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1. 发明申请

WO2021087043A1 METHOD AND DEVICE FOR IMPROVED PERFORMANCE WITH MICRO-ELECTROSPRAY IONIZATION 审中-公开
公开(公告)号：WO2021087043A1
公开(公告)日：2021-05-06
申请号：PCT/US2020/057859
申请日：2020-10-29
申请人： NEW OBJECTIVE, INC.
发明人： VALASKOVIC, Gary A.
IPC分类号： G01N30/72 , H01J49/04
摘要： Disclosed is an emitter device configured to operate as part of an electrospray ionization mass spectrometry device, the emitter device providing droplets of a liquid containing material to be analyzed. Also disclosed are methods of use of the emitter device 1.

2. 发明申请

WO2005119110B1 METHOD AND APPARATUS FOR CONNECTING SMALL DIAMETER TUBING 审中-公开
标题翻译：用于连接小直径管道的方法和装置
公开(公告)号：WO2005119110B1
公开(公告)日：2006-07-20
申请号：PCT/US2005018944
申请日：2005-05-27
申请人： NEW OBJECTIVE INC , VALASKOVIC GARY A , SAWDEY LEE R , MURPHY JAMES P III
发明人： VALASKOVIC GARY A , SAWDEY LEE R , MURPHY JAMES P III
IPC分类号： G01N30/60 , G02B6/38
CPC分类号： G02B6/3809 , B01L3/565 , B01L2300/0838 , G01N30/6039
摘要： A union for coupling two or more segments of tubing (11) or optical fiber, having an elastomeric core (2) with two or more tubular sections encased in a through bore of a union body (4), the ends of the union body bore having compression nuts (10) having through bores for insertion of segments of tubing or optical fiber to be coupled, which, tubular sections, when compressed by the compression nuts, deform radially inwardly to hold and seal the segments of tubing or optical fiber inserted therein. The union housing (6) also has a window cut-out (9).
摘要翻译：用于联接管道（11）或光纤的两个或多个段的联接件，其具有弹性体芯（2），其具有封装在联接体（4）的通孔中的两个或更多个管状部分，联接体孔的端部具有压缩螺母（10），其具有用于插入要联接的管道或光纤的段的通孔，当被压缩螺母压缩时，管状部分径向向内变形以保持和密封插入其中的管道或光纤的段。工会住房（6）也有一个窗口（9）。

3. 发明申请

WO2005119110A3 METHOD AND APPARATUS FOR CONNECTING SMALL DIAMETER TUBING 审中-公开
标题翻译：用于连接小直径管的方法和设备
公开(公告)号：WO2005119110A3
公开(公告)日：2006-05-18
申请号：PCT/US2005018944
申请日：2005-05-27
申请人： NEW OBJECTIVE INC , VALASKOVIC GARY A , SAWDEY LEE R , MURPHY JAMES P III
发明人： VALASKOVIC GARY A , SAWDEY LEE R , MURPHY JAMES P III
IPC分类号： G01N30/60 , G02B6/38
CPC分类号： G02B6/3809 , B01L3/565 , B01L2300/0838 , G01N30/6039
摘要： A union for coupling two or more segments of tubing (11) or optical fiber, having an elastomeric core (2) with two or more tubular sections encased in a through bore of a union body (4), the ends of the union body bore having compression nuts (10) having through bores for insertion of segments of tubing or optical fiber to be coupled, which, tubular sections, when compressed by the compression nuts, deform radially inwardly to hold and seal the segments of tubing or optical fiber inserted therein. The union housing (6) also has a window cut-out (9).
摘要翻译：一种用于连接两个或多个管段（11）或光纤段的接头，该接头具有一个弹性体芯（2），该弹性芯（2）具有两个或更多个管状部分，该管状部分包在联合体（4）的通孔内，联接体孔具有压缩螺母（10），所述压缩螺母具有用于插入将要耦合的管段或光纤段的通孔，其中管段在被压缩螺母压缩时径向向内变形以保持和密封插入其中的管段或光纤段。联合壳体（6）还具有窗口切口（9）。

