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1. 发明申请

WO9704812A3 Pulmonary ventilation imagery agents 审中-公开
标题翻译： MRI造影剂对通气的使用bildegebung肺
公开(公告)号：WO9704812A3
公开(公告)日：1997-09-18
申请号：PCT/DE9601435
申请日：1996-07-25
申请人： MUEHLER ANDREAS , FRENZEL THOMAS , MISSELWITZ BERND , WEINMANN HANNS-JOACHIM , SACHSE ANDREAS , ALBAYRAK CELAL , SCHERING AG
发明人： MUEHLER ANDREAS , FRENZEL THOMAS , MISSELWITZ BERND , WEINMANN HANNS-JOACHIM , SACHSE ANDREAS , ALBAYRAK CELAL
IPC分类号： A61K49/18 , A61K49/00
CPC分类号： A61K49/1815
摘要： The invention concerns the use of contrasting agent formulations for providing diagnoses concerning the ventilation of the pulmonary alveoli.

2. 发明申请

WO9704811A3 USE OF LIPOSOMAL PREPARATIONS IN INDIRECT MRI LYMPHOGRAPHY 审中-公开
标题翻译：在间接MRI淋巴结中使用脂质制剂
公开(公告)号：WO9704811A3
公开(公告)日：1997-08-07
申请号：PCT/DE9601433
申请日：1996-07-25
申请人： SCHERING AG , SACHSE ANDREAS , PLATZEK JOHANNES , MISSELWITZ BERND , MUEHLER ANDREAS , ROESSLING GEORG
发明人： SACHSE ANDREAS , PLATZEK JOHANNES , MISSELWITZ BERND , MUEHLER ANDREAS , ROESSLING GEORG
IPC分类号： A61K49/18 , A61K49/00
CPC分类号： A61K49/1812
摘要： The invention concerns the use of liposomes charged with contrasting agents for interstitial lymphography.

3. 发明申请

WO2007009638A3 COMPLEXES CONTAINING PERFLUOROALKYL, METHOD FOR THE PRODUCTION AND USE THEREOF 审中-公开
标题翻译：全氟烷基复合物，方法生产及其用途
公开(公告)号：WO2007009638A3
公开(公告)日：2007-04-26
申请号：PCT/EP2006006777
申请日：2006-07-11
申请人： SCHERING AG , EPIX PHARM INC , SCHIRMER HEIKO , WEINMANN HANNS-JOACHIM , PLATZEK JOHANNES , ZORN LUDWIG , MISSELWITZ BERND , MEDING JOERG , SCHMITT-WILLICH HERIBERT , BRUMBY THOMAS
发明人： SCHIRMER HEIKO , WEINMANN HANNS-JOACHIM , PLATZEK JOHANNES , ZORN LUDWIG , MISSELWITZ BERND , MEDING JOERG , SCHMITT-WILLICH HERIBERT , BRUMBY THOMAS
IPC分类号： C07D257/02 , A61K49/06
CPC分类号： C07D257/02
摘要： The invention relates to objects which are characterised in the claims, that is, metal complexes containing perfluoroalky, comprising radicals of general formula I containing nitrogen, to a method for the production and use thereof in the NMR field and x-ray diagnosis, radiodiagnosis and radiotherapy, in addition to lymphography in the MRT field and for blood pool imaging.
摘要翻译：本发明涉及一种特征在于在权利要求中，即含有全氟烷金属络合物与通式I的含氮基团的主题，其制备方法以及它们在NMR和X射线诊断，放射诊断和放射治疗，使用过程以及在MRT-淋巴和血液池显像，

