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1. 发明申请

WO2019121942A1 METHODS FOR DIAGNOSING PANCREATIC CANCER 审中-公开
公开(公告)号：WO2019121942A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/085882
申请日：2018-12-19
申请人： METANOMICS HEALTH GMBH , UNIVERSITAETSMEDIZIN GREIFSWALD
发明人： KAMLAGE, Beate , CHRISTIANSEN, Nicole , SCHATZ, Philipp , PILARSKY, Christian , GRUETZMANN, Robert , BAHRA, Marcus , MAYERLE, Julia , LERCH, Markus , CHROMIK, Ansgar Michael
IPC分类号： G01N33/574 , G01N33/68
CPC分类号： G01N33/57438 , G01N33/6812
摘要： The present invention relates to a method for diagnosing pancreatic cancer in a subject suspected to suffer from pancreatic cancer comprising the steps of: (a) determining in a sample of said subject the value of (i) at least one biomarker of the categories carnitines, amino acids, and mitochondrial energy metabolites, and (ii) a first and a second sphingolipid, wherein the fatty acid residue of the first sphingolipid is at least four carbon atoms longer than the fatty acid residue of the second sphingolipid, and wherein the sphingosine backbone of the first sphingolipid and the second sphingolipid are identical;and (b) comparing the values of the biomarkers with references, whereby pancreatic cancer is diagnosed; and to a method for identifying whether a subject is in need of a pancreatic cancer therapy related thereto. The present invention further relates to a device for diagnosing pancreatic cancer in a sample of a subject comprising (a) an analyzing unit for the sample of the subject comprising a detector for the amounts of at least one biomarker each of the categories carnitines, amino acids, energy metabolites, and sphingolipids; said detector allowing for the determination of the amounts of the biomarkers of the said group of biomarkers in the sample; and operatively linked thereto, (b) an evaluation unit comprising a data processing unit and a data base, said data base comprising a stored reference and said data processing unit having tangibly embedded an algorithm for carrying out a comparison of the amounts of the biomarkers of the group of biomarkers determined by the analyzing unit and the stored reference and for generating an output information based on which the diagnosis can be established. Further, the present invention relates to a data collection and too a use related to the aforesaid subject matter.

2. 发明申请

WO2015145387A1 MEANS AND METHODS FOR DETERMINATION OF QUALITY OF BLOOD SAMPLES BASED ON METABOLITE PANEL 审中-公开
标题翻译：用于确定基于代谢物面板的血液样品质量的手段和方法
公开(公告)号：WO2015145387A1
公开(公告)日：2015-10-01
申请号：PCT/IB2015/052243
申请日：2015-03-26
申请人： METANOMICS HEALTH GMBH , BASF (CHINA) COMPANY LIMITED
发明人： KAMLAGE, Beate , SCHMITZ, Oliver , BETHAN, Bianca , SCHATZ, Philipp , PETER, Erik
IPC分类号： G01N33/574
CPC分类号： G01N33/96
摘要： A method for assessing the quality of a blood product sample, comprises determining in said sample the value of the markers of at least one marker panel of the invention, comparing the values determined with corresponding references, and assessing the quality of said blood sample.
摘要翻译：用于评估血液制品样品质量的方法包括在所述样品中确定本发明的至少一个标记物组的标记物的值，比较用相应参考文献确定的值，并评估所述血液样品的质量。

