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1. 发明申请

WO2012026766A3 NOVEL HETEROCYCLIC COMPOUND, AND COMPOSITION FOR TREATING INFLAMMATORY DISEASES USING SAME 审中-公开
标题翻译：新型杂环化合物和使用相同组合物治疗炎症性疾病
公开(公告)号：WO2012026766A3
公开(公告)日：2012-06-07
申请号：PCT/KR2011006281
申请日：2011-08-25
申请人： NEOPHARM CO LTD , GWAK HYUNG SUB , KIM YONG ZU , KIM UK IL , PARK BYEONG DEOG , PARK TAE KYO , WOO SUNG HO , YUN JOUNG YUL , LEE DAE YON , LEE HYANG SOOK , JEON JEONG EUN , JEONG SE KYOO , CHOI HYUNG MOOK
发明人： GWAK HYUNG SUB , KIM YONG ZU , KIM UK IL , PARK BYEONG DEOG , PARK TAE KYO , WOO SUNG HO , YUN JOUNG YUL , LEE DAE YON , LEE HYANG SOOK , JEON JEONG EUN , JEONG SE KYOO , CHOI HYUNG MOOK
IPC分类号： C07D471/04 , A61K31/437 , A61P17/00 , C07D401/06
CPC分类号： C07D235/08 , A61K8/4946 , A61Q19/00 , A61Q19/007 , A61Q19/008 , C07D471/04
摘要： The present invention relates to a heterocyclic compound having the effects of treating and preventing inflammatory diseases and healing skin wounds, and particularly, having the effects of restoring damaged skin barriers and relieving inflammation and pruritus resulting from inflammatory skin diseases. A composition including the compound of the present invention as an active ingredient may be used to relieve various inflammatory diseases and diseases in which the expression of protease activated receptor-2 (PAR-2) is increased. Particularly, the composition including the compound of the present invention as an active ingredient inhibits the activity of PAR-2 in the skin, and therefore can be used as an anti-inflammatory composition for inflammatory skin diseases such as atopic dermatitis.
摘要翻译：本发明涉及具有治疗和预防炎性疾病和治疗皮肤伤口的作用的杂环化合物，特别是具有恢复受损皮肤屏障和缓解由炎性皮肤病引起的炎症和瘙痒的作用。包含本发明化合物作为活性成分的组合物可用于缓解各种炎性疾病和蛋白酶活化受体-2（PAR-2）表达增加的疾病。特别是含有本发明化合物作为有效成分的组合物可以抑制皮肤中PAR-2的活性，因此可以用作特应性皮炎等炎症性皮肤病的抗炎组合物。

2. 发明申请

WO2012026765A3 NOVEL HETEROCYCLIC COMPOUND, AND COMPOSITION FOR TREATING INFLAMMATORY DISEASES USING SAME 审中-公开
标题翻译：新颖的杂环化合物，以及使用其处理炎症疾病的组合物
公开(公告)号：WO2012026765A3
公开(公告)日：2012-06-07
申请号：PCT/KR2011006278
申请日：2011-08-25
申请人： NEOPHARM CO LTD , GWAK HYUNG SUB , KIM YONG ZU , KIM UK IL , PARK BYEONG DEOG , PARK TAE KYO , WOO SUNG HO , YUN JOUNG YUL , LEE DAE YON , LEE HYANG SOOK , JEON JEONG EUN , JEONG SE KYOO , CHOI HYUNG MOOK
发明人： GWAK HYUNG SUB , KIM YONG ZU , KIM UK IL , PARK BYEONG DEOG , PARK TAE KYO , WOO SUNG HO , YUN JOUNG YUL , LEE DAE YON , LEE HYANG SOOK , JEON JEONG EUN , JEONG SE KYOO , CHOI HYUNG MOOK
IPC分类号： C07D471/04 , A61K31/437 , A61P17/00 , C07D401/06
CPC分类号： C07D235/08 , A61K8/4946 , A61Q19/00 , A61Q19/007 , A61Q19/008 , C07D471/04
摘要： The present invention relates to a heterocyclic compound having the effects of treating and preventing inflammatory diseases and healing skin wounds, and particularly, having the effects of restoring damaged skin barriers and relieving inflammation and pruritus resulting from inflammatory skin diseases. A composition including the compound of the present invention as an active ingredient may be used to relieve various inflammatory diseases and diseases in which the expression of protease activated receptor-2 (PAR-2) is increased. Particularly, the composition including the compound of the present invention as an active ingredient inhibits the activity of PAR-2 in the skin, and therefore can be used as an anti-inflammatory composition for inflammatory skin diseases such as atopic dermatitis.
摘要翻译：本发明涉及具有治疗和预防炎性疾病和愈合皮肤伤口的作用的杂环化合物，特别涉及恢复受损的皮肤屏障并减轻由炎性皮肤疾病引起的炎症和瘙痒的作用。包含本发明化合物作为活性成分的组合物可用于缓解各种炎性疾病和蛋白酶活化受体-2（PAR-2）的表达增加的疾病。特别地，包含本发明化合物作为活性成分的组合物抑制皮肤中PAR-2的活性，因此可以用作炎性皮肤病如特应性皮炎的抗炎组合物。