4. 发明申请

WO2008022263A2 METHODS FOR LYMPH SYSTEM IMAGING 审中-公开
标题翻译：淋巴系统成像方法
公开(公告)号：WO2008022263A2
公开(公告)日：2008-02-21
申请号：PCT/US2007076109
申请日：2007-08-16
申请人： EPIX PHARM INC , SCHERING AG , JACQUES VINCENT , CARAVAN PETER D , MISSELWITZ BERND , WEINMANN HANNS-JOACHIM
发明人： JACQUES VINCENT , CARAVAN PETER D , MISSELWITZ BERND , WEINMANN HANNS-JOACHIM
IPC分类号： A61B5/055 , A61P35/00
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , G01R33/5601
摘要： Methods and contrast agents for imaging the lymph system are provided. The methods allow the diagnosis and staging of diseases of the lymph system, such as cancer and infections.
摘要翻译：提供了用于使淋巴系统成像的方法和造影剂。该方法可以诊断和分期淋巴系统疾病，如癌症和感染。

5. 发明申请

WO2007009637A3 COMPLEXES CONTAINING PERFLUOROALKYL, THEIR USE AS CONTRAST MEDIA FOR NMR, X-RAY AND RADIO DIAGNOSIS AND RADIOTHERAPY 审中-公开
标题翻译：它们作为造影剂使用核磁共振，X射线和无线电和诊断RADIOTHERAPHIE
公开(公告)号：WO2007009637A3
公开(公告)日：2007-05-10
申请号：PCT/EP2006006775
申请日：2006-07-11
申请人： SCHERING AG , EPIX PHARM INC , SCHIRMER HEIKO , WEINMANN HANNS-JOACHIM , PLATZEK JOHANNES , ZORN LUDWIG , MISSELWITZ BERND , MEDING JOERG , SCHMITT-WILLICH HERIBERT , BRUMBY THOMAS
发明人： SCHIRMER HEIKO , WEINMANN HANNS-JOACHIM , PLATZEK JOHANNES , ZORN LUDWIG , MISSELWITZ BERND , MEDING JOERG , SCHMITT-WILLICH HERIBERT , BRUMBY THOMAS
IPC分类号： C07D257/02 , A61B5/055 , A61K31/555 , A61K49/04 , A61K49/10 , A61P43/00 , C07D405/12 , C07H15/00
CPC分类号： A61K49/0002 , A61K49/10 , A61K49/103 , A61K49/106 , A61K51/0482 , A61K51/0497 , C07D257/02 , C07D405/06
摘要： The invention relates to the objects which are characterised in the patent claims, that is, metal complexes which contain perfluoroalkyl having N-alkyl groups of general formula (I), to a method for the production thereof and to the use thereof in NMR and X-ray diagnosis, radiodiagnosis and radiotherapy, and in MRT lymphography.
摘要翻译：本发明涉及一种特征在于在权利要求中，即含有全氟烷 - 金属配合物与N-烷基的通式（I）的主题，其制备方法以及它们在NMR和X射线诊断，放射诊断和放射治疗的使用，以及在MRT淋巴流程，

