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1. 发明申请

WO0214350A3 PEPTIDE AND PEPTIDE MIMETIC DERIVATIVES WITH INTEGRIN INHIBITOR PROPERTIES II 审中-公开
标题翻译：肽和拟肽衍生物与整合酶抑制剂特点II
公开(公告)号：WO0214350A3
公开(公告)日：2002-09-19
申请号：PCT/EP0108931
申请日：2001-08-02
申请人： MERCK PATENT GMBH , MEYER JOERG , NIES BERTHOLD , DARD MICHEL , HOELZEMANN GUENTER , KESSLER HORST , KANTLEHNER MARTIN , HERSEL ULRICH , GIBSON CHRISTOPH , SULYOK GABOR
发明人： MEYER JOERG , NIES BERTHOLD , DARD MICHEL , HOELZEMANN GUENTER , KESSLER HORST , KANTLEHNER MARTIN , HERSEL ULRICH , GIBSON CHRISTOPH , SULYOK GABOR
IPC分类号： A61L27/00 , A61K38/00 , A61P41/00 , C07K7/06 , C07K7/08 , C07K14/78 , A61K31/195 , A61K38/39 , A61L33/00 , C07C279/18
CPC分类号： C07K7/06 , A61K38/00 , C07K14/78 , Y02P20/125
摘要： The invention relates to compounds of formula (I) B-Q-X1, wherein B is a bioactive, cell adhesive mediating molecule, selected from the group (i) and Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (ii), Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (iii), Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (iv), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg (v), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn (vi), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg (vii), wherein (i) X, Y, Z, R , R , R , A, Ar, Hal, Het, Het , n, m, o, p, q, s, t have the meanings cited in Claim 1, Q is absent or is an organic spacer molecule, X1 is an anchor molecule selected from the group cited in Claim 1, and the salts thereof, which can be used as integrin inhibitors particularly for treatment of illnesses, deficiencies and inflammations caused by implants and osteolytic illnesses such as osteoporosis, thrombosis, cardiac infarction and arteriosclerosis, in addition to the acceleration and strengthening of the integration process of implants or the biocompatible surface in tissue.
摘要翻译：式（I）的化合物：BQ-X1，其中B是生物活性，zelladhäsionsvermittelndes分子从组（i）和Thr-TRP-酪氨酸 - 赖氨酸 - 异亮氨酸 - 丙氨酸 - 苯丙氨酸 - 谷氨酰胺 - 精氨酸 - 天冬酰胺 - 精氨酸 - 赖氨酸选择（ii）中，TRP-酪氨酸 - 赖氨酸 - 异亮氨酸 - 丙氨酸 - 苯丙氨酸 - 谷氨酰胺 - 精氨酸 - 天冬酰胺 - 精氨酸 - 赖氨酸（iii）中，酪氨酸 - 赖氨酸 - 异亮氨酸 - 丙氨酸 - 苯丙氨酸 - 谷氨酰胺 - 精氨酸 - 天冬酰胺 - 精氨酸 - 赖氨酸（ⅳ ），苏氨酸-TRP-酪氨酸 - 赖氨酸 - 异亮氨酸 - 丙氨酸 - 苯丙氨酸 - 谷氨酰胺 - 精氨酸 - 天冬酰胺 - 精氨酸（v），苏氨酸-TRP-酪氨酸 - 赖氨酸 - 异亮氨酸 - 丙氨酸 - 苯丙氨酸 - 谷氨酰胺 - 精氨酸 - 天冬酰胺（VI）， THR-TRP-酪氨酸 - 赖氨酸 - 异亮氨酸 - 丙氨酸 - 苯丙氨酸 - 谷氨酰胺 - 精氨酸（VII），其中对于（I）中X，Y，Z，R <2>，R <3>，R <4>中，A中，Ar 中，Hal中，Het中，Het <1>中，n，M，O，p，Q，S，T具有权利要求1中所示的含义，Q不存在或者为有机间隔分子，X 1是锚定分子，权利要求在从所选择的图1是指定的组，以及它们的盐可以用作整联蛋白抑制剂，特别是用于引起植入物，缺陷，炎症和溶骨性疾病如骨质疏松症，血栓形成，心脏梗塞和动脉粥样硬化的疾病的治疗，并且还为INTEGRA的加速和强化植入物或生物相容的表面的onsprozesses在所述组织中。

