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1. 发明申请

WO2004000858A3 NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 审中-公开
标题翻译：作为RNA依赖性RNA病毒聚合酶抑制剂的核苷衍生物
公开(公告)号：WO2004000858A3
公开(公告)日：2005-05-12
申请号：PCT/US0319172
申请日：2003-06-17
申请人： MERCK & CO INC , ISIS PHARMACEUTICALS INC , CARROLL STEVEN S , OLSEN DAVID B , DURETTE PHILIPPE L , BHAT BALKRISHEN , DANDE PRASAD , ELDRUP ANNE B
发明人： CARROLL STEVEN S , OLSEN DAVID B , DURETTE PHILIPPE L , BHAT BALKRISHEN , DANDE PRASAD , ELDRUP ANNE B
IPC分类号： C07H19/067 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K38/21 , A61K45/00 , A61P31/14 , A61P43/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/167 , C07H19/20 , A61K31/70
CPC分类号： C07H19/04 , C07H19/06 , C07H19/10 , C07H19/12 , C07H19/16 , C07H19/167 , C07H19/20
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
摘要翻译：本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。还公开了本发明的核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

2. 发明申请

WO02057287A2 NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 审中-公开
标题翻译：作为RNA依赖性RNA病毒聚合酶抑制剂的核苷衍生物
公开(公告)号：WO02057287A2
公开(公告)日：2002-07-25
申请号：PCT/US0203086
申请日：2002-01-18
申请人： MERCK & CO INC , ISIS PHARMACEUTICALS INC , CARROLL STEVEN S , MACCOSS MALCOLM , OLSEN DAVID B , BHAT BALKRISHEN , BHAT NEELIMA , COOK PHILLIP DAN , ELDRUP ANNE B , PRAKASH THAZHA P , PRHAVC MARIJA , SONG QUANLAI
发明人： CARROLL STEVEN S , MACCOSS MALCOLM , OLSEN DAVID B , BHAT BALKRISHEN , BHAT NEELIMA , COOK PHILLIP DAN , ELDRUP ANNE B , PRAKASH THAZHA P , PRHAVC MARIJA , SONG QUANLAI
IPC分类号： C07D487/04 , A61K31/519 , A61K31/70 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K31/712 , A61K38/21 , A61K45/00 , A61K45/06 , A61P1/16 , A61P31/14 , A61P43/00 , C07D473/00 , C07D487/02 , C07H20060101 , C07H19/00 , C07H19/04 , C07H19/048 , C07H19/06 , C07H19/067 , C07H19/09 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/167 , C07H19/173 , C07H19/19 , C07H19/20 , C12N20060101
CPC分类号： C07H19/16 , A61K9/4858 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , A61K45/06 , C07D473/00 , C07D487/04 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/12 , C07H19/14 , C07H19/20 , Y02P20/582 , A61K2300/00
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
摘要翻译：本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。还公开了本发明的核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

3. 发明申请

WO02057425A3 NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 审中-公开
标题翻译：作为RNA依赖性RNA病毒聚合酶抑制剂的核苷衍生物
公开(公告)号：WO02057425A3
公开(公告)日：2005-04-21
申请号：PCT/US0201531
申请日：2002-01-18
申请人： MERCK & CO INC , ISIS PHARMACEUTICALS INC , CARROLL STEVEN S , LAFEMINA ROBERT L , HALL DAWN L , HIMMELBERGER AMY L , KUO LAWRENCE C , MACCOSS MALCOLM , OLSEN DAVID B , RUTKOWSKI CARRIE A , TOMASSINI JOANNE E , AN HAOYUN , BHAT BALKRISHEN , BHAT NEELIMA , COOK PHILLIP DAN , ELDRUP ANNE B , GUINOSSO CHARLES J , PRHAVC MARIJA , PRAKASH THAZHA P
发明人： CARROLL STEVEN S , LAFEMINA ROBERT L , HALL DAWN L , HIMMELBERGER AMY L , KUO LAWRENCE C , MACCOSS MALCOLM , OLSEN DAVID B , RUTKOWSKI CARRIE A , TOMASSINI JOANNE E , AN HAOYUN , BHAT BALKRISHEN , BHAT NEELIMA , COOK PHILLIP DAN , ELDRUP ANNE B , GUINOSSO CHARLES J , PRHAVC MARIJA , PRAKASH THAZHA P
IPC分类号： C07D487/04 , A61K31/519 , A61K31/70 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K31/712 , A61K38/21 , A61K45/00 , A61K45/06 , A61P1/16 , A61P31/14 , A61P43/00 , C07D473/00 , C07D487/02 , C07H20060101 , C07H19/00 , C07H19/04 , C07H19/048 , C07H19/06 , C07H19/067 , C07H19/09 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/167 , C07H19/173 , C07H19/19 , C07H19/20 , C12N20060101
CPC分类号： C07H19/16 , A61K9/4858 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , A61K45/06 , C07D473/00 , C07D487/04 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/12 , C07H19/14 , C07H19/20 , Y02P20/582 , A61K2300/00
摘要： The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside derivatives of the present invention.
摘要翻译：本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷衍生物。这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。本发明还描述了单独或与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合的药物组合物。还公开了本发明的核苷衍生物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

