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1. 发明申请

WO2004034880A3 TIMED DELAY FOR REDELIVERY OF TREATMENT THERAPY FOR A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：定时延迟用于医疗设备系统的治疗治疗
公开(公告)号：WO2004034880A3
公开(公告)日：2004-07-22
申请号：PCT/US0332909
申请日：2003-10-15
申请人： MEDTRONIC INC , FREI MARK G , OSORIO IVAN , BHAVARAJU NARESH C , CARLSON DAVID L , GIFTAKIS JONATHON E , GRAVES NINA M
发明人： FREI MARK G , OSORIO IVAN , BHAVARAJU NARESH C , CARLSON DAVID L , GIFTAKIS JONATHON E , GRAVES NINA M
IPC分类号： A61B20060101 , A61B5/00 , A61B5/04 , A61B5/0476
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61N1/36025 , A61N1/36082 , A61N1/361 , Y10S128/92
摘要： Apparatus (100) and method support a repetitive administration of a therapeutic treatment through a delivery unit (953) during a neurological event, such as a seizure, of a nervous system disorder. The medical device system monitors signal data from a sensor and through an amplifier. A neurological event is detected by a medical device system using a detection algorithm. Consequently, a electrical stimulation pulse is applied to an electrode. During the delivery of the electrical stimulation pulse, the medical device system blanks signal data that is associated with the electrode. Subsequently, additional blanking is providing during a time interval in which signal artifacts may occur and the amplifier is stabilizing. The medical device system then collects signal data for the detection algorithm to stabilize. Subsequently, the medical device system collects additional signal data in order to obtain statistically meaningful data. If the medical device system detects a continuation of the seizure, therapeutic treatment continues.
摘要翻译：装置（100）和方法支持在神经系统疾病的神经事件（例如癫痫发作）期间通过递送单元（953）重复施用治疗性治疗。医疗设备系统监控来自传感器和放大器的信号数据。通过使用检测算法的医疗装置系统检测到神经系统事件。因此，电刺激脉冲被施加到电极。在递送电刺激脉冲期间，医疗装置系统消除与电极相关联的信号数据。随后，在可能发生信号伪影的时间间隔内提供额外的消隐，并且放大器正在稳定。然后，医疗装置系统收集用于检测算法的信号数据以稳定。随后，医疗设备系统收集附加信号数据，以获得统计上有意义的数据。如果医疗器械系统检测到持续的癫痫发作，则继续治疗。

2. 发明申请

WO2004034879A3 SCREENING TECHNIQUES FOR MANAGEMENT OF A NERVOUS SYSTEM DISORDER 审中-公开
标题翻译：用于管理神经系统疾病的筛选技术
公开(公告)号：WO2004034879A3
公开(公告)日：2004-07-22
申请号：PCT/US0332906
申请日：2003-10-15
申请人： MEDTRONIC INC , OSORIO IVAN , FREI MARK G , BHAVARAJU NARESH C , PETERS THOMAS E , GRAVES NINA M , SCHAFFNER SCOTT F , GIFTAKIS JONATHON E , RISE MARK T , WERDER JONATHAN C
发明人： OSORIO IVAN , FREI MARK G , BHAVARAJU NARESH C , PETERS THOMAS E , GRAVES NINA M , SCHAFFNER SCOTT F , GIFTAKIS JONATHON E , RISE MARK T , WERDER JONATHAN C
IPC分类号： A61B20060101 , A61B5/00 , A61B17/52 , A61F7/00 , A61N1/00 , A61N2/00
CPC分类号： A61N1/08 , A61B5/0476 , A61B5/4094 , A61B5/7275 , A61N1/36025 , A61N1/36082 , A61N1/361 , A61N1/37217
摘要： Apparatus (100) and method support a neurological event screening for a medical device. The medical device (100) assists a user in determining a configuration of the medical device for delivering an effective treatment for a nervous system disorder. The medical device detects a neurological event, such as a seizure, and reports a neurological event focus location and a neurological event spread to the user. The user may use the information to provide a configuration of a therapeutic delivery unit and associated therapy parameters. Therapeutic treatment is delivered to the patient, and the medical device is provided an indication of the patient's acceptance to the treatment. The user may modify the configuration and therapy parameters in order to achieve efficacy and acceptance. Depending upon the patient's acceptance, therapy is applied in either an open loop mode or a closed loop mode. The medical device determines whether the treatment is successful in accordance with a criterion.
摘要翻译：装置（100）和方法支持用于医疗装置的神经事件筛查。医疗装置（100）帮助用户确定医疗装置的配置以递送用于神经系统障碍的有效治疗。医疗装置检测诸如癫痫发作的神经系统事件，并向用户报告神经系统事件焦点位置和神经系统事件。用户可以使用该信息来提供治疗递送单元的配置和相关联的治疗参数。向患者传送治疗性治疗，并且向患者提供患者接受治疗的指示。用户可以修改配置和治疗参数，以达到功效和验收。根据患者的接受程度，治疗以开环模式或闭环模式应用。医疗设备根据标准确定治疗是否成功。

