portion of the catheter body and be in communication with the first lumen. The sheath can be rotatable, axially movable, or otherwise changeable from at least a first position to a second position, wherein the sheath can substantially cover the first opening in the catheter body in the first position, and can substantially expose the first opening in the catheter body in the second position.
摘要翻译：一些实施例涉及具有可变的或可调节的工作长度的导管系统。导管系统可以包括近端，远端和构造成接收通过导管主体的至少一部分形成的导丝的第一轴向腔。可以通过导管主体的一部分形成第一开口并与第一管腔连通。护套可以是可旋转的，可轴向移动的或者可以从至少第一位置改变到第二位置，其中护套可以在第一位置基本上覆盖导管主体中的第一开口，并且可以基本上暴露在第一位置的第一开口导管体位于第二位置。

2. 发明申请

WO2010033231A3 INTERVENTIONAL DEVICES INCLUDING DILUTE NANOTUBE-POLYMER COMPOSITIONS, AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：含有稀土纳米管聚合物组合物的传统装置及其制造方法和使用方法
公开(公告)号：WO2010033231A3
公开(公告)日：2011-02-03
申请号：PCT/US2009005224
申请日：2009-09-18
申请人： NEXEON MEDSYSTEMS INC , D AQUANNI PETER , BATES MARK C , STALKER KENT , PHILLIPS JASON
发明人： D AQUANNI PETER , BATES MARK C , STALKER KENT , PHILLIPS JASON
IPC分类号： A61F2/958 , A61L29/12
CPC分类号： A61L29/126 , A61L2400/12 , Y10T156/1002
摘要： Under one aspect, an interventional device includes a balloon having a flexible wall. The flexible wall includes a composition including between 0.005 wt.% and 0.2O wt.% of carbon nanotubes dispersed in a polymer. Under another aspect, a method of making an interventional device includes contacting a plurality of polymer particles with a plurality of nanotubes; extruding the polymer particles and the nanotubes to form a composition comprising the polymer and the nanotubes; and blow-casting the composition into a balloon.
摘要翻译：在一个方面，介入装置包括具有柔性壁的气囊。柔性壁包括包含分散在聚合物中的碳纳米管的0.005重量％至0.2重量％的组合物。在另一方面，制备介入装置的方法包括使多个聚合物颗粒与多个纳米管接触; 挤出聚合物颗粒和纳米管以形成包含聚合物和纳米管的组合物; 并将组合物吹塑成气球。

3. 发明申请

WO2010005575A3 NANOTUBE-REINFORCED BALLOONS FOR DELIVERING THERAPEUTIC AGENTS WITHIN OR BEYOND THE WALL OF BLOOD VESSELS, AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：用于在血液瓶壁之间或之外递送治疗剂的纳米级增强型气泡，以及制造和使用它们的方法
公开(公告)号：WO2010005575A3
公开(公告)日：2011-02-03
申请号：PCT/US2009004006
申请日：2009-07-09
申请人： NEXEON MEDSYSTEMS INC , BATES MARK C
发明人： BATES MARK C
IPC分类号： A61F2/958 , A61L29/12 , A61L29/16
CPC分类号： A61L29/126 , A61K38/00 , A61L29/16 , A61L31/00 , A61L2300/602 , A61L2300/624 , A61L2400/12 , A61M25/10 , A61M25/104 , A61M2025/105 , A61M2025/1075 , A61M2025/1084 , A61M2025/1086
摘要： A dilatation catheter for delivering a therapeutic agent within a body lumen having a wall with a thickness is provided having a balloon having a flexible wall including a polymer with dispersed nanotubes and pores configured to close below a predefined pressure and to open at or above a predefined pressure. In some embodiments, an actuator is provided to controllably inflate the balloon with a fluid at a pressure sufficient to bring the flexible wall of the balloon into contact with at least a portion of the wall of the body lumen but below the predefined pressure, and to controllably increase the pressure of the fluid within the inflated balloon to at least the predefined pressure at a rate and with a force sufficient to deliver the therapeutic agent from the pores and through at least a portion of the thickness of the wall of the body lumen.
摘要翻译：提供了一种用于在具有厚度的壁的体腔内递送治疗剂的扩张导管，其具有球囊，所述球囊具有柔性壁，弹性壁包括具有分散的纳米管的聚合物和构造成接近低于预定压力的孔，并且在预定义压力。在一些实施例中，致动器被提供以用足以使气囊的柔性壁与体腔的至少一部分壁接触但低于预定压力的压力的流体可控制地膨胀气囊，并且可膨胀气囊内的流体的压力以足以从治疗剂输送治疗剂和通过体腔壁厚度的至少一部分的速度和速度将至少预定的压力增加至至少预定的压力。

