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1. 发明申请

WO2006049404A1 SPHINGOSINE KINASE ACTIVATOR AND SKIN DISEASE TREATING AGENT COMPRISING THE SAME 审中-公开
标题翻译：丝氨酸激酶激活剂和包含其的皮肤病治疗药物
公开(公告)号：WO2006049404A1
公开(公告)日：2006-05-11
申请号：PCT/KR2005/003586
申请日：2005-10-27
申请人： NEOPHARM CO., LTD. , PARK, Byeong-Deog , YOUM, Jong-Kyung , GWAK, Hyung-Sub , KWON, Mi-Jong , LEE, Yong-Moon , KIM, Yoo-Hun , KIM, Hwan-Mook , PARK, Song-Kyu , LEE, Ki-Ho , LEE, Chang-Woo , LEE, Myong-Lyoll
发明人： PARK, Byeong-Deog , YOUM, Jong-Kyung , GWAK, Hyung-Sub , KWON, Mi-Jong , LEE, Yong-Moon , KIM, Yoo-Hun , KIM, Hwan-Mook , PARK, Song-Kyu , LEE, Ki-Ho , LEE, Chang-Woo , LEE, Myong-Lyoll
IPC分类号： A61K31/164
CPC分类号： C07C235/08 , A61K8/68 , A61Q19/08 , C07C235/74
摘要： Disclosed is a non-natural ceramide compound effective for a sphingosine kinase activator, and thus useful for a skin disease treating agent. The sphingosine kinase activator enhances production of sphingosine-1-phosphate to show various physiological activities provided by sphingosine-1-phosphate. The physiological activities include the effects of: controlling multiplication and differentiation of keratinocytes, multiplication of fibroblasts and collagen synthesis, resulting in treatment of wounds, recovery of damaged skin functions in atopic dermatitis and psoriasis; inhibiting wrinkles and skin irritation caused by ultraviolet rays, followed by improvement of wrinkles and inhibition of skin aging; and reducing skin atrophy, which is a typical side effect of local application steroids. Therefore, the sphingosine kinase activator is useful for a skin disease treating agent for treating skin wounds, wrinkles, atopic dermatitis, eczema, psoriasis, or skin atrophy caused by side effects of local application steroids.
摘要翻译：公开了对鞘氨醇激酶活化剂有效的非天然神经酰胺化合物，因此可用于皮肤疾病治疗剂。鞘氨醇激酶激活剂增强了鞘氨醇-1-磷酸的产生，以显示由鞘氨醇-1-磷酸提供的各种生理活性。生理活动包括：控制角质形成细胞的增殖和分化，成纤维细胞的增殖和胶原合成，导致伤口的治疗，恢复特应性皮炎和牛皮癣损伤的皮肤功能; 抑制由紫外线引起的皱纹和皮肤刺激，随后改善皱纹和抑制皮肤老化; 并减少皮肤萎缩，这是局部应用类固醇的典型副作用。因此，鞘氨醇激酶激活剂可用于皮肤疾病治疗剂，用于治疗由局部应用类固醇的副作用引起的皮肤伤口，皱纹，特应性皮炎，湿疹，牛皮癣或皮肤萎缩。

2. 发明申请

WO2012026766A3 NOVEL HETEROCYCLIC COMPOUND, AND COMPOSITION FOR TREATING INFLAMMATORY DISEASES USING SAME 审中-公开
标题翻译：新型杂环化合物和使用相同组合物治疗炎症性疾病
公开(公告)号：WO2012026766A3
公开(公告)日：2012-06-07
申请号：PCT/KR2011006281
申请日：2011-08-25
申请人： NEOPHARM CO LTD , GWAK HYUNG SUB , KIM YONG ZU , KIM UK IL , PARK BYEONG DEOG , PARK TAE KYO , WOO SUNG HO , YUN JOUNG YUL , LEE DAE YON , LEE HYANG SOOK , JEON JEONG EUN , JEONG SE KYOO , CHOI HYUNG MOOK
发明人： GWAK HYUNG SUB , KIM YONG ZU , KIM UK IL , PARK BYEONG DEOG , PARK TAE KYO , WOO SUNG HO , YUN JOUNG YUL , LEE DAE YON , LEE HYANG SOOK , JEON JEONG EUN , JEONG SE KYOO , CHOI HYUNG MOOK
IPC分类号： C07D471/04 , A61K31/437 , A61P17/00 , C07D401/06
CPC分类号： C07D235/08 , A61K8/4946 , A61Q19/00 , A61Q19/007 , A61Q19/008 , C07D471/04
摘要： The present invention relates to a heterocyclic compound having the effects of treating and preventing inflammatory diseases and healing skin wounds, and particularly, having the effects of restoring damaged skin barriers and relieving inflammation and pruritus resulting from inflammatory skin diseases. A composition including the compound of the present invention as an active ingredient may be used to relieve various inflammatory diseases and diseases in which the expression of protease activated receptor-2 (PAR-2) is increased. Particularly, the composition including the compound of the present invention as an active ingredient inhibits the activity of PAR-2 in the skin, and therefore can be used as an anti-inflammatory composition for inflammatory skin diseases such as atopic dermatitis.
摘要翻译：本发明涉及具有治疗和预防炎性疾病和治疗皮肤伤口的作用的杂环化合物，特别是具有恢复受损皮肤屏障和缓解由炎性皮肤病引起的炎症和瘙痒的作用。包含本发明化合物作为活性成分的组合物可用于缓解各种炎性疾病和蛋白酶活化受体-2（PAR-2）表达增加的疾病。特别是含有本发明化合物作为有效成分的组合物可以抑制皮肤中PAR-2的活性，因此可以用作特应性皮炎等炎症性皮肤病的抗炎组合物。