6. 发明申请

WO2008087017A3 NOVEL CASCADE POLYMER COMPLEXES, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THE SAME 审中-公开
标题翻译：新CASCADE聚合物复合，方法用于生产和制药含
公开(公告)号：WO2008087017A3
公开(公告)日：2009-01-22
申请号：PCT/EP2008000285
申请日：2008-01-16
申请人： BAYER SCHERING PHARMA AG , EPIX PHARM INC , SCHMITT-WILLICH HERIBERT , SCHIRMER HEIKO , MISSELWITZ BERND , WEINMANN HANNS-JOACHIM , CARAVAN PETER
发明人： SCHMITT-WILLICH HERIBERT , SCHIRMER HEIKO , MISSELWITZ BERND , WEINMANN HANNS-JOACHIM , CARAVAN PETER
IPC分类号： A61K49/12 , A61K47/48
CPC分类号： A61K49/085 , A61K49/124
摘要： The invention relates to novel cascade polymer complexes, to agents containing said compounds, to the use of said complexes in NMR diagnostics and to methods for producing said compounds and agents. The complex forming cascade polymer complexes according to the invention can be described by the following general formula (I): R - L - A -{ X - [ Y - ( Z - { W - Kw }z )y ]x}a-1, in which R represents an HSA binding unit, L represents a linker or a bond, A represents a cascade core of base multiplicity a containing nitrogen, X and Y independently of one another represent a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, Z and W independently of one another represent a direct bond or a cascade reproduction unit of reproduction multiplicity z or w, K represents the group of a complex former, a represents the numbers 2 to 12, and x, y, z and w represent independently of one another the numbers 1 to 4, with the proviso that exactly one multiplicity of base multiplicity a of the cascade core A represents exactly one bond site to L and with the proviso that the cascade polymer complexes in the complex former groups K contain in total at least 4 ions of an element of the atomic number 20 to 29, 39, 42 to 44 or 57 to 83 and optionally comprise cations of inorganic and/or organic bases, amino acids or amino acid amides.
摘要翻译：本发明涉及新的级联聚合物络合物，含有这些化合物，在NMR诊断使用复合物和制备这些化合物和药剂的方法的试剂。本发明的络合级联聚合物复合物可以用通式（I）表示描述：R t - L - A - {X - [Y - （Z - {W - 千瓦} Z）Y] x}α-1，其中R =的HSA结合单元，L =连接子或键，基多重A，X和的=含氮级联核Y =彼此独立地为直接键或再现多重x或y，Z和W的级联再现单元 =彼此独立地是直接键或再现多重Z或W的级联再现单元的，K =自由基络合剂，A =是数字2〜12，X，Y，Z和W彼此独立地数字1至是如图4所示，与基体的多个中的正好一个多重级联核a表示恰好一个结合位点到L条件，并且条件是在配位剂的基团总共K个级联聚合物络合物包含至少4个离子原子序数20的元件的以29，39，含有42至44或57至83和无机和/或有机碱，氨基酸或氨基酸酰胺任选阳离子。

7. 发明申请

WO9726017A3 PERFLUOROALKYL-CONTAINING METAL COMPLEXES AND THEIR USE IN NMR DIAGNOSTICS 审中-公开
标题翻译：含全氟烷基金属络合物及其在核磁共振诊断中的应用
公开(公告)号：WO9726017A3
公开(公告)日：1997-11-20
申请号：PCT/EP9700209
申请日：1997-01-16
申请人： SCHERING AG
发明人： PLATZEK JOHANNES , NIEDBALLA ULRICH , RADUECHEL BERND , SCHLECKER WOLFGANG , WEINMANN HANNS-JOACHIM , FRENZEL THOMAS , MISSELWITZ BERND , EBERT WOLFGANG
IPC分类号： C07D295/22 , A61K49/00 , A61K49/10 , A61P35/00 , A61P43/00 , B65D25/16 , B65D47/08 , B65D83/00 , C07C229/16 , C07C229/22 , C07C229/76 , C07C235/10 , C07C237/08 , C07C237/10 , C07C311/05 , C07C311/06 , C07D257/02 , C07D295/26 , C07F5/00 , C07F13/00
CPC分类号： C07D295/26 , A61K49/0002 , A61K49/0004 , B65D25/16 , B65D47/0847 , B65D83/0055 , C07C229/76 , C07C237/10 , C07D257/02
摘要： The invention concerns new monomer perfluoroalkyl-substituted metal complexes, a process for their production, and their use in diagnostics and therapy. The compounds according to the invention to the invention are particularly suited for use as in vivo contrast agents in nuclear spin resonance tomography (MRT). They can be preferably used as blood pool agents and contrast agents for lymphography.

