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1. 发明申请

WO2017091501A1 IMPROVED ION MIRROR AND ION-OPTICAL LENS FOR IMAGING 审中-公开
标题翻译：用于成像的改进的离子反射镜和离子光学透镜
公开(公告)号：WO2017091501A1
公开(公告)日：2017-06-01
申请号：PCT/US2016/063076
申请日：2016-11-21
申请人： MICROMASS UK LIMITED , LECO CORPORATION
发明人： HOYES, John Brian , VERENCHIKOV, Anatoly , YAVOR, Mikhail , RICHARDSON, Keith
IPC分类号： H01J49/40
CPC分类号： H01J49/406
摘要： An ion mirror is disclosed comprising an ion entrance electrode section (62) at the ion entrance to the ion mirror, an energy focussing electrode section (66) for reflecting ions back along a longitudinal axis towards said ion entrance, and a spatial focussing electrode section (64) arranged between the ion entrance electrode section (62) and the energy focussing electrode section (66) for spatially focussing the ions. One or more DC voltage supply is provided to apply a DC potential to the ion entrance electrode section (62) that is intermediate the DC potential applied to the spatial focussing electrode section (64) and the DC potential applied to the energy focussing electrode section (66). The ion mirror further comprises: (i) at least one first transition electrode (68) arranged between said ion entrance electrode section (62) and said spatial focussing electrode section (64), wherein said one or more DC voltage supply is configured to apply a DC potential to said at least one first transition electrode that is intermediate the DC potential applied to the ion entrance electrode section (62) and the DC potential applied to the spatial focussing electrode section (64); and (ii) at least one second transition electrode (69) arranged between said energy focussing electrode section (66) and said spatial focussing electrode section (64), wherein said one or more DC voltage supply is configured to apply a DC potential to said at least one second transition electrode (69) that is intermediate the DC potential applied to the spatial focussing electrode section (64) and the DC potential applied to the ion entrance electrode section (62).
摘要翻译：公开了一种离子镜，其包括在离子镜的离子入口处的离子入口电极部分（62），用于沿着纵向轴线将离子反射回所述离子的能量聚焦电极部分（66）以及一个布置在离子入口电极部分（62）和能量聚焦电极部分（66）之间用于空间聚焦离子的空间聚焦电极部分（64）。提供一个或多个DC电压源以将DC电势施加到离子入口电极部分（62），该DC电势介于施加到空间聚焦电极部分（64）的DC电势和施加到能量聚焦电极部分（64）的DC电势中间 66）。离子镜还包括：（i）布置在所述离子入口电极部分（62）和所述空间聚焦电极部分（64）之间的至少一个第一过渡电极（68），其中所述一个或多个DC电压供应器被配置为施加所述至少一个第一转换电极的DC电位位于施加于所述离子入口电极部分（62）的DC电位与施加至所述空间聚焦电极部分（64）的DC电位之间; 和（ii）布置在所述能量聚焦电极部分（66）和所述空间聚焦电极部分（64）之间的至少一个第二过渡电极（69），其中所述一个或多个DC电压源被配置为施加DC电位到所述至少一个第二转换电极（69），其位于施加于空间聚焦电极部分（64）的DC电位和施加于离子入口电极部分（62）的DC电位之间。

