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1. 发明申请

WO2017160756A1 TRANSCATHETER STENTED PROSTHETIC HEART VALVE DELIVERY DEVICES WITH PRIMARY AND SECONDARY RELEASE MECHANISMS 审中-公开
标题翻译：具有初级和次级释放机构的经导管人造心脏瓣膜输送装置
公开(公告)号：WO2017160756A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022160
申请日：2017-03-13
申请人： MEDTRONIC VASCULAR INC.
发明人： GROEN, Timothy , ROTHSTEIN, Paul , SANDSTROM, Jeffrey , HAARSTAD, Phil , RACCHINI, Joel , DOAN, Tuan
IPC分类号： A61F2/24
摘要： Disclosed embodiments and methods provide solutions for coupling and decoupling of a delivery device (10) from a stented prosthetic heart valve (40) with one or more release mechanisms. In situations when one or more sutures get tangled or caught upon attempted retraction of the delivery device and sutures after deployment of the stented prosthetic heart valve, a secondary release mechanism is provided to sever the suture(s) from the delivery device. Exemplary secondary release mechanisms include high resistance inserts, cutters and balloon expandable devices.
摘要翻译：所公开的实施例和方法提供了用于利用一个或多个释放机构将递送装置（10）与带支架的人造心脏瓣膜（40）耦合和解除耦合的解决方案。在一个或多个缝合线在展开支架假体心脏瓣膜之后尝试缩回输送装置和缝合线时，一根或多根缝合线缠绕或抓住时，提供第二释放机构以从输送装置切断缝合线。示例性的第二释放机构包括高电阻插入件，切割器和球囊扩张装置。

2. 发明申请

WO2017106161A3 DEVICES AND METHODS FOR TRANSCATHETER VALVE LOADING AND IMPLANTATION 审中-公开
公开(公告)号：WO2017106161A3
公开(公告)日：2017-06-22
申请号：PCT/US2016/066323
申请日：2016-12-13
申请人： MEDTRONIC VASCULAR INC.
发明人： BARAJAS-TORRES, Martha , MAUCH, Kevin , SANDSTROM, Jeffrey , MENDELSON, Jill , TRAN, Don
IPC分类号： A61F2/24
摘要： The present disclosure relates to numerous devices and methods for transcatheter stented prosthetic heart valve loading and delivery. Such devices and methods reduce suture tangling and also provide the ability to adjust the stented prosthetic heart valve expansion and contraction prior to the final release of the stented prosthetic heart valve (100) from the delivery device (200).

3. 发明申请

WO2017106161A2 DEVICES AND METHODS FOR TRANSCATHETER VALVE LOADING AND IMPLANTATION 审中-公开
标题翻译：装置和方法传输线阀加载和植入
公开(公告)号：WO2017106161A2
公开(公告)日：2017-06-22
申请号：PCT/US2016/066323
申请日：2016-12-13
申请人： MEDTRONIC VASCULAR INC.
发明人： ROTHSTEIN, Paul , BARAJAS-TORRES, Martha , MAUCH, Kevin , SANDSTROM, Jeffrey , MENDELSON, Jill , TRAN, Don
CPC分类号： A61F2/2439 , A61F2/2415 , A61F2/2418
摘要： The present disclosure relates to numerous devices and methods for transcatheter stented prosthetic heart valve loading and delivery. Such devices and methods reduce suture tangling and also provide the ability to adjust the stented prosthetic heart valve expansion and contraction prior to the final release of the stented prosthetic heart valve from the delivery device.
摘要翻译：本公开涉及用于经导管支架假体心脏瓣膜装载和输送的多种装置和方法。这种装置和方法减少了缝合线缠结，并且还提供了在支架假体心脏瓣膜从输送装置最终释放之前调整支架假体心脏瓣膜扩张和收缩的能力。

4. 发明申请

WO2017106156A1 DEVICES AND METHODS FOR TRANSCATHETER VALVE LOADING AND IMPLANTATION 审中-公开
标题翻译：装置和方法传输线阀加载和植入
公开(公告)号：WO2017106156A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/066313
申请日：2016-12-13
申请人： MEDTRONIC VASCULAR INC.
发明人： ROTHSTEIN, Paul , BARAJAS-TORRES, Martha , MAUCH, Kevin , SANDSTROM, Jeffrey , MENDELSON, Jill , TRAN, Don
IPC分类号： A61F2/24
CPC分类号： A61F2/2439 , A61F2/2415 , A61F2/2418
摘要： The present disclosure relates to numerous delivery devices (10) and methods for transcatheter prosthetic heart valve (100) loading, deployment and delivery utilizing at least one suture (20, 22, 24). Disclosed delivery devices utilize improved suture routing methods and configurations that reduce suture tangling and also provide the ability to adjust the prosthetic heart valve expansion and contraction prior to the final release of the prosthetic heart valve from the delivery device.
摘要翻译：本公开涉及利用至少一根缝合线（20,22,24）的多种输送装置（10）和用于经导管人工心脏瓣膜（100）装载，展开和输送的方法。公开的输送装置利用改进的缝合线路线方法和构造，其减少缝合线缠结，并且还提供在假体心脏瓣膜从输送装置最终释放之前调节假体心脏瓣膜膨胀和收缩的能力。