2. 发明申请

WO9852619A3 PEPTIDE-COATED IMPLANTS AND METHODS FOR PRODUCING SAME 审中-公开
标题翻译：用于生产它们的胶粘剂的植入物及其方法
公开(公告)号：WO9852619A3
公开(公告)日：1999-03-18
申请号：PCT/EP9802753
申请日：1998-05-09
申请人： MERCK PATENT GMBH , KESSLER HORST , FINSINGER DIRK , JONCZYK ALFRED , MEYER JOERG , NIES BERTHOLD , KANTLEHNER MARTIN
发明人： KESSLER HORST , FINSINGER DIRK , JONCZYK ALFRED , MEYER JOERG , NIES BERTHOLD , KANTLEHNER MARTIN
IPC分类号： A61F2/02 , A61K35/12 , A61L27/00 , A61L27/34 , C07K5/08 , C07K5/10 , C07K5/12 , C12N5/00 , C12N5/077 , A61L
CPC分类号： C12N5/0068 , A61K35/12 , A61L27/34 , C12N5/0654 , C12N2533/50 , C08L89/00
摘要： The invention describes the possibility of the biofunctionalization of biomaterials, in particular implants, by their made-to-measure coating with synthesized cell- or tissue-selective RGD peptides which in vitro stimulate the adhesion of mainly those cell species which in each case are intended to accomplish the tissue integration of the appropriate biomaterial.

3. 发明申请

WO9843685A3 BONE CEMENT PASTE CONTAINING AN ANTIBIOTIC 审中-公开
标题翻译：骨灰泥含有抗生素
公开(公告)号：WO9843685A3
公开(公告)日：1999-01-07
申请号：PCT/EP9801546
申请日：1998-03-17
申请人： MERCK PATENT GMBH , WENZ ROBERT , NIES BERTHOLD
发明人： WENZ ROBERT , NIES BERTHOLD
IPC分类号： A61F2/00 , A61L24/00 , A61L24/02 , A61L27/12 , A61L27/54 , A61L25/00
CPC分类号： A61L27/12 , A61F2310/00293 , A61L24/0015 , A61L24/02 , A61L27/54 , A61L2300/406 , A61L2300/602 , A61L2300/80 , A61L2400/06 , A61L2430/02
摘要： The invention relates to a bone cement paste which can be injected and hardened, with a base consisting of compounds similar to bioresorbable hydroxyapatite, containing calcium phosphate. The cement paste also contains a cationic antibiotic in the form of a salt, preferably its sulfate. The hardened, biodegradable bone cement releases the antibiotic over a long period of time in biologically effective concentrations, in a depot-type effect. The inventive bone cements are suitable for treating infectious inflammations of bone and bone marrow, especially those resulting from bone defects and bone fractures.

4. 发明申请

WO9836782A3 BONE SUBSTITUTE MATERIAL WITH A SURFACE COATING OF PEPTIDES HAVING AN RGD AMINO ACID SEQUENCE 审中-公开
标题翻译：具有RGD氨基酸序列的肽的表面涂层的骨代替材料
公开(公告)号：WO9836782A3
公开(公告)日：1998-11-19
申请号：PCT/EP9800742
申请日：1998-02-11
申请人： MERCK PATENT GMBH , NIES BERTHOLD
发明人： NIES BERTHOLD
IPC分类号： A61L27/00 , A61L27/34 , A61L27/56
CPC分类号： A61L27/56 , A61L27/34 , C08L89/00
摘要： The invention relates to a bone substitute material based on a porous polymer material the surface of which is coated with peptides having an RGD amino acid sequence.

