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1. 发明申请

WO2018033401A1 A CLOT RETRIEVAL SYSTEM FOR REMOVING OCCLUSIVE CLOT FROM A BLOOD VESSEL 审中-公开
标题翻译：一种用于从血管中清除堵塞物的CLOT RETRIEVAL系统
公开(公告)号：WO2018033401A1
公开(公告)日：2018-02-22
申请号：PCT/EP2017/069668
申请日：2017-08-03
申请人： NEURAVI LIMITED
发明人： VALE, David , CASEY, Brendan , FAHY, Brian , MCARDLE, Kevin , BRADY, Eamon , AMSTUTZ, Jill , HOLIAN, Maeve , KING, Daniel , GILVARRY, Michael
IPC分类号： A61B17/22 , A61B17/221 , A61M25/10
摘要： A clot capture catheter comprises an elongate tubular shaft having a proximal end, a distal end and an inflatable expansile member at the distal end. The expansile member is inflatable from a collapsed delivery configuration to an expanded configuration. In the expanded configuration, the expansile member extends to define a funnel shape having an enlarged distal clot entry mouth at the distal-most end of the catheter. In the expanded configuration, the expansile member may extend distally beyond the distalmost tip of the shaft. The expansile member may be integral with the distal tip of the catheter shaft.
摘要翻译：凝块捕获导管包括具有近端，远端和位于远端处的可膨胀的可膨胀构件的细长管状轴。膨胀构件可从收缩的输送构造膨胀成膨胀构造。在膨胀构型中，可膨胀构件延伸以限定漏斗形状，所述漏斗形状在导管的最远端具有扩大的远端凝块进入口。在扩张构型中，可扩张构件可以向远侧延伸超过轴的最远侧尖端。扩张件可以与导管轴的远端尖端成一体。

2. 发明申请

WO2014140090A1 A CLOT REMOVAL DEVICE 审中-公开
标题翻译： CLOT移除装置
公开(公告)号：WO2014140090A1
公开(公告)日：2014-09-18
申请号：PCT/EP2014/054826
申请日：2014-03-12
申请人： NEURAVI LIMITED
发明人： BRADY, Eamon , CASEY, Brendan , GILVARRY, Michael , VALE, David
IPC分类号： A61B17/221 , A61B17/00
CPC分类号： A61B17/22031 , A61B17/221 , A61B2017/00309 , A61B2017/00336 , A61B2017/00853 , A61B2017/00858 , A61B2017/22001 , A61B2017/2215 , A61B2090/08021
摘要： A clot retrieval system comprises a clot retrieval device, a catheter 51, and a tubular shield element 61. The clot retrieval device comprises an elongate member 53 having a proximal end and a distal end, and a clot engaging element 54 at the distal end of the elongate member 53 the clot engaging element 54 having a collapsed delivery configuration and an expanded deployed configuration. The catheter is adapted for placement at a location at which a distal end of the catheter is proximal of the clot engaging element and the tubular shield element 61 extends over the elongate member 53 and is adapted for location between the distal end of the catheter and the proximal end of the clot engaging element 54. The tubular shield element 61 is movable relative to the elongate member 54 when the clot engaging element is in the expanded configuration in that the force that is applied on retraction of the elongate member is spread over the outer surface of the tubular shield element. The force that would usually be exerted on vessels on retrieval of the clot engaging element is spread by the shield element thus reducing the effects of abrasion.
摘要翻译：凝块回收系统包括凝块取回装置，导管51和管状屏蔽元件61.凝块回收装置包括具有近端和远端的细长构件53和在远端处的血块接合元件54 细长构件53具有折叠输送构型的凝块接合元件54和扩展的展开构型。导管适于放置在导管远端处于凝块接合元件的近侧的位置处，并且管状屏蔽元件61延伸在细长构件53上并且适于位于导管的远端和凝块接合元件54的近端。当凝块接合元件处于膨胀构型时，管状屏蔽元件61可相对于细长构件54移动，因为在细长构件缩回时施加的力分布在外部管状屏蔽元件的表面。通常在血管接合元件回收时对血管施加的力由屏蔽元件扩散，从而减少磨损的影响。