5. 发明申请

WO2016149083A1 DELIVERY DEVICE FOR PROSTHETIC HEART VALVE WITH CAPSULE ADJUSTMENT DEVICE 审中-公开
标题翻译：用于具有胶囊调节装置的前置心脏瓣膜的输送装置
公开(公告)号：WO2016149083A1
公开(公告)日：2016-09-22
申请号：PCT/US2016/021974
申请日：2016-03-11
申请人： MEDTRONIC VASCULAR INC.
发明人： SANDSTROM, Jeffrey
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2002/9517
摘要： A delivery device (100) for percutaneously delivering a stented prosthetic heart (30) includes a sheath (102), a handle (180), and adjustment device (150) including a fine adjustment mechanism, and an outer stability shaft (110). The sheath defines a lumen and is configured to compressively constrain the stented prosthetic heart valve. The handle is coupled to the proximal portion of the sheath and includes an actuator mechanism (184) coupled to a proximal portion of the sheath that is configured to selectively move the sheath relative to the housing (182) to release the stented prosthetic heat valve. The adjustment device is coupled to the handle and includes an adjustment lumen through which the sheath and the handle slidably extend. The outer stability shaft is coupled to the adjustment device. The fine adjustment mechanism is configured to selectively move the handle and the sheath relative to the adjustment device and the outer stability shaft.
摘要翻译：用于经皮输送支架假体心脏（30）的输送装置（100）包括护套（102），手柄（180）和包括微调机构和外稳定轴（110）的调节装置（150）。护套限定内腔并且构造成压缩地约束支架假体心脏瓣膜。手柄联接到护套的近端部分并且包括联接到护套的近侧部分的致动器机构（184），其构造成相对于壳体（182）选择性地移动护套以释放支架的假体热阀。调节装置联接到手柄并且包括调节内腔，护套和手柄通过该调节内腔可滑动地延伸。外稳定轴与调节装置连接。微调机构配置成相对于调节装置和外稳定轴选择性地移动手柄和护套。

6. 发明申请

WO2016148910A1 DELIVERY DEVICE FOR PROSTHETIC HEART VALVE WITH CAPSULE ADJUSTMENT DEVICE 审中-公开
标题翻译：用于具有胶囊调节装置的前置心脏瓣膜的输送装置
公开(公告)号：WO2016148910A1
公开(公告)日：2016-09-22
申请号：PCT/US2016/020275
申请日：2016-03-01
申请人： MEDTRONIC VASCULAR INC.
发明人： SANDSTROM, Jeffrey
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2002/9517
摘要： DELIVERY DEVICE FOR PROSTHETIC HEART VALVE WITH CAPSULE ADJUSTMENT DEVICE A delivery device (100) for percutaneously delivering a stented prosthetic heart (30) includes a sheath (102), a handle (180), and adjustment device (150) including a fine adjustment mechanism, and an outer stability shaft (110). The sheath defines a lumen and is configured to compressively constrain the stented prosthetic heart valve. The handle is coupled to the proximal portion of the sheath and includes an actuator mechanism (184) coupled to a proximal portion of the sheath that is configured to selectively move the sheath relative to the housing to release the stented prosthetic heat valve. The adjustment device is coupled to the handle and includes an adjustment lumen through which the sheath and the handle slidably extend. The outer stability shaft is coupled to the adjustment device. The fine adjustment mechanism is configured to selectively move the handle and the sheath relative to the adjustment device and the outer stability shaft.
摘要翻译：用于具有胶囊调节装置的前置心脏瓣膜的输送装置用于经皮输送支架假体心脏（30）的输送装置（100）包括护套（102），手柄（180）和调节装置（150），其包括微调机构，和外稳定轴（110）。护套限定内腔并且构造成压缩地约束支架假体心脏瓣膜。手柄联接到护套的近端部分并且包括联接到护套的近侧部分的致动器机构（184），其构造成选择性地相对于壳体移动护套以释放支架的假体热阀。调节装置联接到手柄并且包括调节内腔，护套和手柄通过该调节内腔可滑动地延伸。外稳定轴与调节装置连接。微调机构配置成相对于调节装置和外稳定轴选择性地移动手柄和护套。