2. 发明申请

WO2015150808A1 ORTHOGONAL ACCELERATION COAXIAL CYLINDER MASS ANALYSER 审中-公开
标题翻译：正交加速同轴气缸质谱分析仪
公开(公告)号：WO2015150808A1
公开(公告)日：2015-10-08
申请号：PCT/GB2015/051022
申请日：2015-04-01
申请人： MICROMASS UK LIMITED
发明人： HOYES, John Brian , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
IPC分类号： H01J49/42 , H01J49/40
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/025 , H01J49/406 , H01J49/4245 , H01J49/427
摘要： A mass analyser is disclosed comprising an annular ion guide having a longitudinal axis and comprising a first annular ion guide section and a second annular ion guide section, wherein the annular ion guide comprises: (i) an inner cylindrical electrode arrangement which is axially segmented and comprises a plurality of first electrodes and (ii) an outer cylindrical electrode arrangement which is axially segmented and comprises a plurality of second electrodes. Ions are introduced into the first annular ion guide section so that the ions form substantially stable circular orbits within the first annular ion guide section about the longitudinal axis. Ions are orthogonally accelerated from the first annular ion guide section into the second annular ion guide section and one or more parabolic DC potentials are maintained along a portion of the second annular ion guide section so that ions undergo simple harmonic motion. An inductive ion detector is arranged and adapted to detect ions within the second annular ion guide section.
摘要翻译：公开了一种质量分析器，其包括具有纵向轴线并包括第一环形离子引导部分和第二环形离子引导部分的环形离子引导件，其中所述环形离子引导件包括：（i）轴向分段的内圆柱形电极装置包括多个第一电极和（ii）轴向分段并包括多个第二电极的外圆柱形电极装置。离子被引入到第一环形离子引导部分中，使得离子在第一环形离子引导部分内围绕纵向轴线形成基本上稳定的圆周轨道。离子从第一环形离子引导部分正交加速到第二环形离子引导部分中，沿着第二环形离子引导部分的一部分保持一个或多个抛物线直流电位，使得离子进行简单的谐波运动。感应离子检测器被布置并适于检测第二环形离子引导部分内的离子。

3. 发明申请

WO2015071650A1 METHOD OF CORRELATING PRECURSOR AND FRAGMENT IONS 审中-公开
标题翻译：相关前提条件和碎片离子的方法
公开(公告)号：WO2015071650A1
公开(公告)日：2015-05-21
申请号：PCT/GB2014/053336
申请日：2014-11-11
申请人： MICROMASS UK LIMITED
发明人： HOYES, John Brian , PRINGLE, Steven Derek , SALARZAEI, Farnoush , WILDGOOSE, Jason Lee
IPC分类号： H01J49/00 , G01N27/62
CPC分类号： H01J49/0031 , G01N27/622 , H01J49/0045 , H01J49/421
摘要： A method of mass spectrometry is disclosed comprising separating precursor ions using an ion mobility separator such that different precursor ions have different drift times through the ion mobility separator;mass filtering said separated precursor ions with a mass filter, wherein the mass to charge ratios of the precursor ions transmitted by the mass filter vary as a function of the drift times of the precursor ions through the ion mobility separator; performing a first mode of operation comprising fragmenting the separated and mass filtered precursor ions in a fragmentation device to form fragment ions; urging the fragment ions through the fragmentation device such that fragment ions derived from different precursor ions that have been separated by the ion mobility separator are maintained spatially separated from each other as they are urged through the fragmentation device; and detecting the fragment ions. The method enables precursor ions to be associated with their related fragment ions more accurately.
摘要翻译：公开了一种质谱法，其包括使用离子迁移率分离器分离前体离子，使得不同的前体离子通过离子迁移率分离器具有不同的漂移时间;用质量过滤器大量过滤所分离的前体离子，其中质量比由质量过滤器传播的前体离子作为前体离子通过离子迁移分离器的漂移时间的函数而变化; 执行第一操作模式，包括在分离装置中分离和质量过滤的前体离子碎裂以形成碎片离子; 促使碎片离子通过碎裂装置，使得衍生自已被离子迁移率分离器分离的不同前体离子的碎片离子保持空间上彼此分离，因为它们通过破碎装置被推动; 并检测碎片离子。该方法使前体离子更准确地与其相关的片段离子相关联。

4. 发明申请

WO2017087470A1 IMAGING MASS SPECTROMETER 审中-公开
标题翻译：成像质谱仪
公开(公告)号：WO2017087470A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062203
申请日：2016-11-16
申请人： MICROMASS UK LIMITED , LECO CORPORATION
发明人： HOYES, John Brian , VERENCHIKOV, Anatoly , YAVOR, Mikhail , RICHARDSON, Keith , WILDGOOSE, Jason
IPC分类号： H01J49/40
CPC分类号： H01J49/40 , H01J49/0004
摘要： A time-of-flight mass spectrometer is disclosed comprising: an ion deflector (305) configured to deflect ions to different positions in a first array of positions at different times; a position sensitive ion detector (187); and ion optics (180) arranged and configured to guide ions from the first array of positions to the position sensitive detector (187) so as to map ions from the first array of positions to a second array of positions on the position sensitive detector (187); wherein the ion optics includes at least one ion mirror for reflecting the ions.
摘要翻译：公开了一种飞行时间质谱仪，其包括：离子偏转器（305），其被配置成将离子偏转到不同时间的第一位置阵列中的不同位置; 位置敏感离子检测器（187）; 和离子光学器件（180），所述离子光学器件布置和构造成将离子从所述第一阵列位置引导至所述位置敏感检测器（187），以将来自所述第一阵列位置的离子映射到所述位置敏感检测器（187）上的第二阵列位置）; 其中离子光学器件包括至少一个用于反射离子的离子镜。

