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1. 发明申请

WO2011035221A2 APPARATUS AND METHODS FOR LOADING A DRUG ELUTING MEDICAL DEVICE 审中-公开
标题翻译：装载药物装置的装置和方法
公开(公告)号：WO2011035221A2
公开(公告)日：2011-03-24
申请号：PCT/US2010/049437
申请日：2010-09-20
申请人： MEDTRONIC VASCULAR INC. , MITCHELL, James E. , PETERSON, Justin , CHU, Dishuan (Sean) , TRAINA, Joseph , AVELAR, Salvador , SILVER, Michele
发明人： MITCHELL, James E. , PETERSON, Justin , CHU, Dishuan (Sean) , TRAINA, Joseph , AVELAR, Salvador , SILVER, Michele
IPC分类号： A61L31/16
CPC分类号： A61L31/16 , A61F2240/001 , A61F2250/0068
摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.
摘要翻译：公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。可以对中空支架的外表面执行支架清洁步骤。

2. 发明申请

WO2010120415A2 METHODS AND SYSTEMS FOR LOADING A STENT 审中-公开
标题翻译：用于加载一个STENT的方法和系统
公开(公告)号：WO2010120415A2
公开(公告)日：2010-10-21
申请号：PCT/US2010/026937
申请日：2010-03-11
申请人： MEDTRONIC VASCULAR INC. , SILVER, Michele , PUNGA, Karan , CHANG, William , BERTHIAUME, William
发明人： SILVER, Michele , PUNGA, Karan , CHANG, William , BERTHIAUME, William
IPC分类号： A61F2/84 , A61M25/01 , A61L27/58 , A61L27/14
CPC分类号： A61F2/966 , A61F2/90 , A61F2/95 , A61F2002/9505 , A61F2002/9511 , A61F2002/9522 , A61F2002/9665
摘要： A stent loading and delivery system includes a delivery catheter having a catheter lumen, a stent loading assembly adjacent a distal end of the delivery catheter, and a braided stent disposed on the stent loading assembly. The stent loading assembly is configured to retain the stent in an expanded state until just prior to insertion into a patient at which time the stent loading assembly elongates and compresses the stent into a delivery configuration.
摘要翻译：支架装载和递送系统包括具有导管内腔，邻近输送导管的远端的支架装载组件和设置在支架装载组件上的编织支架的输送导管。支架装载组件构造成将支架保持在展开状态，直到插入到患者体内，此时支架装载组件伸长并将支架压缩成输送构型。

3. 发明申请

WO2009088750A1 OBSTRUCTION REMOVAL SYSTEM 审中-公开
标题翻译：取走系统
公开(公告)号：WO2009088750A1
公开(公告)日：2009-07-16
申请号：PCT/US2008/088032
申请日：2008-12-22
申请人： MEDTRONIC VASCULAR INC. , THOMPSON, Dustin , PERKINS, Dh , JOHNSON, Jeremy , SILVER, Michele , MAUCH, Kevin
发明人： THOMPSON, Dustin , PERKINS, Dh , JOHNSON, Jeremy , SILVER, Michele , MAUCH, Kevin
IPC分类号： A61B17/22 , A61B17/00 , A61B17/32 , A61B10/02
CPC分类号： A61B17/320758 , A61B10/0266 , A61B17/32002 , A61B17/320708 , A61B17/320725 , A61B2010/0225 , A61B2017/00345 , A61B2017/00867 , A61B2017/320008 , A61B2017/320012 , A61B2017/32006 , A61B2017/320064 , A61B2017/320741
摘要： An obstruction removal system (100) for percutaneous removal of clots or obstructions within the vascular system is disclosed. The obstruction removal system includes a multi-lumen catheter (102) with a plurality of circulating capture devices (114) occurring along a drive belt (112). The plurality of capture devices may be' basket-like devices attached to the drive belt, or may be formed by integral coiled or protuberant sections of the drive belt. The circulating capture or interference devices affect removal of the clot or obstruction bit-by-bit through a series of passes.
摘要翻译：公开了一种用于经皮去除血管系统内的凝块或障碍物的阻塞去除系统（100）。阻塞去除系统包括具有多个循环捕获装置（114）的多腔导管（102），沿着驱动带（112）发生。多个捕获装置可以是“连接到驱动带的篮状装置”，或者可以由驱动带的一体的卷绕或突出部分形成。循环捕获或干扰装置通过一系列通路影响凝块的清除或逐位阻塞。

