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1. 发明申请

WO2010083366A1 IMPLANTABLE MEDICAL DEVICE WITH ADAPTIVE SIGNAL PROCESSING AND ARTIFACT CANCELLATION 审中-公开
标题翻译：具有自适应信号处理和人工取消的可植入医疗器械
公开(公告)号：WO2010083366A1
公开(公告)日：2010-07-22
申请号：PCT/US2010/021124
申请日：2010-01-15
申请人： MEDTRONIC, INC. , O'BRIEN, Richard J. , DENO, D. Curtis , ANDERSON, David A. , BLOEM, David R.
发明人： O'BRIEN, Richard J. , DENO, D. Curtis , ANDERSON, David A. , BLOEM, David R.
IPC分类号： A61B5/0205
CPC分类号： A61B5/0205 , A61B5/1455 , A61B5/7207 , A61N1/3718 , A61N1/3925 , G06K9/00503 , G06K9/6247 , G06K2009/00939
摘要： A medical device (10) having a sensor sensing (30) an n-dimensional signal during a first known variable condition and during a second known variable condition different from the first known variable condition, a processor performing principal component analysis (PCA) on the sensed π-dimensional signal to generate a first template corresponding to a principal component of variation associated with the first known variable condition and a second template corresponding to a principal component of variation associated with the second known variable condition, a storage device storing the first template and the second template, and a controller detecting a patient condition in response to the stored templates.
摘要翻译：一种医疗设备（10），其具有在第一已知可变条件期间以及在与所述第一已知可变条件不同的第二已知可变条件期间感测（30）n维信号的传感器，处理器在所述第一已知可变条件下执行主成分分析（PCA）感测的p维信号以产生对应于与第一已知可变条件相关联的变化的主成分的第一模板和对应于与第二已知可变条件相关联的变化的主成分的第二模板;存储装置，存储第一模板和第二模板，以及响应于存储的模板检测患者状况的控制器。

2. 发明申请

WO2010083363A1 IMPLANTABLE MEDICAL DEVICE WITH ADAPTIVE SIGNAL PROCESSING AND ARTIFACT CANCELLATION 审中-公开
标题翻译：具有自适应信号处理和人工取消的可植入医疗器械
公开(公告)号：WO2010083363A1
公开(公告)日：2010-07-22
申请号：PCT/US2010/021120
申请日：2010-01-15
申请人： MEDTRONIC, INC. , O'BRIEN, Richard, J. , DENO, D. Curtis , ANDERSON, David, A. , BLOEM, David R.
发明人： O'BRIEN, Richard, J. , DENO, D. Curtis , ANDERSON, David, A. , BLOEM, David R.
IPC分类号： A61B5/0205 , A61B5/04 , A61B5/024 , A61B5/0245
CPC分类号： A61B5/0002 , A61B5/0006 , A61B5/0031 , A61B5/076 , A61B5/7207
摘要： A medical device includes one or more sensors used to acquire a multi-dimensional signal. In one embodiment, principal component analysis is performed on the multi-dimensional signal to produce signal data. The principal component analysis results are used to cancel signal artifact in one embodiment. A medical device controller produces one of a therapy control and a diagnostic output in response to the signal data.
摘要翻译：医疗装置包括用于获取多维信号的一个或多个传感器。在一个实施例中，对多维信号执行主成分分析以产生信号数据。在一个实施例中，主成分分析结果用于消除信号伪像。医疗设备控制器响应于信号数据产生治疗控制和诊断输出之一。

