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1. 发明申请

WO2006068653A2 NANOPARTICLES WITH INORGANIC CORE AND METHODS OF USING THEM 审中-公开
标题翻译：无机碳纳米管及其使用方法
公开(公告)号：WO2006068653A2
公开(公告)日：2006-06-29
申请号：PCT/US2005/011110
申请日：2005-04-01
申请人： GENERAL ELECTRIC COMPANY , MALENFANT, Patrick , ACAR, Havva , BONITATEBUS, JR., Peter , DIXON, William , KULKARNI, Amit
发明人： MALENFANT, Patrick , ACAR, Havva , BONITATEBUS, JR., Peter , DIXON, William , KULKARNI, Amit
CPC分类号： A61K49/1848 , A61K49/186 , B82Y5/00
摘要： An aspect of the invention includes a nanoparticle including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating includes of at least coating structure I, II, or III wherein the nanoparticle is substantially non-agglomerated and has diameter in a range from about 1nm to about 100 nm. An aspect of the invention also encompasses a method of making a substantially non-agglomerated nanoparticle having a diameter in a range from about 1nm to about 100 nm including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating comprises coating structure I, II, or III. An aspect of the invention also encompasses various methods of using the substantially non-agglomerated nanoparticle having a diameter in a range from about 1nm to about 100 nm including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating comprises coating structure I, II, or III.
摘要翻译：本发明的一个方面包括纳米颗粒，其包括具有表面的基本上单分散的无机核，涂层基本覆盖基本上单分散的无机核的表面，其中该涂层至少包括涂层结构I，II或III，其中纳米颗粒是基本上非团聚并且具有在约1nm至约100nm范围内的直径。本发明的一个方面还包括制备直径在约1nm至约100nm范围内的基本上非团聚的纳米颗粒的方法，包括基本上单分散的无机芯，其表面和涂层基本上覆盖基本上单分散的表面无机芯，其中涂层包括涂层结构I，II或III。本发明的一个方面还包括使用直径在约1nm至约100nm范围内的基本上未附聚的纳米颗粒的各种方法，包括基本上单分散的无机芯，其表面和涂层基本上覆盖基本上单分散的表面无机芯，其中涂层包括涂层结构I，II或III。

2. 发明申请

WO2005112758A1 CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：磁共振成像对比剂
公开(公告)号：WO2005112758A1
公开(公告)日：2005-12-01
申请号：PCT/US2005/017341
申请日：2005-05-18
申请人： GENERAL ELECTRIC COMPANY , ACAR, Havva, Y. , SYUD, Faisal , GARAAS, Rachel , BONITATEBUS, JR., Peter , KULKARNI, Amit
发明人： ACAR, Havva, Y. , SYUD, Faisal , GARAAS, Rachel , BONITATEBUS, JR., Peter , KULKARNI, Amit
IPC分类号： A61B5/055
CPC分类号： A61K49/186 , B82Y5/00
摘要： A contrast agent for magnetic resonance imaging having a plurality of nanoparticles (100, 200). Each of the nanoparticles (100, 200) has: a signal generating core (110, 210) having a diameter of up to 10 nm; at least one organic layer (120, 230) of at least one of a polymer, a monomer (122), and a surfactant; and a water soluble outer shell of at least one of a polymer, a monomer (122), and a ligand. The organic layer (120, 230) is adsorbed upon and substantially surrounds and stabilizes the signal generating core. The water soluble outer shell solubilizes and provides biocompatibility for each of the nanoparticles (100, 200). The contrast agents provide enhanced relaxivity, high signal-to-noise ratios, and targeting abilities. In addition, the contrast agents possess resistance to agglomeration, controlled particle size, blood clearance rate, and biodistribution. Methods of making such contrast agents and nanoparticles (100, 200) are also disclosed.
摘要翻译：一种用于具有多个纳米颗粒（100,200）的磁共振成像的造影剂。每个纳米颗粒（100,200）具有：具有高达10nm的直径的信号产生芯（110,210）; 至少一种聚合物，单体（122）和表面活性剂中的至少一种的有机层（120,230）; 和聚合物，单体（122）和配体中的至少一种的水溶性外壳。有机层（120,230）被吸附在基本上并且基本上包围和稳定信号产生芯。水溶性外壳增溶并为每种纳米颗粒（100,200）提供生物相容性。造影剂提供增强的松弛度，高信噪比和靶向能力。此外，造影剂具有抗凝集，受控粒度，血清清除率和生物分布。还公开了制备这种造影剂和纳米颗粒（100,200）的方法。

3. 发明申请

WO2007069040A2 TARGETED NANOPARTICLES FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用于磁共振成像的目标纳米颗粒
公开(公告)号：WO2007069040A2
公开(公告)日：2007-06-21
申请号：PCT/IB2006/003584
申请日：2006-12-12
申请人： GENERAL ELECTRIC COMPANY , TORRES, Andrew , SYUD, Faisal , KULKARNI, Amit , WOOD, Nichole , BAILLIE, Mark , MOASSER, Bahram , BALES, Brian , BELETSKII, Anton , BONITATEBUS, JR., Peter
发明人： TORRES, Andrew , SYUD, Faisal , KULKARNI, Amit , WOOD, Nichole , BAILLIE, Mark , MOASSER, Bahram , BALES, Brian , BELETSKII, Anton , BONITATEBUS, JR., Peter
IPC分类号： A61K49/18
CPC分类号： A61K49/1848 , A61K47/59 , A61K47/62 , A61K47/6923 , A61K47/6929 , A61K49/1857 , A61K49/1866 , B82Y5/00 , B82Y25/00 , G01N33/552 , G01R33/5601 , H01F1/0054
摘要： In some embodiments, the present invention is directed to novel targeted contrast agents for magnetic resonance imaging (MRI). The present invention is also directed to methods of making such targeted MRI contrast agents, and to methods of using such MRI contrast agents. Typically, such targeted MRI contrast agents provide enhanced relaxivity, improved signal-to-noise, targeting ability, and resistance to agglomeration. Methods of making such MRI contrast agents typically afford better control over particle size, and methods of using such MRI contrast agents typically afford enhanced blood clearance rates and biodistribution.
摘要翻译：在一些实施方案中，本发明涉及用于磁共振成像（MRI）的新型靶向造影剂。本发明还涉及制备这种靶向MRI造影剂的方法，以及使用这种MRI造影剂的方法。通常，这种靶向MRI造影剂提供增强的舒张度，改善的信噪比，靶向能力和抵抗聚集。制造这种MRI造影剂的方法通常能够更好地控制粒径，并且使用这种MRI造影剂的方法通常提供增强的血液清除率和生物分布。

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