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1. 发明申请

WO2021173525A1 SPLIT FLOW MODULATOR FOR COMPREHENSIVE TWO-DIMENSIONAL CHROMATOGRAPHY 审中-公开
公开(公告)号：WO2021173525A1
公开(公告)日：2021-09-02
申请号：PCT/US2021/019186
申请日：2021-02-23
申请人： LECO CORPORATION
发明人： BLUMBERG, Leonid, M.
IPC分类号： G01N30/46 , G01N30/10 , G01N30/02
摘要： A re-sampling device for two-dimensional gas chromatography includes a modulator and at least one of a first splitter disposed upstream from the modulator and configured to split an effluent from a primary column and deliver a portion of the effluent to waste and a portion of the effluent to the modulator, or a second splitter disposed downstream from the modulator and configured to split the effluent to deliver a portion of the effluent to waste and a portion of the effluent to a secondary column.

2. 发明申请

WO2020150547A1 MULTI-DIMENSIONAL CHROMATOGRAPHY MODULATOR WITH VARIABLE MODULATION PERIOD 审中-公开
公开(公告)号：WO2020150547A1
公开(公告)日：2020-07-23
申请号：PCT/US2020/013989
申请日：2020-01-17
申请人： LECO CORPORATION
发明人： BORTON, David, Jesse , SHIEL, Jonelle, Ley , MERRICK, Mark, Firmer
IPC分类号： G01N30/46 , G01N30/02
摘要： A multi-dimensional gas chromatograph for analyzing compounds in a sample during a single run is disclosed. The multi-dimensional gas chromatograph includes a first column, a second column, and a modulator disposed between the first column and the second column. The modulator modulates at (i) a first modulation period over a first time period during the run and (ii) a second modulation period over a second time period during the run later than the first time, the second modulation period being different than the first modulation period.

3. 发明申请

WO2018203082A1 MULTI-REFLECTING TIME-OF-FLIGHT MASS SPECTROMETERS 审中-公开
公开(公告)号：WO2018203082A1
公开(公告)日：2018-11-08
申请号：PCT/GB2018/051206
申请日：2018-05-04
申请人： MICROMASS UK LIMITED , LECO CORPORATION
发明人： HOYES, John Brian , VERENCHIKOV, Anatoly
IPC分类号： H01J49/40
摘要： A multi-reflecting time of flight mass analyser is disclosed in which the ion flight path is maintained relatively small and the duty cycle is made relatively high. Spatial focussing of the ions in the dimension (z-dimension) in which the mirrors (36) are elongated can be eliminated whilst maintaining a reasonably high sensitivity and resolution.

4. 发明申请

WO2016174462A1 MULTI-REFLECTING TOF MASS SPECTROMETER 审中-公开
标题翻译：多反射TOF质谱仪
公开(公告)号：WO2016174462A1
公开(公告)日：2016-11-03
申请号：PCT/GB2016/051238
申请日：2016-04-29
申请人： MICROMASS UK LIMITED , LECO CORPORATION
发明人： HOYES, John Brian , RICHARDSON, Keith , VERENCHIKOV, Anatoly , YAVOR, Mikhail
IPC分类号： H01J49/40 , H01J49/06
CPC分类号： H01J49/405 , H01J49/061 , H01J49/406 , H01J49/426
摘要： A method of time-of-flight mass spectrometry is disclosed comprising: providing two ion mirrors (42) that are spaced apart in a first dimension (X-dimension) and that are each elongated in a second dimension (Z-dimension) orthogonal to the first dimension; introducing packets of ions (47) into the space between the mirrors using an ion introduction mechanism (43) such that the ions repeatedly oscillate in the first dimension (X-dimension) between the mirrors (42) as they drift through said space in the second dimension (Z-dimension); oscillating the ions in a third dimension (Y-dimension) orthogonal to both the first and second dimensions as the ions drift through said space in the second dimension (Z-dimension); and receiving the ions in or on an ion receiving mechanism (44) after the ions have oscillated multiple times in the first dimension (X-dimension); wherein at least part of the ion introduction mechanism (43) and/or at least part of the ion receiving mechanism (44) is arranged between the mirrors (42).
摘要翻译：公开了一种飞行时间质谱法的方法，其包括：提供在第一维度（X维）上间隔开的两个离子镜（42），并且每个离子镜在与第二维度（X维）正交的第二维度第一维度使用离子引入机构（43）将离子束（47）引入到反射镜之间的空间中，使得当它们漂移通过所述空间中的所述空间时，离子在反射镜（42）之间的第一维度（X维）中重复地振荡第二维（Z维）; 当离子漂移通过第二维度（Z维）中的所述空间时，使垂直于第一和第二维度的第三维（Y-维）中的离子振荡; 以及在所述离子在所述第一维度（X维度）中多次振荡之后，接收离子接收机构（44）中或其上的离子; 其中所述离子引入机构（43）的至少一部分和/或所述离子接收机构（44）的至少一部分配置在所述反射镜（42）之间。