4. 发明申请

WO2008111973A1 PACKAGING, SHIPPING AND STORAGE DEVICE FOR CAPILLARY TUBES 审中-公开
标题翻译：用于毛细管的包装，运输和存储装置
公开(公告)号：WO2008111973A1
公开(公告)日：2008-09-18
申请号：PCT/US2007/063776
申请日：2007-03-12
申请人： NEW OBJECTIVE, INC. , VALASKOVIC, Gary, A. , SAWDEY, Lee , SELLERS, James, M. , TAYLOR, Haydn, B. , WINTERS, Nathan, E.
发明人： VALASKOVIC, Gary, A. , SAWDEY, Lee , SELLERS, James, M. , TAYLOR, Haydn, B. , WINTERS, Nathan, E.
IPC分类号： B01L9/06 , H01J49/04 , B65D8/00 , B65D43/16
CPC分类号： B01L9/06 , B01L9/065 , B01L2200/025 , B01L2200/18 , B01L2300/0609 , B01L2300/0838 , B01L2400/027
摘要： Capillary tube holder, a storage and shipping container in which a loaded capillary tube holder is securely held, a fixture for loading capillary tubes onto a capillary tube holder and a tube transfer fixture for transferring, removing or replacing individual capillary tubes from a loaded capillary tube holder.
摘要翻译：毛细管支架，一个储存和运输容器，其中一个加载的毛细管支架被牢固地固定在一起，用于将毛细管加载到毛细管支架上的固定装置和一个用于从加载的毛细管传送，移除或更换单个毛细管的管转移夹具持有人。

5. 发明申请

WO2002095362A3 METHOD AND APPARATUS FOR FEEDBACK CONTROLLED ELECTROSPRAY 审中-公开
公开(公告)号：WO2002095362A3
公开(公告)日：2002-11-28
申请号：PCT/US2002/016559
申请日：2002-05-24
申请人： NEW OBJECTIVE, INC. , VALASKOVIC, Gary, A. , LEE, Mike, S.
发明人： VALASKOVIC, Gary, A. , LEE, Mike, S.
IPC分类号： G06F19/00
摘要： A capillary nozzle (1) is provided with mobile phase by mobile phase pump (2), which pumps the mobile phase through the capillary to discharge from the nozzle at opening (I1) Electrical voltage is applied to capillary nozzle (1) by high voltage power supply (3) through electrode (4). A counter electrode (5), which is incorporated into to the inlet of a mass spectrometer is "grounded", i.e., is at ground potential. The light source (7) illuminates electospray (6) with intense light, which is positioned and focused by lens (71) to optimize contrast and the scattering of light by the electrospray (6) droplets.

6. 发明申请

WO2002095360A3 METHOD AND APPARATUS FOR MULTIPLE ELECTROSPRAY SAMPLE INTRODUCTION 审中-公开
公开(公告)号：WO2002095360A3
公开(公告)日：2002-11-28
申请号：PCT/US2002/016350
申请日：2002-05-23
申请人： NEW OBJECTIVE, INC. , VALASKOVIC, Gary, A.
发明人： VALASKOVIC, Gary, A.
IPC分类号： B01D59/44 , H01J49/00
摘要： A method for the coupling of a plurality sample streams eluting from a plurality of High Pressure Liquid Chromatography columns into a single inlet mass spectrometer, wherein samples from individual chromatography columns are suppled to individual electrospray nozzles in an array of a plurality of electrospray nozzles positioned in front of said single inlet, each nozzle being switchable to an on or off state, and each nozzle being supplied by a sample supply tube or channel and having, in addition to said sample supply tube or channel, a separate fluid removal tube or channel, and wherein each nozzle, when in the off state, is held at a voltage that is between the voltage of the mass spectrometer inlet and the electrospray threshold value for that nozzle.

7. 发明申请

WO2002058814A1 METHOD FOR PACKING CAPILLARY COLUMNS WITH PARTICULATE MATERIALS 审中-公开
标题翻译：用颗粒材料包装毛细管柱的方法
公开(公告)号：WO2002058814A1
公开(公告)日：2002-08-01
申请号：PCT/US2002/002116
申请日：2002-01-23
申请人： NEW OBJECTIVE, INC.
发明人： VALASKOVIC, Gary, A. , EHRENFELD, Emily, E.
IPC分类号： B01D15/08
CPC分类号： B01D15/206 , B01J2220/84 , G01N30/56 , G01N2030/565
摘要： Method for loading a capillary channel with a packing material to form a capillary column which includes placing a first frit on a capillary channel, forcing a slurry of a solid packing material in a liquid (70) through said first channel so that the liquid (70), but not the solid packing material, passes through the frit and out of the capillary channel, to form a first bed (21) of packing material within said first capillary channel and adjacent to the frit; thereby forming a pre-pack column (20), then removing the frit and joining the pre-pack column (20) to an empty second capillary channel (30) and attaching a second frit (9) to the end of said second channel (30), then forcing a liquid (70) into the end of pre-pack column (20), so that the liquid (70) passes through the pre-pack column (20), mobilizing the packing therein and carrying it into the second capillary channel (30).
摘要翻译：一种用填充材料加载毛细管通道以形成毛细管柱的方法，该毛细管柱包括将第一玻璃料放置在毛细通道上，迫使固体包装材料的浆液通过所述第一通道流入液体（70），使得液体（70 ），但不是固体包装材料通过玻璃料并离开毛细通道，以在第一毛细管通道内并与玻璃料相邻形成包装材料的第一床（21）; 从而形成预包装柱（20），然后除去玻璃料并将预包装柱（20）连接到空的第二毛细通道（30），并将第二玻璃料（9）附接到所述第二通道的端部 30），然后迫使液体（70）进入预包装柱（20）的末端，使得液体（70）通过预包装柱（20），在其中移动填料并将其携带到第二毛细管通道（30）。