3. 发明申请

WO2004036370A3 CHANNEL-SELECTIVE BLANKING FOR A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：用于医疗设备系统的通道选择性保护
公开(公告)号：WO2004036370A3
公开(公告)日：2004-07-15
申请号：PCT/US0332908
申请日：2003-10-15
申请人： MEDTRONIC INC , FREI MARK G , OSORIO IVAN , RISE MARK T , GIFTAKIS JONATHON E , GRAVES NINA M , CARLSON DAVID L , JENSEN RANDY M
发明人： FREI MARK G , OSORIO IVAN , RISE MARK T , GIFTAKIS JONATHON E , GRAVES NINA M , CARLSON DAVID L , JENSEN RANDY M
IPC分类号： A61N1/08 , A61N1/32 , A61N1/36 , A61N2/00
CPC分类号： A61N1/37264 , A61N1/36146 , A61N2/00
摘要： Apparatuses and methods selectively blank a neurological channel of a medical device system (100) in the treatment of a nervous system disorder.
摘要翻译：装置和方法选择性地消除医疗装置系统（100）在治疗神经系统疾病中的神经通道。

4. 发明申请

WO2004034882A3 MEASURING A NEUROLOGICAL EVENT USING CLUSTERING 审中-公开
标题翻译：使用聚类测量神经病学事件
公开(公告)号：WO2004034882A3
公开(公告)日：2005-08-11
申请号：PCT/US0332940
申请日：2003-10-15
申请人： MEDTRONIC INC , FREI MARK G , OSORIO IVAN , GRAVES NINA M , SCHAFFNER SCOTT F , RISE MARK T , GIFTAKIS JONATHON E , CARLSON DAVID L
发明人： FREI MARK G , OSORIO IVAN , GRAVES NINA M , SCHAFFNER SCOTT F , RISE MARK T , GIFTAKIS JONATHON E , CARLSON DAVID L
IPC分类号： A61B20060101 , A61B5/00 , A61B5/04 , A61B5/0476
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61N1/36025 , A61N1/36082 , A61N1/361 , Y10S128/92
摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each m successive group of applications of the treatment therapy or for each n detection cluster.
摘要翻译：装置和方法检测与神经系统疾病（例如癫痫发作），与治疗疗法相关的神经系统疾病和更新治疗参数相关联的检测簇。当最大比例超过强度阈值时，检测到簇的出现。如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联。因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。可以通过提供电刺激，药物输注或组合来提供治疗治疗。可以针对治疗疗法的每个连续的应用组或每个第n个检测簇更新治疗参数。

5. 发明申请

WO2004036372A3 SCORING OF SENSED NEUROLOGICAL SIGNALS FOR USE WITH A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：感染神经信号与医疗设备系统的使用
公开(公告)号：WO2004036372A3
公开(公告)日：2004-07-15
申请号：PCT/US0332944
申请日：2003-10-15
申请人： MEDTRONIC INC , OSORIO IVAN , FREI MARK G , GRAVES NINA M , GIFTAKIS JONATHON E
发明人： OSORIO IVAN , FREI MARK G , GRAVES NINA M , GIFTAKIS JONATHON E
IPC分类号： A61B5/00 , A61B5/04 , A61B5/048 , A61N1/36 , A61N1/37 , A61N1/372 , G06F20060101
CPC分类号： A61N1/3702 , A61B5/048 , A61B5/4064 , A61B5/4094 , A61N1/36017 , A61N1/36064 , A61N1/36082 , A61N1/36135 , A61N1/37252 , Y10S128/92
摘要： A medical device system (100) capable of scoring a severity of sensed neurological signals relating to a nervous system disorder. The system comprises a monitoring element that receives a neurological signal having at least one event to be scored. The medical device system identifies one or more features of the neurological signal to use in scoring and computes a score of relative severity of the event using the identified feature. Once two or more events have been scored, the events may be ranked by severity relative to each other.
摘要翻译：一种医疗装置系统（100），其能够评估与神经系统疾病相关的感觉神经信号的严重性。该系统包括监测元件，其接收具有至少一个待评分事件的神经信号。医疗装置系统识别用于评分的神经信号的一个或多个特征，并且使用所识别的特征来计算事件的相对严重程度的得分。一旦两次或更多次的事件得分，事件可能会相对于彼此的严重程度排序。

