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1. 发明申请

WO2019118060A1 METHODS AND SYSTEMS FOR CONTINUOUS GLUCOSE MONITORING 审中-公开
公开(公告)号：WO2019118060A1
公开(公告)日：2019-06-20
申请号：PCT/US2018/055845
申请日：2018-10-15
申请人： MEDTRONIC MINIMED, INC.
发明人： NISHIDA, Jeffrey , VARSAVSKY, Andrea , ENGEL, Taly G. , NOGUEIRA, Keith , TSAI, Andy Y. , AJEMBA, Peter
IPC分类号： A61B5/145 , A61B5/1495
摘要： A method for optional external calibration of a calibration-free glucose sensor uses values of measured working electrode current (Isig) and EIS data to calculate a final sensor glucose (SG) value. Counter electrode voltage (Vcntr) may also be used as an input. Raw Isig and Vcntr values may be preprocessed, and low-pass filtering, averaging, and/or feature generation may be applied. SG values may be generated using one or more models for predicting SG calculations. Complex redundancy may be employed to take operational advantage of disparate characteristics of two or more dissimilar, or non-identical, sensors, including, e.g., characteristics relating to hydration, stabilization, and durability of such sensors. Fusion algorithms, EIS, and advanced Application Specific Integrated Circuits (ASICs) may be used to implement use of such redundant glucose sensors, devices, and sensor systems in such a way as to bridge the gaps between fast start-up, sensor longevity, and accuracy of calibration-free algorithms.

2. 发明申请

WO2017116505A1 RETROSPECTIVE SENSOR CALIBRATION METHODS 审中-公开
标题翻译：回顾性传感器校准方法
公开(公告)号：WO2017116505A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/043599
申请日：2016-07-22
申请人： MEDTRONIC MINIMED, INC.
发明人： NOGUEIRA, Keith , ENGEL, Taly G. , GROSMAN, Benyamin , LI, Xiaolong , LIANG, Bradley C. , SHAH, Rajiv , LIU, Mike C. , TSAI, Andy Y. , VARSAVSKY, Andrea , NISHIDA, Jeffrey
IPC分类号： A61B5/145 , A61B5/1495 , A61B5/053
CPC分类号： G06F19/3412 , A61B5/14532 , A61B5/14735 , A61B5/1495 , A61B5/6849 , G06F19/00 , G06N3/126 , G06N99/005 , G16H40/40
摘要： A method for retrospective calibration of a glucose sensor uses stored values of measured working electrode current (Isig) to calculate a final sensor glucose (SG) value retrospectively. The Isig values may be preprocessed, discrete wavelet decomposition applied. At least one machine learning model, such as, e.g., Genetic Programing (GP) and Regression Decision Tree (DT), may be used to calculate SG values based on the Isig values and the discrete wavelet decomposition. Other inputs may include, e.g., counter electrode voltage (Vcntr) and Electrochemical Impedance Spectroscopy (EIS) data. A plurality of machine learning models may be used to generate respective SG values, which are then fused to generate a fused SG. Fused SG values may be filtered to smooth the data, and blanked if necessary.
摘要翻译：回顾性校准葡萄糖传感器的方法使用测量的工作电极电流（Isig）的存储值来回顾性地计算最终的传感器葡萄糖（SG）值。可以对Isig值进行预处理，应用离散小波分解。基于Isig值和离散小波分解，可以使用至少一个机器学习模型，例如遗传编程（GP）和回归决策树（DT）来计算SG值。其他输入可以包括例如对电极电压（V cntr）和电化学阻抗谱（EIS）数据。多个机器学习模型可以用于生成相应的SG值，然后将其融合以生成融合的SG。可以过滤融合的SG值以平滑数据，并在必要时消隐。