8. 发明申请

WO2005119110A2 METHOD AND APPARATUS FOR CONNECTING SMALL DIAMETER TUBING 审中-公开
标题翻译：用于连接小直径管道的方法和装置
公开(公告)号：WO2005119110A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/018944
申请日：2005-05-27
申请人： NEW OBJECTIVE, INC. , VALASKOVIC, Gary, A. , SAWDEY, Lee, R. , MURPHY, James, P., III
发明人： VALASKOVIC, Gary, A. , SAWDEY, Lee, R. , MURPHY, James, P., III
IPC分类号： F16L
CPC分类号： G02B6/3809 , B01L3/565 , B01L2300/0838 , G01N30/6039
摘要： A union for coupling two or more segments of tubing or optical fiber, having an elastomeric core with two or more tubular sections encased in a through bore of a union body, the ends of the union body bore having compression nuts having through bores for insertion of segments of tubing or optical fiber to be coupled, which, tubular sections, when compressed by the compression nuts, deform radially inwardly to hold and seal the segments of tubing or optical fiber inserted therein.
摘要翻译：用于联接两个或更多个管段或光纤段的联接件，其具有包裹在联管体的通孔中的具有两个或多个管状部分的弹性体芯，所述联接体孔的端部具有压缩螺母，该压缩螺母具有通孔，要联接的管道或光纤的段，当压缩螺母压缩时，管状部分径向向内变形以保持和密封插入其中的管道或光纤的段。

9. 发明申请

WO2002095362A2 METHOD AND APPARATUS FOR FEEDBACK CONTROLLED ELECTROSPRAY 审中-公开
标题翻译：反馈控制电泳的方法和装置
公开(公告)号：WO2002095362A2
公开(公告)日：2002-11-28
申请号：PCT/US2002/016559
申请日：2002-05-24
申请人： NEW OBJECTIVE, INC. , VALASKOVIC, Gary, A. , LEE, Mike, S.
发明人： VALASKOVIC, Gary, A. , LEE, Mike, S.
IPC分类号： G01N
CPC分类号： H01J49/165
摘要： Feedback control system for electrospray nozzle using optical system for monitoring and controlling dynamic or static morphology of the fluid exiting the electrospray nozzle.
摘要翻译：使用光学系统的电喷雾喷嘴的反馈控制系统，用于监测和控制离开电喷雾喷嘴的流体的动态或静态形态。

10. 发明申请

WO02095360A2 METHOD AND APPARATUS FOR MULTIPLE ELECTROSPRAY SAMPLE INTRODUCTION 审中-公开
标题翻译：多电极样品介绍的方法和装置
公开(公告)号：WO02095360A2
公开(公告)日：2002-11-28
申请号：PCT/US0216350
申请日：2002-05-23
申请人： NEW OBJECTIVE INC , VALASKOVIC GARY A
发明人： VALASKOVIC GARY A
IPC分类号： G01N30/46 , G01N30/62 , G01N30/72 , H01J49/04 , G01N
CPC分类号： G01N30/7266 , G01N30/466 , G01N2030/628 , H01J49/04 , H01J49/165
摘要： A method for the coupling of a plurality sample streams eluting from a plurality of High Pressure Liquid Chromatography columns into a single inlet mass spectrometer, wherein samples from individual chromatography columns are suppled to individual electrospray nozzles in an array of a plurality of electrospray nozzles positioned in front of said single inlet, each nozzle being switchable to an on or off state, and each nozzle being supplied by a sample supply tube or channel and having, in addition to said sample supply tube or channel, a separate fluid removal tube or channel, and wherein each nozzle, when in the off state, is held at a voltage that is between the voltage of the mass spectrometer inlet and the electrospray threshold value for that nozzle.
摘要翻译：将从多个高压液相色谱柱洗脱的多个样品流耦合到单个入口质谱仪中的方法，其中来自单个色谱柱的样品被提供给位于多个电喷雾喷嘴的阵列中的各个电喷雾喷嘴所述单个入口的前部，每个喷嘴可切换到打开或关闭状态，并且每个喷嘴由样品供应管或通道供应，并且除了所述样品供应管或通道之外，还具有单独的流体移除管或通道，并且其中当处于关闭状态时，每个喷嘴保持在质谱仪入口的电压和该喷嘴的电喷雾阈值之间的电压。

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