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1. 发明申请

WO2019121942A1 METHODS FOR DIAGNOSING PANCREATIC CANCER 审中-公开
公开(公告)号：WO2019121942A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/085882
申请日：2018-12-19
申请人： METANOMICS HEALTH GMBH , UNIVERSITAETSMEDIZIN GREIFSWALD
发明人： KAMLAGE, Beate , CHRISTIANSEN, Nicole , SCHATZ, Philipp , PILARSKY, Christian , GRUETZMANN, Robert , BAHRA, Marcus , MAYERLE, Julia , LERCH, Markus , CHROMIK, Ansgar Michael
IPC分类号： G01N33/574 , G01N33/68
CPC分类号： G01N33/57438 , G01N33/6812
摘要： The present invention relates to a method for diagnosing pancreatic cancer in a subject suspected to suffer from pancreatic cancer comprising the steps of: (a) determining in a sample of said subject the value of (i) at least one biomarker of the categories carnitines, amino acids, and mitochondrial energy metabolites, and (ii) a first and a second sphingolipid, wherein the fatty acid residue of the first sphingolipid is at least four carbon atoms longer than the fatty acid residue of the second sphingolipid, and wherein the sphingosine backbone of the first sphingolipid and the second sphingolipid are identical;and (b) comparing the values of the biomarkers with references, whereby pancreatic cancer is diagnosed; and to a method for identifying whether a subject is in need of a pancreatic cancer therapy related thereto. The present invention further relates to a device for diagnosing pancreatic cancer in a sample of a subject comprising (a) an analyzing unit for the sample of the subject comprising a detector for the amounts of at least one biomarker each of the categories carnitines, amino acids, energy metabolites, and sphingolipids; said detector allowing for the determination of the amounts of the biomarkers of the said group of biomarkers in the sample; and operatively linked thereto, (b) an evaluation unit comprising a data processing unit and a data base, said data base comprising a stored reference and said data processing unit having tangibly embedded an algorithm for carrying out a comparison of the amounts of the biomarkers of the group of biomarkers determined by the analyzing unit and the stored reference and for generating an output information based on which the diagnosis can be established. Further, the present invention relates to a data collection and too a use related to the aforesaid subject matter.

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