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1. 发明申请

WO2007134678A2 TRIAZOLE DERIVATIVES II 审中-公开
标题翻译：三唑衍生物II
公开(公告)号：WO2007134678A2
公开(公告)日：2007-11-29
申请号：PCT/EP2007003478
申请日：2007-04-20
申请人： MERCK PATENT GMBH , EGGENWEILER HANS-MICHAEL , WOLF MICHAEL , BUCHSTALLER HANS-PETER , SIRRENBERG CHRISTIAN
发明人： EGGENWEILER HANS-MICHAEL , WOLF MICHAEL , BUCHSTALLER HANS-PETER , SIRRENBERG CHRISTIAN
IPC分类号： C07D249/08 , A61K31/4196 , A61P35/00
CPC分类号： C07D249/08 , C07D401/12 , C07D403/12
摘要： Novel triazole derivatives of formula (I), where R 1 , R 6 and Y have the meanings given in claim 1 are HSP90 inhibitors and can be used for production of a medicament for treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译：式（I）的新的三唑衍生物，其中R ^{1 -R ^{6 和Y具有权利要求1中给出的含义，是HSP90抑制剂，可用于制备药物的用于治疗是其中HSP90的抑制，调节和/或调制起着用于作用的疾病。}}

2. 发明申请

WO2006087077A3 HSP90-INHIBITING TRIAZOLE DERIVATIVES 审中-公开
标题翻译： HSP90抑制作用三唑
公开(公告)号：WO2006087077A3
公开(公告)日：2006-11-02
申请号：PCT/EP2006000631
申请日：2006-01-25
申请人： MERCK PATENT GMBH , EGGENWEILER HANS-MICHAEL , WOLF MICHAEL
发明人： EGGENWEILER HANS-MICHAEL , WOLF MICHAEL
IPC分类号： C07D249/12 , A61K31/4192 , A61K31/4196 , A61K31/427 , A61P3/10 , A61P11/06 , A61P17/00 , A61P19/02 , A61P31/12 , A61P35/00
CPC分类号： C07D249/12
摘要： The invention relates to novel triazole derivatives of formula (I) wherein R 1 - R 6 and Y have the designations cited in patent claim 1. Said derivatives are HSP90 inhibitors, and can be used to produce a medicament for treating diseases wherefore the inhibition, regulation and/or modulation of HSP90 plays an important role.
摘要翻译：式（I）的新的三唑衍生物，其中R ^{1 - R的^{6 和Y具有权利要求1中给出的含义，是HSP90抑制剂，可用于制备药物的用于治疗是其中HSP90的抑制，调节和/或调制起着用于作用的疾病。}}

3. 发明申请

WO0136425A3 IMIDAZOLE COMPOUNDS USED AS PHOSPHODIESTERASE VII INHIBITORS 审中-公开
标题翻译：咪唑化合物作为磷酸VII抑制剂
公开(公告)号：WO0136425A3
公开(公告)日：2002-01-10
申请号：PCT/EP0010765
申请日：2000-10-31
申请人： MERCK PATENT GMBH , EGGENWEILER HANS MICHAEL , JONAS ROCHUS , WOLF MICHAEL , GASSEN MICHAEL , WELGE THOMAS
发明人： EGGENWEILER HANS MICHAEL , JONAS ROCHUS , WOLF MICHAEL , GASSEN MICHAEL , WELGE THOMAS
IPC分类号： A61K31/5383 , A61K31/542 , A61P1/04 , A61P3/10 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D498/06 , C07D513/06 , A61K31/5365 , A61P37/00
CPC分类号： C07D513/06
摘要： The invention relates to the use of imidazole compounds of formula (I), wherein: R and R , independent of one another, represent H, A , OA , SA or Hal; A represents H, A, alkenyl, cycloalkyl or alkylene cycloalkyl; A represents alkyl having 1-10 C atoms; Hal represents F, Cl, Br or I, and; X represents O, S, SO or SO2, as well as the physiologically compatible salts and/or solvates of said imidazole compounds as phosphodiesterase VII inhibitors, and to their use for producing a medicament.
摘要翻译：式（I）其中，R <1>，R <2>各自独立地是H，A <1>，OA <1>，SA <1>或Hal，A <1>是H，A，烯基，环烷基的咪唑化合物平均值或alkylenecycloalkyl，A表示具有1-10个C原子的烷基中，Hal是F，Cl，Br或I，和X是O，S，SO，或SO 2，和生理学可接受的盐和/或溶剂化物，如磷酸二酯酶VII抑制剂和它们的使用制备药物。