5. 发明申请

WO2015175988A1 METHOD AND APPARATUS FOR DECODING MULTIPLEXED INFORMATION IN A CHROMATOGRAPHIC SYSTEM 审中-公开
标题翻译：用于在色谱系统中解码多重信息的方法和装置
公开(公告)号：WO2015175988A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/031173
申请日：2015-05-15
申请人： LECO CORPORATION
发明人： WILLIS, Peter, Markel , JALOSZYNSKI, Jonathan , HAUCK, Evan
IPC分类号： H01J49/40
CPC分类号： H01J49/40 , H01J49/0027 , H01J49/10
摘要： Implementations of methods and apparatuses are disclosed for decoding multiplexed information in a chromatographic system. Implementations may include the method of pulsing ions from an ion source through an analyzer according to a predetermined multiplexing scheme, each pulse including one or more ions corresponding to a sample, detecting a plurality of ion strikes at a detector, determining a data point for each ion strike, wherein each data point includes an intensity of a detected ion strike and a time of the detected ion strike, maintaining a multiplexed spectrum of the data points, the multiplexed spectrum including the data points, and demultiplexing the time shifted spectrum using the data points of the multiplexed spectrum.
摘要翻译：公开了用于在色谱系统中解码复用信息的方法和装置的实现。实施方案可以包括根据预定的多路复用方案将来自离子源的离子脉冲通过分析器的方法，每个脉冲包括对应于样品的一个或多个离子，检测检测器处的多个离子冲击，确定每个离子冲击，其中每个数据点包括检测到的离子冲击的强度和检测到的离子冲击的时间，保持数据点的多路复用频谱，包括数据点的多路复用频谱，以及使用数据解复用时移频谱多路复用频谱点。

6. 发明申请

WO2014142897A1 MULTI-REFLECTING MASS SPECTROMETER 审中-公开
标题翻译：多重反射质谱仪
公开(公告)号：WO2014142897A1
公开(公告)日：2014-09-18
申请号：PCT/US2013/031506
申请日：2013-03-14
申请人： LECO CORPORATION
发明人： VERENCHIKOV, Anatoly , YAVOR, Mikhail
IPC分类号： H01J49/40
CPC分类号： H01J49/406 , H01J49/067 , H01J49/405
摘要： To improve spatial and energy acceptance of multi-reflecting time-of-flight, open traps, and electrostatic trap analyzers, a novel ion mirror is disclosed. Incorporation of immersion lens between ion mirrors allows reaching the fifth order time per energy focusing simultaneously with the third order time per spatial focusing including energy-spatial cross terms. Preferably the analyzer has hollow cylindrical geometry for extended flight path. The time-of-flight analyzer preferably incorporates spatially modulated ion mirror field for isochronous ion focusing in the tangential direction.
摘要翻译：为了提高多反射飞行时间，开路陷阱和静电捕集分析仪的空间和能量接受度，公开了一种新型离子镜。在离子镜之间并入浸没透镜允许每次能量聚焦达到第五阶时间，同时每个空间聚焦的三阶时间同时包括能量 - 空间交叉项。优选地，分析器具有用于延伸飞行路径的中空圆柱形几何形状。飞行时间分析仪优选地在切向方向上并入空间调制的离子镜场用于等时离子聚焦。

7. 发明申请

WO2014074822A1 CYLINDRICAL MULTI-REFLECTING TIME-OF-FLIGHT MASS SPECTROMETER 审中-公开
标题翻译：圆柱多反射飞行时间质谱仪
公开(公告)号：WO2014074822A1
公开(公告)日：2014-05-15
申请号：PCT/US2013/069155
申请日：2013-11-08
申请人： LECO CORPORATION
发明人： VERENCHIKOV, Anatoly, N.
IPC分类号： H01J49/26
CPC分类号： H01J49/406 , H01J49/0031 , H01J49/405 , H01J2237/121
摘要： A method and apparatus are disclosed for improving resolution and duty-cycle of a multi-reflecting TOF mass spectrometer (MR-TOF) by arranging a. cylindrical analyzer having an appropriate radial deflection means, means for limiting ion divergence in the tangential direction and a pulsed source providing ion packet divergence of less than 1mm*deg. There are disclosed embodiments for fifth-order focusing cylindrical ion mirrors. Separate embodiments provide parallel tandem MS-MS within a single cylindrical MR-TOF.
摘要翻译：公开了一种用于通过布置a来改善多反射TOF质谱仪（MR-TOF）的分辨率和占空比的方法和装置。圆柱形分析器具有适当的径向偏转装置，用于限制切向方向上的离子发散的装置和提供小于1mm * deg的离子包发散的脉冲源。公开了五阶聚焦圆柱离子镜的实施例。单独的实施例在单个圆柱形MR-TOF内提供并联串联MS-MS。