4. 发明申请

WO2017214094A3 TRANSCATHETER PROSTHETIC HEART VALVE DELIVERY SYSTEM WITH PROTECTIVE FEATURE 审中-公开
公开(公告)号：WO2017214094A3
公开(公告)日：2017-12-14
申请号：PCT/US2017/036077
申请日：2017-06-06
申请人： MEDTRONIC VASCULAR INC.
发明人： VAUGHAN, Brendan , BRITTON, Maeve , BARAJAS-TORRES, Martha , DESHMUKH, Susheel , MENDOZA, Leonal , SOM, Siyan , SILVER, Michele , TRAN, Don , BROWN, Nathan , MENDELSON, Jill
IPC分类号： A61F2/24 , A61F2/95
摘要： Delivery devices for a stented prosthetic heart valve. The delivery device includes a spindle, at least one cord, and a covering feature associated with the spindle for selectively covering at least a portion of a stented prosthetic heart valve tethered to the spindle in a delivery state. In some embodiments, the covering feature includes a tip mounted to the spindle. The tip can include an overhang region for selectively covering a portion of the stented prosthetic heart valve. In other embodiments, the tip can include a tip body and a compressible foam bumper. In yet other embodiments, the covering feature includes an outer sheath arranged to selectively cover the stented prosthetic heart valve. The outer sheath can be elastic and stretchable for recapturing a partially expanded prosthesis, for example by including one or more windows covered by a stretchable covering layer.

5. 发明申请

WO2017214094A2 TRANSCATHETER PROSTHETIC HEART VALVE DELIVERY SYSTEM WITH PROTECTIVE FEATURE 审中-公开
标题翻译：具有保护功能的经心脏传播心脏瓣膜输送系统
公开(公告)号：WO2017214094A2
公开(公告)日：2017-12-14
申请号：PCT/US2017/036077
申请日：2017-06-06
申请人： MEDTRONIC VASCULAR INC.
发明人： VAUGHAN, Brendan , BRITTON, Maeve , BARAJAS-TORRES, Martha , DESHMUKH, Susheel , MENDOZA, Leonal , SOM, Siyan , SILVER, Michele , TRAN, Don , BROWN, Nathan , MENDELSON, Jill
IPC分类号： A61F2/24
摘要： Delivery devices for a stented prosthetic heart valve. The delivery device includes a spindle, at least one cord, and a covering feature associated with the spindle for selectively covering at least a portion of a stented prosthetic heart valve tethered to the spindle in a delivery state. In some embodiments, the covering feature includes a tip mounted to the spindle. The tip can include an overhang region for selectively covering a portion of the stented prosthetic heart valve. In other embodiments, the tip can include a tip body and a compressible foam bumper. In yet other embodiments, the covering feature includes an outer sheath arranged to selectively cover the stented prosthetic heart valve. The outer sheath can be elastic and stretchable for recapturing a partially expanded prosthesis, for example by including one or more windows covered by a stretchable covering layer.
摘要翻译：用于支架假体心脏瓣膜的输送装置。输送装置包括心轴，至少一个绳索和与心轴相关联的覆盖特征，用于选择性地覆盖在输送状态下拴系到心轴的带支架假体心脏瓣膜的至少一部分。在一些实施例中，覆盖特征包括安装到心轴的尖端。尖端可以包括用于选择性地覆盖支架假体心脏瓣膜的一部分的悬垂区域。在其他实施例中，尖端可以包括尖端主体和可压缩泡沫缓冲器。在其他实施例中，覆盖特征包括布置成选择性地覆盖带支架假体心脏瓣膜的外部护套。外护套可以是弹性的并且可拉伸的，以便重新捕获部分扩张的假体，例如通过包括一个或多个覆盖有可拉伸覆盖层的窗口。

6. 发明申请

WO2017214098A1 TRANSCATHETER PROSTHETIC HEART VALVE DELIVERY SYSTEM WITH LATERAL OFFSET CONTROL 审中-公开
标题翻译：具有横向失调控制的经导管人造心脏瓣膜输送系统
公开(公告)号：WO2017214098A1
公开(公告)日：2017-12-14
申请号：PCT/US2017/036082
申请日：2017-06-06
申请人： MEDTRONIC VASCULAR INC.
发明人： MENDELSON, Jill , SILVER, Michele , GLOSS, Michael , GROEN, Timothy , ROTHSTEIN, Paul , SANDSTROM, Jeffrey , HAARSTAD, Phil , RACCHINI, Joel , BLAESER, David
IPC分类号： A61F2/24
摘要： Delivery devices for a stented prosthetic heart valve. The delivery device includes a spindle, at least one cord, and a lateral control feature. The cord is tensioned to crimp the prosthesis to a compressed condition for delivery to a target site. Tension is lessened to allow the prosthesis to self-expand. In a tethered and expanded state in which the prosthesis has self-expanded and is connected to the spindle by the cord, the lateral control feature directs the spindle to a prescribed location relative to the prosthesis appropriate for a functional evaluation of the prosthesis. In some embodiments, the spindle is directed to a center of the prosthesis; in other embodiments, the spindle is held at a commissure of the prosthesis. The lateral control features of the present disclosure assume numerous forms.
摘要翻译：用于支架假体心脏瓣膜的输送装置。输送装置包括主轴，至少一根绳索和横向控制特征。将绳索张紧以将假体卷曲至压缩状态以递送至目标部位。张力减轻，使假体自行扩张。在假体自扩张并且通过索连接到心轴的拴系和扩张状态下，横向控制特征将心轴引导到相对于假体适合于功能评估假体的规定位置。在一些实施例中，心轴被引导至假体的中心; 在其他实施例中，心轴保持在假体的连合处。本公开的横向控制特征采取多种形式。