3. 发明申请

WO2014125443A1 MEANS AND METHODS FOR ASSESSING THE QUALITY OF A BIOLOGICAL SAMPLE 审中-公开
标题翻译：用于评估生物样品质量的方法和方法
公开(公告)号：WO2014125443A1
公开(公告)日：2014-08-21
申请号：PCT/IB2014/059002
申请日：2014-02-14
申请人： METANOMICS HEALTH GMBH , BASF (CHINA) COMPANY LIMITED
发明人： KAMLAGE, Beate , SCHMITZ, Oliver , KASTLER, Jürgen , CATCHPOLE, Gareth , DOSTLER, Martin , LIEBENBERG, Volker
IPC分类号： A61K31/00
CPC分类号： G01N33/492 , G01N33/491 , G01N2560/00 , G01N2570/00 , G06F19/18
摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention relates to a method for assessing the quality of a biological sample comprising the steps of determining in a sample the amount of at least one biomarker from Tables 1, 1', 2, 2', 3, 3', 4, 5, 5', 6, 7, and/or 8 and comparing the said amount of the at least one biomarker with a reference, whereby the quality of the sample is assessed. The invention also relates to tools for carrying out the aforementioned method, such as devices and kits.
摘要翻译：本发明涉及诊断方法领域。具体地说，本发明涉及一种用于评价生物样品质量的方法，包括以下步骤：在样品中测定表1,1'，2,2'，3,3'，4'中至少一种生物标志物的量，5,5'，6,7和/或8，并将所述至少一种生物标志物的量与参考比较，由此评估样品的质量。本发明还涉及用于执行上述方法的工具，例如装置和套件。

4. 发明申请

WO2016207391A1 MEANS AND METHODS FOR DIAGNOSING PANCREATIC CANCER IN A SUBJECT BASED ON A BIOMARKER PANEL 审中-公开
标题翻译：用于诊断基于生物标记物面板的主体中的胰腺癌的手段和方法
公开(公告)号：WO2016207391A1
公开(公告)日：2016-12-29
申请号：PCT/EP2016/064736
申请日：2016-06-24
申请人： METANOMICS HEALTH GMBH
发明人： KAMLAGE, Beate , RESZKA, Regina , SCHATZ, Philipp , DOSTLER, Martin , CARVALHO, Susan , PETER, Erik , MAPPES, Philipp , KALTHOFF, Holger , SCHNIEWIND, Bodo , MAYERLE, Julia , LERCH, Markus , GRUETZMANN, Robert , PILARSKY, Christian
IPC分类号： G01N33/574 , G01N33/68
CPC分类号： G01N33/57438 , G01N33/6806 , G01N33/6812 , G01N2405/08 , G01N2800/60 , G01N2800/7028 , G01N2800/7076 , G01N2800/7085
摘要： The present invention relates to a method for diagnosing pancreatic cancer in a subject comprising the steps of: (a) determining in at least one sample of said subject the amounts of a group of diagnostic biomarkers comprising (i) at least one diagnostic amino acid, said diagnostic amino acid being proline, histidine or tryptophan, preferably, being proline; (ii) at least one diagnostic ceramide, said diagnostic ceramide being ceramide (d18:1,C24:0) or ceramide (d18:2,C24:0), preferably being ceramide (d18:1,C24:0); (iii) at least one diagnostic sphingomyelin, said diagnostic sphingomyelin being sphingomyelin (35:1), sphingomyelin (d17:1,C16:0), sphingomyelin (41 :2) or sphingomyelin (d18:2,C17:0), preferably being sphingomyelin (35:1); and (iv) CA19-9; and (b) comparing said amounts of the diagnostic biomarkers with a reference, whereby pancreatic cancer is diagnosed. Moreover, the present invention relates to a method for determining the probability for a subject to suffer from pancreatic cancer, and to devices and uses related to said methods.
摘要翻译：本发明涉及一种用于诊断受试者的胰腺癌的方法，包括以下步骤：（a）在所述受试者的至少一个样品中测定一组诊断性生物标志物的量，所述诊断生物标志物组包含（i）至少一种诊断性氨基酸，所述诊断性氨基酸为脯氨酸，组氨酸或色氨酸，优选为脯氨酸; （ii）至少一种诊断性神经酰胺，所述诊断性神经酰胺为神经酰胺（d18：1，C24：0）或神经酰胺（d18：2，C24：0），优选为神经酰胺（d18：1，C24：0）; （iii）至少一种诊断性鞘磷脂，所述诊断性鞘磷脂是鞘磷脂（35:1），鞘磷脂（d17：1，C16：0），鞘磷脂（41：2）或鞘磷脂（d18：2，C17：0）是鞘磷脂（35：1）; 和（iv）CA19-9; 和（b）将所述诊断生物标志物的量与参考文献进行比较，由此诊断胰腺癌。此外，本发明涉及一种用于确定受试者患有胰腺癌的可能性的方法以及与所述方法相关的装置和用途。