3. 发明申请

WO2018046408A3 A CLOT RETRIEVAL DEVICE FOR REMOVING OCCLUSIVE CLOT FROM A BLOOD VESSEL 审中-公开
标题翻译：一种用于从血管中去除闭塞血栓的血液回收装置
公开(公告)号：WO2018046408A3
公开(公告)日：2018-03-15
申请号：PCT/EP2017/072030
申请日：2017-09-01
申请人： NEURAVI LIMITED
发明人： VALE, David , CASEY, Brendan , FAHY, Brian , BRADY, Eamon , HOLIAN, Maeve , KING, Daniel , GILVARRY, Michael , O'GORMAN, Jacqueline
IPC分类号： A61B17/221 , A61B17/3207 , A61B17/22 , A61B90/00
摘要： A clot retrieval device (1) has a clot engaging portion configured at the distal end of an elongate shaft (6) having an outer expandable member (2) comprising multiple expandable segments (26), and an inner expandable member (3) to facilitate restoration of blood flow through clot immediately after the clot retrieval device (1) is deployed at an obstructive site. The outer member (2) and inner expandable (member (3) comprises a collapsed configuration for delivery and an expanded configuration for clot retrieval, flow restoration and fragmentation protection. Proximal radiopaque markers (82) are positioned at the distal end of struts (20) of the outer member (2) just proximal to two proximal crowns (81). This position is advantageous because it denotes the start of the fully expanded diameter of the device, which is the portion of the device that is most desirable to deploy under the clot for optimal grip of the clot.
摘要翻译：（1）具有配置在具有包括多个可膨胀节段（26）的外部可膨胀元件（2）的细长轴（6）的远端处的凝块接合部分，以及内部可膨胀元件（3），以便在凝块取出装置（1）部署在阻塞部位之后立即恢复通过凝块的血流。外部构件2和内部可膨胀构件3包括用于输送的收缩构造和用于凝块收回，流动恢复和碎裂保护的扩张构造。最近的不透射线标记（82）位于支柱（20）的远端）紧邻两个近端冠（81），这个位置是有利的，因为它表示装置的完全扩张直径的开始，该装置是最想要展开的装置的部分凝块的最佳抓地力。

4. 发明申请

WO2017097616A1 DEVICES AND METHODS FOR REMOVAL OF ACUTE BLOCKAGES FROM BLOOD VESSELS 审中-公开
标题翻译：用于从血管中去除急性阻塞的装置和方法
公开(公告)号：WO2017097616A1
公开(公告)日：2017-06-15
申请号：PCT/EP2016/078973
申请日：2016-11-28
申请人： NEURAVI LIMITED
发明人： VALE, David , CASEY, Brendan , GILVARRY, Michael , MCARDLE, Kevin , HOLIAN, Maeve , HARDIMAN, David , KEANE, Alan , KING, Daniel , O'GORMAN, Jacqueline , BRADY, Eamon
IPC分类号： A61B17/22 , A61M1/00
CPC分类号： A61B17/22031 , A61B17/22 , A61B17/29 , A61B17/3421 , A61B2017/22034 , A61B2017/22067 , A61B2017/22079 , A61B2017/2212 , A61B2017/2215 , A61B2217/005 , A61M1/008
摘要： A catheter has an expansile tip 901 that can be delivered in a constricted form. The increased tip diameter facilitates the aspiration and removal of large clot volumes by increasing the area of the catheter tip that applies aspiration to the clot. The tip 901 comprises a support frame which can be cut from a metal or polymer tube, covered with a thin polymer sleeve 909 containing highly elastic properties. This construction provides good pushability and high compressive resistance. The cut pattern can contain axial connections of the support frame 908 and ring members 906, which will provide a large level of axial support, lateral flexibility and hoop strength to withstand aspiration. The tip of the device can contain a section 907 proximal of the highly flexible area 905 that can expand to except clot. This potential to increase body diameter facilitates the retrieval of large volume clots while the construction of the catheter provides good column stiffness to avoid axial collapse and still maintain good flexibility.
摘要翻译：导管具有可以收缩形式递送的可膨胀尖端901。增加的尖端直径通过增加导管尖端的适用于凝块的抽吸区域来促进大量凝块体积的抽吸和去除。尖端901包括支撑框架，该支撑框架可以由金属或聚合物管切割，覆盖有包含高度弹性特性的薄聚合物套筒909。这种结构提供了良好的可推送性和高抗压性。切割图案可以包含支撑框架908和环形构件906的轴向连接，这将提供大水平的轴向支撑，侧向柔性和箍强度以抵抗抽吸。装置的尖端可以包含高度柔性区域905的近端部分907，其可以膨胀至除凝块外。这种增加身体直径的可能性有助于取回大体积凝块，而导管的构造提供良好的柱刚度以避免轴向坍塌并仍保持良好的柔韧性。