5. 发明申请

WO2008116905A3 IMPLANT MATERIAL BASED ON A POLYMER SYSTEM AND THE USE THEREOF 审中-公开
标题翻译：植入材料基于聚合物系统及其用途
公开(公告)号：WO2008116905A3
公开(公告)日：2009-09-17
申请号：PCT/EP2008053640
申请日：2008-03-27
申请人： INNOTERE GMBH , NIES BERTHOLD
发明人： NIES BERTHOLD
IPC分类号： A61L24/00 , A61L24/04 , A61L27/14 , A61L27/44
CPC分类号： A61L24/0042 , A61L24/0036 , A61L24/0073 , A61L27/44 , A61L27/56 , A61L27/58
摘要： The invention relates to an implant material based on a polymer system composed of at least two components and the use thereof as a bone cement, bone replacement material, or active ingredient carrier. The implant material according to the invention is based on a polymer system and composed of at least two components that react with one another upon mixing and form a polymer-based solid, wherein the first component of the polymer system is a paste comprising at least one biocompatible polymer powder and a starter component for the initiation of a polymerization reaction upon mixing, wherein the paste is formed with the aid of a carrier liquid, wherein, under normal conditions, the polymer powder does not dissolve or significantly swell in the carrier liquid and the starter component remains stable until being mixed with the second component of the polymer system, and wherein the second component of the polymer system comprises at least one reactive organic liquid or a solution or a suspension of a reactive organic liquid and a polymer.
摘要翻译：本发明涉及基于包含至少2种组分的聚合物系统上的植入材料，其作为骨水泥，骨替换材料或赋形剂的用途。根据本发明的聚合物体系的基础上，所述植入物材料由其中当混合在一起以形成反应至少2成分的聚合物为基础的固体，其中所述聚合物系统的第一组分是含有至少一种生物相容的聚合物粉末的糊剂，并用于在混合引发聚合反应的引发剂组分包括，其中所述糊状物是通过载液，其中在所述载体液中，所述聚合物粉末不正常条件下溶解或显著溶胀的装置形成，并且所述引发剂组分到混合物中保持稳定的聚合物体系的第二组分，并且其中所述聚合物体系的第二组分的至少一种反应性含有有机液体或溶液或悬浮液的反应性有机液体和聚合物。

6. 发明申请

WO2007090373A3 NOVEL ADHESIVES FOR MEDICAL APPLICATIONS 审中-公开
标题翻译：新胶粘剂用于医疗应用
公开(公告)号：WO2007090373A3
公开(公告)日：2008-08-07
申请号：PCT/DE2007000192
申请日：2007-02-02
申请人： UNIV ROSTOCK , BEHREND DETLEF , SCHMITZ KLAUS-PETER , STERNBERG KATRIN , SCHMOHL KATHLEEN , KRAMER SVEN , NIES BERTHOLD
发明人： BEHREND DETLEF , SCHMITZ KLAUS-PETER , STERNBERG KATRIN , SCHMOHL KATHLEEN , KRAMER SVEN , NIES BERTHOLD
IPC分类号： A61L24/10 , C09J189/00
CPC分类号： C09J175/04 , A61L24/043 , C08G18/10 , C08G18/428 , C08G18/6446 , C08L89/00 , C09J189/00 , Y10T428/2982 , C08L67/04 , C08G18/64
摘要： The invention relates to adhesives, particularly medical adhesives, suited for gluing hard and soft tissue. A combinatory preparation consisting of peptides, terminally functionalized oligolactones and, optionally, catalysts of a cross-linking reaction between these components is disclosed.
摘要翻译：本发明涉及粘合剂，尤其适用于硬和软组织的接合医用粘合剂。本发明公开的肽末端官能oligolactones和任选的催化剂，交联这些组分之间的反应的组合制剂。

