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1. 发明申请

WO2005119110A2 METHOD AND APPARATUS FOR CONNECTING SMALL DIAMETER TUBING 审中-公开
标题翻译：用于连接小直径管道的方法和装置
公开(公告)号：WO2005119110A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/018944
申请日：2005-05-27
申请人： NEW OBJECTIVE, INC. , VALASKOVIC, Gary, A. , SAWDEY, Lee, R. , MURPHY, James, P., III
发明人： VALASKOVIC, Gary, A. , SAWDEY, Lee, R. , MURPHY, James, P., III
IPC分类号： F16L
CPC分类号： G02B6/3809 , B01L3/565 , B01L2300/0838 , G01N30/6039
摘要： A union for coupling two or more segments of tubing or optical fiber, having an elastomeric core with two or more tubular sections encased in a through bore of a union body, the ends of the union body bore having compression nuts having through bores for insertion of segments of tubing or optical fiber to be coupled, which, tubular sections, when compressed by the compression nuts, deform radially inwardly to hold and seal the segments of tubing or optical fiber inserted therein.
摘要翻译：用于联接两个或更多个管段或光纤段的联接件，其具有包裹在联管体的通孔中的具有两个或多个管状部分的弹性体芯，所述联接体孔的端部具有压缩螺母，该压缩螺母具有通孔，要联接的管道或光纤的段，当压缩螺母压缩时，管状部分径向向内变形以保持和密封插入其中的管道或光纤的段。

2. 发明申请

WO2013158858A1 SAMPLE PREPARATION AND NANOELECTROSPRAY IONIZATION MASS SPECTROMETRY 审中-公开
标题翻译：样品制备和纳米电子显微离子质谱法
公开(公告)号：WO2013158858A1
公开(公告)日：2013-10-24
申请号：PCT/US2013/037138
申请日：2013-04-18
申请人： NEW OBJECTIVE, INC. , VALASKOVIC, Gary, A.
发明人： VALASKOVIC, Gary, A.
IPC分类号： B01L3/00 , B01L3/02
CPC分类号： H01J49/167 , B01L3/502 , H01J49/0431
摘要： Method for loading a sample of a target compound into a nanospray emitter tube for analysis by nanospray ionization mass spectrometry, wherein a cartridge having a fluid container, an inlet and an outlet is mounted onto a nanospray emitter tube on a nanospray emitter mount to form a nanospray emitter tube assembly, the assembly is mounted on a micro-centrifuge tube, a volume of the sample to be analyzed is loaded into the fluid container and the micro-centrifuge tube is spun on a centrifuge to transfer the sample into the nanospray emitter tube.
摘要翻译：将目标化合物样品加载到纳米喷雾发射管中用于通过纳米喷雾电离质谱法进行分析的方法，其中具有流体容器，入口和出口的药筒安装在纳米喷雾发射器支架上的纳喷射发射管上，以形成纳米喷雾发射管组件，将组件安装在微离心管上，将待分析的样品的体积装载到流体容器中，并将微离心管在离心机上旋转以将样品转移到纳喷射发射管。

3. 发明申请

WO2008111973A1 PACKAGING, SHIPPING AND STORAGE DEVICE FOR CAPILLARY TUBES 审中-公开
标题翻译：用于毛细管的包装，运输和存储装置
公开(公告)号：WO2008111973A1
公开(公告)日：2008-09-18
申请号：PCT/US2007/063776
申请日：2007-03-12
申请人： NEW OBJECTIVE, INC. , VALASKOVIC, Gary, A. , SAWDEY, Lee , SELLERS, James, M. , TAYLOR, Haydn, B. , WINTERS, Nathan, E.
发明人： VALASKOVIC, Gary, A. , SAWDEY, Lee , SELLERS, James, M. , TAYLOR, Haydn, B. , WINTERS, Nathan, E.
IPC分类号： B01L9/06 , H01J49/04 , B65D8/00 , B65D43/16
CPC分类号： B01L9/06 , B01L9/065 , B01L2200/025 , B01L2200/18 , B01L2300/0609 , B01L2300/0838 , B01L2400/027
摘要： Capillary tube holder, a storage and shipping container in which a loaded capillary tube holder is securely held, a fixture for loading capillary tubes onto a capillary tube holder and a tube transfer fixture for transferring, removing or replacing individual capillary tubes from a loaded capillary tube holder.
摘要翻译：毛细管支架，一个储存和运输容器，其中一个加载的毛细管支架被牢固地固定在一起，用于将毛细管加载到毛细管支架上的固定装置和一个用于从加载的毛细管传送，移除或更换单个毛细管的管转移夹具持有人。

4. 发明申请

WO2002095362A3 METHOD AND APPARATUS FOR FEEDBACK CONTROLLED ELECTROSPRAY 审中-公开
公开(公告)号：WO2002095362A3
公开(公告)日：2002-11-28
申请号：PCT/US2002/016559
申请日：2002-05-24
申请人： NEW OBJECTIVE, INC. , VALASKOVIC, Gary, A. , LEE, Mike, S.
发明人： VALASKOVIC, Gary, A. , LEE, Mike, S.
IPC分类号： G06F19/00
摘要： A capillary nozzle (1) is provided with mobile phase by mobile phase pump (2), which pumps the mobile phase through the capillary to discharge from the nozzle at opening (I1) Electrical voltage is applied to capillary nozzle (1) by high voltage power supply (3) through electrode (4). A counter electrode (5), which is incorporated into to the inlet of a mass spectrometer is "grounded", i.e., is at ground potential. The light source (7) illuminates electospray (6) with intense light, which is positioned and focused by lens (71) to optimize contrast and the scattering of light by the electrospray (6) droplets.