5. 发明申请

WO2011135556A1 CLOT ENGAGEMENT AND REMOVAL SYSTEMS 审中-公开
标题翻译：衣服接合和拆卸系统
公开(公告)号：WO2011135556A1
公开(公告)日：2011-11-03
申请号：PCT/IE2011/000026
申请日：2011-04-28
申请人： NEURAVI LIMITED , BRADY, Eamon , VALE, David , GILVARRY, Michael , MAHMOOD, Razavi
发明人： BRADY, Eamon , VALE, David , GILVARRY, Michael , MAHMOOD, Razavi
IPC分类号： A61B17/221
CPC分类号： A61F2/01 , A61B17/221 , A61B17/32056 , A61B2017/00287 , A61B2017/2212
摘要： A device for the removal of clot obstructing the flow of blood through an arterial vessel comprises an elongate member, a clot engaging element and a capture basket. The elongate member extends in use from a point adjacent a target treatment site interior of the patient to a point exterior of the patient. The capture basket comprises a frame and a net, and has an expanded and a collapsed configuration. The clot engaging element comprises a plurality of struts having an expanded and a collapsed configuration. The plurality of struts form a first section and a second section, the first section tapering outward and distally from the elongate member and connected to the second section. The second section comprises a plurality of cells defined by a plurality of struts and arranged around at least a portion of the circumference of an axis substantially parallel to that of the elongate member. The clot engaging element and the capture basket are restrained in the collapsed configuration for delivery to the target site. The clot engaging element is located adjacent the distal end of the elongate member and proximal of the capture basket.
摘要翻译：用于去除阻塞血液通过动脉血管的血块的装置包括细长构件，凝块接合元件和捕获篮。细长构件在使用中从邻近患者的目标治疗部位内部的点延伸到患者外部的点。捕获篮包括框架和网，并且具有展开和折叠构造。凝块接合元件包括具有膨胀和收缩构型的多个支柱。所述多个支柱形成第一部分和第二部分，所述第一部分从所述细长部件向外和远端逐渐变细并连接到所述第二部分。第二部分包括由多个支柱限定并且围绕基本上平行于细长构件的轴线的圆周的至少一部分布置的多个单元。凝块接合元件和捕获筐被限制在折叠构型中以输送到目标位置。凝块接合元件位于细长构件的远端和捕获篮的近侧附近。