7. 发明申请

WO2006122678A2 BIOACTIVE BONE CEMENT AND METHOD FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：生物活性骨水泥及其制造方法
公开(公告)号：WO2006122678A2
公开(公告)日：2006-11-23
申请号：PCT/EP2006004330
申请日：2006-05-09
申请人： NIES BERTHOLD
发明人： NIES BERTHOLD
IPC分类号： A61L24/06
CPC分类号： A61L24/06 , A61L24/001 , A61L27/16 , A61L27/50 , A61L2430/02 , C08L33/08
摘要： The invention relates to a novel bioactive and osteoconductive bone cement and a method for producing the same from polyacrylates or polymethylacrylates by adding small amounts of polymerizable monomers containing anionic groups which cause the cement surface to mineralize after being incubated in simulated body fluid and in which the obtained mineralized layers contain calcium phosphate phases such that the formation of fibrous intermediate layers is prevented once the bone cement has been implanted in bones. Optionally, other additives, e.g. biocompatible calcium salts, and/or biocompatible buffer substances, or x-ray contrasting agents, antibiotics, antimicrobial agents, and/or anti-inflammatory agents can be added in order to improve the properties of the cement for individual purposes. The invention also relates to the use of the disclosed bone cement for anchoring prosthesis components in the bone, stiffening bones, filling and reconstructing all types of bone defects, as dowels for bone screws, or as an implant material for anchoring screws and other implants used for osteosynthesis.
摘要翻译：本发明描述了一种新的骨粘固剂，其是生物活性和骨传导性，以及用于其生产的聚丙烯酸酯或聚与添加少量含有可导致水泥表面的矿化在模拟体液中温育后的阴离子基团的聚合性单体中的方法，并在其中矿化所得的各层包含在它们的组成磷酸钙相，从而使植入到骨后，纤维中间层的形成被抑制。，此外，任选的进一步的添加剂，例如。 B.生物相容的钙盐，和/或生物相容的缓冲液中添加，或甚至X射线造影剂，抗生素; 为了抗微生物剂和/或抗炎剂，以改善水泥个别用途的性质。本发明进一步提供根据本发明的用于在骨锚固假体部件，用于加强骨，用于填充和任何种类的骨缺损的修复中使用的骨水泥，作为锚用于骨螺钉或作为用于锚定螺钉包括植入材料植入物接骨。

8. 发明申请

WO2005009481A3 SURFACTANT-CONTAINING BONE CEMENT 审中-公开
标题翻译：可持续的骨水泥
公开(公告)号：WO2005009481A3
公开(公告)日：2005-03-24
申请号：PCT/DE2004001572
申请日：2004-07-16
申请人： BIOMET DEUTSCHLAND GMBH , NIES BERTHOLD , SCHILKE FRANK , PIETSCH HANNS
发明人： NIES BERTHOLD , SCHILKE FRANK , PIETSCH HANNS
IPC分类号： A61L24/00 , A61L24/06
CPC分类号： A61L24/0094 , A61L24/0015 , A61L24/06 , A61L2300/406 , A61L2300/602 , A61L2300/802 , A61L2430/02 , C08L33/12
摘要： The invention relates to a bone cement based on PMMA, comprising a liquid component and a solid component, whereby said liquid component contains 50 - 85 wt. % of monomeric methylmethacrylate, 5 - 50 wt. % of surfactant, 0.2 - 5 wt. % of an accelerator and optionally small amounts of other adjuvants. Said invention also relates to the use of non-ionic surfactants, such as sorbitan monolaurate, sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate or polyoxyethylene sorbitan trioleate in PMMA bone cements containing active substances, for an improved release of antibiotic agents.
摘要翻译：本发明描述了，50的液体成分基于PMMA由液体和固体成分的骨水泥 - 85％（重量）的单体甲基丙烯酸甲酯，5 - 50重量％的表面活性剂，0.2 - 5重量％的促进剂，任选地小。其他赋形剂的量。此外，本发明涉及使用非离子表面活性剂如脱水山梨醇单月桂酸酯，山梨醇单油酸酯，聚氧乙烯山梨醇单硬脂酸酯，聚氧乙烯山梨醇单油酸酯或在含有药物的PMMA骨聚氧乙烯山梨醇三油酸酯水泥改进抗生素药剂的释放。