5. 发明申请

WO2013079594A1 DEVICE AND METHODS TO DIAGNOSE PANCREATIC CANCER 审中-公开
标题翻译：诊断胰腺癌的装置和方法
公开(公告)号：WO2013079594A1
公开(公告)日：2013-06-06
申请号：PCT/EP2012/073965
申请日：2012-11-29
申请人： METANOMICS HEALTH GMBH , UNIVERSITÄTSKLINIKUM SCHLESWIG-HOLSTEIN , ERNST-MORITZ-ARNDT UNIVERSITÄT GREIFSWALD , RESZKA, Regina , KAMLAGE, Beate , KALTHOFF, Holger , SCHNIEWIND, Bodo , MAYERLE, Julia , LERCH, Markus M. , PILARSKY, Christian , GRÜTZMANN, Robert
发明人： RESZKA, Regina , KAMLAGE, Beate , KALTHOFF, Holger , SCHNIEWIND, Bodo , MAYERLE, Julia , LERCH, Markus M. , PILARSKY, Christian , GRÜTZMANN, Robert
IPC分类号： G01N33/574
CPC分类号： G01N33/57438 , G01N2033/57461
摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreatic cancer in a subject, a method for identifying whether a subject is in need for a therapy of pancreatic cancer or a method for determining whether a pancreatic cancer therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.
摘要翻译：本发明涉及诊断方法领域。具体地，本发明考虑了用于诊断受试者中胰腺癌的方法，用于鉴定受试者是否需要胰腺癌治疗的方法或者确定胰腺癌治疗是否成功的方法。本发明还涉及用于执行上述方法的工具，例如诊断装置。

6. 发明申请

WO2015091962A1 MEANS AND METHODS FOR DIAGNOSING PANCREATIC CANCER IN A SUBJECT BASED ON A METABOLITE PANEL 审中-公开
标题翻译：用于诊断基于代谢物面板的主体中的胰腺癌的手段和方法
公开(公告)号：WO2015091962A1
公开(公告)日：2015-06-25
申请号：PCT/EP2014/078765
申请日：2014-12-19
申请人： METANOMICS HEALTH GMBH
发明人： KAMLAGE, Beate , RESZKA, Regina , PETER, Erik , KASTLER, Jürgen , SCHATZ, Philipp , KALTHOFF, Holger , SCHNIEWIND, Bodo , MAYERLE, Julia , LERCH, Markus , PILARSKY, Christian , GRÜTZMANN, Robert
IPC分类号： G01N33/574
CPC分类号： G01N33/57438 , G01N33/49 , G01N33/92 , G01N2400/00 , G01N2405/00 , G01N2405/04 , G01N2405/08
摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreas cancer in a subject and, preferably for differentiating between pancreatic cancer and pancreatitis and a method for identifying whether a subject is in need for a therapy of pancreatic cancer. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.
摘要翻译：本发明涉及诊断方法领域。具体地，本发明考虑了用于诊断受试者中的胰腺癌的方法，优选用于胰腺癌和胰腺炎的分化以及用于鉴定受试者是否需要胰腺癌治疗的方法。本发明还涉及用于执行上述方法的工具，例如诊断装置。

7. 发明申请

WO2011151252A2 MEANS AND METHODS FOR DIAGNOSING PANCREATIC CANCER IN A SUBJECT 审中-公开
标题翻译：用于诊断主体中胰腺癌的手段和方法
公开(公告)号：WO2011151252A2
公开(公告)日：2011-12-08
申请号：PCT/EP2011/058670
申请日：2011-05-26
申请人： METANOMICS HEALTH GMBH , UNIKLINIKUM SCHLESWIG-HOLSTEIN , ERNST-MORITZ-ARNDT UNIVERSITÄT , KAMLAGE, Beate , RESZKA, Regina , KLUTTIG, Martin , KALTHOFF, Holger , SCHNIEWIND, Bodo , MEYERLE, Julia , LERCH, Markus
发明人： KAMLAGE, Beate , RESZKA, Regina , KLUTTIG, Martin , KALTHOFF, Holger , SCHNIEWIND, Bodo , MEYERLE, Julia , LERCH, Markus
IPC分类号： G01N33/574
CPC分类号： G01N33/574 , G01N33/57438
摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing pancreatic cancer in a subject, a method for identifying whether a subject is in need for a therapy of pancreatic cancer or a method for determining whether a pancreatic cancer therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.
摘要翻译：本发明涉及诊断方法领域。具体地，本发明考虑了用于诊断受试者中胰腺癌的方法，用于鉴定受试者是否需要胰腺癌治疗的方法或者确定胰腺癌治疗是否成功的方法。本发明还涉及用于执行上述方法的工具，例如诊断装置。