7. 发明申请

WO2017152097A1 STENTED PROSTHESIS DELIVERY SYSTEM HAVING A BUMPER 审中-公开
标题翻译：专用假体送货系统，具有保险杠
公开(公告)号：WO2017152097A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/020738
申请日：2017-03-03
申请人： MEDTRONIC VASCULAR INC.
发明人： TRAN, Don , BARAJAS-TORRES, Martha , LALLY, Marian , GLOSS, Michael , GROEN, Timothy , MENDOZA, Leonel , SOM, Siyan , SILVER, Michele , BROWN, Nathan , MENDELSON, Jill
IPC分类号： A61F2/24 , A61F2/966
CPC分类号： A61F2/2436 , A61F2/2418 , A61F2/966 , A61F2002/9665 , A61F2230/0067 , A61F2250/0039
摘要： Numerous delivery devices for delivery of a stented prosthesis, such as a stented prosthetic heart valve. Various delivery devices include a capsule that is advanced proximally to retain the stented prosthesis, which is secured over an inner shaft assembly of the delivery device. The delivery device further includes a bumper or bumper assembly to provide a smooth transition of the capsule over the stented prosthesis. In some alternate disclosed embodiments, the bumper further serves to connect various elements of the inner shaft assembly. Additional embodiments include a bumper assembly arranged and configured to longitudinally expand and contract to substantially fill any open space as the capsule is retracted from the stented prosthesis, which prevents kinking in the capsule. Additional embodiments include proximal and/or distal bumpers for temporarily covering and smoothing the ends of the stented prosthesis as part of a delivery device that does not include a capsule.
摘要翻译：许多用于输送支架假体的输送装置，例如带支架假体心脏瓣膜。各种输送装置包括向近侧推进以保持支架假体的胶囊，其被固定在输送装置的内轴组件上。输送装置还包括保险杠或保险杠组件，以提供胶囊在支架假体上的平滑过渡。在一些替代公开的实施例中，缓冲器还用于连接内轴组件的各种元件。另外的实施例包括缓冲器组件，该缓冲器组件被布置和构造成当胶囊从带支架的假体缩回时纵向膨胀和收缩以基本上填充任何开放空间，这防止了胶囊中的扭结。另外的实施例包括近端和/或远端缓冲器，用于暂时覆盖并平滑支架假体的端部，作为不包括胶囊的输送装置的一部分。

8. 发明申请

WO2009088783A2 OBSTRUCTION REMOVAL SYSTEM 审中-公开
标题翻译：取走系统
公开(公告)号：WO2009088783A2
公开(公告)日：2009-07-16
申请号：PCT/US2008/088234
申请日：2008-12-23
申请人： MEDTRONIC VASCULAR INC. , THOMPSON, Dustin , PERKINS, DH , JOHNSON, Jeremy , SILVER, Michele , MAUCH, Kevin , MACAULAY, Patrick
发明人： THOMPSON, Dustin , PERKINS, DH , JOHNSON, Jeremy , SILVER, Michele , MAUCH, Kevin , MACAULAY, Patrick
IPC分类号： A61B17/22 , A61B17/00 , A61B17/32 , A61B10/02
CPC分类号： A61B17/320758 , A61B10/0266 , A61B17/320708 , A61B17/320725 , A61B2010/0225 , A61B2017/00345 , A61B2017/00398 , A61B2017/00867 , A61B2017/320008 , A61B2017/320012 , A61B2017/32006 , A61B2017/320064 , A61B2017/320741
摘要： An obstruction removal system for percutaneous removal of clots or obstructions within the vascular system is disclosed. The obstruction removal system includes a multi-lumen catheter with a plurality of circulating capture devices attached to or integral with a drive belt. The circulating capture or interference devices affect removal of the clot or obstruction bit-by-bit through a series of passes. The obstruction removal system may include one or more drive mechanisms, such as a pulley system and/or a vacuum source and/or a pressurization source, on its proximal end for driving the drive belt and capture devices through the catheter in a circulating manner. The obstruction removal system may also include one or more cleaning mechanisms, such as a vacuum chamber and/or a fluid rinse chamber, for removing the captured clot pieces from the capture devices.
摘要翻译：公开了一种用于经皮去除血管系统内的血块或障碍物的阻塞去除系统。阻塞去除系统包括多腔导管，其具有附接到驱动带或与传动带一体的多个循环捕获装置。循环捕获或干扰装置通过一系列通路影响凝块的清除或逐位阻塞。障碍物移除系统可以在其近端包括一个或多个驱动机构，例如皮带轮系统和/或真空源和/或加压源，用于驱动驱动带并以循环方式通过导管捕获装置。阻塞去除系统还可以包括一个或多个清洁机构，例如真空室和/或流体冲洗室，用于从捕获装置移除捕获的凝块。

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