3. 发明申请

WO2005035056A1 SECURE AND EFFICACIOUS THERAPY DELIVERY FOR AN EXTRA-SYSTOLIC STIMULATION PACING ENGINE 审中-公开
标题翻译：安全和有效的治疗用于超声波刺激发动机的治疗
公开(公告)号：WO2005035056A1
公开(公告)日：2005-04-21
申请号：PCT/US2004/033276
申请日：2004-10-07
申请人： MEDTRONIC, INC. , KLECKNER, Karen, J. , PRIEVE, Kathleen, A. , GILLBERG, Jeffrey, M. , ZHOU, Rebn , ANDERSON, Kenneth, M. , DENO, D. Curtis , ZILLMER, Glenn, C. , KLEPFER, Ruth, N. , SPLETT, Vincent, E.
发明人： KLECKNER, Karen, J. , PRIEVE, Kathleen, A. , GILLBERG, Jeffrey, M. , ZHOU, Rebn , ANDERSON, Kenneth, M. , DENO, D. Curtis , ZILLMER, Glenn, C. , KLEPFER, Ruth, N. , SPLETT, Vincent, E.
IPC分类号： A61N1/39
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3684 , A61N1/3962
摘要： An extra-systolic stimulation (ESS) therapy addresses cardiac dysfunction including heart failure. ESS therapy employs atrial and/or ventricular extra-systoles via pacing-level stimulation to a heart. These extra-systoles must be timed correctly to achieve beneficial effects on myocardial mechanics (efficacy) while maintaining an extremely low level of risk of arrhythmia induction and excellent ICD-like arrhythmia sensing and detection (security). The present invention relates to therapy delivery guidance and options for improved ESS therapy delivery. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.
摘要翻译：收缩期刺激（ESS）治疗涉及心脏功能障碍，包括心力衰竭。 ESS治疗通过对心脏的起搏水平刺激使用心房和/或心室超心动过速。这些额外的收缩期必须正确定时，以达到对心肌力学（功效）的有益影响，同时保持心律失常诱导和优异的ICD样心律失常感知和检测（安全性）的极低水平的风险。本发明涉及治疗递送指导和改善ESS治疗递送的选择。这些方法可以在外部或可植入的ESS治疗递送装置中单独使用或组合使用。

4. 发明申请

WO2006044406A1 SOFTWARE CONFIGURABLE MEDICAL DEVICE PLATFORM 审中-公开
标题翻译：软件可配置医疗设备平台
公开(公告)号：WO2006044406A1
公开(公告)日：2006-04-27
申请号：PCT/US2005/036562
申请日：2005-10-13
申请人： MEDTRONIC, INC. , DENO, D. Curtis , WILKINSON, Jeffrey, D. , STROEBEL, John, C.
发明人： DENO, D. Curtis , WILKINSON, Jeffrey, D. , STROEBEL, John, C.
IPC分类号： A61N1/365
CPC分类号： A61N1/3625 , A61N1/365 , A61N1/3956
摘要： A new design platform for implantable and external medical devices such as pacemakers, defibrillators, neurostimulators, heart monitors, etc. is provided. A real-time, highly flexible system of software and hardware modules enables both phototypes and products to respond to patient and customer needs with greater design and manufacturing efficiency. Certain embodiments integrate a general-purpose processor with interface circuitry to provide a standard platform for implement. The invention relates to medical devices such as pacemakers, pulse generators, cardioverter-defibrillators and the like and more particularly relates to modular and reconfigurable medical system platforms and methods of designing, testing, controlling and implementing diverse therapies, diagnostics, physiologic sensors and related instrumentation using said medical system platforms. Methods, systems and devices provide a new design platform for implantable and external medical devices such as pacemakers, defibrillators, neurostimulators, heart monitors, etc. A real-time, highly flexible system of software and hardware modules enables both prototypes and products to respond.
摘要翻译：提供了一种用于植入式和外部医疗设备（如起搏器，除颤器，神经刺激器，心脏监护仪等）的新设计平台。实时，高度灵活的软件和硬件模块系统使照片和产品能够以更高的设计和制造效率满足患者和客户的需求。某些实施例将通用处理器与接口电路集成以提供用于实现的标准平台。本发明涉及诸如起搏器，脉冲发生器，心律转复除颤器等的医疗装置，更具体地涉及模块化和可重构医疗系统平台以及设计，测试，控制和实施多种疗法，诊断，生理传感器和相关仪器的方法使用医疗系统平台。方法，系统和设备为植入式和外部医疗设备（如起搏器，除颤器，神经刺激器，心脏监测器等）提供了一个新的设计平台。实时，高度灵活的软件和硬件模块系统使原型和产品都能够响应。