3. 发明申请

WO2012169741A3 FC?RI-SPECIFIC HUMAN ANTIBODY AND COMPOSITION COMPRISING SAME FOR TREATING OR DIAGNOSING ALLERGIC DISEASES 审中-公开
标题翻译： FC？RI特异性人体抗体及其组合物，用于治疗或诊断过敏性疾病
公开(公告)号：WO2012169741A3
公开(公告)日：2013-03-07
申请号：PCT/KR2012004247
申请日：2012-05-30
申请人： NEOPHARM CO LTD , PARK BYEONG-DEOG , YOON SEON JOO , BAE JONG HWAN , PARK EUN HYE , KIM WOOK-DONG , KIM MIN HEE , KANG HYUN JUNG , YOO KYUNG SOOK
发明人： PARK BYEONG-DEOG , YOON SEON JOO , BAE JONG HWAN , PARK EUN HYE , KIM WOOK-DONG , KIM MIN HEE , KANG HYUN JUNG , YOO KYUNG SOOK
IPC分类号： C07K16/28 , A61K39/395 , A61P37/08 , C12N15/13
CPC分类号： C07K16/283 , A61K2039/505 , C07K2317/21 , C07K2317/92
摘要： The present invention relates to a human antibody specific to FceRI, which is a receptor having a high affinity to Fc of IgE, and to a method for manufacturing same. The FceRI-specific human antibody according to the present invention effectively inhibits the coupling of IgE and FceRI, and may be applicable for treating or diagnosing allergic diseases mediated by IgE, such as allergic rhinitis, asthma, atopic dermatitis, urticaria, and contagious dermatitis.
摘要翻译：本发明涉及对FceRI特异性的人抗体，其是与IgE的Fc具有高亲和力的受体及其制造方法。根据本发明的FceRI特异性人抗体有效抑制IgE和FceRI的偶联，并且可用于治疗或诊断由IgE介导的过敏性疾病，如过敏性鼻炎，哮喘，特应性皮炎，荨麻疹和传染性皮炎。