3. 发明申请

WO2017116504A1 METHODS, SYSTEMS, AND DEVICES FOR SENSOR FUSION 审中-公开
标题翻译：用于传感器融合的方法，系统和设备
公开(公告)号：WO2017116504A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/043573
申请日：2016-07-22
申请人： MEDTRONIC MINIMED, INC.
发明人： VARSAVSKY, Andrea , LU, Yunfeng , MUNG, Jay
IPC分类号： A61B5/053 , A61B5/145 , A61B5/00
CPC分类号： A61B5/14532 , A61B5/0537 , A61B5/0538 , A61B5/14865 , A61B5/1495 , A61B5/7203 , A61B5/7221 , A61B5/7278
摘要： A single, optimal, fused sensor glucose value may be calculated based on respective sensor glucose values of a plurality of redundant working electrodes (WEs) of a glucose sensor. Respective electrochemical impedance spectroscopy (EIS) procedures may be performed for each of the WEs to obtain values of membrane resistance (Rmem) for each WE. A noise value and a calibration factor (CF) value may be calculated for each WE, and respective fusion weights may be calculated for Rmem, noise, and CF for each WE. An overall fusion weight may then be calculated based on the WE' s Rmem fusion weight, noise fusion weight, and CF fusion weight, such that a single, optimal, fused sensor glucose value may be calculated based on the respective overall fusion weight and sensor glucose value of each of the plurality of redundant working electrodes.
摘要翻译：可以基于葡萄糖传感器的多个冗余工作电极（WE）的相应传感器葡萄糖值来计算单个最优的融合传感器葡萄糖值。可以对每个WE执行相应的电化学阻抗谱（EIS）程序以获得每个WE的膜电阻值（Rmem）。可以为每个WE计算噪声值和校准因子（CF）值，并且可以针对每个WE计算Rmem，噪声和CF的各个融合权重。然后可以基于WE的Rmem融合权重，噪声融合权重和CF融合权重来计算总体融合权重，使得可以基于相应的总体融合权重和传感器来计算单个的，最佳的融合传感器葡萄糖值多个冗余工作电极中的每一个的葡萄糖值。

4. 发明申请

WO2021178072A1 ANALYTE SENSOR CONFIGURATION AND CALIBRATION BASED ON DATA COLLECTED FROM A PREVIOUSLY USED ANALYTE SENSOR 审中-公开
公开(公告)号：WO2021178072A1
公开(公告)日：2021-09-10
申请号：PCT/US2021/014875
申请日：2021-01-25
申请人： MEDTRONIC MINIMED, INC.
发明人： MONTERO, Erik , ANTONIO, David C. , LARSON, Eric Allan , YU, Meng Dai , FINNEY, Samuel , WENSTAD, Hans K. , AGUIRRE, David M. , LYNCH, Andrew P. , VARSAVSKY, Andrea , DIANATY, Ali
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1495
摘要： A method of automatically initializing an analyte sensor for a user is disclosed here. A first analyte sensor is operated in a first measurement mode to generate first sensor signals indicative of an analyte level of the user. A second analyte sensor is deployed to measure the analyte level of the user, and is operated in an initialization mode, concurrently with operation of the first analyte sensor in the first measurement mode, to receive sensor configuration data generated by the first analyte sensor. During operation of the second analyte sensor in the initialization mode, the second analyte sensor is calibrated with at least some of the received sensor configuration data. After the calibrating, operation of the second analyte sensor is transitioned from the initialization mode to a second measurement mode during which the second analyte sensor generates second sensor signals indicative of the analyte level of the user.

5. 发明申请

WO2017035022A1 PERSONALIZED PARAMETER MODELING METHODS AND RELATED DEVICES AND SYSTEMS 审中-公开
标题翻译：个性化参数建模方法及相关设备和系统
公开(公告)号：WO2017035022A1
公开(公告)日：2017-03-02
申请号：PCT/US2016/047879
申请日：2016-08-19
申请人： MEDTRONIC MINIMED, INC.
发明人： VARSAVSKY, Andrea , LU, Yunfeng , NOGUEIRA, Keith , NISHIDA, Jeffrey
IPC分类号： G06F19/00 , A61M5/14 , A61B5/145
CPC分类号： G06F19/3468 , A61B5/14532 , A61B5/4839 , G06F19/00 , G16H15/00 , G16H40/40 , G16H40/63 , G16H50/20
摘要： Medical devices and related patient management systems and parameter modeling methods are provided. An exemplary method of operating a sensing device associated with a patient involves obtaining current operational context information associated with the sensing device, obtaining a parameter model associated with the patient, calculating a current parameter value based on the parameter model and the current operational context information, obtaining one or more signals from a sensing element configured to measure a condition in a body of the patient, and providing an output that is influenced by the calculated current parameter value and the one or more signals.
摘要翻译：提供了医疗设备和相关的患者管理系统和参数建模方法。操作与患者相关联的感测装置的示例性方法涉及获得与感测装置相关联的当前操作上下文信息，获得与患者相关联的参数模型，基于参数模型和当前操作上下文信息计算当前参数值，从被配置为测量患者体内的状况的感测元件获得一个或多个信号，以及提供受所计算的当前参数值和所述一个或多个信号影响的输出。