4. 发明申请

WO2004007512A3 NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 审中-公开
公开(公告)号：WO2004007512A3
公开(公告)日：2004-04-08
申请号：PCT/US0321589
申请日：2003-07-11
申请人： MERCK & CO INC , ISIS PHARMACEUTICALS INC , BHAT BALKRISHEN , CARROLL STEVEN S , ELDRUP ANNE B , MACCOSS MALCOLM , OLSEN DAVID B , PRAKASH THAZHA P
发明人： BHAT BALKRISHEN , CARROLL STEVEN S , ELDRUP ANNE B , MACCOSS MALCOLM , OLSEN DAVID B , PRAKASH THAZHA P
IPC分类号： C12N9/99 , A61K31/7056 , A61K31/7064 , A61K38/21 , A61K45/00 , A61P1/16 , A61P31/14 , A61P43/00 , C07H19/14 , A61K31/70
CPC分类号： C07H19/14 , C07H19/22
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

5. 发明申请

WO2004003138A3 NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 审中-公开
标题翻译：作为RNA依赖性RNA病毒聚合酶抑制剂的核苷衍生物
公开(公告)号：WO2004003138A3
公开(公告)日：2006-12-28
申请号：PCT/US0319776
申请日：2003-06-23
申请人： MERCK & CO INC , ISIS PHARMACEUTICALS INC , OLSEN DAVID B , MACCOSS MALCOLM , BHAT BALKRISHEN , ELDRUP ANNE B
发明人： OLSEN DAVID B , MACCOSS MALCOLM , BHAT BALKRISHEN , ELDRUP ANNE B
IPC分类号： A61K31/70 , C07H19/14 , C07H19/16 , C07H19/167 , C07H19/20
CPC分类号： C07H19/22 , C07H19/14 , C07H19/16 , C07H19/20
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
摘要翻译：本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷化合物及其某些衍生物。这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合的药物组合物。还公开了本发明的核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

6. 发明申请

WO2004009020A2 THIONUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 审中-公开
标题翻译：作为RNA依赖性RNA病毒聚合酶抑制剂的硫代胞苷衍生物
公开(公告)号：WO2004009020A2
公开(公告)日：2004-01-29
申请号：PCT/US0322556
申请日：2003-07-18
申请人： MERCK & CO INC , ISIS PHARMACEUTICALS INC , OLSEN DAVID B , BHAT BALKRISHEN , COOK PHILLIP DAN
发明人： OLSEN DAVID B , BHAT BALKRISHEN , COOK PHILLIP DAN
IPC分类号： A61K45/06 , A61P31/12 , A61P31/14 , C07H19/14 , A61K
CPC分类号： A61K45/06 , C07H19/14
摘要： The present invention provides thionucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such thionucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the thionucleoside compounds of the present invention.
摘要翻译：本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷类化合物及其某些衍生物。这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合含有这样的硫代核苷化合物的药物组合物。还公开了用本发明的硫代核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

7. 发明申请

WO2006065335A3 FLUORINATED PYRROLO[2,3-D]PYRIMIDINE NUCLEOSIDES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION 审中-公开
标题翻译：用于治疗RNA依赖性RNA病毒感染的氟化吡咯烷[2,3-D]嘧啶核苷
公开(公告)号：WO2006065335A3
公开(公告)日：2006-09-14
申请号：PCT/US2005037224
申请日：2005-10-17
申请人： MERCK & CO INC , MACCOSS MALCOLM , OLSEN DAVID B , LEONE JOSEPH , DURETTE PHILIPPE L
发明人： MACCOSS MALCOLM , OLSEN DAVID B , LEONE JOSEPH , DURETTE PHILIPPE L
IPC分类号： A61K31/7052 , A61K31/7042 , C07H19/14
CPC分类号： C07H19/14
摘要： The present invention provides fluorinated pyrrolo[2,3,d]pyrimidine nucleoside compounds which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaeutical compositions containing such fluorinated pyrrolo[2,3-d]pyrimidine nucleoside alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the fluorinated pyrrolo[2,3-d]pyrimidine nucleoside of the present invention.
摘要翻译：本发明提供了作为RNA依赖性RNA病毒聚合酶抑制剂的氟化吡咯并[2,3，d]嘧啶核苷化合物。这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体，作为HCV复制抑制剂的前体和/或治疗丙型肝炎感染。本发明还描述了含有这种氟化吡咯并[2,3-d]嘧啶核苷的药物组合物，或者与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合。还公开了本发明的氟化吡咯并[2,3-d]嘧啶核苷抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

