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1. 发明申请

WO2008078965A1 CERAMIDE DERIVATIVES, METHOD FOR PREPARING THE SAME, AND THERAPEUTIC AGENT FOR TREATING ATOPIC DERMATITIS COMPRISING THE CERAMIDE DERIVATIVES 审中-公开
标题翻译： CERAMIDE衍生物，其制备方法以及用于处理包含CERAMIDE衍生物的原位衍生物的治疗剂
公开(公告)号：WO2008078965A1
公开(公告)日：2008-07-03
申请号：PCT/KR2007/006860
申请日：2007-12-27
申请人： NEOPHARM CO., LTD. , PARK, Byeong-Deog , YOUM, Jong-Kyung , GWAK, Hyung-Sub , KWON, Mi-Jung , KIM, Hwan-Mook , KANG, Jong-Soon , HAN, Sang-Bae
发明人： PARK, Byeong-Deog , YOUM, Jong-Kyung , GWAK, Hyung-Sub , KWON, Mi-Jung , KIM, Hwan-Mook , KANG, Jong-Soon , HAN, Sang-Bae
IPC分类号： C07F9/44
CPC分类号： A61K8/68 , A61Q19/00 , C07F9/091
摘要： Disclosed are ceramide derivatives represented by the following formula 1 or 2, a method for preparing the same, and a therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients the Formula 1 and Formula 2. The therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients according to the present invention may be useful to treat atopic dermatitis, or treat other skin diseases that are required for improving skin inflammations or suppressing epidermal proliferation, by sup¬ pressing or improving inflammatory conditions in the atopic dermatitis in addition to giving im- munoregulatory functions, and suppressing or improving skin disorders, for example epidermal proliferation that is generally observed in the atopic dermatitis.
摘要翻译：公开了由下式1或2表示的神经酰胺衍生物，其制备方法和治疗特应性皮炎的治疗剂，其包括神经酰胺衍生物作为式1和式2的活性成分。用于治疗特应性皮炎的治疗剂包括根据本发明的神经酰胺衍生物作为活性成分可以用于治疗特应性皮炎或治疗改善皮肤炎症或抑制表皮增生所需的其它皮肤疾病，通过抑制或改善特应性皮炎中的炎性病症给予调节功能，抑制或改善皮肤病，例如通常在特应性皮炎中观察到的表皮增生。

2. 发明申请

WO2006049404A1 SPHINGOSINE KINASE ACTIVATOR AND SKIN DISEASE TREATING AGENT COMPRISING THE SAME 审中-公开
标题翻译：丝氨酸激酶激活剂和包含其的皮肤病治疗药物
公开(公告)号：WO2006049404A1
公开(公告)日：2006-05-11
申请号：PCT/KR2005/003586
申请日：2005-10-27
申请人： NEOPHARM CO., LTD. , PARK, Byeong-Deog , YOUM, Jong-Kyung , GWAK, Hyung-Sub , KWON, Mi-Jong , LEE, Yong-Moon , KIM, Yoo-Hun , KIM, Hwan-Mook , PARK, Song-Kyu , LEE, Ki-Ho , LEE, Chang-Woo , LEE, Myong-Lyoll
发明人： PARK, Byeong-Deog , YOUM, Jong-Kyung , GWAK, Hyung-Sub , KWON, Mi-Jong , LEE, Yong-Moon , KIM, Yoo-Hun , KIM, Hwan-Mook , PARK, Song-Kyu , LEE, Ki-Ho , LEE, Chang-Woo , LEE, Myong-Lyoll
IPC分类号： A61K31/164
CPC分类号： C07C235/08 , A61K8/68 , A61Q19/08 , C07C235/74
摘要： Disclosed is a non-natural ceramide compound effective for a sphingosine kinase activator, and thus useful for a skin disease treating agent. The sphingosine kinase activator enhances production of sphingosine-1-phosphate to show various physiological activities provided by sphingosine-1-phosphate. The physiological activities include the effects of: controlling multiplication and differentiation of keratinocytes, multiplication of fibroblasts and collagen synthesis, resulting in treatment of wounds, recovery of damaged skin functions in atopic dermatitis and psoriasis; inhibiting wrinkles and skin irritation caused by ultraviolet rays, followed by improvement of wrinkles and inhibition of skin aging; and reducing skin atrophy, which is a typical side effect of local application steroids. Therefore, the sphingosine kinase activator is useful for a skin disease treating agent for treating skin wounds, wrinkles, atopic dermatitis, eczema, psoriasis, or skin atrophy caused by side effects of local application steroids.
摘要翻译：公开了对鞘氨醇激酶活化剂有效的非天然神经酰胺化合物，因此可用于皮肤疾病治疗剂。鞘氨醇激酶激活剂增强了鞘氨醇-1-磷酸的产生，以显示由鞘氨醇-1-磷酸提供的各种生理活性。生理活动包括：控制角质形成细胞的增殖和分化，成纤维细胞的增殖和胶原合成，导致伤口的治疗，恢复特应性皮炎和牛皮癣损伤的皮肤功能; 抑制由紫外线引起的皱纹和皮肤刺激，随后改善皱纹和抑制皮肤老化; 并减少皮肤萎缩，这是局部应用类固醇的典型副作用。因此，鞘氨醇激酶激活剂可用于皮肤疾病治疗剂，用于治疗由局部应用类固醇的副作用引起的皮肤伤口，皱纹，特应性皮炎，湿疹，牛皮癣或皮肤萎缩。

