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1. 发明申请

WO2005092436A1 METHOD AND APPARATUS FOR DELIVERING MULTI-DIRECTIONAL DEFIBRILLATION WAVEFORMS 审中-公开
标题翻译：用于提供多方向定位波形的方法和装置
公开(公告)号：WO2005092436A1
公开(公告)日：2005-10-06
申请号：PCT/US2005/009216
申请日：2005-03-18
申请人： MEDTRONIC, INC. , WANASEK, Kevin, A. , HAVEL, William, J.
发明人： WANASEK, Kevin, A. , HAVEL, William, J.
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering a pulse waveform to a target site of a patient that includes an energy storage device storing electrical energy, and a plurality of electrodes electrically coupled to the energy storage device. Control circuitry, coupled to a plurality of switching elements coupled to the plurality of electrodes, selectively switches the plurality of switching elements between a first state and a second state to direct discharge of the stored energy to be simultaneously output at selected electrodes of the plurality of electrodes to generate discrete sequential resultant output pulses across multiple pathways, the discrete sequential resultant output pulses generating a multi-directional waveform at the target site.
摘要翻译：一种用于将脉搏波形传送到患者的靶位置的方法和装置，所述方法和装置包括存储电能的能量存储装置，以及电耦合到所述能量存储装置的多个电极。耦合到耦合到多个电极的多个开关元件的控制电路在第一状态和第二状态之间选择性地切换多个开关元件，以直接放电存储的能量，以同时在多个电极中的选定电极处输出电极，用于在多个路径上产生离散的顺序结果输出脉冲，离散的顺序结果输出脉冲在目标位置处产生多方向波形。

2. 发明申请

WO2012151302A1 VERIFICATION OF PRESSURE METRICS 审中-公开
标题翻译：压力测量的验证
公开(公告)号：WO2012151302A1
公开(公告)日：2012-11-08
申请号：PCT/US2012/036158
申请日：2012-05-02
申请人： MEDTRONIC, INC. , HAVEL, William, J. , BENNETT, Tommy D. , CHO, Yong Kyun , TAEPKE, II, Robert T.
发明人： HAVEL, William, J. , BENNETT, Tommy D. , CHO, Yong Kyun , TAEPKE, II, Robert T.
IPC分类号： A61N1/37 , A61B5/024
CPC分类号： A61N1/3702 , A61B5/0215 , A61B5/686 , A61B5/7207 , A61B5/7239 , A61N1/36564
摘要： An example system may include at least one pressure sensor configured to measure a cardiovascular pressure signal and another medical device configured to measure an electrical depolarization signal of the heart. The system determines a plurality of cardiovascular pressure metrics based on the measured cardiovascular pressure signal, including at least one cardiovascular pressure metric indicative of a timing of at least one cardiac pulse. The system also determines a metric indicative of a timing of at least one heart depolarization within the measured electrical depolarization signal. The system compares the timing of the at least one cardiac pulse to the timing of the at least one depolarization, and determines whether to discard the plurality of cardiovascular pressure metrics based on whether the timings substantially agree.
摘要翻译：示例性系统可以包括配置成测量心血管压力信号的至少一个压力传感器和被配置成测量心脏的电去极化信号的另一医疗装置。该系统基于所测量的心血管压力信号确定多个心血管压力指标，所述心血管压力信号包括指示至少一个心脏脉搏的定时的至少一个心血管压力指标。该系统还确定指示所测量的电去极化信号内的至少一次心脏去极化的定时的度量。所述系统将所述至少一个心脏脉搏的定时与所述至少一个去极化的定时进行比较，并且基于所述时间是否基本上同意来确定是否丢弃所述多个心血管压力指标。

3. 发明申请

WO2011031727A1 METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 审中-公开
标题翻译：使用组织氧化测量法进行后期评估的方法和装置
公开(公告)号：WO2011031727A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048088
申请日：2010-09-08
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David, A. , HAVEL, William, J.
发明人： KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David, A. , HAVEL, William, J.
IPC分类号： A61N1/39 , A61B5/00
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a monitoring module detecting a cardiac event in response to the sensed cardiac signals using first detection criteria, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the monitoring module, the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, determine a recovery index in response to the determined tissue oxygenation trend, and control one or both of detecting a cardiac event by the monitoring module and delivery of therapy by the therapy delivery module in response to the determined recovery index.
摘要翻译：一种用于递送疗法的方法和装置，其包括用于感测心脏信号并递送治疗的电极，监测模块，响应于使用第一检测标准的所感测到的心脏信号检测心脏事件;发射光的传感器，检测由与所述传感器相邻的组织体积以产生相应的检测到的光强度输出信号;耦合到所述传感器的控制模块，以响应于递送所述治疗而控制所述传感器的光发射;以及控制器，耦合到所述监测模块，所述治疗递送模块以及所述传感器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，响应于所述组织氧合测量确定组织氧合趋势，响应于所确定的组织氧合趋势确定恢复指数，并且控制一个或两个通过监测模块检测心脏事件并进行治疗 y由治疗递送模块响应于确定的恢复指数。