9. 发明申请

WO2008148878A3 HYDRAULIC CEMENT-BASED IMPLANT MATERIAL AND USE THEREOF 审中-公开
标题翻译：植入材料，以一个硬性水泥，及其用途
公开(公告)号：WO2008148878A3
公开(公告)日：2009-11-26
申请号：PCT/EP2008057099
申请日：2008-06-06
申请人： INNOTERE GMBH , NIES BERTHOLD
发明人： NIES BERTHOLD
IPC分类号： A61K6/02 , A61K6/06 , A61L24/02
CPC分类号： A61L24/0084 , A61K6/0008 , A61K6/0023 , A61K6/0067 , A61K6/0643 , A61K6/0675 , A61L24/02 , A61L27/40 , A61L2430/02 , C08L71/02 , C08L33/08
摘要： The invention relates to implant materials that are based on hydraulic cements in the form of one or more pastes, suspensions or dispersions that contain mineral and/or organic and/or organomineral solids and that react, when combined or when reacted with an aqueous liquid, to a solid in a cement-type initiation reaction. The invention also relates to the use of these materials as technical, medical-technical and/or pharmaceutical products, especially as bone cements, bone replacement materials, bone glues, dental filling materials and implantable active ingredient carriers. The implant materials according to the invention in the form of one or more pastes, suspensions or dispersions that contain mineral and/or organic and/or organomineral solids are formulated in an excipient liquid in such a manner that the pastes, suspensions or dispersions are stable in storage at normal conditions over a prolonged period of time and that they react, when combined with an aqueous liquid or when added to an aqueous liquid, in a cement-type initiation reaction and set to a solid. The excipient liquid of the mineral paste, suspension or dispersion is substantially water-free, and water immiscible or insoluble or hardly soluble in water in the chemical sense.
摘要翻译：本发明涉及基于在一种或多种矿物的形式的水硬性水泥植入物材料和/或有机的和/或有机矿物糊剂，悬浮液或分散体，其组合或反应中反应以在水泥凝固反应的固体的含水液体以及含固体的其使用作为工业，医疗和/或药物产品，特别是作为骨接合剂，骨替换材料，骨粘合剂，牙齿的填充材料和可植入的药物递送。根据本发明中一种或多种矿物的形式的植入物材料和/或有机的和/或有机矿物糊，悬浮液中或在载体液体配制的分散体含固体的，该糊剂，悬浮液或分散体是储存在正常条件下长时间稳定，并且它们在组合与水性液体或通过引入反应成水性液体在水泥凝固反应并凝固成固体。这里，矿物浆，悬浮液或分散体，基本上无水的，并且在化学意义上的载体液是不与水混溶或不或仅微溶于水。

10. 发明申请

WO2008064672A3 BONE IMPLANT, AND SET FOR THE PRODUCTION OF BONE IMPLANTS 审中-公开
标题翻译：骨植入并为骨植入物生产
公开(公告)号：WO2008064672A3
公开(公告)日：2009-07-23
申请号：PCT/DE2007002185
申请日：2007-11-27
申请人： NIES BERTHOLD
发明人： NIES BERTHOLD
IPC分类号： A61F2/28 , A61L27/04 , A61L27/12 , A61L27/30 , A61L27/54 , A61L27/56
CPC分类号： A61F2/28 , A61F2/0095 , A61F2/30767 , A61F2/3094 , A61F2002/2817 , A61F2002/30011 , A61F2002/30062 , A61F2002/30092 , A61F2002/30677 , A61F2002/3092 , A61F2210/0004 , A61F2210/0014 , A61F2250/0023 , A61F2310/00011 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00041 , A61F2310/00095 , A61F2310/00113 , A61F2310/00125 , A61F2310/00131 , A61F2310/00155 , A61F2310/00293 , A61F2310/00365 , A61F2310/00383 , A61F2310/00395 , A61L27/04 , A61L27/12 , A61L27/30 , A61L27/54 , A61L27/56 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/602 , A61L2430/02
摘要： The invention relates to bone implants and sets for producing bone implants. Said bone implants are made from pasty or cementitious preparations which are introduced into open-cell metal structures comprising an interconnected pore system as solid or porous materials and are optionally allowed to set, the metal structure per se being biocompatible in biological conditions and being stable or corrodible. The bone implant according to the invention contains at least one open-cell metal structure that has an interconnected pore system which is at least partially filled with a preparation made of at least one bone replacement material. The open-cell metal structure is significantly less rigid than the solid material made of the same metal.
摘要翻译：本发明涉及一种骨植入物，并设置用于生产骨植入物的。它们由糊状或水泥样制剂，其被引入作为与interkonnektieiendem孔系统开孔金属结构的固体或多孔群众，如果有必要的固化，金属结构，即使在生物条件是生物相容的，并且可以是稳定的或可腐蚀的。本发明的骨植入物包含与一个互连孔体系孔系统至少部分地填充有制剂的至少一种骨替代材料的，其中该开孔金属结构的刚性比相同的金属的固体材料的现有的显著下的至少一个开孔的金属结构。

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