4. 发明申请

WO2012026765A3 NOVEL HETEROCYCLIC COMPOUND, AND COMPOSITION FOR TREATING INFLAMMATORY DISEASES USING SAME 审中-公开
标题翻译：新颖的杂环化合物，以及使用其处理炎症疾病的组合物
公开(公告)号：WO2012026765A3
公开(公告)日：2012-06-07
申请号：PCT/KR2011006278
申请日：2011-08-25
申请人： NEOPHARM CO LTD , GWAK HYUNG SUB , KIM YONG ZU , KIM UK IL , PARK BYEONG DEOG , PARK TAE KYO , WOO SUNG HO , YUN JOUNG YUL , LEE DAE YON , LEE HYANG SOOK , JEON JEONG EUN , JEONG SE KYOO , CHOI HYUNG MOOK
发明人： GWAK HYUNG SUB , KIM YONG ZU , KIM UK IL , PARK BYEONG DEOG , PARK TAE KYO , WOO SUNG HO , YUN JOUNG YUL , LEE DAE YON , LEE HYANG SOOK , JEON JEONG EUN , JEONG SE KYOO , CHOI HYUNG MOOK
IPC分类号： C07D471/04 , A61K31/437 , A61P17/00 , C07D401/06
CPC分类号： C07D235/08 , A61K8/4946 , A61Q19/00 , A61Q19/007 , A61Q19/008 , C07D471/04
摘要： The present invention relates to a heterocyclic compound having the effects of treating and preventing inflammatory diseases and healing skin wounds, and particularly, having the effects of restoring damaged skin barriers and relieving inflammation and pruritus resulting from inflammatory skin diseases. A composition including the compound of the present invention as an active ingredient may be used to relieve various inflammatory diseases and diseases in which the expression of protease activated receptor-2 (PAR-2) is increased. Particularly, the composition including the compound of the present invention as an active ingredient inhibits the activity of PAR-2 in the skin, and therefore can be used as an anti-inflammatory composition for inflammatory skin diseases such as atopic dermatitis.
摘要翻译：本发明涉及具有治疗和预防炎性疾病和愈合皮肤伤口的作用的杂环化合物，特别涉及恢复受损的皮肤屏障并减轻由炎性皮肤疾病引起的炎症和瘙痒的作用。包含本发明化合物作为活性成分的组合物可用于缓解各种炎性疾病和蛋白酶活化受体-2（PAR-2）的表达增加的疾病。特别地，包含本发明化合物作为活性成分的组合物抑制皮肤中PAR-2的活性，因此可以用作炎性皮肤病如特应性皮炎的抗炎组合物。

5. 发明申请

WO2012169735A9 COMPLEX COMPRISING WATER-SOLUBLE FRAGMENTS OF FCEpsilonRI AND COMPOSITION COMPRISING SAME FOR TREATING ALLERGIC DISEASES MEDIATED BY IGE 审中-公开
标题翻译：复合包含FCEpsilonRI的水溶性片剂和包含相同的治疗由IGE介导的过敏性疾病的组合物
公开(公告)号：WO2012169735A9
公开(公告)日：2013-05-02
申请号：PCT/KR2012004075
申请日：2012-05-23
申请人： NEOPHARM CO LTD , PARK BYEONG-DEOG , YOON SEON JOO , KIM WOOK-DONG , BAE JONG HWAN , KIM MIN HEE , KANG HYUN JUNG , PARK EUN HYE
发明人： PARK BYEONG-DEOG , YOON SEON JOO , KIM WOOK-DONG , BAE JONG HWAN , KIM MIN HEE , KANG HYUN JUNG , PARK EUN HYE
IPC分类号： A61K38/00 , A61K38/16 , A61K39/395 , A61K47/30 , A61K47/48
CPC分类号： A61K38/1774 , A61K9/0014 , A61K9/0043 , A61K9/007 , A61K47/6811 , A61K47/6835 , C07K14/70535
摘要： The present invention relates to a complex in which water-soluble fragments of FcepsilonRI, which is a receptor having a high affinity to the Fc region of immunoglobulin E (IgE), are bound with a material having biocompatibility. The complex in which the water-soluble fragments of FcepsilonRI are bound with the material having biocompatibility according to the present invention inhibits the coupling of IgE and the FcepsilonRI, which is a receptor of the IgE, so as to suppress the secretion of allergic cytokine. Thus, the complex has the effect of treating and preventing allergic diseases.
摘要翻译：本发明涉及一种复合物，其中作为对免疫球蛋白E（IgE）的Fc区具有高亲和力的受体的FcepsilonRI的水溶性片段与具有生物相容性的物质结合。 FcepsilonRI的水溶性片段与根据本发明的具有生物相容性的材料结合的复合物抑制IgE和作为IgE受体的FcepsilonRI的偶联，以抑制过敏性细胞因子的分泌。因此，该复合物具有治疗和预防过敏性疾病的作用。