4. 发明申请

WO2007087551A1 IMPLANTABLE SUBCUTANEOUS MEDICAL DEVICE PROVIDING POST-EXTRA-SYSTOLIC POTENTIATION THERAPY 审中-公开
标题翻译：提供后期 - 同步电位治疗的可植入辅助医疗器械
公开(公告)号：WO2007087551A1
公开(公告)日：2007-08-02
申请号：PCT/US2007/060949
申请日：2007-01-24
申请人： MEDTRONIC, INC. , DENO, Curtis, D. , HAVEL, William, J.
发明人： DENO, Curtis, D. , HAVEL, William, J.
IPC分类号： A61N1/365 , A61N1/37 , A61N1/39
CPC分类号： A61N1/36514 , A61N1/36528 , A61N1/36542 , A61N1/3702 , A61N1/3962
摘要： An ICD system adapted for subcutaneous implantation, the system comprising: a pair of electrodes adapted to deliver electrical stimulation to a heart; a set of low polarization electrodes for sensing a response to electrical potentiation pulses delivered from the first pair of electrodes; and a counter for logging a duration of fast VT and VF between high voltage shocks that restore normal sinus rhythm to the heart, the shocks delivered by the first pair of electrodes.
摘要翻译：一种适于皮下植入的ICD系统，所述系统包括：一对适于向心脏传递电刺激的电极; 一组用于感测从第一对电极传递的电加强脉冲的响应的低极化电极; 以及用于记录在恢复心脏正常窦性心律的高电压冲击之间的快速VT和VF持续时间的计数器，由第一对电极传递的冲击。

5. 发明申请

WO2010051486A1 SHUNT-CURRENT REDUCTION HOUSING FOR AN IMPLANTABLE THERAPY SYSTEM 审中-公开
标题翻译：用于可植入治疗系统的分流电流减少外壳
公开(公告)号：WO2010051486A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/062839
申请日：2009-10-30
申请人： MEDTRONIC, INC. , DONOFRIO, William, T. , HAVEL, William, J. , CHRISTIANSEN, Chris, C. , KRAUSE, Paul, G.
发明人： DONOFRIO, William, T. , HAVEL, William, J. , CHRISTIANSEN, Chris, C. , KRAUSE, Paul, G.
IPC分类号： A61N1/37 , A61N1/375 , A61N1/08 , A61N1/372 , A61N1/39
CPC分类号： A61N1/375 , A61N1/08 , A61N1/36114 , A61N1/37 , A61N1/3718 , A61N1/37211 , A61N1/37288 , A61N1/3925 , A61N1/3962
摘要： Techniques for minimizing interference between first and second medical devices of a therapy system may include providing an outer housing for at least one of the medical devices that comprises an electrically insulative layer formed over at least the electrically conductive portions (e.g., an electrically conductive layer) of the housing, or providing an electrically insulative pouch around an electrically conductive housing of at least the first medical device. The electrically insulative layer or electrically insulative pouch may reduce or even eliminate shunt-current that flows into the medical device via the housing. The shunt-current may be generated by the delivery of electrical stimulation by the second medical device. In some examples, the techniques may also include shunt-current mitigation circuitry that helps minimize or even eliminate shunt-current that feeds into the first medical device via one or more electrodes electrically connected to the first medical device.
摘要翻译：用于最小化治疗系统的第一和第二医疗装置之间的干扰的技术可以包括提供用于至少一个医疗装置的外壳，其包括在至少导电部分（例如，导电层）上形成的电绝缘层，或者提供围绕至少第一医疗装置的导电外壳的电绝缘袋。电绝缘层或电绝缘袋可以减少甚至消除经由外壳流入医疗装置的分流电流。分流电流可以通过第二医疗装置的电刺激的传递来产生。在一些示例中，所述技术还可以包括分流电流缓解电路，其帮助最小化或甚至消除通过电连接到第一医疗设备的一个或多个电极馈入第一医疗设备的分流电流。