4. 发明申请

WO2006125531A3 THIENOPYRIDINES 审中-公开
标题翻译：噻吩并吡啶
公开(公告)号：WO2006125531A3
公开(公告)日：2007-04-12
申请号：PCT/EP2006004426
申请日：2006-05-11
申请人： MERCK PATENT GMBH , EGGENWEILER HANS-MICHAEL , WOLF MICHAEL
发明人： EGGENWEILER HANS-MICHAEL , WOLF MICHAEL
IPC分类号： C07D495/04 , A61K31/4365 , A61P35/00
CPC分类号： C07D495/04
摘要： The invention relates to novel thienopyridine derivatives of formula (I), wherein R1, R2, R3, R4 and Y have the meaning cited in claim 1, are HSP90-inhibitors and can be used for producing a medicament for treating illnesses, wherein the inhibition, regulation and/or modulation of HSP90 plays a roll.
摘要翻译：式（I）的新的噻吩并吡啶衍生物，其中R1，R2，R3，R4和Y具有权利要求1中给出的含义，是HSP90抑制剂，可用于制备用于治疗疾病的治疗，其中抑制，调节和/或调制是HSP90的发挥了作用，使用。

5. 发明申请

WO0134601A2 IMIDAZOPYRIDINE DERIVATIVES USED AS PHOSPHODIESTERASE VII INHIBITORS 审中-公开
标题翻译：作为磷酸二酯酶VII的咪唑并吡啶衍生物
公开(公告)号：WO0134601A2
公开(公告)日：2001-05-17
申请号：PCT/EP0010525
申请日：2000-10-25
申请人： MERCK PATENT GMBH , EGGENWEILER HANS MICHAEL , ACKERMANN KARL AUGUST , JONAS ROCHUS , WOLF MICHAEL , GASSEN MICHAEL , WELGE THOMAS
发明人： EGGENWEILER HANS MICHAEL , ACKERMANN KARL-AUGUST , JONAS ROCHUS , WOLF MICHAEL , GASSEN MICHAEL , WELGE THOMAS
IPC分类号： A61K31/437 , A61P1/00 , A61P1/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/10 , A61P31/18 , A61P37/06 , A61P37/08 , A61P43/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I), wherein R means CONR R ; R means H or A; R means Hal; R and R each mean H or A , independently of each other; Hal is F, Cl, Br or I, A means alkyl with 1-4 C atoms, A means alkyl with 1-10 C atoms; and X means alkylene with 1-4 C atoms, an ethylene group also being replaceable by a double or triple bond, and their physiologically compatible salts and/or solvates, used as phosphodiesterase VII inhibitors. The invention also relates to their use for producing a medicament.
摘要翻译：式（I）化合物，其中R 1 CONR 4 R 5; R 2 H或A; R 3 Hal; R 4，R 5各自独立地为H或A 1; Hal，F，Cl，Br或I; A是具有1-4个C原子的烷基，A 1是具有1-10个C原子的烷基; X是具有1-4个C原子的亚烷基，其中亚乙基也可以被双键或三键代替，和它们的生理上可接受的盐和/或溶剂合物，作为磷酸二酯酶VII抑制剂及其在制备药物中的用途。