8. 发明申请

WO2004006965A3 USE OF METAL COMPLEXES CONTAINING PERFLUOROALKYL AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING FOR REPRESENTING INTRAVASCULAR THROMBI 审中-公开
标题翻译：全氟烷基金属配合物在MR成像中作为对比剂用于显示血管内静脉血栓
公开(公告)号：WO2004006965A3
公开(公告)日：2004-07-15
申请号：PCT/EP0307274
申请日：2003-07-05
申请人： SCHERING AG
发明人： MISSELWITZ BERND , PLATZEK JOHANNES , KAWATA YOKO , WEINMANN HANNS-JOACHIM , YOKAWA TAKISHI , NIEDBALLA ULRICH
IPC分类号： G01R33/28 , A61B5/055 , A61K49/00 , A61K49/08 , A61K49/10
CPC分类号： A61K49/1806 , A61K49/085 , A61K49/10
摘要： The invention relates to the use of metal complexes containing perfluoroalkyl as contrast agents in MR imaging for representing intravascular thrombi. Said complexes have a critical micelle-formation concentration mol/l, a hydrodynamic micelle diameter (2 Rh) > 1 nm and a proton relaxivity in plasma (R ) > 10 l/mmol.s.
摘要翻译：本发明涉及使用含全氟烷基的金属络合物，具有临界胶束形成浓度<10 <-3>摩尔/升，液力胶束直径（2 RH）> 1nm且在等离子体质子弛豫（R <1>）> 10升/ mmol.s作为造影剂用于MR血管内血栓的显示。

9. 发明申请

WO0213875A3 COMPLEXES CONTAINING PERFLUOROALKYL WITH POLAR RADICALS, METHOD FOR THE PRODUCTION AND USE THEREOF 审中-公开
标题翻译：与极地全氟烷基复合遗迹，其制造方法相同，它们的用途
公开(公告)号：WO0213875A3
公开(公告)日：2002-08-22
申请号：PCT/EP0108500
申请日：2001-07-23
申请人： SCHERING AG
发明人： PLATZEK JOHANNES , MARESKI PETER , NIEDBALLA ULRICH , RADUECHEL BERND , WEINMANN HANNS-JOACHIM , MISSELWITZ BERND
IPC分类号： C07D295/22 , A61K38/00 , A61K49/00 , A61K49/04 , A61K49/08 , A61K49/10 , A61K51/00 , C07D257/02 , C07D295/26 , C07D405/12 , C07D405/14 , A61K31/555 , A61P42/00
CPC分类号： C07D295/26 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/106 , C07D257/02
摘要： The invention relates to complexes containing perfluoroalkyl with polar radicals of general formula (I), wherein R represents the polar radical, Rf is a perfluorated carbon chain, K is a metal complex and Z is a linker group. The inventive complexes are suitable for intravenous lymphography, tumor diagnosis and infarct and necrosis imaging.
摘要翻译：含全氟烷基与通式（I），其中R表示极性基，R f是全氟化碳链的极性基的复合物，K是金属络合物和Z是用于静脉内淋巴的连接基团，用于肿瘤的诊断和梗死和坏死成像合适的。

10. 发明申请

WO0213874A8 USE OF METAL COMPLEXES CONTAINING PERFLUOROALKYL AS CONTRAST AGENTS IN MR-IMAGING FOR THE REPRESENTATION OF PLAQUES, TUMOURS AND NECROSES 审中-公开
标题翻译：金属络合物全氟烷基，如磁共振成像造影剂用于表示斑块，肿瘤坏死USE
公开(公告)号：WO0213874A8
公开(公告)日：2002-06-13
申请号：PCT/EP0108498
申请日：2001-07-23
申请人： SCHERING AG
发明人： PLATZEK JOHANNES , MARESKI PETER , NIEDBALLA ULRICH , RADUECHEL BERND , WEINMANN HANNS-JOACHIM , MISSELWITZ BERND
IPC分类号： C07H15/26 , A61K49/00 , A61K49/08 , A61K49/10 , C07D257/02
CPC分类号： A61K49/1806 , A61K49/085 , A61K49/10 , A61K49/103 , A61K49/106

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