8. 发明申请

WO2010139711A1 MEANS AND METHODS FOR DIAGNOSING PROSTATE CARCINOMAS 审中-公开
标题翻译：用于诊断前列腺癌的手段和方法
公开(公告)号：WO2010139711A1
公开(公告)日：2010-12-09
申请号：PCT/EP2010/057680
申请日：2010-06-02
申请人： METANOMICS HEALTH GMBH , CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN , KAMLAGE, Beate , BETHAN, Bianca , RESZKA, Regina , LEIBOLD, Edgar , JUNG, Klaus , LEIN, Michael , KRISTIANSEN, Glen
发明人： KAMLAGE, Beate , BETHAN, Bianca , RESZKA, Regina , LEIBOLD, Edgar , JUNG, Klaus , LEIN, Michael , KRISTIANSEN, Glen
IPC分类号： G01N33/574
CPC分类号： G01N33/57484 , G01N33/57434
摘要： The present invention relates to a method, preferably an ex vivo method, for diagnosing prostate carcinomas and/or predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from prostate carcinomas or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby prostate carcinomas or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metaboiite and the use of said at least one metabolite for the manufacture of diagnostic means for or for diagnosing prostate carcinomas. Finally, the present invention pertains to a method for identifying prostate carcinoma-related metabolites.
摘要翻译：本发明涉及用于诊断前列腺癌和/或其倾向性的方法，优选离体方法，其包括测定怀疑患有前列腺癌的受试者的测试样品中的至少一种代谢物或具有易感性并比较将至少一种代谢物称为参考，由此前列腺癌或其易感性被诊断。此外，本发明包括代谢物的集合，包括代谢物的特征值的数据收集和包含所述数据收集的存储介质。此外，本发明还涉及一种系统，其包括用于比较可操作地连接到数据存储介质的样品的代谢物的特征值的装置。本发明进一步包括的是诊断方法，其包括至少一种生物元素和所述至少一种代谢产物用于制造用于诊断前列腺癌或用于诊断前列腺癌的诊断方法。最后，本发明涉及鉴定前列腺癌相关代谢物的方法。

9. 发明申请

WO2010007106A1 MEANS AND METHODS DIAGNOSING GASTRIC BYPASS AND CONDITIONS RELATED THERETO 审中-公开
标题翻译：方法和方法诊断与之相关的气体旁路和条件
公开(公告)号：WO2010007106A1
公开(公告)日：2010-01-21
申请号：PCT/EP2009/059091
申请日：2009-07-15
申请人： METANOMICS HEALTH GMBH , INSERM-TRANSFERT SA , FUHRMANN, Jens , REIN, Dietrich , KAMLAGE, Beate , WIEMER, Jan C , HEROLD, Michael Manfred , CLEMENT, Karine , MUTCH, David M.
发明人： FUHRMANN, Jens , REIN, Dietrich , KAMLAGE, Beate , WIEMER, Jan C , HEROLD, Michael Manfred , CLEMENT, Karine , MUTCH, David M.
IPC分类号： G01N33/50
CPC分类号： G01N33/6893 , G01N33/5023 , G01N2800/042 , G01N2800/044
摘要： The present invention relates to the field of diagnostic measures. Specifically, it contemplates a method for assessing whether gastric bypass therapy was successful in a subject, a method of predicting whether gastric bypass therapy will be beneficial for a subject in need thereof, and a method of diagnosing whether a supportive therapy accompanying gastric bypass has beneficial effects on a subject in need thereof. Further provided are diagnostic methods for diabetes and body lean mass. Furthermore, the invention relates to a method for identifying a treatment against diabetes and/or obesity.
摘要翻译：本发明涉及诊断措施领域。具体地，本发明涉及一种用于评估胃旁路治疗是否成功的方法，预测胃旁路治疗是否有益于有需要的受试者的方法，以及诊断伴随胃旁路的支持治疗是否具有益处的方法对有需要的受试者的影响。还提供了糖尿病和身体瘦体重的诊断方法。此外，本发明涉及鉴定抗糖尿病和/或肥胖症的治疗方法。