5. 发明申请

WO2002095360A3 METHOD AND APPARATUS FOR MULTIPLE ELECTROSPRAY SAMPLE INTRODUCTION 审中-公开
公开(公告)号：WO2002095360A3
公开(公告)日：2002-11-28
申请号：PCT/US2002/016350
申请日：2002-05-23
申请人： NEW OBJECTIVE, INC. , VALASKOVIC, Gary, A.
发明人： VALASKOVIC, Gary, A.
IPC分类号： B01D59/44 , H01J49/00
摘要： A method for the coupling of a plurality sample streams eluting from a plurality of High Pressure Liquid Chromatography columns into a single inlet mass spectrometer, wherein samples from individual chromatography columns are suppled to individual electrospray nozzles in an array of a plurality of electrospray nozzles positioned in front of said single inlet, each nozzle being switchable to an on or off state, and each nozzle being supplied by a sample supply tube or channel and having, in addition to said sample supply tube or channel, a separate fluid removal tube or channel, and wherein each nozzle, when in the off state, is held at a voltage that is between the voltage of the mass spectrometer inlet and the electrospray threshold value for that nozzle.

6. 发明申请

WO2002095362A2 METHOD AND APPARATUS FOR FEEDBACK CONTROLLED ELECTROSPRAY 审中-公开
标题翻译：反馈控制电泳的方法和装置
公开(公告)号：WO2002095362A2
公开(公告)日：2002-11-28
申请号：PCT/US2002/016559
申请日：2002-05-24
申请人： NEW OBJECTIVE, INC. , VALASKOVIC, Gary, A. , LEE, Mike, S.
发明人： VALASKOVIC, Gary, A. , LEE, Mike, S.
IPC分类号： G01N
CPC分类号： H01J49/165
摘要： Feedback control system for electrospray nozzle using optical system for monitoring and controlling dynamic or static morphology of the fluid exiting the electrospray nozzle.
摘要翻译：使用光学系统的电喷雾喷嘴的反馈控制系统，用于监测和控制离开电喷雾喷嘴的流体的动态或静态形态。

7. 发明申请

WO2010148339A3 ELECTROSPRAY AND NANOSPRAY IONIZATION OF DISCRETE SAMPLES IN DROPLET FORMAT 审中-公开
公开(公告)号：WO2010148339A3
公开(公告)日：2010-12-23
申请号：PCT/US2010/039233
申请日：2010-06-18
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , KENNEDY, Robert , PEI, Jian , LI, Qiang , LEE, Mike, S. , VALASKOVIC, Gary, A.
发明人： KENNEDY, Robert , PEI, Jian , LI, Qiang , LEE, Mike, S. , VALASKOVIC, Gary, A.
IPC分类号： G01N1/28
摘要： Droplets or plugs within multiphase microfluidic systems have rapidly gained interest as a way to manipulate samples and chemical reactions on the femtoliter to microliter scale. Chemical analysis of the plugs remains a challenge. It has been discovered that nanoliter plugs of sample separated by air or oil can be analyzed by electrospray ionization mass spectrometry when pumped directly into a fused silica nanospray emitter nozzle. Using leu-enkephalin in methanol and 1% acetic acid in water (50:50 v:v) as a model sample, we found carry-over between plugs was

8. 发明申请

WO2002058814A1 METHOD FOR PACKING CAPILLARY COLUMNS WITH PARTICULATE MATERIALS 审中-公开
标题翻译：用颗粒材料包装毛细管柱的方法
公开(公告)号：WO2002058814A1
公开(公告)日：2002-08-01
申请号：PCT/US2002/002116
申请日：2002-01-23
申请人： NEW OBJECTIVE, INC.
发明人： VALASKOVIC, Gary, A. , EHRENFELD, Emily, E.
IPC分类号： B01D15/08
CPC分类号： B01D15/206 , B01J2220/84 , G01N30/56 , G01N2030/565
摘要： Method for loading a capillary channel with a packing material to form a capillary column which includes placing a first frit on a capillary channel, forcing a slurry of a solid packing material in a liquid (70) through said first channel so that the liquid (70), but not the solid packing material, passes through the frit and out of the capillary channel, to form a first bed (21) of packing material within said first capillary channel and adjacent to the frit; thereby forming a pre-pack column (20), then removing the frit and joining the pre-pack column (20) to an empty second capillary channel (30) and attaching a second frit (9) to the end of said second channel (30), then forcing a liquid (70) into the end of pre-pack column (20), so that the liquid (70) passes through the pre-pack column (20), mobilizing the packing therein and carrying it into the second capillary channel (30).
摘要翻译：一种用填充材料加载毛细管通道以形成毛细管柱的方法，该毛细管柱包括将第一玻璃料放置在毛细通道上，迫使固体包装材料的浆液通过所述第一通道流入液体（70），使得液体（70 ），但不是固体包装材料通过玻璃料并离开毛细通道，以在第一毛细管通道内并与玻璃料相邻形成包装材料的第一床（21）; 从而形成预包装柱（20），然后除去玻璃料并将预包装柱（20）连接到空的第二毛细通道（30），并将第二玻璃料（9）附接到所述第二通道的端部 30），然后迫使液体（70）进入预包装柱（20）的末端，使得液体（70）通过预包装柱（20），在其中移动填料并将其携带到第二毛细管通道（30）。

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