6. 发明申请

WO2015094618A1 USE OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY (EIS) IN CONTINUOUS GLUCOSE MONITORING 审中-公开
标题翻译：电化学阻抗谱（EIS）在连续葡萄糖监测中的应用
公开(公告)号：WO2015094618A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/067725
申请日：2014-11-26
申请人： MEDTRONIC MINIMED, INC.
发明人： VARSAVSKY, Andrea , YU, Fei , MILLER, Michael E. , LIANG, Bradley C. , YANG, Ning
IPC分类号： A61B5/00 , A61M5/158 , A61B5/145 , A61B5/1486 , A61B5/1495
CPC分类号： A61B5/1495 , A61B5/0537 , A61B5/0538 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B5/6849 , A61B5/7221 , A61B5/7246 , A61M5/14244 , A61M5/14276 , A61M5/1582 , A61M2005/1726 , G01N27/026
摘要： Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.
摘要翻译：电化学阻抗谱（EIS）与连续葡萄糖监测仪和连续葡萄糖监测（CGM）结合使用，以实现体内传感器校准，总体（传感器）故障分析和智能传感器诊断和故障检测。定义了等效电路模型，电路元件用于表征传感器行为。

7. 发明申请

WO2020247729A1 FLUID INFUSION SYSTEMS 审中-公开
公开(公告)号：WO2020247729A1
公开(公告)日：2020-12-10
申请号：PCT/US2020/036290
申请日：2020-06-05
申请人： MEDTRONIC MINIMED, INC.
发明人： CHEN, Shixin , LARSON, Eric Allan , KOW, Hsiao-Yu S. , GARAI, Ellis , TROCK, Adam S. , MIYA, Isabella Ella , ZHANG, Xinrui , CHIU, Chia-Hung , GOTTLIEB, Rebecca K. , SRINIVASAN, Akhil , VARSAVSKY, Andrea , RAO, Ashwin K. , WANG, Hsifu , PESANTEZ, Daniel E. , MEENAKSHISUNDARAM, Guruguhan
IPC分类号： A61M5/142 , A61M5/145 , A61M5/168 , A61M39/10
摘要： A fluid infusion system such as a portable fluid infusion device includes a housing to accommodate a fluid reservoir. The housing has a largest dimension and a smallest dimension. The fluid infusion device includes a drive system to be serially coupled to the removable fluid reservoir such that a combined dimension of the drive system and the fluid reservoir is less than or equal to the largest dimension. The fluid infusion device includes a planar battery configured to supply power to the drive system. The planar battery has a plurality of faces with one or more faces having a largest area, and the planar battery is situated such that the one or more faces are parallel to the largest dimension and the smallest dimension.