5. 发明申请

WO2005035054A1 REFRACTORY PERIOD TRACKING AND ARRHYTHMIA DETECTION 审中-公开
标题翻译：耐火期跟踪和ARRHYTHMIA检测
公开(公告)号：WO2005035054A1
公开(公告)日：2005-04-21
申请号：PCT/US2004/033266
申请日：2004-10-07
申请人： MEDTRONIC, INC. , DENO, D. Curtis , KLEPFER, Ruth, N. , HAVEL, William, J. , SCHNEIDER, David, M. , SPLETT, Vincent, E.
发明人： DENO, D. Curtis , KLEPFER, Ruth, N. , HAVEL, William, J. , SCHNEIDER, David, M. , SPLETT, Vincent, E.
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/3622
摘要： Techniques for estimating the temporal refractory period of a heart, for adjusting a parameter for delivery of extra-systolic stimulation (ESS) therapy and for detecting an arrhythmia during delivery of ESS therapy are disclosed. In some embodiments, a medical device periodically delivers probe pulses to the heart to estimate the location of the end, e.g., boundary, of the refractory period, and accordingly estimate its length. In exemplary embodiments, the medical device determines whether two consecutive probe pulses did and did not capture the heart, respectively, and the estimates the length of the refractory period as a value between the intervals of the consecutive probe pulses. In other embodiments, the ESI is adjusted based on a measured delay between delivery of an extra-systolic pulse and detection of an evoked response resulting from the pulse.
摘要翻译：公开了用于估计心脏的时间不应期的技术，用于调整用于递送收缩期刺激（ESS）治疗的参数和用于在递送ESS治疗期间检测心律失常的技术。在一些实施例中，医疗装置周期性地向心脏递送探针脉冲以估计不应期的端部（例如边界）的位置，并因此估计其长度。在示例性实施例中，医疗装置确定两个连续的探针脉冲是否分别捕获心脏并且不捕获心脏，并且将不应期的长度估计为连续探针脉冲的间隔之间的值。在其它实施方案中，基于在收集脉搏的递送和由脉冲产生的诱发反应的检测之间的测量延迟来调整ESI。

6. 发明申请

WO2006115890A2 MULTI-SITE PESP WITH FUSION PACING 审中-公开
标题翻译：多功能聚苯乙烯泡沫塑料
公开(公告)号：WO2006115890A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/014469
申请日：2006-04-14
申请人： MEDTRONIC, INC. , BURNES, John, E. , ZILLMER, Glenn, C. , DENO, D. Curtis
发明人： BURNES, John, E. , ZILLMER, Glenn, C. , DENO, D. Curtis
CPC分类号： A61N1/3627

7. 发明申请

WO2005035052A1 METHOD AND APPARATUS FOR CONTROLLING EXTRA-SYSTOLIC STIMULATION (ESS) THERAPY USING ISCHEMIA DETECTION 审中-公开
标题翻译：用于控制异常刺激（ESS）治疗的方法和装置，使用ISCHEMIA检测
公开(公告)号：WO2005035052A1
公开(公告)日：2005-04-21
申请号：PCT/US2004/033274
申请日：2004-10-07
申请人： MEDTRONIC, INC. , WARKENTIN, Dwight, H. , STADLER, Robert, W. , ZILLMER, Glenn, C. , DENO, D. Curtis
发明人： WARKENTIN, Dwight, H. , STADLER, Robert, W. , ZILLMER, Glenn, C. , DENO, D. Curtis
IPC分类号： A61N1/362
CPC分类号： A61N1/3627
摘要： An implantable cardiac stimulation device capable of delivering ESS, monitoring for myocardial ischemia and responding to the detection of myocardial ischemia by modifying the delivery of ESS. Modification of ESS delivery may include disabling ESS, initiating ESS, and/or modifying ESS control parameters.
摘要翻译：一种植入式心脏刺激装置，能够传递ESS，监测心肌缺血，并通过修改ESS的传递来应对心肌缺血的检测。 ESS传送的修改可能包括禁用ESS，启动ESS和/或修改ESS控制参数。

8. 发明申请

WO2005034746A1 METHOD AND APPARATUS FOR OPTIMIZATION AND ASSESSMENT OF RESPONSE TO EXTRA-SYSTOLIC STIMULATION (ESS) THERAPY 审中-公开
标题翻译：用于优化和评估对外部刺激（ESS）治疗的反应的方法和装置
公开(公告)号：WO2005034746A1
公开(公告)日：2005-04-21
申请号：PCT/US2004/033275
申请日：2004-10-07
申请人： MEDTRONIC, INC. , MULLIGAN, Lawrence, J , DENO, D. Curtis , BURNES, John, E. , SHETH, Nirav Vijay
发明人： MULLIGAN, Lawrence, J , DENO, D. Curtis , BURNES, John, E. , SHETH, Nirav Vijay
IPC分类号： A61B5/0472
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36578
摘要： Method and apparatus for optimization and assessing the response to extra-systolic stimulation (ESS) are provided. An optimization/monitoring parameter is calculated as a function of potentiation ratio, PR and recirculation fraction, RF, derived from measurements of myocardial contractile during and after ESS. PR may be computed as the ratio of the contractile function on post-extra-systolic beats during ESS to baseline contractile function. RF may be computed as the slope of a linear regression performed on a plot of the contractile function for a post-extra-systolic beat versus the contractile function for the previous post-extra-systolic beat after ESS is ceased. Th ESI resulting in a maximum optimization/monitoring parameter. Preferably computed as the product of PR and RF, is determined as the optimal ESI. The operating ESI may be automatically adjusted and/or PR and RF data may be stored for monitoring purposes.
摘要翻译：提供了用于优化和评估对收缩期刺激（ESS）的反应的方法和装置。根据ESS期间和之后的心肌收缩测量，计算优化/监测参数作为增强比，PR和再循环分数RF的函数。 PR可以计算为ESS期间收缩功能对收缩后收缩期与基线收缩功能的比值。 RF可以被计算为在ESS停止之后针对收缩后收缩压的收缩功能图与先前的收缩后节拍后的收缩功能的曲线进行的线性回归的斜率。 Th ESI导致最大优化/监测参数。优选地计算为PR和RF的乘积，被确定为最佳ESI。可以自动调整操作ESI，并且可以存储PR和RF数据以用于监视目的。