3. 发明申请

WO2009038349A3 MASK PACK USING THE WATER-VAPOR CONTROLLABLE SHEET 审中-公开
标题翻译：使用水蒸气控制片的掩模包装
公开(公告)号：WO2009038349A3
公开(公告)日：2009-05-22
申请号：PCT/KR2008005499
申请日：2008-09-18
申请人： NEOPHARM CO LTD , HONG KEUM-DUCK , LEE SHIN-HEE , PARK HYUN-JUNG , LEE CHANG-RAE , JEONG SE-KYOO , PARK BYEONG-DEOG
发明人： HONG KEUM-DUCK , LEE SHIN-HEE , PARK HYUN-JUNG , LEE CHANG-RAE , JEONG SE-KYOO , PARK BYEONG-DEOG
IPC分类号： A61K8/02
CPC分类号： A61K8/0212 , A61K8/0208 , A61K8/34 , A61K8/355 , A61K8/365 , A61K8/49 , A61K8/602 , A61K8/64 , A61K8/65 , A61K8/676 , A61K8/735 , A61K8/922 , A61K8/97 , A61K8/9706 , A61K8/988 , A61Q19/005 , A61Q19/02 , A61Q19/08
摘要： There is provided a functional mask pack using a moisture-controllable mask sheet having an effect to promote absorption of an active component in the skin by adjusting directionality with respect to a moisture penetration direction, or showing a skin soothing effect by providing a sense of coldness to the skin. The mask pack comprises a moisture absorbing layer (7) having a relatively lower density and hydrophilicity, a moisture diffusing layer (5) having a relatively higher density and hydrophilicity, and a moisture transfer laye (6) having an intermediate density and hydrophilicity between the moisture absorbing layer and the moisture diffusing layer. Here, the mask sheet is used in the mask pack to promote the absorption of the active component when the mask sheet has a 3-layered structure of the moisture diffusing layer (5), the moisture transfer layer (6) and the moisture absorbing layer (7) which are sequentially stacked from the inside of the mask sheet, and used in the mask pack to soothe the skin when the mask sheet has a 3-layered structure of the moisture absorbing layer (7), the moisture transfer layer (6) and the moisture diffusing layer (5) which are sequentially stacked from the inside of the mask sheet. Therefore, the mask pack according to the present invention may be useful to promote the absorption of the active component and soothe the skin since its particular structure leads to a high moisture mobility, and thus to prevent resource waste and make a contribution to the environmental protections through the re-use of the resources.
摘要翻译：提供了一种使用水分可控制掩模片的功能性面膜包，其具有通过调节相对于水分渗透方向的方向性而促进皮肤中的活性成分的吸收，或通过提供感觉来显示皮肤舒缓效果到皮肤。掩模包包括具有相对较低密度和亲水性的吸湿层（7），具有相对较高密度和亲水性的湿气扩散层（5）和在其间具有中间密度和亲水性的湿气传播层（6）吸湿层和湿气扩散层。这里，当掩模片具有湿气扩散层（5），水分转移层（6）和吸湿层（3）的3层结构时，掩模板被用于掩模包中以促进活性成分的吸收（7），其从掩模片的内部依次层叠，并且当掩模片具有吸湿层（7）的3层结构时，用于面罩包装中以舒缓皮肤，湿气转移层（6））和从掩模片的内侧依次层叠的湿气扩散层（5）。因此，根据本发明的面膜包可以有助于促进活性成分的吸收和舒缓皮肤，因为其特定的结构导致高的水分流动性，并且因此防止资源浪费并对环境保护作出贡献通过资源的重用。