7. 发明申请

WO2021034497A1 HEART VALVE REPAIR 审中-公开
公开(公告)号：WO2021034497A1
公开(公告)日：2021-02-25
申请号：PCT/US2020/044809
申请日：2020-08-04
申请人： MEDTRONIC VASCULAR, INC.
发明人： GENOVESE, Matthew E. , LEE, Vania , PRIBANIC, Russell , MCPEAK, Thomas J. , SANDSTROM, Jeffrey , O'BRIEN, Dermot , ALLAN, James Calvin
IPC分类号： A61F2/24 , A61B17/068 , A61B17/064
摘要： A medical system includes a catheter navigable through vasculature of patient to introduce a valve clip configured to join the edges of heart valve leaflets. The valve clip includes a deformable wire configured to engage valve leaflets, the wire extending from a first wire portion to a second wire portion. The catheter includes a handle having control members, an elongate body defining a lumen extending from the handle to a distal opening, and first and second delivery devices operatively coupled to a control member and extending through the lumen to the distal opening. Each delivery device is configured to releasably couple to a portion of the wire and moveable relative to the distal opening. The delivery devices are controllable at the handle to move the valve clip between an extended configuration and a contracted configuration to engage the valve leaflets.

8. 发明申请

WO2019099722A3 SYSTEMS AND METHODS FOR PERCUTANEOUSLY SUPPORTING AND MANIPULATING A SEPTAL WALL 审中-公开
公开(公告)号：WO2019099722A3
公开(公告)日：2019-05-23
申请号：PCT/US2018/061360
申请日：2018-11-15
申请人： MEDTRONIC VASCULAR, INC.
发明人： DUFFY, Niall , SANDSTROM, Jeffrey , KEOGH, James R.
IPC分类号： A61B17/34 , A61F2/24 , A61B17/00
摘要： A catheter-based system for percutaneously supporting and articulating a septal wall of a heart includes a catheter and a flanged device. The flanged device includes a distal anchor and a proximal anchor, and has a radially collapsed configuration and a radially expanded configuration. When the flanged device is in the radially expanded configuration and disposed through a transseptal puncture in the septal wall, the flanged device is configured to anchor to the septal wall to permit manipulation thereof whereby an angle between an axis through the transseptal puncture and an axis through a native valve is reduced. The proximal anchor and the distal anchor may each be self-expanding or balloon expandable. The flanged device may further include a flanged device shaft. The flanged device shaft may be releasably coupled to the catheter.

9. 发明申请

WO2019099722A2 SYSTEMS AND METHODS FOR PERCUTANEOUSLY SUPPORTING AND MANIPULATING A SEPTAL WALL 审中-公开
公开(公告)号：WO2019099722A2
公开(公告)日：2019-05-23
申请号：PCT/US2018/061360
申请日：2018-11-15
申请人： MEDTRONIC VASCULAR, INC.
发明人： DUFFY, Niall , SANDSTROM, Jeffrey , KEOGH, James R.
摘要： A catheter-based system for percutaneously supporting and articulating a septal wall of a heart includes a catheter and a flanged device. The flanged device includes a distal anchor and a proximal anchor, and has a radially collapsed configuration and a radially expanded configuration. When the flanged device is in the radially expanded configuration and disposed through a transseptal puncture in the septal wall, the flanged device is configured to anchor to the septal wall to permit manipulation thereof whereby an angle between an axis through the transseptal puncture and an axis through a native valve is reduced. The proximal anchor and the distal anchor may each be self-expanding or balloon expandable. The flanged device may further include a flanged device shaft. The flanged device shaft may be releasably coupled to the catheter.

10. 发明申请

WO2017165194A1 STENTED PROSTHETIC HEART VALVE HAVING WRAP 审中-公开
标题翻译：带有包装的人工心脏瓣膜
公开(公告)号：WO2017165194A1
公开(公告)日：2017-09-28
申请号：PCT/US2017/022784
申请日：2017-03-16
申请人： MEDTRONIC VASCULAR INC.
发明人： RACCHINI, Joel , GARDE, Kshitija , ROTHSTEIN, Paul , SANDSTROM, Jeffrey , CLAGUE, Cynthia
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2412 , A61F2/2427 , A61F2220/0075 , A61F2250/0069
摘要： Systems and methods of delivering and deploying a stented prosthetic heart valve (10) having a wrap (40) that is automatically deployed to prevent or mitigate paravalvular leakage. In various embodiments, during transcatheter delivery of the stented prosthetic heart valve, the wrap is extends beyond a stent frame (14) of the stented prosthetic heart valve so that the profile of the stented prosthetic heart valve is not increased during delivery. The disclosed embodiments are arranged and configured so that upon expansion of a stent frame of the stented prosthetic heart valve, a plurality of elongated members (54) automatically pull the wrap distally into a deployed arrangement.
摘要翻译：输送和展开具有自动展开以防止或减轻瓣周漏的包裹物（40）的支架假体心脏瓣膜（10）的系统和方法。在各种实施例中，在支架人造心脏瓣膜的经导管输送过程中，包裹延伸超过支架假体心脏瓣膜的支架框架（14），使得支架假体心脏瓣膜的轮廓在递送期间不增加。所公开的实施例被布置和构造成使得在支架假体心脏瓣膜的支架框架扩张后，多个细长构件（54）自动地将包裹物拉向远端成展开布置。

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