6. 发明申请

WO0059484A2 USE OF ARYLALKANOYLPYRIDAZINES 审中-公开
标题翻译：使用ARYLALKANOYLPYRIDAZINEN的
公开(公告)号：WO0059484A2
公开(公告)日：2000-10-12
申请号：PCT/EP0002280
申请日：2000-03-15
申请人： MERCK PATENT GMBH , ROCHUS JONAS , WOLF MICHAEL , BEIER NORBERT , KLUXEN FRANZ WERNER , FITTSCHEN CLAUS
发明人： ROCHUS JONAS , WOLF MICHAEL , BEIER NORBERT , KLUXEN FRANZ-WERNER , FITTSCHEN CLAUS
IPC分类号： C07D237/04 , A61K31/50 , A61K31/501 , A61P1/04 , A61P3/10 , A61P9/10 , A61P17/00 , A61P19/02 , A61P19/10 , A61P29/00 , A61P31/18 , A61P35/00 , A61K31/00
CPC分类号： A61K31/501 , A61K31/50
摘要： The invention relates to the use of compounds of formula (I), wherein R , R , Q and B have the meanings given in claim 1, and/or their physiologically compatible salts for producing a medicament for treating osteoporosis, tumours, arteriosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, ulcerative colitis and AIDS.
摘要翻译：式（I）的化合物的用途，其中R <1>，R <2>，Q和B具有权利要求1和/或它们的生理学上可接受的盐在给定的用于制造药物中的骨质疏松症的治疗的含义，肿瘤，动脉粥样硬化，类风湿关节炎，多发性硬化症，糖尿病，溃疡性结肠炎和AIDS。

7. 发明申请

WO0129049A3 IMIDAZOLE DERIVATIVES AS PHOSPHODIESTERASE VII INHIBITORS 审中-公开
标题翻译：咪唑衍生物AS磷酸二酯酶抑制剂VII
公开(公告)号：WO0129049A3
公开(公告)日：2001-11-01
申请号：PCT/EP0009926
申请日：2000-10-10
申请人： MERCK PATENT GMBH , EGGENWEILER MICHAEL , ROCHUS JONAS , WOLF MICHAEL , GASSEN MICHAEL , POESCHKE OLIVER
发明人： EGGENWEILER MICHAEL , ROCHUS JONAS , WOLF MICHAEL , GASSEN MICHAEL , POESCHKE OLIVER
IPC分类号： A61K31/4188 , A61P1/04 , A61P3/10 , A61P7/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/06 , A61P43/00 , C07D491/04 , C07D491/052 , C07D495/04
CPC分类号： C07D491/04 , C07D495/04
摘要： The invention relates to imidazole derivatives of formula (I), wherein R means H, A, benzyl, indane-5-yl, 1,2,3,4-tetrahydro-naphthaline-5-yl, dibenzothiophene-2-yl or phenyl that is unsubstituted or substituted once, twice or three times by means of Hal, A, A-CO-NH, benzyloxy, alkoxy, COOH or COOA, R means H or A, X means O or S, Hal means F, Cl, Br or I and A means alkyl with 1 to 6 C-atoms. The invention also relates to the physiologically acceptable salts and/or solvates thereof acting as phosphodiesterase VII inhibitors. The invention further relates to the use thereof for producing a medicament.
摘要翻译：（I）式的咪唑衍生物，其中R是单 - <1> H，A，苄基，茚满-5-基，1,2,3,4-四氢萘-5-基，二苯并噻吩-2-基或未取代的或，二 - 或被Hal，A，A-CO-NH，苄氧基，烷氧基，COOH或COOA苯基，R三取代的<2> H或A，X是O或S中，Hal是F，Cl，Br或I，A是具有烷基意味着1〜6个碳原子，以及它们的physioligisch上可接受的盐和/或溶剂化物作为磷酸二酯酶VII抑制剂以及它们用于制备药物的用途。

8. 发明申请

WO2011063938A2 HEAT INSULATION SYSTEM FOR A BUILDING SHELL 审中-公开
标题翻译：建筑外壳的隔热系统
公开(公告)号：WO2011063938A2
公开(公告)日：2011-06-03
申请号：PCT/EP2010007108
申请日：2010-11-24
申请人： DOERKEN EWALD AG , SCHROEER JOERN , WAGNER-DITTRICH JANINE , KLINGELHAGE NORBERT , RAIDT HEINZ PETER , SCHOEBE DIRK , WITZKE ARNE , WOLF MICHAEL
发明人： SCHROEER JOERN , WAGNER-DITTRICH JANINE , KLINGELHAGE NORBERT , RAIDT HEINZ PETER , SCHOEBE DIRK , WITZKE ARNE , WOLF MICHAEL
IPC分类号： E04B1/80
CPC分类号： E04B1/803 , E04D13/1618 , Y02A30/242 , Y02B80/12
摘要： The invention relates to a heat insulation system (1) for a building shell, comprising at least one insulation board (5) having at least one vacuum insulation panel (6). According to the invention, an auxiliary batten (9) is provided on at least one edge of the insulation board (5) for connection to the base surface.
摘要翻译：本发明涉及一种用于建筑围护结构的隔热系统（1），其包括具有至少一个真空隔热板（6）的至少一个隔热板（5）。根据本发明，用于连接到地面的辅助板条（9）设置在绝缘板（5）的至少一个边缘侧上。