8. 发明申请

WO2019147578A1 IMPLANTABLE POLYMER SURFACES EXHIBITING REDUCED IN VIVO INFLAMMATORY RESPONSES 审中-公开
公开(公告)号：WO2019147578A1
公开(公告)日：2019-08-01
申请号：PCT/US2019/014568
申请日：2019-01-22
申请人： MEDTRONIC MINIMED, INC.
发明人： YAO, Jia , PESANTEZ, Daniel E. , BHATIA, Anuradha Biswas , SRINIVASAN, Akhil , ZHANG, Guangping , VARSAVSKY, Andrea , GAUTHAM, Raghavendhar
IPC分类号： A61B5/145 , A61B5/1486 , A61B5/00 , C09D5/16
CPC分类号： A61B5/14865 , A61B5/1451 , A61B5/14532 , A61B5/41 , A61L31/04 , A61L31/14 , A61L2400/18 , C09D5/1681 , C12Q1/006 , C12Q1/26 , C12Q1/54
摘要： Embodiments of the invention provide optimized polymeric surfaces adapted for use with implantable medical devices as well as methods for making and using such polymeric surfaces. These polymer surfaces have a constellation of features that function to inhibit or avoid an inflammatory immune response generated by implantable medical devices. Typical embodiments of the invention include an implantable glucose sensor used in the management of diabetes having a polymer surface with the disclosed constellation of features.

9. 发明申请

WO2015094576A2 METHODS AND SYSTEMS FOR IMPROVING THE RELIABILITY OF ORTHOGONALLY REDUNDANT SENSORS 审中-公开
标题翻译：改善正交冗余传感器可靠性的方法和系统
公开(公告)号：WO2015094576A2
公开(公告)日：2015-06-25
申请号：PCT/US2014/066794
申请日：2014-11-21
申请人： MEDTRONIC MINIMED, INC.
发明人： VARSAVSKY, Andrea , LI, Xiaolong , LIU, Mike C. , ZHONG, Yuxiang , YANG, Ning
IPC分类号： A61B5/145
CPC分类号： A61B5/1495 , A61B5/0004 , A61B5/14503 , A61B5/14532 , A61B5/1455 , A61B5/14556 , A61B5/1459 , A61B5/1468 , A61B5/1473 , A61B5/4839 , A61B5/7221 , A61B5/7278 , A61B2560/0223 , A61B2560/0238 , A61B2562/06 , A61M5/142 , A61M5/14244 , A61M5/1723 , A61M2005/1726 , A61M2205/3306 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/505 , A61M2205/52 , A61M2230/005 , A61M2230/201 , C12Q1/006 , G01N21/00 , G01N21/59 , G01N21/84 , G01N27/27 , G01N27/3274 , G01N27/4163 , G01N33/49 , G01N33/66 , G01N2201/127
摘要： Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.
摘要翻译：用于传感器校准和传感器葡萄糖（SG）融合的方法和系统有利地用于提高正交冗余葡萄糖传感器装置的精度和可靠性，其可以包括光学和电化学葡萄糖传感器。可以通过固定偏移和/或动态回归方法来实现两个传感器的校准，这取决于例如传感器稳定性和Isig-Ratio对相关性。对于SG融合，可以对来自光学和电化学传感器的SG值执行相应的完整性检查，并且如果通过完整性检查，校准SG值。完整性检查可能包括检查灵敏度损失，噪声和漂移。如果完整性检查失败，则可以在校准之前执行电化学和光学传感器之间的在线传感器映射。电化学和光学SG值可以被加权（作为各个传感器的整体可靠性指数（RI）的函数），并且加权的SG组合以获得单个融合的SG值。

10. 发明申请

WO2019055237A1 METHODS, SYSTEMS, AND DEVICES FOR CALIBRATION AND OPTIMIZATION OF GLUCOSE SENSORS AND SENSOR OUTPUT 审中-公开
公开(公告)号：WO2019055237A1
公开(公告)日：2019-03-21
申请号：PCT/US2018/049190
申请日：2018-08-31
申请人： MEDTRONIC MINIMED, INC.
发明人： AJEMBA, Peter , NOGUEIRA, Keith , NISHIDA, Jeffrey , TSAI, Andy Y. , KANNARD, Brian T. , MILLER, Michael E. , JACKS, Steven C. , VARSAVSKY, Andrea
IPC分类号： A61B5/145 , A61B5/1486 , A61B5/1468 , A61B5/00
摘要： A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects. Correction actors, fusion algorithms, EIS, and advanced ASICs may be used to implement the foregoing, thereby achieving the goal of improved accuracy and reliability without the need for blood-glucose calibration, and providing a calibration-free, or near calibration-free, sensor.

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