6. 发明申请

WO2004036377A3 CONFIGURING AND TESTING TREATMENT THERAPY PARAMETERS FOR A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：配置和测试治疗医疗设备系统的参数
公开(公告)号：WO2004036377A3
公开(公告)日：2004-07-29
申请号：PCT/US0333000
申请日：2003-10-15
申请人： MEDTRONIC INC , OSORIO IVAN , FREI MARK G , BHAVARAJU NARESH C , PETERS THOMAS E , JENSEN RANDY M
发明人： OSORIO IVAN , FREI MARK G , BHAVARAJU NARESH C , PETERS THOMAS E , JENSEN RANDY M
IPC分类号： A61N1/05 , A61N1/08 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36132 , A61N1/08
摘要： Apparatus and method support the configuration and testing of therapy parameters for a medical device system (100) in the treatment of nervous system disorders.
摘要翻译：装置和方法支持用于医疗装置系统（100）治疗神经系统疾病的治疗参数的配置和测试。

7. 发明申请

WO2004034883A3 SYNCHRONIZATION AND CALIBRATION OF CLOCKS FOR A MEDICAL DEVICE AND CALIBRATED CLOCK 审中-公开
标题翻译：医疗仪器和校准钟的时钟同步和校准
公开(公告)号：WO2004034883A3
公开(公告)日：2004-06-10
申请号：PCT/US0332941
申请日：2003-10-15
申请人： MEDTRONIC INC , OSORIO IVAN , BHAVARAJU NARESH C , PETERS THOMAS E , FREI MARK G , WERDER JONATHAN C
发明人： OSORIO IVAN , BHAVARAJU NARESH C , PETERS THOMAS E , FREI MARK G , WERDER JONATHAN C
IPC分类号： A61B20060101 , A61B5/00 , A61B5/048 , A61N1/372 , G04F1/00 , G04G7/00
CPC分类号： A61N1/37229 , A61B5/0006 , A61B5/048 , A61B5/4094 , A61N1/025 , A61N1/36025 , A61N1/36082 , A61N1/37 , A61N1/372 , G04G7/00
摘要： Apparatus and method support the synchronization and calibration of a plurality of clocks in a medical device system that may provide treatment to a patient with a nervous system disorder. The plurality of clocks, which may be located at different components of the medical device system, comprises a first clock and a second clock. The second clock may be synchronized (1517) to a first clock by disabling a run mode operation and setting the second clock to a selected time. When a reference time of the first clock approximately equals the selected time, the second clock enables the run mode operation. Additionally, a drift time that is indicative of a time difference between the first clock and the second clock is determined. If the drift time is greater than a predetermined amount, an indication to resynchronize the first and second clocks is provided.
摘要翻译：装置和方法支持医疗装置系统中的多个时钟的同步和校准，其可以向患有神经系统病症的患者提供治疗。可以位于医疗设备系统的不同组件处的多个时钟包括第一时钟和第二时钟。通过禁用运行模式操作并将第二时钟设置为选定时间，第二时钟可以与第一时钟同步（1517）。当第一个时钟的参考时间大约等于所选时间时，第二个时钟启用运行模式操作。另外，确定指示第一时钟和第二时钟之间的时间差的漂移时间。如果漂移时间大于预定量，则提供重新同步第一和第二时钟的指示。