4. 发明申请

WO2009038349A2 MASK PACK USING THE WATER-VAPOR CONTROLLABLE SHEET 审中-公开
标题翻译：使用水蒸气控制片的掩模包装
公开(公告)号：WO2009038349A2
公开(公告)日：2009-03-26
申请号：PCT/KR2008/005499
申请日：2008-09-18
申请人： NEOPHARM CO., LTD. , HONG, Keum-Duck , LEE, Shin-Hee , PARK, Hyun-Jung , LEE, Chang-Rae , JEONG, Se-Kyoo , PARK, Byeong-Deog
发明人： HONG, Keum-Duck , LEE, Shin-Hee , PARK, Hyun-Jung , LEE, Chang-Rae , JEONG, Se-Kyoo , PARK, Byeong-Deog
IPC分类号： A61K8/02
CPC分类号： A61K8/0212 , A61K8/0208 , A61K8/34 , A61K8/355 , A61K8/365 , A61K8/49 , A61K8/602 , A61K8/64 , A61K8/65 , A61K8/676 , A61K8/735 , A61K8/922 , A61K8/97 , A61K8/9706 , A61K8/988 , A61Q19/005 , A61Q19/02 , A61Q19/08
摘要： There is provided a functional mask pack using a moisture-controllable mask sheet having an effect to promote absorption of an active component in the skin by adjusting directionality with respect to a moisture penetration direction, or showing a skin soothing effect by providing a sense of coldness to the skin. The mask pack comprises a moisture absorbing layer 7 having a relatively lower density and hydrophilicity, a moisture diffusing layer 5 having a relatively higher density and hydrophilicity, and a moisture transfer layer 6 having an intermediate density and hydrophilicity between the moisture absorbing layer and the moisture diffusing layer. Here, the mask sheet is used in the mask pack to promote the absorption of the active component when the mask sheet has a 3-layered structure of the moisture diffusing layer 5, the moisture transfer layer 6 and the moisture absorbing layer 7 which are sequentially stacked from the inside of the mask sheet, and used in the mask pack to soothe the skin when the mask sheet has a 3-layered structure of the moisture absorbing layer 7, the moisture transfer layer 6 and the moisture diffusing layer 5 which are sequentially stacked from the inside of the mask sheet. Therefore, the mask pack according to the present invention may be useful to promote the absorption of the active component and soothe the skin since its particular structure leads to a high moisture mobility, and thus to prevent resource waste and make a contribution to the environmental protections through the re-use of the resources.
摘要翻译：提供了一种使用水分可控制掩模片的功能性面膜包，其具有通过调节相对于水分渗透方向的方向性而促进皮肤中的活性成分的吸收，或通过提供感觉来显示皮肤舒缓效果到皮肤。掩模组包括具有较低密度和亲水性的吸湿层7，具有较高密度和亲水性的湿气扩散层5和在吸湿层和湿气之间具有中等密度和亲水性的湿气转移层6 扩散层。这里，当掩模片具有顺序地具有湿气扩散层5，湿度转移层6和吸湿层7的3层结构时，掩模片用于掩模包中以促进活性成分的吸收并且当掩模片具有顺序地具有吸湿层7，湿度转移层6和湿气扩散层5的3层结构时，用于面罩包装中以舒缓皮肤从掩模片的内侧堆叠。因此，根据本发明的面膜包可以有助于促进活性成分的吸收和舒缓皮肤，因为其特定的结构导致高的水分流动性，并且因此防止资源浪费并对环境保护作出贡献通过资源的重用。

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