5. 发明申请

WO2014174260A1 IMPROVED ION MOBILITY SPECTROMETER 审中-公开
标题翻译：改进离子移动光谱仪
公开(公告)号：WO2014174260A1
公开(公告)日：2014-10-30
申请号：PCT/GB2014/051224
申请日：2014-04-17
申请人： MICROMASS UK LIMITED
发明人： GILES, Kevin , GREEN, Martin Raymond , HOYES, John Brian , PRINGLE, Steven Derek , WILDGOOSE, Jason Lee
IPC分类号： G01N27/62
CPC分类号： G01N27/622
摘要： A method of analysing ions by ion mobility separation is disclosed. The method comprises controlling the amount of charge within an ion trap (3) and then pulsing the ions from the ion trap (3) into an ion mobility separator (5). This enables the charge injected into the ion mobility separator (5) to be controlled and hence prevents space-charge interactions between the ions from distorting the ion mobility peaks detected by the detector (7).
摘要翻译：公开了通过离子迁移率分离分析离子的方法。该方法包括控制离子阱（3）内的电荷量，然后将来自离子阱（3）的离子脉冲成离子迁移率分离器（5）。这使得能够控制注入到离子迁移率分离器（5）中的电荷，并且因此防止离子之间的空间 - 电荷相互作用扭曲由检测器（7）检测到的离子迁移率峰值。

6. 发明申请

WO2011154731A1 MASS SPECTROMETER WITH BEAM EXPANDER 审中-公开
标题翻译：带光束扩散器的质谱仪
公开(公告)号：WO2011154731A1
公开(公告)日：2011-12-15
申请号：PCT/GB2011/051068
申请日：2011-06-07
申请人： MICROMASS UK LIMITED , BROWN, Jeffery Mark , GILBERT, Anthony James , HOYES, John Brian , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
发明人： BROWN, Jeffery Mark , GILBERT, Anthony James , HOYES, John Brian , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
IPC分类号： H01J49/40 , H01J49/06
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/0095 , H01J49/062 , H01J49/067 , H01J49/405
摘要： A mass spectrometer ts disclosed comprising a RF confinement device (6), a beam expander (7,9) and a Time of Fight mass analyser. The beam expander (7,9) is arranged to expand an ion beam emerging from the RF confinement device (6) so that the ion beam (10) is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyser.
摘要翻译：所公开的质谱仪ts包括RF限制装置（6），光束扩展器（7,9）和时间质量分析器。光束扩展器（7,9）被布置成扩大从RF限制装置（6）出射的离子束，使得离子束（10）在正交加速提取区域中扩展至至少3mm的直径飞行时间质量分析仪。

7. 发明申请

WO2021053342A1 ION MOBILITY SEPARATION DEVICE 审中-公开
公开(公告)号：WO2021053342A1
公开(公告)日：2021-03-25
申请号：PCT/GB2020/052259
申请日：2020-09-17
申请人： MICROMASS UK LIMITED
发明人： HOYES, John Brian
IPC分类号： G01N27/62
摘要： A method of separating ions according to their ion mobility using an ion mobility separation device including a first section and a second section is disclosed, comprising: urging ions through the first section against a first opposing electric field using a first driving force provided by a first set of time varying voltage(s) or voltage waveform(s); progressively reducing the magnitude of the first opposing electric field and/or progressively increasing the magnitude of the first driving force; and driving ions through the second section against a second opposing electric field using a second drive force provided by a second set of time-varying voltage(s) or voltage waveform(s); wherein the magnitude of the second opposing electric field is progressively reduced and/or the magnitude of the second driving force is progressively increased in tandem with reducing the magnitude of the first opposing electric field and/or increasing the magnitude of the first driving force.