8. 发明申请

WO2004036376A2 MULTI-MODAL OPERATION OF A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：医疗器械系统的多模式操作
公开(公告)号：WO2004036376A2
公开(公告)日：2004-04-29
申请号：PCT/US0332997
申请日：2003-10-15
申请人： MEDTRONIC INC , OSORIO IVAN , FREI MARK G , RISE MARK T , SCHAFFNER SCOTT F , GRAVES NINA M
发明人： OSORIO IVAN , FREI MARK G , RISE MARK T , SCHAFFNER SCOTT F , GRAVES NINA M
IPC分类号： A61N1/08 , A61N1/36 , A61N2/00 , G06F
CPC分类号： A61N1/36025 , A61N1/08 , A61N1/36082
摘要： Apparatuses and methods support multi-modal operation of a medical device system for a nervous system disorder. The medical device system comprises an implanted component and an external component and supports a first feature and a second feature that are associated with the treatment therapy. The medical device system supports both features when the implanted component and the external component are coupled. If the external component is decoupled, the implanted component continues to support the first feature. Moreover, the embodiment may support a plurality of features during a treatment interval. Another aspect of the invention allows for modularly expanding a medical device system in order to add a feature that enhances existing functionality or that provides additional functionality. In an embodiment, a module that is associated with an external component of the medical device system supports the added feature.
摘要翻译：装置和方法支持用于神经系统障碍的医疗装置系统的多模式操作。医疗装置系统包括植入部件和外部部件，并且支撑与治疗疗法相关联的第一特征和第二特征。当植入部件和外部部件联接时，医疗装置系统支持两个特征。如果外部组件解耦，则植入组件继续支持第一个特征。此外，该实施例可以在治疗间隔期间支持多个特征。本发明的另一方面允许模块化地扩展医疗设备系统，以便添加增强现有功能或提供附加功能的特征。在一个实施例中，与医疗设备系统的外部部件相关联的模块支持附加的特征。

9. 发明申请

WO2004034881A3 SIGNAL QUALITY MONITORING AND CONTROL FOR A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：医疗设备系统的信号质量监测与控制
公开(公告)号：WO2004034881A3
公开(公告)日：2004-07-01
申请号：PCT/US0332938
申请日：2003-10-15
申请人： MEDTRONIC INC , FREI MARK G , OSORIO IVAN , WERDER JONATHAN C , CARLSON DAVID L
发明人： FREI MARK G , OSORIO IVAN , WERDER JONATHAN C , CARLSON DAVID L
IPC分类号： A61B20060101 , A61B1/00 , A61B5/00 , A61B5/04 , A61B5/05 , A61N1/36 , A61N1/37 , A61N1/372
CPC分类号： A61N1/37252 , A61B5/04012 , A61B5/048 , A61B5/4094 , A61N1/36014 , A61N1/36064 , A61N1/36082 , A61N1/3702 , A61N1/37229
摘要： Method and apparatus for detecting possible interference in a neurological signal received from a monitoring element of a medical device system. The monitoring element monitors a condition or a symptom of a nervous system disorder being treated and provides a neurological signal to the medical device system for purposes of providing closed-loop feedback control. The system analyzes various parameters of the received signal by taking instantaneous measurements of data points in moving window and thereby determining whether the signal is of poor quality. If the signal is of determined poor quality, it is removed from consideration in the closed-loop feedback control system until it is determined that the signal quality has sufficiently been restored.
摘要翻译：用于检测从医疗设备系统的监视元件接收的神经信号中可能的干扰的方法和装置。监测元件监测正在治疗的神经系统疾病的状况或症状，并为了提供闭环反馈控制的目的而向医疗设备系统提供神经信号。系统通过对移动窗口中的数据点进行瞬时测量来分析接收信号的各种参数，从而确定信号质量是否差。如果信号质量差，则在闭环反馈控制系统中将其从考虑中移除，直到确定信号质量已被充分恢复。

10. 发明申请

WO2004034998A3 CONTROL OF TREATMENT THERAPY DURING START-UP AND DURING OPERATION OF A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：医疗器械系统启动和运行期间治疗治疗的控制
公开(公告)号：WO2004034998A3
公开(公告)日：2005-01-13
申请号：PCT/US0332868
申请日：2003-10-15
申请人： MEDTRONIC INC , OSORIO IVAN , FREI MARK G , CARLSON DAVID L
发明人： OSORIO IVAN , FREI MARK G , CARLSON DAVID L
IPC分类号： A61N1/18 , A61N1/36 , A61N1/372
CPC分类号： A61N1/37235 , A61B5/4094 , A61B5/725 , A61N1/36014 , A61N1/36025 , A61N1/36082 , A61N1/36135 , A61N1/37229
摘要： A method and medical device system (100) for controlling treatment therapy delivered to treat a nervous system disorder.
摘要翻译：一种用于控制递送以治疗神经系统疾病的治疗疗法的方法和医疗装置系统（100）。

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