9. 发明申请

WO2009053218A3 GALVANIC SEPARATION BETWEEN CELL CHARGE BALANCE AND CONTROL OF A HYBRID DRIVE 审中-公开
标题翻译：细胞电荷补偿与混合驱动控制之间的电泳分离
公开(公告)号：WO2009053218A3
公开(公告)日：2009-10-29
申请号：PCT/EP2008062954
申请日：2008-09-26
申请人： BOSCH GMBH ROBERT , WOLF MICHAEL
发明人： WOLF MICHAEL
IPC分类号： H02J7/00 , B60L11/18
CPC分类号： H02J7/0014 , B60L11/18 , Y02T10/7005 , Y02T10/7055
摘要： The invention relates to a separating circuit for galvanic separation of a load circuit balance circuit of a hybrid drive for a control circuit, provided for controlling the load circuit balance circuit. The separating circuit has a balance circuit side, designed for galvanically connecting to the load circuit balance circuit and a control side designed for galvanically connecting to the control circuit. The separating circuit comprises a serial capacitive connection between the balance circuit side and the control side, designed to transmit an alternating voltage component of a modulated control circuit signal. The invention further relates to a balance circuit comprising said separating circuit and a corresponding method for galvanically uncoupled transmission of a balance control signal to a load circuit balance circuit.
摘要翻译：本发明涉及一种用于混合驱动器的负载电路补偿电路与用于控制负载电路补偿电路的控制电路的电流隔离的分离电路。该隔离器电路具有配置成电连接到负载电路平衡电路的平衡电路侧和配置成电连接到控制电路的控制侧。隔离电路包括均衡电路侧和控制侧之间的串联电容性连接，被配置为传输调制控制电路信号的AC电压分量。此外，本发明涉及具有根据本发明的分离电路的补偿电路以及用于将补偿控制信号电流解耦传输到负载电路补偿电路的相应方法。

10. 发明申请

WO2009027235A4 DEVICE AND METHOD FOR REPAIRING A PIPELINE 审中-公开
标题翻译： DEVICE AND METHOD FOR修复管道
公开(公告)号：WO2009027235A4
公开(公告)日：2009-05-22
申请号：PCT/EP2008060642
申请日：2008-08-13
申请人： FRAUNHOFER GES FORSCHUNG , PESCHKA MANFRED , WOLF MICHAEL
发明人： PESCHKA MANFRED , WOLF MICHAEL
IPC分类号： F16L55/168
CPC分类号： F16L55/1683
摘要： The invention relates to a method for repairing a pipeline by means of at least one shell (3) that is adapted to the outer contour of the pipeline (1), wherein the at least one shell (3) is attached to the outer wall of the pipeline (1) using an intermediate layer (4) between the interior of the shell (3) and the outer wall of the pipeline (1). According to the invention, the intermediate layer (4) is made of an adhesive that can be activated, which is used to substantially completely coat the interior of the at least one shell (3). The attachment of the shell is carried out by applying a force acting at least in the radial direction, and the activation of the adhesive (4). The invention further relates to a shell that is coated in this manner.
摘要翻译：本发明涉及由所述管的外轮廓中的至少一个的装置修复管道的方法（1），适用于外壳（3），其中，所述至少一个壳（3）与外壳的内侧之间的中间层（4）（3）和外壁管（1）在管（1）的外壁是固定的。中间层（4）是根据本发明的可活化的粘合剂与至少一个壳（3）的内部是完全涂覆的通过施加在半径方向上的力至少作用的力，并激活所述粘合剂（4）发生基本上杯的附着。本发明还涉及这种涂覆的托盘。

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