4. 发明申请

WO2013142204A3 APPARATUS FOR FILTERING EMBOLI DURING PERCUTANEOUS AORTIC VALVE REPLACEMENT AND REPAIR PROCEDURES WITH FILTRATION SYSTEM COUPLED TO DISTAL END OF SHEATH 审中-公开
标题翻译：用于在超声波阀门更换过程中的装置和与过滤系统相连的修复程序
公开(公告)号：WO2013142204A3
公开(公告)日：2014-03-13
申请号：PCT/US2013030943
申请日：2013-03-13
申请人： NEXEON MEDSYSTEMS INC , BATES MARK C
发明人： BATES MARK C
IPC分类号： A61F2/01 , A61F2/24
CPC分类号： A61F2/013 , A61F2/2427 , A61F2002/011
摘要： The present invention provides several embodiments of an apparatus for embolic filtering during percutaneous valve replacement and repair procedures. Under one aspect, an apparatus (100) comprises a sheath (110)and a filter (120). The sheath has proximal (111) and distal (112) ends and a lumen (113) therebetween. The distal end may be introduced into the aortic arch via the peripheral arteries and ascending aorta, while the proximal end may be disposed outside of the body. The lumen permits percutaneous aortic valve replacement or repair therethrough. The filter has a frame (121) with an inlet and an outlet and an emboli-filtering mesh (122) attached to the frame. The inlet substantially spans the aortic arch in a region between the aortic valve and the great arteries. The outlet is coupled to the distal end of the sheath without leaving any gaps through which emboli could pass and without obstructing the lumen at the distal end of the sheath.
摘要翻译：本发明提供了在经皮瓣膜置换和修复过程期间用于栓塞过滤的装置的几个实施例。在一个方面，装置（100）包括护套（110）和过滤器（120）。护套具有近端（111）和远端（112）端部以及其间的内腔（113）。远端可以通过外周动脉和升主动脉引入主动脉弓，而近端可以设置在身体的外部。管腔允许经皮主动脉瓣置换或修复。过滤器具有带入口和出口的框架（121）和附接到框架的栓塞过滤网（122）。入口基本跨越主动脉瓣和主动脉瓣之间的区域。出口连接到护套的远端，而不留下任何间隙，栓塞通过该间隙，而不会阻塞鞘的远端处的内腔。

5. 发明申请

WO2007126729A3 FRACTURE-RESISTANT HELICAL STENT INCORPORATING BISTABLE CELLS AND METHODS OF USE 审中-公开
标题翻译：抗破坏性螺旋固定治疗双胞胎细胞及其使用方法
公开(公告)号：WO2007126729A3
公开(公告)日：2008-11-20
申请号：PCT/US2007007377
申请日：2007-03-23
申请人： PARAGON INTELLECTUAL PROPERTIE , BESSELINK PETRUS ANTONIUS , BATES MARK C
发明人： BESSELINK PETRUS ANTONIUS , BATES MARK C
IPC分类号： A61B17/11 , A61F2/00 , A61F2/06
CPC分类号： A61F2/88 , A61B17/11 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/91541
摘要： Vascular prostheses and methods of use are provided, wherein the vascular prosthesis includes a plurality of bistable unit cells configured to form a helical structure. A visualization catheter also is provided for use ensuring accurate measurement of a lesion and ensuring delivery and placement of the vascular prosthesis.
摘要翻译：提供了血管假体和使用方法，其中血管假体包括构造成形成螺旋结构的多个双稳态单位电池。还提供了可视化导管，用于确保对病变进行精确测量并确保血管假体的传送和放置。