8. 发明申请

WO2006119061A2 HCV NS3 PROTEASE INHIBITORS 审中-公开
标题翻译： HCV NS3蛋白酶抑制剂
公开(公告)号：WO2006119061A2
公开(公告)日：2006-11-09
申请号：PCT/US2006016343
申请日：2006-04-28
申请人： MERCK & CO INC , HOLLOWAY M KATHARINE , LIVERTON NIGEL J , LUDMERER STEVEN W , MCCAULEY JOHN A , OLSEN DAVID B , RUDD MICHAEL T , VACCA JOSEPH P
发明人： HOLLOWAY M KATHARINE , LIVERTON NIGEL J , LUDMERER STEVEN W , MCCAULEY JOHN A , OLSEN DAVID B , RUDD MICHAEL T , VACCA JOSEPH P
IPC分类号： A61K38/05
CPC分类号： C07K5/0808 , C07K5/0806 , C07K5/0812 , C07K5/0815 , C07K5/0821
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections. I
摘要翻译：本发明涉及可用作丙型肝炎病毒（HCV）NS3蛋白酶抑制剂及其合成及其用于治疗或预防HCV感染的用途的式（I）的大环化合物。一世

9. 发明申请

WO2007021610A3 RIBONUCLEOSIDE CYCLIC ACETAL DERIVATIVES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION 审中-公开
标题翻译：核糖核苷环状乙酰基衍生物用于治疗RNA依赖性RNA病毒感染
公开(公告)号：WO2007021610A3
公开(公告)日：2007-10-04
申请号：PCT/US2006030549
申请日：2006-08-04
申请人： MERCK & CO INC , BUTORA GABOR , KOEPLINGER KENNETH ALAN , MACCOSS MALCOLM , MCMASTERS DANIEL R , OLSEN DAVID B , YANG LIHU
发明人： BUTORA GABOR , KOEPLINGER KENNETH ALAN , MACCOSS MALCOLM , MCMASTERS DANIEL R , OLSEN DAVID B , YANG LIHU
IPC分类号： A01N43/04 , A01N57/00 , A61K31/519
CPC分类号： C07H19/06 , C07H19/16
摘要： The present invention provides ribonucleoside 2',3'-cyclic acetals of structural formula I which are precursors or prodrugs of inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors of inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors or prodrugs of inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors or prodrugs of inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such ribonucleoside 2',3'-cyclic acetals alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the ribonucleoside 2',3'-cyclic acetals of the present invention.
摘要翻译：本发明提供结构式I的核糖核苷2'，3'-环状缩醛，其为RNA依赖性RNA病毒聚合酶抑制剂的前体或前体药物。这些化合物是RNA依赖性RNA病毒复制抑制剂的前体，并且可用于治疗RNA依赖性RNA病毒感染。它们作为丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体或前体药物，作为HCV复制抑制剂的前体或前体药物和/或用于治疗丙型肝炎感染特别有用。本发明还描述了含有这种核糖核苷2'，3'-环状缩醛的药物组合物，所述组合物单独地或与其它对RNA依赖性RNA病毒感染特别是HCV感染有活性的药物组合。还公开了抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或用本发明的核糖核苷2'，3'-环缩醛治疗RNA依赖性RNA病毒感染的方法。

10. 发明申请

WO2009132273A3 MICRORNA BIOMARKERS OF TISSUE INJURY 审中-公开
标题翻译：组织损伤的MICRORNA生物标志物
公开(公告)号：WO2009132273A3
公开(公告)日：2010-01-21
申请号：PCT/US2009041666
申请日：2009-04-24
申请人： MERCK & CO INC , FARE THOMAS L , GARRETT-ENGELE PHILIP W , GLAAB WARREN E , JOHNSON JASON M , LATERZA OMAR F , LIM LEE , LUDMERER STEVE W , OLSEN DAVID B , SINA JOSEPH F , SISTARE FRANK D
发明人： FARE THOMAS L , GARRETT-ENGELE PHILIP W , GLAAB WARREN E , JOHNSON JASON M , LATERZA OMAR F , LIM LEE , LUDMERER STEVE W , OLSEN DAVID B , SINA JOSEPH F , SISTARE FRANK D
IPC分类号： G01N33/00
CPC分类号： C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , Y10T436/143333
摘要： One aspect of the invention generally relates to use of tissue enriched miRNAs as biomarker to estimate tissue damage in a fluid sample. In a second aspect, methods are provided for monitoring a subject who is exposed or might have been exposed to an agent that has a risk of causing tissue injury. In a third aspect, methods are provided for identifying an agent as having a risk of causing tissue injury to a vertebrate subject. In a fourth aspect, kits are provided for practicing the methods of above-listed aspects. The contents of this ABSTRACT are not intended to in anyway limit the scope of the inventions claimed herein.
摘要翻译：本发明的一个方面通常涉及使用组织富集的miRNA作为生物标志物来估计流体样品中的组织损伤。在第二方面，提供了用于监测暴露于或可能暴露于具有引起组织损伤风险的药剂的受试者的方法。在第三方面，提供了用于鉴定具有对脊椎动物受试者造成组织损伤风险的药剂的方法。在第四方面，提供了用于实践上述方面的方法的试剂盒。本摘要的内容并不旨在限制本文所要求保护的发明的范围。

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