8. 发明申请

WO2021038242A1 ADAPTIVE INTRINSIC LOCK MASS CORRECTION 审中-公开
公开(公告)号：WO2021038242A1
公开(公告)日：2021-03-04
申请号：PCT/GB2020/052069
申请日：2020-08-28
申请人： MICROMASS UK LIMITED
发明人： RICHARDSON, Keith George , GREEN, Martin Raymond , HOYES, John Brian , DENNY, Richard , NIXON, Peter , CHAPMAN, Richard
IPC分类号： H01J49/00
摘要： A method of correcting mass spectral data comprises making calibration measurements of first intrinsic components (A, B, C) at one or more calibration times (tl) using calibrants which have known mass to charge ratio (m/z) values or previously mass measured mass to charge ratio (m/z) values, making a list of second intrinsic components (D, E, F) which are present during more than one acquisition periods, wherein the second intrinsic components have mass to charge ratio (m/z) values that were not present or observed during or close to the one or more calibration times (tl) but which do overlap in time with the first intrinsic components (A, B, C), and utilising the list to calculate a mass or mass to charge ratio (m/z) correction factor for one or more acquisition periods which are not close or adjacent in time to an acquisition period containing a directly calibrated mass to charge ratio (m/z) value.

9. 发明申请

WO2018007810A1 STANDING WAVE ION MANIPULATION DEVICE 审中-公开
标题翻译：驻波离子操纵装置
公开(公告)号：WO2018007810A1
公开(公告)日：2018-01-11
申请号：PCT/GB2017/051981
申请日：2017-07-05
申请人： MICROMASS UK LIMITED
发明人： HOYES, John Brian
IPC分类号： H01J49/06
摘要： An ion manipulation device is disclosed comprising: an ion receiving region (30) for receiving ions; a pair of electrodes (14,16) adjacent the ion receiving region (30); and an AC or RF voltage supply (18) arranged to apply an AC or RF voltage to said electrodes (14,16), or arranged and configured to generate an electromagnetic field that couples to said electrodes (14,16) in use, such that an electromagnetic standing wave (24) is generated between said electrodes (14,16). A first of the electrodes (14) comprises one or more apertures through which an electric field from the standing wave (24) penetrates and enters the ion receiving region (30), in use, for urging said ions away from the one or more apertures.
摘要翻译：公开了一种离子操纵装置，包括：用于接收离子的离子接收区域（30）一对邻近离子接收区域（30）的电极（14,16）; 以及AC或RF电压源（18），其被布置为将AC或RF电压施加到所述电极（14,16），或者被布置和配置为产生在使用中耦合到所述电极（14,16）的电磁场，例如在所述电极（14,16）之间产生电磁驻波（24）。第一电极（14）包括一个或多个孔，在使用中，来自驻波（24）的电场穿过并进入离子接收区（30），用于迫使所述离子远离一个或多个孔

10. 发明申请

WO2017087456A1 IMAGING MASS SPECTROMETER 审中-公开
标题翻译：成像质谱仪
公开(公告)号：WO2017087456A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062174
申请日：2016-11-16
申请人： MICROMASS UK LIMITED , LECO CORPORATION
发明人： HOYES, John Brian , VERENCHIKOV, Anatoly , YAVOR, Mikhail , RICHARDSON, Keith , WILDGOOSE, Jason
IPC分类号： H01J49/40
CPC分类号： H01J49/406 , H01J49/0004
摘要： A time-of-flight mass spectrometer is disclosed comprising ion optics that map an array of ions at an ion source array (71) to a corresponding array of positions on a position sensitive ion detector (79). The ion optics include at least one gridless ion mirror (76) for reflecting ions, which may compensate for various aberrations and allows the spectrometer to have relatively high mass and spatial resolutions.
摘要翻译：公开了一种飞行时间质谱仪，其包括将离子源阵列（71）处的离子阵列映射到位置灵敏离子检测器（79）上的相应阵列位置的离子光学器件，。离子光学器件包括至少一个用于反射离子的无网格离子镜（76），其可以补偿各种像差并且允许光谱仪具有相对较高的质量和空间分辨率。

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