6. 发明申请

WO2012169735A3 COMPLEX COMPRISING WATER-SOLUBLE FRAGMENTS OF FC?RI AND COMPOSITION COMPRISING SAME FOR TREATING ALLERGIC DISEASES MEDIATED BY IGE 审中-公开
标题翻译：复合包含FC？RI的水溶性片和包含相同的组合物治疗IGE介导的过敏性疾病
公开(公告)号：WO2012169735A3
公开(公告)日：2013-03-07
申请号：PCT/KR2012004075
申请日：2012-05-23
申请人： NEOPHARM CO LTD , PARK BYEONG-DEOG , YOON SEON JOO , KIM WOOK-DONG , BAE JONG HWAN , KIM MIN HEE , KANG HYUN JUNG , PARK EUN HYE
发明人： PARK BYEONG-DEOG , YOON SEON JOO , KIM WOOK-DONG , BAE JONG HWAN , KIM MIN HEE , KANG HYUN JUNG , PARK EUN HYE
IPC分类号： A61K38/00 , A61K38/16 , A61K39/395 , A61K47/30 , A61K47/48
CPC分类号： A61K38/1774 , A61K9/0014 , A61K9/0043 , A61K9/007 , A61K47/6811 , A61K47/6835 , C07K14/70535
摘要： The present invention relates to a complex in which water-soluble fragments of FceRI, which is a receptor having a high affinity to the Fc region of immunoglobulin E (IgE), are bound with a material having biocompatibility. The complex in which the water-soluble fragments of FceRI are bound with the material having biocompatibility according to the present invention inhibits the coupling of IgE and the FceRI, which is a receptor of the IgE, so as to suppress the secretion of allergic cytokine. Thus, the complex has the effect of treating and preventing allergic diseases.
摘要翻译：本发明涉及一种复合物，其中作为对免疫球蛋白E（IgE）的Fc区具有高亲和力的受体的FceRI的水溶性片段与具有生物相容性的物质结合。 FceRI的水溶性片段与根据本发明的具有生物相容性的材料结合的复合物抑制IgE和作为IgE受体的FceRI的偶联，以抑制过敏性细胞因子的分泌。因此，该复合物具有治疗和预防过敏性疾病的作用。

7. 发明申请

WO2009038349A2 MASK PACK USING THE WATER-VAPOR CONTROLLABLE SHEET 审中-公开
标题翻译：使用水蒸气控制片的掩模包装
公开(公告)号：WO2009038349A2
公开(公告)日：2009-03-26
申请号：PCT/KR2008/005499
申请日：2008-09-18
申请人： NEOPHARM CO., LTD. , HONG, Keum-Duck , LEE, Shin-Hee , PARK, Hyun-Jung , LEE, Chang-Rae , JEONG, Se-Kyoo , PARK, Byeong-Deog
发明人： HONG, Keum-Duck , LEE, Shin-Hee , PARK, Hyun-Jung , LEE, Chang-Rae , JEONG, Se-Kyoo , PARK, Byeong-Deog
IPC分类号： A61K8/02
CPC分类号： A61K8/0212 , A61K8/0208 , A61K8/34 , A61K8/355 , A61K8/365 , A61K8/49 , A61K8/602 , A61K8/64 , A61K8/65 , A61K8/676 , A61K8/735 , A61K8/922 , A61K8/97 , A61K8/9706 , A61K8/988 , A61Q19/005 , A61Q19/02 , A61Q19/08
摘要： There is provided a functional mask pack using a moisture-controllable mask sheet having an effect to promote absorption of an active component in the skin by adjusting directionality with respect to a moisture penetration direction, or showing a skin soothing effect by providing a sense of coldness to the skin. The mask pack comprises a moisture absorbing layer 7 having a relatively lower density and hydrophilicity, a moisture diffusing layer 5 having a relatively higher density and hydrophilicity, and a moisture transfer layer 6 having an intermediate density and hydrophilicity between the moisture absorbing layer and the moisture diffusing layer. Here, the mask sheet is used in the mask pack to promote the absorption of the active component when the mask sheet has a 3-layered structure of the moisture diffusing layer 5, the moisture transfer layer 6 and the moisture absorbing layer 7 which are sequentially stacked from the inside of the mask sheet, and used in the mask pack to soothe the skin when the mask sheet has a 3-layered structure of the moisture absorbing layer 7, the moisture transfer layer 6 and the moisture diffusing layer 5 which are sequentially stacked from the inside of the mask sheet. Therefore, the mask pack according to the present invention may be useful to promote the absorption of the active component and soothe the skin since its particular structure leads to a high moisture mobility, and thus to prevent resource waste and make a contribution to the environmental protections through the re-use of the resources.
摘要翻译：提供了一种使用水分可控制掩模片的功能性面膜包，其具有通过调节相对于水分渗透方向的方向性而促进皮肤中的活性成分的吸收，或通过提供感觉来显示皮肤舒缓效果到皮肤。掩模组包括具有较低密度和亲水性的吸湿层7，具有较高密度和亲水性的湿气扩散层5和在吸湿层和湿气之间具有中等密度和亲水性的湿气转移层6 扩散层。这里，当掩模片具有顺序地具有湿气扩散层5，湿度转移层6和吸湿层7的3层结构时，掩模片用于掩模包中以促进活性成分的吸收并且当掩模片具有顺序地具有吸湿层7，湿度转移层6和湿气扩散层5的3层结构时，用于面罩包装中以舒缓皮肤从掩模片的内侧堆叠。因此，根据本发明的面膜包可以有助于促进活性成分的吸收和舒缓皮肤，因为其特定的结构导致高的水分流动性，并且因此防止资源浪费并对环境保护作出贡献通过资源的重用。