3. 发明申请

WO2009038349A2 MASK PACK USING THE WATER-VAPOR CONTROLLABLE SHEET 审中-公开
标题翻译：使用水蒸气控制片的掩模包装
公开(公告)号：WO2009038349A2
公开(公告)日：2009-03-26
申请号：PCT/KR2008/005499
申请日：2008-09-18
申请人： NEOPHARM CO., LTD. , HONG, Keum-Duck , LEE, Shin-Hee , PARK, Hyun-Jung , LEE, Chang-Rae , JEONG, Se-Kyoo , PARK, Byeong-Deog
发明人： HONG, Keum-Duck , LEE, Shin-Hee , PARK, Hyun-Jung , LEE, Chang-Rae , JEONG, Se-Kyoo , PARK, Byeong-Deog
IPC分类号： A61K8/02
CPC分类号： A61K8/0212 , A61K8/0208 , A61K8/34 , A61K8/355 , A61K8/365 , A61K8/49 , A61K8/602 , A61K8/64 , A61K8/65 , A61K8/676 , A61K8/735 , A61K8/922 , A61K8/97 , A61K8/9706 , A61K8/988 , A61Q19/005 , A61Q19/02 , A61Q19/08
摘要： There is provided a functional mask pack using a moisture-controllable mask sheet having an effect to promote absorption of an active component in the skin by adjusting directionality with respect to a moisture penetration direction, or showing a skin soothing effect by providing a sense of coldness to the skin. The mask pack comprises a moisture absorbing layer 7 having a relatively lower density and hydrophilicity, a moisture diffusing layer 5 having a relatively higher density and hydrophilicity, and a moisture transfer layer 6 having an intermediate density and hydrophilicity between the moisture absorbing layer and the moisture diffusing layer. Here, the mask sheet is used in the mask pack to promote the absorption of the active component when the mask sheet has a 3-layered structure of the moisture diffusing layer 5, the moisture transfer layer 6 and the moisture absorbing layer 7 which are sequentially stacked from the inside of the mask sheet, and used in the mask pack to soothe the skin when the mask sheet has a 3-layered structure of the moisture absorbing layer 7, the moisture transfer layer 6 and the moisture diffusing layer 5 which are sequentially stacked from the inside of the mask sheet. Therefore, the mask pack according to the present invention may be useful to promote the absorption of the active component and soothe the skin since its particular structure leads to a high moisture mobility, and thus to prevent resource waste and make a contribution to the environmental protections through the re-use of the resources.
摘要翻译：提供了一种使用水分可控制掩模片的功能性面膜包，其具有通过调节相对于水分渗透方向的方向性而促进皮肤中的活性成分的吸收，或通过提供感觉来显示皮肤舒缓效果到皮肤。掩模组包括具有较低密度和亲水性的吸湿层7，具有较高密度和亲水性的湿气扩散层5和在吸湿层和湿气之间具有中等密度和亲水性的湿气转移层6 扩散层。这里，当掩模片具有顺序地具有湿气扩散层5，湿度转移层6和吸湿层7的3层结构时，掩模片用于掩模包中以促进活性成分的吸收并且当掩模片具有顺序地具有吸湿层7，湿度转移层6和湿气扩散层5的3层结构时，用于面罩包装中以舒缓皮肤从掩模片的内侧堆叠。因此，根据本发明的面膜包可以有助于促进活性成分的吸收和舒缓皮肤，因为其特定的结构导致高的水分流动性，并且因此防止资源浪费并对环境保护作出贡献通过资源的重用。

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