6. 发明申请

WO2014140092A2 DEVICES AND METHODS FOR REMOVAL OF ACUTE BLOCKAGES FROM BLOOD VESSELS 审中-公开
标题翻译：从血管中移除急性阻塞的装置和方法
公开(公告)号：WO2014140092A2
公开(公告)日：2014-09-18
申请号：PCT/EP2014/054828
申请日：2014-03-12
申请人： NEURAVI LIMITED
发明人： BRADY, Eamon , CASEY, Brendan , GILVARRY, Michael , HARDIMAN, David , VALE, David
IPC分类号： A61B17/221
CPC分类号： A61B17/221 , A61B2017/00526 , A61B2017/00867 , A61B2017/00942 , A61B2017/00951 , A61B2017/22034 , A61B2017/2212 , A61B2017/2217 , A61B2090/3966 , A61L31/022 , B05D1/322 , B05D3/12
摘要： A clot retrieval device comprises an elongate shaft (104) and an expandable clot retrieval element (2101) on the shaft, the clot retrieval element comprising a framework formed from a substrate material such as Nitinol and having a plurality of struts (2105) and crowns (2102), at least some of the struts (2105) comprises at least one widened portion (2104) of the substrate material to provide enhanced radiopacity. The framework is coated with a radiopaque material such as gold. The device is rendered radiopaque with reduced damping effects.
摘要翻译：凝块取出装置包括在轴上的细长轴（104）和可膨胀的凝块回缩元件（2101），所述凝块回收元件包括由诸如镍钛诺的基底材料形成的骨架，并且具有多个支柱（2105）和冠（2102）中，所述支柱（2105）中的至少一些包括所述基底材料的至少一个加宽部分（2104），以提供增强的不透射线性。该框架涂有不透射线的材料，例如金。该设备被渲染为不透射线，减少了阻尼效应。

7. 发明申请

WO2012120490A2 A CLOT RETRIEVAL DEVICE FOR REMOVING OCCLUSIVE CLOT FROM A BLOOD VESSEL 审中-公开
标题翻译：一种用于从血管中去除闭塞血栓的血液回收装置
公开(公告)号：WO2012120490A2
公开(公告)日：2012-09-13
申请号：PCT/IE2012/000011
申请日：2012-03-09
申请人： NEURAVI LIMITED , BRADY, Eamon , GILVARRY, Michael , RAZAVI, Mahmood , VALE, David , GRIFFIN, Patrick , CASEY, Brendan , MCNAMARA, Jason
发明人： BRADY, Eamon , GILVARRY, Michael , RAZAVI, Mahmood , VALE, David , GRIFFIN, Patrick , CASEY, Brendan , MCNAMARA, Jason
IPC分类号： A61B17/221 , A61F2/01
CPC分类号： A61B17/221 , A61B17/22031 , A61B17/320725 , A61B2017/00292 , A61B2017/00526 , A61B2017/00867 , A61B2017/22034 , A61B2017/22094 , A61B2017/2212 , A61B2017/2215 , A61F2/013 , A61F2002/011 , A61F2002/016 , A61F2002/018 , A61F2230/0069 , A61F2230/008 , A61F2230/0091 , A61F2230/0093
摘要： A clot retrieval device (9501) for removing occlusive clot from a blood vessel comprises an inner elongate body (9503) and an outer elongate body (9504) at least partially overlying the inner elongate body (9503). The device also comprises an elongate member or shaft (9502) having a proximal end which extends exterior of a patient so that a user can retrieve the stent-basket device and captured clot by retracting the shaft (9502). The outer elongate body (9504) and the inner elongate body (9503) are connected to the distal end of the shaft (9502) and are expandable relative to the shaft (9502) from a collapsed delivery configuration to an expanded deployed configuration. The outer elongate body (9504) is expandable relative to the inner elongate body (9503) to a radial extent which is greater than the radial extent of the inner body (9503) in the deployed configuration. The stent-basket construction of the device creates a reception space (9507) between the inner (9503) and outer (9504) to receive the target clot. The outer body (9504) is configured to allow as much as possible of the clot to migrate through it into the internal reception space (9507). Housing the clot in this reception space rather than pinning it to the wall of the vessel means that the clot is under less compression and can thus be retracted at a lower force. The inner elongate body (9503) and a distal capture net (9505) protect the distal vascular bed from embolisation.
摘要翻译：用于从血管移除闭塞凝块的凝块取出装置（9501）包括内部细长主体（9503）和至少部分地覆盖内部细长主体（9503）的外部细长主体（9504）。该装置还包括细长构件或轴（9502），该细长构件或轴具有延伸到患者外部的近端，使得使用者可以通过缩回轴（9502）来取回支架篮装置并捕获凝块。外部细长主体（9504）和内部细长主体（9503）连接到轴（9502）的远端并且可相对于轴（9502）从塌缩的递送构造扩展到展开的展开构造。外部细长主体（9504）可相对于内部细长主体（9503）膨胀至比展开构造中的内部主体（9503）的径向范围更大的径向范围。装置的支架篮构造在内部（9503）和外部（9504）之间形成接收空间（9507）以接收目标血块。外体（9504）被构造成尽可能允许凝块通过它进入内部接收空间（9507）。将血块容纳在该接收空间中而不是将其固定在血管壁上意味着血块处于较小的压缩下，因此可以以较小的力收回。内部细长体（9503）和远端捕获网（9505）保护远端血管床免受栓塞。