6. 发明申请

WO2010014375A1 MEDICAL DEVICE SYSTEM AND APPARATUS FOR GUIDING THE PLACEMENT OF A SUBCUTANEOUS DEVICE 审中-公开
标题翻译：医疗装置系统及用于指导装置的装置
公开(公告)号：WO2010014375A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/050188
申请日：2009-07-10
申请人： MEDTRONIC, INC. , HAVEL, William, J. , NIKOLSKI, Vladimir, P.
发明人： HAVEL, William, J. , NIKOLSKI, Vladimir, P.
IPC分类号： A61B17/34
CPC分类号： A61B17/3468 , A61B17/3462 , A61B17/3472 , A61B2017/00026 , A61B2017/0003 , A61B2017/00561 , A61B2017/306 , A61B2017/320044 , A61B2017/320056 , A61M5/425 , A61M5/427 , A61M2005/1586 , A61N1/046 , A61N1/0504
摘要： A medical device system (300) for advancing a subcutaneous device to a desired implant site that includes a strap (302) extending along a length from a proximal end (311) to a distal end (313), a first curved flange (303) and a second curved flange (305) extending along a portion of the length of the strap (302), a base portion (306) extending along a portion of the length of the strap (302) between the first curved flange (303) and the second curved flange (305), and an indentation (304) extending from the proximal end (311) to the distal end (313)of the strap (302), the indentation (304)formed by the first curved flange (303), the second curved flange (305), and the base portion (306), wherein the first curved flange (303) and the second curved flange (305) include curved bottom portions (320) that make contact with and compress a tissue layer (372, 374) to position the tissue layer (372,374) within the indentation (304) during the placement of the subcutaneous device, such as a coil electrode for an implantable cardioverter defibrillator (ICD).
摘要翻译：一种用于将皮下装置推进到期望的植入部位的医疗装置系统（300），其包括沿着从近端（311）到远端（313）的长度延伸的带（302），第一弯曲凸缘（303）和沿所述带（302）的长度的一部分延伸的第二弯曲凸缘（305），沿所述带（302）的所述长度的一部分延伸的基部（306），所述基部在所述第一弯曲凸缘（303）和所述第二弯曲凸缘（305）和从所述近端（311）延伸到所述带（302）的远端（313）的凹陷（304），由所述第一弯曲凸缘（303）形成的所述凹陷（304），第二弯曲凸缘（305）和基部（306），其中第一弯曲凸缘（303）和第二弯曲凸缘（305）包括与组织层接触并压缩组织层的弯曲底部（320） 372,374），以在皮下装置（例如线圈）的放置期间将组织层（372,374）定位在凹陷（304）内用于植入式心律转复除颤器（ICD）的电极。

7. 发明申请

WO2006115940A1 METHOD AND APPARATUS FOR VALIDATING A PACING TRAIN ASSOCIATED WITH T-SHOCK DELIVERY 审中-公开
标题翻译：用于确认与T-SHOCK交货相关的火车的方法和装置
公开(公告)号：WO2006115940A1
公开(公告)日：2006-11-02
申请号：PCT/US2006/014761
申请日：2006-04-17
申请人： MEDTRONIC, INC. , HAVEL, William, J. , SWERDLOW, Charles, D.
发明人： HAVEL, William, J. , SWERDLOW, Charles, D.
IPC分类号： A61N1/39 , A61N1/37
CPC分类号： A61N1/385 , A61N1/371
摘要： A method and apparatus for validating cardiac pacing pulse train preceding a T- shock. Validation of the pacing pulse train includes verifying capture of at least the last pacing pulse of the pulse train and verifying that intrinsic ventricular events are not sensed during a pacing train interval that includes at least the interval between the last pacing pulse and a scheduled T-shock delivery. Capture verification may include sensing an event during an ER (evoced response) sensing window, morphological analysis of a sensed event, and analysis of the temporal relationship between sensed events occurring on different EGM sources. The scheduled T-shock is delivered in response to a valid pacing pulse train. A response to an invalid pacing pulse train may include any of an invalid pacing train notification, withholding a scheduled T-shock, extension of the pacing train, repeating the pacing train, or adjusting the pacing pulse train parameters.
摘要翻译：一种在T-休克之前验证心脏起搏脉冲串的方法和装置。起搏脉冲串的验证包括验证脉冲序列的至少最后一个起搏脉冲的捕获并验证在起搏训练间隔期间没有感测到内部心室事件，其中至少包括最后起搏脉冲和调度T脉冲之间的间隔，休克送货捕获验证可以包括在ER（唤起响应）感测窗口期间检测事件，感测事件的形态分析以及在不同EGM源之间发生的感测事件之间的时间关系的分析。响应于有效的起搏脉冲序列传送预定的T型冲击。对无效的起搏脉冲串的响应可以包括无效起搏列车通知，预扣T-shock，起搏列的延长，重复起搏列或调整起搏脉冲序列参数中的任何一个。