10. 发明申请

WO2016016065A1 MEANS AND METHODS FOR ASSESSING A QUALITY OF A BIOLOGICAL SAMPLE 审中-公开
标题翻译：用于评估生物样品质量的手段和方法
公开(公告)号：WO2016016065A1
公开(公告)日：2016-02-04
申请号：PCT/EP2015/066777
申请日：2015-07-22
申请人： METANOMICS HEALTH GMBH
发明人： KAMLAGE, Beate , SCHMITZ, Oliver , PETER, Erik
IPC分类号： G06F19/00
CPC分类号： G06F19/24 , G06F19/707
摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention relates to a method for assessing a quality of a biological sample comprising the steps of: (a) providing a table comprising a number of entries, wherein each entry comprises a compound, at least one parameter, and a scoring factor, wherein, in case the compound is a natural compound it refers to an analyte, or in case the compound is an artificial compound it refers to a ratio of two analytes, wherein the at least one parameter is related to the compound, wherein the parameter related to the analyte is derived from at least one recorded value for the analyte while the parameter related to the ratio of the two analytes is derived from a ratio of at least one recorded value of the two analytes, and wherein the scoring factor is related to the compound; (b) determining for each of the compounds in the table a compound quality score, wherein the compound quality score is determined by taking a multiple value of the scoring factor related to the compound, wherein, depending on the actual value of the at least one parameter related to the compound, the multiple value is selected, wherein the multiple value comprises an integral number or a decimal number by which the scoring factor related to the compound is multiplied; (c) deriving at least one sample quality score by summing up the compound quality scores for the compounds in the table as determined in step (b); and (d) comparing the at least one sample quality score as derived in step (c) with at least one reference quality score, by which comparison the quality of the sample is assessed. The invention further relates to tools for performing the mentioned method, such as a device and a kit, as well as a use of components or a detection agent therefore for assessing the quality of a biological sample. The invention particularly provides for, preferably automatically, identifying a correct sample type and, concurrently, assessing the sample quality, in particular, with respect to its preanalytical phase.
摘要翻译：本发明涉及诊断方法领域。具体地，本发明涉及一种用于评估生物样品质量的方法，包括以下步骤：（a）提供包括多个条目的表，其中每个条目包含化合物，至少一个参数和评分因子其中，在化合物是天然化合物的情况下，其指分析物，或者在化合物是人造化合物的情况下，其是指两种分析物的比例，其中至少一个参数与化合物相关，其中参数与分析物相关的衍生自分析物的至少一个记录值，而与两种分析物的比率相关的参数来自两种分析物的至少一个记录值的比率，并且其中评分因子与化合物（b）确定表格中每一化合物的化合物品质分数，其中化合物质量分数是通过取与化合物相关的评分因子的多重值来确定的，其中根据至少一种化合物的实际值与该化合物相关的参数，选择该多重值，其中该多值包括与化合物相关的评分因子相乘的整数或十进制数; （c）通过总结在步骤（b）中确定的表中化合物的化合物质量得分来得出至少一个样品质量分数; 和（d）将步骤（c）中导出的至少一个样品质量分数与至少一个参考质量分数进行比较，通过该比较评估样品的质量。本发明还涉及用于执行所述方法的工具，例如装置和试剂盒，以及因此用于评估生物样品质量的组分或检测剂的使用。本发明特别提供，优选地自动地识别正确的样品类型，并且特别地，特别地关于其分析前阶段来评估样品质量。

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