8. 发明申请

WO2010010545A1 CLOT CAPTURE SYSTEMS AND ASSOCIATED METHODS 审中-公开
标题翻译：收集系统和相关方法
公开(公告)号：WO2010010545A1
公开(公告)日：2010-01-28
申请号：PCT/IE2009/000051
申请日：2009-07-22
申请人： NEURAVI LIMITED , BRADY, Eamon , RAZAVI, Mahmood , VALE, David , O'SHAUGHNESSY, John
发明人： BRADY, Eamon , RAZAVI, Mahmood , VALE, David , O'SHAUGHNESSY, John
IPC分类号： A61B17/221
CPC分类号： A61B17/221 , A61B17/22031 , A61B2017/00867 , A61B2017/22035 , A61B2017/22038 , A61B2017/22051 , A61B2017/22094 , A61B2017/2212 , A61B2017/2215 , A61B2017/2217 , A61F2/01 , A61F2230/0008 , A61F2230/001 , A61F2230/005 , A61F2230/0058
摘要： A clot capture system for disengaging a clot 2001 from a vessel wall 2002 and removing the clot 2001 from the vessel 202, comprises a clot capture device 2140 for placement on a distal side of a clot 2001. The clot capture device 2140 has a retracted delivery configuration and an expanded deployed configuration. The clot removal device has a proximal support frame 2012, and a distal fibre net 2130. The support frame 2012 has a retracted delivery configuration and an expanded deployed configuration. The proximal support frame 2012 in the expanded configuration defines a proximal inlet mouth for engaging a clot 2001 and a net 2130 for confining the clot 2001. An elongate member facilitates capture and/or withdrawal of a clot 2001 from a vessel 2002. The system also comprises a clot debonding device 2091 for placement on a proximal side of a clot 2001. The clot debonding device 2091 has a retracted delivery configuration and an expanded deployed configuration and comprises a clot engagement element 2112 which defines a distal abutment in the deployed configuration for urging a clot 2001 into the clot capture device 2140.
摘要翻译：用于使凝块2001与血管壁2002分离并从血管202移除血块2001的血块捕获系统包括用于放置在凝块2001的远侧上的凝块捕获装置2140.凝块捕获装置2140具有缩回的输送配置和扩展部署配置。凝块移除装置具有近端支撑框架2012和远端纤维网2130.支撑框架2012具有缩回的输送构型和扩张的展开构型。处于扩展构型的近端支撑框架2012限定了用于接合凝块2001的近端入口和用于限制凝块2001的网2130.细长构件有利于从血管2002捕获和/或撤出凝块2001.系统还包括用于放置在凝块2001的近侧的凝块剥离装置2091.凝块脱粘装置2091具有缩回的输送构型和扩张的展开构型，并且包括凝块接合元件2112，其在展开构型中限定了远端邻接件，用于推动凝块2001进入血块捕获装置2140。