6. 发明申请

WO2006122152A3 APPARATUS AND METHODS FOR RENAL STENTING 审中-公开
标题翻译：装置和方法进行手术
公开(公告)号：WO2006122152A3
公开(公告)日：2008-10-09
申请号：PCT/US2006017986
申请日：2006-05-09
申请人： PARAGON INTELLECTUAL PROPERTIE , BATES MARK C
发明人： BATES MARK C
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： The present invention provides and apparatus and methods for emboli removal and stenting within the renal arteries having a catheter system having a distal occlusion element, a stent deployment section, and an emboli removal lumen. The occlusion element is disposed at a predetermined distance from the stent deployment section specific for use in the renal artery, and is constructed to reduce the potential for perforation or jailing during stent deployment. The apparatus further includes an array of radio-opaque markers disposed on the stent delivery catheter to facilitate accurate stent deployment within a renal artery.
摘要翻译：本发明提供了用于在具有具有远端闭塞元件，支架展开部分和栓塞移除内腔的导管系统的肾动脉内的栓塞移除和支架置入的装置和方法。闭塞元件设置在与用于肾动脉中特异的支架展开部分预定的距离处，并且被构造成在支架展开期间减小穿孔或挂钩的可能性。该装置还包括设置在支架输送导管上的无线电不透明标记阵列，以便于肾动脉内准确的支架展开。

7. 发明申请

WO2006020256A2 SYSTEMS AND METHODS FOR ATRAUMATIC IMPLANTATION OF BIO-ACTIVE AGENTS 审中-公开
标题翻译：用于生物活性剂的ATRAUMATIC植入物的系统和方法
公开(公告)号：WO2006020256A2
公开(公告)日：2006-02-23
申请号：PCT/US2005025470
申请日：2005-07-18
申请人： PARAGON INTELLECTUAL PROPERTIE , BATES MARK C
发明人： BATES MARK C
IPC分类号： A61M31/00
CPC分类号： A61B17/3478 , A61B2017/00247 , A61B2017/00398 , A61B2017/00871 , A61B2017/3411 , A61B2017/3484 , A61B2018/00392 , A61M5/3287
摘要： Methods and apparatus are provided for delivering a bioactive agent in a needle track formed in a target tissue mass, following formation of the needle track, by avoiding impingement of the agent against target tissue at high velocity or by using capillary action to draw the bioactive agent out of the needle during needle withdrawal. The apparatus comprises a catheter and a needle disposed within the catheter and configured to be selectively extended into the tissue mass to a predetermined depth, while dispensing the agent simultaneously with retraction of the needle along the needle track. Alternatively, or in addition, the needle may be configured to create a tissue space surrounding a distal or lateral surface of the needle, into which the bioactive agent to be infused.
摘要翻译：提供了方法和装置，用于在形成针迹后，在形成于靶组织块中的针迹中递送生物活性剂，方法是避免药物以高速度撞击目标组织，或通过使用毛细管作用来吸引生物活性剂拔针时出针。该装置包括导管和设置在导管内的针，并且被配置成选择性地延伸到组织块中至预定的深度，同时在沿着针轨缩回针的同时分配药剂。或者或另外，针可以被配置为产生围绕针的远侧或侧表面的组织空间，待注入的生物活性剂。

8. 发明申请

WO2007075959A3 INTERVENTIONAL CATHETER FOR RETROGRADE USE HAVING EMBOLIC PROTECTION CAPABILITY AND METHODS OF USE 审中-公开
标题翻译：用于具有刺激保护能力和使用方法的改造用传统导管
公开(公告)号：WO2007075959A3
公开(公告)日：2008-12-24
申请号：PCT/US2006048921
申请日：2006-12-20
申请人： PARAGON INTELLECTUAL PROPERTIE , BATES MARK C
发明人： BATES MARK C
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2/90 , A61F2/958 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61F2230/008 , A61F2230/0097 , A61F2250/0039
摘要： Interventional catheters are disclosed for use in performing diagnostic and therapeutic procedures in vessels that are accessed retrograde to blood flow. The catheters include an elongated shaft slidably disposed within a sheath, a distal region having an end effector and a filter disposed proximal to the end effector to capture emboli liberated during the diagnostic or therapeutic procedure. The filter includes a plurality of struts that cooperate with an exterior surface of the catheter to define a reservoir to retain captured emboli, the reservoir configured so that advancement of the sheath contracts the filter without squeezing or dislodging captured emboli beyond a distal end of the filter.
摘要翻译：公开了介入导管用于在逆行到血液流动的血管中进行诊断和治疗程序。导管包括可滑动地设置在护套内的细长轴，具有末端执行器的远侧区域和设置在末端执行器附近的过滤器，以捕获在诊断或治疗过程期间释放的栓塞。过滤器包括多个支柱，其与导管的外表面协作以限定储存器以保持被捕获的栓塞，储存器构造成使得护套的前进收缩过滤器而不挤压或移除超过过滤器的远端的捕获的栓塞。