8. 发明申请

WO2009038349A3 MASK PACK USING THE WATER-VAPOR CONTROLLABLE SHEET 审中-公开
标题翻译：使用水蒸气控制片的掩模包装
公开(公告)号：WO2009038349A3
公开(公告)日：2009-05-22
申请号：PCT/KR2008005499
申请日：2008-09-18
申请人： NEOPHARM CO LTD , HONG KEUM-DUCK , LEE SHIN-HEE , PARK HYUN-JUNG , LEE CHANG-RAE , JEONG SE-KYOO , PARK BYEONG-DEOG
发明人： HONG KEUM-DUCK , LEE SHIN-HEE , PARK HYUN-JUNG , LEE CHANG-RAE , JEONG SE-KYOO , PARK BYEONG-DEOG
IPC分类号： A61K8/02
CPC分类号： A61K8/0212 , A61K8/0208 , A61K8/34 , A61K8/355 , A61K8/365 , A61K8/49 , A61K8/602 , A61K8/64 , A61K8/65 , A61K8/676 , A61K8/735 , A61K8/922 , A61K8/97 , A61K8/9706 , A61K8/988 , A61Q19/005 , A61Q19/02 , A61Q19/08
摘要： There is provided a functional mask pack using a moisture-controllable mask sheet having an effect to promote absorption of an active component in the skin by adjusting directionality with respect to a moisture penetration direction, or showing a skin soothing effect by providing a sense of coldness to the skin. The mask pack comprises a moisture absorbing layer (7) having a relatively lower density and hydrophilicity, a moisture diffusing layer (5) having a relatively higher density and hydrophilicity, and a moisture transfer laye (6) having an intermediate density and hydrophilicity between the moisture absorbing layer and the moisture diffusing layer. Here, the mask sheet is used in the mask pack to promote the absorption of the active component when the mask sheet has a 3-layered structure of the moisture diffusing layer (5), the moisture transfer layer (6) and the moisture absorbing layer (7) which are sequentially stacked from the inside of the mask sheet, and used in the mask pack to soothe the skin when the mask sheet has a 3-layered structure of the moisture absorbing layer (7), the moisture transfer layer (6) and the moisture diffusing layer (5) which are sequentially stacked from the inside of the mask sheet. Therefore, the mask pack according to the present invention may be useful to promote the absorption of the active component and soothe the skin since its particular structure leads to a high moisture mobility, and thus to prevent resource waste and make a contribution to the environmental protections through the re-use of the resources.
摘要翻译：提供了一种使用水分可控制掩模片的功能性面膜包，其具有通过调节相对于水分渗透方向的方向性而促进皮肤中的活性成分的吸收，或通过提供感觉来显示皮肤舒缓效果到皮肤。掩模包包括具有相对较低密度和亲水性的吸湿层（7），具有相对较高密度和亲水性的湿气扩散层（5）和在其间具有中间密度和亲水性的湿气传播层（6）吸湿层和湿气扩散层。这里，当掩模片具有湿气扩散层（5），水分转移层（6）和吸湿层（3）的3层结构时，掩模板被用于掩模包中以促进活性成分的吸收（7），其从掩模片的内部依次层叠，并且当掩模片具有吸湿层（7）的3层结构时，用于面罩包装中以舒缓皮肤，湿气转移层（6））和从掩模片的内侧依次层叠的湿气扩散层（5）。因此，根据本发明的面膜包可以有助于促进活性成分的吸收和舒缓皮肤，因为其特定的结构导致高的水分流动性，并且因此防止资源浪费并对环境保护作出贡献通过资源的重用。