9. 发明申请

WO2018046408A2 A CLOT RETRIEVAL DEVICE FOR REMOVING OCCLUSIVE CLOT FROM A BLOOD VESSEL 审中-公开
标题翻译：一种用于从血管中去除闭塞血栓的血液回收装置
公开(公告)号：WO2018046408A2
公开(公告)日：2018-03-15
申请号：PCT/EP2017/072030
申请日：2017-09-01
申请人： NEURAVI LIMITED
发明人： VALE, David , CASEY, Brendan , FAHY, Brian , BRADY, Eamon , HOLIAN, Maeve , KING, Daniel , GILVARRY, Michael , O'GORMAN, Jacqueline
IPC分类号： A61B17/221
摘要： A clot retrieval device (1) has a clot engaging portion configured at the distal end of an elongate shaft (6) having an outer expandable member (2) comprising multiple expandable segments (26), and an inner expandable member (3) to facilitate restoration of blood flow through clot immediately after the clot retrieval device (1) is deployed at an obstructive site. The outer member (2) and inner expandable member (3) comprises a collapsed configuration for delivery and an expanded configuration for clot retrieval, flow restoration and fragmentation protection. Proximal radiopaque markers (82) are positioned at the distal end of struts (20) of the outer member (2) just proximal to two proximal crowns (81). This position is advantageous because it denotes the start of the fully expanded diameter of the device, which is the portion of the device that is most desirable to deploy under the clot for optimal grip of the clot.
摘要翻译：（1）具有配置在具有包括多个可膨胀节段（26）的外部可膨胀元件（2）的细长轴（6）的远端处的凝块接合部分，以及内部可膨胀元件（3），以便在凝块取出装置（1）部署在阻塞部位之后立即恢复通过凝块的血流。外部构件（2）和内部可膨胀构件（3）包括用于输送的折叠构造和用于凝块取回，流动恢复和防碎片保护的扩展构造。近端不透射线标记（82）位于外部构件（2）的支柱（20）的远端处，恰好在两个近端冠（81）的近侧。这个位置是有利的，因为它表示装置的完全扩张直径的开始，该装置是最想要在凝块下部署以便最佳抓住凝块的装置的部分。

10. 发明申请

WO2018019829A1 A CLOT RETRIEVAL SYSTEM FOR REMOVING OCCLUSIVE CLOT FROM A BLOOD VESSEL 审中-公开
标题翻译：一种用于从血管中清除堵塞物的CLOT RETRIEVAL系统
公开(公告)号：WO2018019829A1
公开(公告)日：2018-02-01
申请号：PCT/EP2017/068759
申请日：2017-07-25
申请人： NEURAVI LIMITED
发明人： BRADY, Eamon , VALE, David , GILVARRY, Michael , CASEY, Brendan , HOARY, Marto , SIDDIQUI, Adnan
IPC分类号： A61B17/22 , A61M1/00
CPC分类号： A61B17/22 , A61B17/22012 , A61B2017/00141 , A61B2017/00146 , A61B2017/00154 , A61B2217/005 , A61M1/0035 , A61M1/0037
摘要： A system for removing occlusive clot from a blood vessel comprises a catheter and an apparatus for generating a pulsatile vacuum force to pulse the pressure gradient at a distal end of the catheter. The pulse generator may be integral with or separate from the vacuum pump. The pulse generator may be applied to a flexible tubing between the vacuum pump and the proximal end of the catheter.
摘要翻译：用于从血管中去除闭塞血块的系统包括导管和用于产生脉动真空力以脉动导管远端处的压力梯度的装置。脉冲发生器可以与真空泵成一体或分开。脉冲发生器可以应用于真空泵和导管近端之间的柔性管。

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