9. 发明申请

WO2006050063A3 METHODS AND APPARATUS FOR TREATING AN INJURED NERVE PATHWAY 审中-公开
标题翻译：治疗神经病变途径的方法和装置
公开(公告)号：WO2006050063A3
公开(公告)日：2007-12-21
申请号：PCT/US2005038876
申请日：2005-10-26
申请人： PARAGON INTELLECTUAL PROPERTIE , BATES MARK C
发明人： BATES MARK C
IPC分类号： A61F2/00 , A01N63/00 , A61F2/02
CPC分类号： A61M37/0069
摘要： Methods and apparatus are provided for treating an injured or severed nerve pathway, wherein one or more microporous tubes are implanted into the nerve pathway to bridge the injured or severed region. A bioactive matrix including stem cells and nutrients is disposed within the microporous tube to facilitate growth of the stem cells and reestablishment of the sensory and motor conductive pathways through the injured or severed region. The microporous tube protects the bioactive matrix during development of the stem cells, and also retains the end regions in proper alignment during the nerve pathway regeneration.
摘要翻译：提供了用于治疗受伤或切断的神经通路的方法和装置，其中将一个或多个微孔管植入神经通路以桥接受伤或切断的区域。将包含干细胞和营养物质的生物活性基质置于微孔管内，以促进干细胞的生长和通过受伤或切断的区域重新建立感官和运动导电通路。微孔管在干细胞发育过程中保护生物活性基质，并且在神经通路再生过程中也保持端区正确对准。

10. 发明申请

WO2006020256B1 SYSTEMS AND METHODS FOR ATRAUMATIC IMPLANTATION OF BIO-ACTIVE AGENTS 审中-公开
标题翻译：用于生物活性剂的ATRAUMATIC植入物的系统和方法
公开(公告)号：WO2006020256B1
公开(公告)日：2007-01-25
申请号：PCT/US2005025470
申请日：2005-07-18
申请人： PARAGON INTELLECTUAL PROPERTIE , BATES MARK C
发明人： BATES MARK C
IPC分类号： A61M5/178 , A61M31/00
CPC分类号： A61B17/3478 , A61B2017/00247 , A61B2017/00398 , A61B2017/00871 , A61B2017/3411 , A61B2017/3484 , A61B2018/00392 , A61M5/3287
摘要： Methods and apparatus are provided for delivering a bioactive agent in a needle track formed in a target tissue mass, following formation of the needle track, by avoiding impingement of the agent against target tissue at high velocity or by using capillary action to draw the bioactive agent out of the needle during needle withdrawal. The apparatus comprises a catheter (31) and a needle (37) disposed within the catheter (31) and configured to be selectively extended into the tissue mass to a predetermined depth, while dispensing the agent simultaneously with retraction of the needle along the needle track. Alternatively, or in addition, the needle (37) may be configured to create a tissue space surrounding a distal or lateral surface of the needle (37), into which the bioactive agent to be infused.
摘要翻译：提供了方法和装置，用于在形成针迹后，在形成于靶组织块中的针迹中递送生物活性剂，方法是避免药物以高速度撞击目标组织，或通过使用毛细管作用来吸引生物活性剂拔针时出针。该装置包括导管（31）和设置在导管（31）内的针（37），并且被配置为选择性地延伸到组织块中至预定深度，同时在沿针针回缩针的同时分配药剂。或者或另外，针（37）可以被配置为产生围绕针（37）的远侧或侧表面的组织空间，待注入的生物活性剂。

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