9. 发明申请

WO2008078965A1 CERAMIDE DERIVATIVES, METHOD FOR PREPARING THE SAME, AND THERAPEUTIC AGENT FOR TREATING ATOPIC DERMATITIS COMPRISING THE CERAMIDE DERIVATIVES 审中-公开
标题翻译： CERAMIDE衍生物，其制备方法以及用于处理包含CERAMIDE衍生物的原位衍生物的治疗剂
公开(公告)号：WO2008078965A1
公开(公告)日：2008-07-03
申请号：PCT/KR2007/006860
申请日：2007-12-27
申请人： NEOPHARM CO., LTD. , PARK, Byeong-Deog , YOUM, Jong-Kyung , GWAK, Hyung-Sub , KWON, Mi-Jung , KIM, Hwan-Mook , KANG, Jong-Soon , HAN, Sang-Bae
发明人： PARK, Byeong-Deog , YOUM, Jong-Kyung , GWAK, Hyung-Sub , KWON, Mi-Jung , KIM, Hwan-Mook , KANG, Jong-Soon , HAN, Sang-Bae
IPC分类号： C07F9/44
CPC分类号： A61K8/68 , A61Q19/00 , C07F9/091
摘要： Disclosed are ceramide derivatives represented by the following formula 1 or 2, a method for preparing the same, and a therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients the Formula 1 and Formula 2. The therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients according to the present invention may be useful to treat atopic dermatitis, or treat other skin diseases that are required for improving skin inflammations or suppressing epidermal proliferation, by sup¬ pressing or improving inflammatory conditions in the atopic dermatitis in addition to giving im- munoregulatory functions, and suppressing or improving skin disorders, for example epidermal proliferation that is generally observed in the atopic dermatitis.
摘要翻译：公开了由下式1或2表示的神经酰胺衍生物，其制备方法和治疗特应性皮炎的治疗剂，其包括神经酰胺衍生物作为式1和式2的活性成分。用于治疗特应性皮炎的治疗剂包括根据本发明的神经酰胺衍生物作为活性成分可以用于治疗特应性皮炎或治疗改善皮肤炎症或抑制表皮增生所需的其它皮肤疾病，通过抑制或改善特应性皮炎中的炎性病症给予调节功能，抑制或改善皮肤病，例如通常在特应性皮炎中观察到的表皮增生。

10. 发明申请

WO1998021176A1 NOVEL PSEUDOCERAMIDES, AND DERMATOLOGIC EXTERNAL PREPARATIONS CONTAINING THE SAME 审中-公开
标题翻译：新型PSEUDOCERAMIDES和含有其的外源性外用制剂
公开(公告)号：WO1998021176A1
公开(公告)日：1998-05-22
申请号：PCT/KR1997000220
申请日：1997-11-10
申请人： AEKYUNG INDUSTRIAL CO., INC. , PARK, Byeong, Deog , BAIK, In, Sob , LEE, Jong, Gi , KIM, Yoon , LEE, Myung, Jin
发明人： AEKYUNG INDUSTRIAL CO., INC.
IPC分类号： C07C235/08
CPC分类号： A61Q19/00 , A61K8/68 , A61Q5/00 , A61Q5/02 , A61Q17/00 , A61Q19/08 , C07C235/08 , C07C235/74 , C07H15/12
摘要： The present invention relates to pseudoceramide derivatives represented by the formula (I) R1-COCHR2CONR3R4 or the formula (II) R1-CH(OH)CHR2CONR3R4 wherein each of R1 and R2 represents linear or branched alkyl group or alkenyl group having 6-22 carbon atoms; each of R3 and R4 represents hydrogen, methyl, ethyl, propyl, or linear or branched C2-C6 alkyl group having one or more hydroxyl group(s), or monosaccharide, a process for preparing the same, and dermatologic external preparations containing the same. When the pseudoceramide derivatives according to the present invention are applied in a dermatologic external preparation the moisture-retaining property and resilience of skin and hair becomes excellent so that the derivatives are useful in protection of skin-aging. Besides, the derivatives are useful for inducing the formation of lipid layer on damaged skin and for preventing the inhibition of lipid synthesis.
摘要翻译：本发明涉及由式（I）R1-COCHR2CONR3R4或式（II）R1-CH（OH）CHR2CONR3R4表示的假花生酰胺衍生物，其中R1和R2各自表示具有6-22个碳原子的直链或支链烷基或烯基原子; R 3和R 4各自表示氢，甲基，乙基，丙基或具有一个或多个羟基的直链或支链C 2 -C 6烷基或单糖，其制备方法和含有该羟基的皮肤外用制剂。当根据本发明的假心囊酰胺衍生物应用于皮肤外用制剂时，皮肤和头发的保湿性和弹性变得优异，使得该衍生物可用于保护皮肤老化。此外，该衍生物可用于诱导损伤皮肤上形成脂质层并防止脂质合成的抑制。

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