8. 发明申请

WO2014021960A1 ION MOBILITY SPECTROMETER WITH HIGH THROUGHPUT 审中-公开
标题翻译：离子移动光谱仪具有高通量
公开(公告)号：WO2014021960A1
公开(公告)日：2014-02-06
申请号：PCT/US2013/039328
申请日：2013-05-02
申请人： LECO CORPORATION
发明人： VERENCHIKOV, Anatoly, N.
IPC分类号： G01N27/62
CPC分类号： G01N27/622 , H01J49/00 , H01J49/06 , H01J49/061 , H01J49/40
摘要： A method and apparatus are disclosed for improving ion mobility spectrometry by using a fast and spatially wide ion gate based on local RF field barrier opposed to a switching DC field. Alternatively, the speed and charge throughput of ion mobility separator are improved by arranging coaxial mobility cell followed by conical coaxial ion channel. The improvement accelerates the ion mobility analysis and improves charge throughput and dynamic range of the IMS. The invention is particularly suited for rapid dual gas chromatography, fast CE. Preferably, the accelerated and wide bore IMS is coupled to a multi-reflecting time-of-flight mass spectrometer with a fast encoded orthogonal acceleration. Speed and sensitivity of IMS with fast pulsing MR-TOF make it practical to arrange analytical methods of comprehensive and orthogonal separation in multiple analytical dimensions.
摘要翻译：公开了一种通过使用基于与开关DC场相对的局部RF场屏障的快速且空间宽的离子栅极来改进离子迁移谱的方法和装置。或者，离子迁移率分离器的速度和电荷产生量通过布置同轴迁移率单元，随后是锥形同轴离子通道来改进。该改进加速了离子迁移率分析，提高了IMS的电荷吞吐量和动态范围。本发明特别适用于快速双气相色谱，快速CE。优选地，加速和宽孔IMS耦合到具有快速编码的正交加速度的多反射飞行时间质谱仪。具有快速脉冲MR-TOF的IMS的速度和灵敏度使得在多个分析维度上布置综合和正交分离的分析方法变得实际。

9. 发明申请

WO2013192161A2 TANDEM TIME-OF-FLIGHT MASS SPECTROMETRY WITH NON-UNIFORM SAMPLING 审中-公开
标题翻译：使用非均匀采样的TANDEM飞行时间质谱分析
公开(公告)号：WO2013192161A2
公开(公告)日：2013-12-27
申请号：PCT/US2013/046279
申请日：2013-06-18
申请人： LECO CORPORATION
发明人： VERENCHIKOV, Anatoly, N. , MAKAROV, Vasily
IPC分类号： H01J49/00 , H01J49/10
CPC分类号： H01J49/406 , H01J49/0027 , H01J49/0031 , H01J49/005 , H01J49/0081 , H01J49/10
摘要： A method and apparatus are disclosed for parallel all-mass tandem mass spectrometry employing multi-reflecting time-of-flight analyzer for both MS stages, preferably arranged within the same analyzer to secure ultra-high resolution. Sensitivity and speed of TOF-TOF tandem are enhanced by non-redundant multiplexing based on signal sparseness and on avoiding repetitive signal overlaps at multiple repetitions of true fragment signals. Non-redundant matrices of gate and delay timing are constructed by extending orthogonal Latin square matrices. The method is generalized for multiplexing of any multiple repetitive signal sources being sparse either spectrally, or spatially, or in time.
摘要翻译：公开了一种用于并行全质量串联质谱法的方法和装置，其采用多反射飞行时间分析器用于两个MS级，优选地布置在同一分析仪内以确保超高分辨率。 TOF-TOF串联的灵敏度和速度通过基于信号稀疏度的非冗余多路复用和避免在多个重复的真分片信号上的重复信号重叠来增强。通过扩展正交拉丁方阵来构造栅极和延迟定时的非冗余矩阵。该方法被广泛地用于多个重复信号源的多路复用，其频谱或空间上或时间上稀疏。

10. 发明申请

WO2013109592A1 SYSTEMS AND METHODS TO PROCESS AND GROUP CHROMATOGRAPHIC PEAKS 审中-公开
标题翻译：处理和组色谱峰的系统和方法
公开(公告)号：WO2013109592A1
公开(公告)日：2013-07-25
申请号：PCT/US2013/021685
申请日：2013-01-16
申请人： LECO CORPORATION
发明人： WANG, Jihong , WILLIS, Peter, Markel
IPC分类号： G01N30/86 , G06F17/18
CPC分类号： H01J49/0036 , G01N30/8624 , G01N2030/862 , G06F17/18
摘要： A method for processing chromatographic peaks in chromatographic systems comprising comparing (S 110) a first peak with a second peak; and determining (180) whether the first peak and second peak should be grouped together.
摘要翻译：一种在色谱系统中处理色谱峰的方法，包括将第一峰与第二峰进行比较（S110）以及确定（180）是否将第一峰值和第二峰值分组在一起。

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