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1. 发明申请

WO2005116623A3 POINT OF CARE HEPARIN DETERMINATION SYSTEM 审中-公开
标题翻译：治疗点肝素测定系统
公开(公告)号：WO2005116623A3
公开(公告)日：2006-01-26
申请号：PCT/US2005016463
申请日：2005-05-11
申请人： MEDTRONIC INC , BONNEMA KELVIN , HOBOT CHRISTOPHER M , MEYER RANDY , NIPPOLDT DOUGLAS D , QIN WEI , RAMAMURTHY NARAYANAN , SITKO VITALLY G , YE QINGSHAN
发明人： BONNEMA KELVIN , HOBOT CHRISTOPHER M , MEYER RANDY , NIPPOLDT DOUGLAS D , QIN WEI , RAMAMURTHY NARAYANAN , SITKO VITALLY G , YE QINGSHAN
IPC分类号： G01N27/333 , G01N33/487 , G01N33/86
CPC分类号： G01N27/3335 , A61M1/3675 , G01N27/333 , G01N33/86
摘要： Methods and devices for point of care determination of heparin concentration in blood. Cartridges (54) including protamine ion sensitive electrodes (ISEs) (62) and reference electrodes (64) and systems for automatically determining heparin concentration in the cartridges are provided. Some systems add blood to a protamine bolus sufficient to bind all heparin, leaving excess protamine. The excess protamine concentration can be determined by measuring the initial slope of the electrode potential rate of change, and comparing the slope to known protamine concentration slope values In some cartridges, an oscillating pressure source moves the blood-protamine mixture back and forth across the protamine ISE. Some systems also use a second blood sample having the heparin removed or degraded to create a blank reference sample. Protamine ISEs can include polyurethane polymer, DNNS ionophore, and NPOE plasticizer. The polyurethane may include hard segments and soft segments, where both hard and soft segments may include cyclic and straight chain aliphatic moieties having essentially no ester or ether groups. Some hard segments may include methylene diphenyl groups. Some reference electrodes have the same polymer, plasticizer, and ionophore as the measurement electrode, but with a different concentration of ionophore.
摘要翻译：血液中肝素浓度测定点的方法和装置。提供了包括鱼精蛋白离子敏感电极（ISE）（62）和参考电极（64）的盒（54）以及用于自动确定药筒中肝素浓度的系统。一些系统将血液添加到足以结合所有肝素的鱼精蛋白推注物，留下过量的鱼精蛋白。过量的鱼精蛋白浓度可以通过测量电极电位变化率的初始斜率来确定，并将斜率与已知的鱼精蛋白浓度斜率值进行比较。在一些药筒中，振荡压力源将血 - 鱼精蛋白混合物来回移动穿过鱼精蛋白 ISE。一些系统还使用除去或降解肝素以创建空白参考样品的第二血液样品。鱼精蛋白ISE可以包括聚氨酯聚合物，DNNS离子载体和NPOE增塑剂。聚氨酯可以包括硬链段和软链段，其中硬链段和软链段都可以包括基本上没有酯或醚基团的环状和直链脂族部分。一些硬链段可以包括亚甲基二苯基。一些参比电极与测量电极具有相同的聚合物，增塑剂和离子载体，但是具有不同浓度的离子载体。

2. 发明申请

WO2008073255A3 SPREADING LAYER AND HUMIDITY CONTROL LAYER FOR ENHANCING SENSOR PERFORMANCE 审中-公开
标题翻译：扩展层和湿度控制层，以提高传感器性能
公开(公告)号：WO2008073255A3
公开(公告)日：2009-01-08
申请号：PCT/US2007024942
申请日：2007-12-06
申请人： OPTI MEDICAL SYSTEMS , RAMAMURTHY NARAYANAN , HE HUARUI , LIN CHAO
发明人： RAMAMURTHY NARAYANAN , HE HUARUI , LIN CHAO
IPC分类号： B01D69/14 , B01D69/10 , B01J20/28 , G01N33/18 , G01N33/52
CPC分类号： G01N33/525 , B01D2253/202 , B01D2257/80 , B01J20/28033 , B01J20/28097 , G01N21/274 , G01N21/6428 , G01N21/8483 , G01N2021/7786 , Y10T428/24273 , Y10T428/265 , Y10T428/31504
摘要： The invention is directed to optical sensors for measuring clinically relevant analytes, their methods of manufacture, and their various uses. In an effort to develop a dry calibration method for the optical sensors of the invention it is discovered that water content inside or in the immediate vicinity of a such a sensor can have a major impact on fluorescence intensity (i.e., a sensor's response in the dry state). Thus, one of the objectives of the invention is the elimination of the bias of sensor responses measured at different humidity environments. The invention concerns a multi-layered laminate comprising inter alia a humidity control layer and a spreading layer. Said layers comprise a water-insoluble porous matrix, including a plurality of channels or through-holes at least some of which extend from one side of the layer to an opposing side, a portion of said holes or channels being filled with a water-soluble, solid, polymeric substance.
摘要翻译：本发明涉及用于测量临床相关分析物，其制造方法及其各种用途的光学传感器。为了开发用于本发明的光学传感器的干式校准方法，发现这种传感器内部或附近的含水量可能对荧光强度具有主要影响（即，传感器在干燥时的响应州）。因此，本发明的目标之一是消除在不同湿度环境下测量的传感器响应的偏差。本发明涉及一种包括湿度控制层和铺展层的多层叠层。所述层包括水不溶性多孔基质，其包括多个通道或通孔，其至少一些通道或通孔从该层的一侧延伸到相对侧，所述孔或通道的一部分填充有水溶性，固体，聚合物质。

3. 发明申请

WO0188520A2 ION-SELECTIVE SOLID-STATE POLYMERIC MEMBRANE ELECTRODES 审中-公开
标题翻译：离子选择性固态聚合物膜电极
公开(公告)号：WO0188520A2
公开(公告)日：2001-11-22
申请号：PCT/US0116165
申请日：2001-05-16
申请人： MEDTRONIC INC , UNIV MICHIGAN
发明人： RAMAMURTHY NARAYANAN , MEYERHOFF MARK E , BAUGH ROBERT P , LARKIN COLIN P
IPC分类号： G01N27/28 , G01N27/333 , G01N27/414 , G01N27/416 , G01N27/00
CPC分类号： G01N27/3335
摘要： An improved ion-sensing electrode for detecting ions or polyions is provided having an electrically conducting member sheathed or coated with a layer of insulation except at an exposed, uninsulated area, where the insulation free surface of the electrically conducting member is texturized, and a polymeric membrane coated on the insulation-free surface of the electrically conducting member, where the ion selective membrane includes an ionophore. The texturized surface improves the starting EMF stability and reproducibility of the ion-sensing electrodes, and further improves membrane adherence to the electrically conducting member.
摘要翻译：提供了一种用于检测离子或聚阴离子的改进的离子感测电极，其具有包覆或涂覆有绝缘层的导电构件，除了暴露的未绝缘区域，其中导电构件的绝缘自由表面被组织化，膜涂覆在导电构件的绝缘表面上，其中离子选择性膜包括离子载体。纹理化表面改善了起始EMF稳定性和离子感测电极的再现性，并且进一步改善了与导电构件的膜粘附性。

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