8. 发明申请

WO2006105458A2 METHOD OF OPTIMIZING MECHANICAL HEART RATE DURING DELIVERY OF COUPLED OR PAIRED PACING 审中-公开
标题翻译：联动或配对交付期间优化机械心率的方法
公开(公告)号：WO2006105458A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/012129
申请日：2006-03-30
申请人： MEDTRONIC, INC. , HAVEL, William, J. , KRAUSE, Paul, G. , KLECKNER, Karen, J. , DENO, D., Curtis
发明人： HAVEL, William, J. , KRAUSE, Paul, G. , KLECKNER, Karen, J. , DENO, D., Curtis
IPC分类号： A61N1/362 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/37
摘要： A method of operating a cardiac pacing device that optimizes the mechanical heart rate using coordinated potentiation therapy while maximizing the opportunity for intrinsic AV conduction to occur. The method may include adjusting the timing of extra stimulus intervals during coupled or paired pacing to promote AV conduction and to effect changes in rate according to certain embodiments of the invention. Other embodiments may include adjusting the atrial pacing rate to achieve a desired target rate consistent with AV conduction. A mode switch to a dual-chamber pacing mode may be provided according to certain embodiments of the invention to ensure a ventricular rate that meets or exceeds a minimum mechanical rate.
摘要翻译：一种操作心脏起搏装置的方法，其使用协同增强疗法优化机械心率，同时最大限度地发挥固有AV传导的机会。该方法可以包括根据本发明的某些实施例在耦合或配对起搏期间调整额外刺激间隔的时间以促进AV传导并且实现速率变化。其他实施例可以包括调整心房起搏速率以实现与AV传导一致的期望目标速率。根据本发明的某些实施例，可以提供到双室起搏模式的模式切换，以确保满足或超过最小机械速率的心室率。

9. 发明申请

WO2004093991A1 TACHYCARDIA SYNCHRONIZATION DELAYS 审中-公开
标题翻译： TACHYCARDIA同步延迟
公开(公告)号：WO2004093991A1
公开(公告)日：2004-11-04
申请号：PCT/US2004/011121
申请日：2004-04-09
申请人： MEDTRONIC, INC. , DEGROOT, Paul, J. , HAVEL, William, J. , STEIN, Paul, M.
发明人： DEGROOT, Paul, J. , HAVEL, William, J. , STEIN, Paul, M.
IPC分类号： A61N1/39
CPC分类号： A61N1/3987 , A61N1/3956
摘要： In general, the invention provides for adaptive timing of the delivery of cardioversion shocks. In particular, the invention provides for an adaptive cardioversion synchronization delay with respect to a cardiac event, such as a sensed P-wave or R-wave. When cardioversion with a first synchronization delay fails to terminate a tachycardia, for example, cardioversion may be attempted again with a second synchronization delay. A medical device may keep track of whether each synchronization delay is effective in terminating the tachycardia, and may employ a historically effective synchronization delay when applying cardioversion therapy to treat a subsequent tachycardia episode.
摘要翻译：通常，本发明提供了复律冲击的递送的自适应时序。特别地，本发明提供了一种相对于心脏事件（例如感测的P波或R波）的自适应心脏复律同步延迟。当具有第一同步延迟的心脏复律不能终止心动过速时，例如，可以以第二同步延迟再次尝试心脏复律。医疗设备可以跟踪每个同步延迟是否有效终止心动过速，并且当应用心脏复律治疗以治疗随后的心动过速发作时，可以采用历史上有效的同步延迟。

10. 发明申请

WO2010014469A2 SUBCUTANEOUS IMPLANTABLE LEAD 审中-公开
标题翻译：不可替代的领先
公开(公告)号：WO2010014469A2
公开(公告)日：2010-02-04
申请号：PCT/US2009/051371
申请日：2009-07-22
申请人： MEDTRONIC, INC. , HAVEL, William, J. , LAZEROMS, Markus, J. , RUTTEN, Jean Joseph, Gerardus , SMITS, Karel, F.A.A.
发明人： HAVEL, William, J. , LAZEROMS, Markus, J. , RUTTEN, Jean Joseph, Gerardus , SMITS, Karel, F.A.A.
IPC分类号： A61N1/39 , A61N1/05
CPC分类号： A61N1/0504 , A61N1/3962
摘要： A subcutaneous implantable device is provided that includes a defibrillation electrode disposed along a portion of a lead, and a lead tip connected to the lead. The lead tip includes a trailing end coupled to a distal end of the lead, and first and second non-parallel sides extending from the trailing end that converge to a leading end that is configured to wedge between tissue layers as the lead is advanced subcutaneously.
摘要翻译：提供了一种皮下可植入装置，其包括沿引线的一部分设置的除颤电极和连接到引线的引线头。引导尖端包括联接到引线的远端的尾端以及从后端延伸的第一和第二非平行侧，所述后端会聚到前端，当引导皮下进行时，构造成在组织层之间楔入。

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