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    • 2. 发明申请
    • WEARABLE BICYCLE TURN LIGHT INDICATORS
    • 耐用的自行车指示灯
    • WO2016120736A1
    • 2016-08-04
    • PCT/IB2016/050019
    • 2016-01-04
    • KULKARNI, RenuKULKARNI, Amit
    • KULKARNI, RenuKULKARNI, Amit
    • B62J6/04
    • B62J6/005
    • The present invention provides a wearable bicycle turn light indicators. According to an embodiment, the wearable bicycle turn light indicators includes separate belt for both shoulders operated through manual ON/OFF mechanism. Both left side belt and right side belt includes individually a front LED, a switch, a battery and a rear LED. A rope of the switch is pulled by a bicyclist to turn on and off the indicator LEDs. In a further embodiment, a timer is provided in the wearable bicycle turn light indicators with separate belt for both shoulders with automatic turn OFF mechanism. In a further embodiment, a wearable bicycle turn light indicators with a single round belt operated in a three state switch through manual ON/OFF mechanism is provided. In a further embodiment, a wearable bicycle turn light indicators with a single round belt operated through two state switch and automatic turn OFF mechanism is provided.
    • 本发明提供一种耐磨自行车转向灯指示器。 根据一个实施例,可穿戴自行车转向灯指示器包括用于通过手动ON / OFF机构操作的两个肩部的分离皮带。 左侧带和右侧带都分别包括前LED,开关,电池和后LED。 开关的绳索由骑自行车者拉动以打开和关闭指示灯。 在另一个实施例中,在可穿戴式自行车转向灯指示器中提供定时器,其具有用于具有自动关闭机构的肩部的分离带。 在另一实施例中,提供了一种带有通过手动ON / OFF机构在三状态开关中操作的单个圆形带的可穿戴自行车转向灯指示器。 在另一实施例中,提供了通过两个状态开关和自动关闭机构操作的具有单个圆形带的可穿戴自行车转向灯指示器。
    • 6. 发明申请
    • NANOPARTICLES WITH INORGANIC CORE AND METHODS OF USING THEM
    • 无机碳纳米管及其使用方法
    • WO2006068653A2
    • 2006-06-29
    • PCT/US2005/011110
    • 2005-04-01
    • GENERAL ELECTRIC COMPANYMALENFANT, PatrickACAR, HavvaBONITATEBUS, JR., PeterDIXON, WilliamKULKARNI, Amit
    • MALENFANT, PatrickACAR, HavvaBONITATEBUS, JR., PeterDIXON, WilliamKULKARNI, Amit
    • A61K49/1848A61K49/186B82Y5/00
    • An aspect of the invention includes a nanoparticle including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating includes of at least coating structure I, II, or III wherein the nanoparticle is substantially non-agglomerated and has diameter in a range from about 1nm to about 100 nm. An aspect of the invention also encompasses a method of making a substantially non-agglomerated nanoparticle having a diameter in a range from about 1nm to about 100 nm including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating comprises coating structure I, II, or III. An aspect of the invention also encompasses various methods of using the substantially non-agglomerated nanoparticle having a diameter in a range from about 1nm to about 100 nm including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating comprises coating structure I, II, or III.
    • 本发明的一个方面包括纳米颗粒,其包括具有表面的基本上单分散的无机核,涂层基本覆盖基本上单分散的无机核的表面,其中该涂层至少包括涂层结构I,II或III,其中纳米颗粒是 基本上非团聚并且具有在约1nm至约100nm范围内的直径。 本发明的一个方面还包括制备直径在约1nm至约100nm范围内的基本上非团聚的纳米颗粒的方法,包括基本上单分散的无机芯,其表面和涂层基本上覆盖基本上单分散的表面 无机芯,其中涂层包括涂层结构I,II或III。 本发明的一个方面还包括使用直径在约1nm至约100nm范围内的基本上未附聚的纳米颗粒的各种方法,包括基本上单分散的无机芯,其表面和涂层基本上覆盖基本上单分散的表面 无机芯,其中涂层包括涂层结构I,II或III。
    • 10. 发明申请
    • CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING
    • 磁共振成像对比剂
    • WO2005112758A1
    • 2005-12-01
    • PCT/US2005/017341
    • 2005-05-18
    • GENERAL ELECTRIC COMPANYACAR, Havva, Y.SYUD, FaisalGARAAS, RachelBONITATEBUS, JR., PeterKULKARNI, Amit
    • ACAR, Havva, Y.SYUD, FaisalGARAAS, RachelBONITATEBUS, JR., PeterKULKARNI, Amit
    • A61B5/055
    • A61K49/186B82Y5/00
    • A contrast agent for magnetic resonance imaging having a plurality of nanoparticles (100, 200). Each of the nanoparticles (100, 200) has: a signal generating core (110, 210) having a diameter of up to 10 nm; at least one organic layer (120, 230) of at least one of a polymer, a monomer (122), and a surfactant; and a water soluble outer shell of at least one of a polymer, a monomer (122), and a ligand. The organic layer (120, 230) is adsorbed upon and substantially surrounds and stabilizes the signal generating core. The water soluble outer shell solubilizes and provides biocompatibility for each of the nanoparticles (100, 200). The contrast agents provide enhanced relaxivity, high signal-to-noise ratios, and targeting abilities. In addition, the contrast agents possess resistance to agglomeration, controlled particle size, blood clearance rate, and biodistribution. Methods of making such contrast agents and nanoparticles (100, 200) are also disclosed.
    • 一种用于具有多个纳米颗粒(100,200)的磁共振成像的造影剂。 每个纳米颗粒(100,200)具有:具有高达10nm的直径的信号产生芯(110,210); 至少一种聚合物,单体(122)和表面活性剂中的至少一种的有机层(120,230); 和聚合物,单体(122)和配体中的至少一种的水溶性外壳。 有机层(120,230)被吸附在基本上并且基本上包围和稳定信号产生芯。 水溶性外壳增溶并为每种纳米颗粒(100,200)提供生物相容性。 造影剂提供增强的松弛度,高信噪比和靶向能力。 此外,造影剂具有抗凝集,受控粒度,血清清除率和生物分布。 还公开了制备这种造影剂和纳米颗粒(100,200)的方法。