9. 发明申请

WO2012091784A1 AUTOMATIC IDENTIFICATION OF INTRACARDIAC DEVICES AND STRUCTURES IN AN INTRACARDIAC ECHO CATHETER IMAGE 审中-公开
标题翻译： INTRACARDIAC设备的结构自动识别和内镜下的ECHO CATHETER图像中的结构
公开(公告)号：WO2012091784A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/056635
申请日：2011-10-18
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , HILL, Anthony , DENO, D. Curtis , ZHONG, Hua , GRASSE, Martin, M.
发明人： HILL, Anthony , DENO, D. Curtis , ZHONG, Hua , GRASSE, Martin, M.
IPC分类号： A61B8/12
CPC分类号： A61B8/12 , A61B8/0841 , A61B8/0883 , A61B8/4245 , A61B8/461 , A61B8/463 , A61B8/5246 , G06T19/00 , G06T2210/41
摘要： An intracardiac imaging system 10 configured to display electrode visualization elements within an intracardiac echocardiography image 12 where the electrode visualization elements represent intracardiac electrodes in close proximity to the plane of the image 12. The system 10 further allows cross sections of tissue structures embodied in intracardiac echocardiography images 12 to be modeled within a visualization, navigation, or mapping system 20 when automatically segmented to generate shell elements 36 for modifying the modeled tissue structures.
摘要翻译：心内成像系统10被配置为在心内超声心动图像12中显示电极可视化元素，其中电极可视化元件代表非常接近图像12的平面的心内电极。系统10进一步允许在心内超声心动图中体现的组织结构的横截面图像12被自动分段以在可视化，导航或映射系统20内被建模以生成用于修改建模的组织结构的壳单元36。

10. 发明申请

WO2012091764A1 IDENTIFICATION OF OBJECTS IN ULTRASOUND 审中-公开
标题翻译：超声对象的识别
公开(公告)号：WO2012091764A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/051446
申请日：2011-09-13
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , HILL, Anthony , DENO, D. Curtis , AIKEN, Robert D. , ZHONG, Hua , KUDAS, Mark
发明人： HILL, Anthony , DENO, D. Curtis , AIKEN, Robert D. , ZHONG, Hua , KUDAS, Mark
IPC分类号： A61B8/14
CPC分类号： A61B8/12 , A61B8/0883 , A61B8/14 , A61B8/4245 , A61B8/463 , A61B8/5292
摘要： An apparatus and method for identifying objects in an ultrasound image that includes acquiring ultrasound information from a catheter (10), locating the ultrasound information (52, 54) to a three-dimensional cardiac model (30) having two or more distinct anatomic objects, displaying at least one of the distinct anatomic objects from the cardiac model (30) within a visual representation of the ultrasound information (52, 54), and identifying the at least one of the distinct anatomic objects within the visual representation of the ultrasound information (52, 54) using the identifier provided for that object in the three-dimensional cardiac model (30).
摘要翻译：一种用于识别超声图像中的物体的装置和方法，包括从导管（10）获取超声信息，将所述超声信息（52,54）定位到具有两个或更多个不同解剖对象的三维心脏模型（30）在超声信息（52,54）的视觉表示内显示来自心脏模型（30）的不同解剖学对象中的至少一个，以及识别超声信息的视觉表示内的不同解剖对象中的至少一个（使用在三维心脏模型（30）中为该对象提供的标识符。

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