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1. 发明申请

WO2012129486A1 MOMENT FRACTION COMPUTATION FOR SENSORS 审中-公开
标题翻译：传感器的动态分段计算
公开(公告)号：WO2012129486A1
公开(公告)日：2012-09-27
申请号：PCT/US2012/030302
申请日：2012-03-23
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , ROBERTS, Jonathan P. , REINKE, James D. , O'BRIEN, Richard J. , TERRY, Michael B. , MOTHILAL, Kamal Deep
发明人： KUHN, Jonathan L. , ROBERTS, Jonathan P. , REINKE, James D. , O'BRIEN, Richard J. , TERRY, Michael B. , MOTHILAL, Kamal Deep
IPC分类号： G01L1/14 , G01L19/00 , G01L3/00 , G01L19/14 , A61B5/00
CPC分类号： G01L9/125 , A61B5/00 , A61B5/0215 , A61B5/031 , A61B5/036 , A61B5/205 , A61B5/42 , G01L15/00 , G01L19/02 , G01L19/149
摘要： An implantable medical sensor system provides signals representative of a magnitude of moment fraction applied to a sensor module at a selected site. A sensor module includes a first transducer producing a first signal having an associated first response to pressure and strain applied to the sensor module and a second transducer producing a second signal having an associated second response to pressure and strain applied to the sensor module. A moment fraction is computed in response to the first signal and the second signal. In various embodiments, the moment fraction is used to guide positioning of the sensor module, indicate a need for repositioning the sensor module, report loading of the sensor module during normal operation for use as sensor design information and in setting sensor calibration ranges.
摘要翻译：可植入医疗传感器系统提供表示在所选位置处施加到传感器模块的力矩分数的大小的信号。传感器模块包括第一传感器，其产生具有对施加到传感器模块的压力和应变的相关联的第一响应的第一信号，以及产生具有对施加到传感器模块的压力和应变的相关联的第二响应的第二信号的第二传感器。响应于第一信号和第二信号计算力矩分数。在各种实施例中，力矩部分用于引导传感器模块的定位，指示需要重新定位传感器模块，在正常操作期间报告传感器模块的负载，以用作传感器设计信息和设置传感器校准范围。

2. 发明申请

WO2012129481A1 STRAIN COMPENSATION FOR PRESSURE SENSORS 审中-公开
标题翻译：压力传感器的应变补偿
公开(公告)号：WO2012129481A1
公开(公告)日：2012-09-27
申请号：PCT/US2012/030293
申请日：2012-03-23
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , O'BRIEN, Richard J. , ROBERTS, Jonathan P. , REINKE, James D. , TERRY, Michael B. , MOTHILAL, Kamal Deep
发明人： KUHN, Jonathan L. , O'BRIEN, Richard J. , ROBERTS, Jonathan P. , REINKE, James D. , TERRY, Michael B. , MOTHILAL, Kamal Deep
IPC分类号： G01L1/14 , G01L19/00
CPC分类号： G01L9/125 , A61B5/00 , A61B5/0215 , A61B5/031 , A61B5/036 , A61B5/205 , A61B5/42 , G01L15/00 , G01L19/02 , G01L19/149
摘要： A pressure sensing system provides signals representative of a magnitude of pressure at a selected site. A sensor module includes a first transducer producing a first signal having an associated first response to pressure and strain applied to the sensor module and a second transducer producing a second signal having an associated second response to pressure and strain applied to the sensor module. A calculated pressure, a bending pressure error and a bend-compensated pressure are computed in response to the first signal and the second signal.
摘要翻译：压力感测系统提供表示选定部位压力大小的信号。传感器模块包括第一传感器，其产生具有对施加到传感器模块的压力和应变的相关联的第一响应的第一信号，以及产生具有对施加到传感器模块的压力和应变的相关联的第二响应的第二信号的第二传感器。响应于第一信号和第二信号计算计算压力，弯曲压力误差和弯曲补偿压力。

3. 发明申请

WO2010144662A1 ABSOLUTE CALIBRATED TISSUE OXYGEN SATURATION AND TOTAL HEMOGLOBIN VOLUME FRACTION 审中-公开
标题翻译：绝对的校准组织氧饱和度和总HEMOGLOBIN体积分数
公开(公告)号：WO2010144662A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038111
申请日：2010-06-10
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , ANDERSON, David A. , CINBIS, Can , O'BRIEN, Richard J. , CHO, Yong K, , MULLEN, Thomas J. , SCHEINER, Avram , KATRA, Rodolphe P.
发明人： KUHN, Jonathan L. , ANDERSON, David A. , CINBIS, Can , O'BRIEN, Richard J. , CHO, Yong K, , MULLEN, Thomas J. , KATRA, Rodolphe P.
IPC分类号： A61B5/00
CPC分类号： A61N1/36557 , A61B5/1459 , A61N1/37258
摘要： A medical device for monitoring a patient condition includes a sensor capable of being advanced transvascularly to be positioned along a volume of tissue, the sensor including a first combination of a light source and a light detector to emit light into a volume of tissue and to detect light scattered by the volume of tissue and to generate a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal and compute a measure of tissue oxygenation using the light detector output signal.
摘要翻译：用于监测患者状况的医疗装置包括能够经血管内先进地沿着组织体积定位的传感器，所述传感器包括光源和光检测器的第一组合，以将光发射到一定体积的组织中并且检测通过组织体积散射的光并产生对应于检测到的光的强度的第一输出信号。控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号并且使用光检测器输出信号。

4. 发明申请

WO2010144668A1 TISSUE OXYGENATION MONITORING IN HEART FAILURE 审中-公开
标题翻译：心脏失效组织氧化监测
公开(公告)号：WO2010144668A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038117
申请日：2010-06-10
申请人： MEDTRONIC, INC. , CINBIS, Can , CARNEY, James K. , KUHN, Jonathan L. , ANDERSON, David A.
发明人： CINBIS, Can , CARNEY, James K. , KUHN, Jonathan L. , ANDERSON, David A.
IPC分类号： A61N1/365
CPC分类号： A61N1/36557
摘要： A medical device for monitoring delivery of a therapy that includes a therapy delivery module to deliver a therapy, a controller to set a therapy delivery control parameter, an optical sensor to produce a signal corresponding to tissue light attenuation, and a processor configured to compute a tissue oxygenation measurement from the optical sensor signal, wherein the controller, the optical sensor, and the processor operate cooperatively to determine a setting of the therapy delivery control parameter corresponding to a maximum tissue oxygenation.
摘要翻译：一种用于监测治疗递送的医疗装置，其包括用于递送疗法的治疗递送模块，用于设置治疗递送控制参数的控制器，用于产生对应于组织光衰减的信号的光学传感器，以及被配置为计算来自光学传感器信号的组织氧合测量，其中所述控制器，所述光学传感器和所述处理器协同工作以确定对应于最大组织氧合的所述治疗传递控制参数的设置。

5. 发明申请

WO2010144649A1 SHOCK REDUCTION USING ABSOLUTE CALIBRATED TISSUE OXYGEN SATURATION AND TOTAL HEMOGLOBIN VOLUME FRACTION 审中-公开
标题翻译：使用绝对标准组织氧气饱和和总HEMOGLOBIN体积分数减少减少
公开(公告)号：WO2010144649A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038084
申请日：2010-06-10
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , CARNEY, James K.
发明人： KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , CARNEY, James K.
IPC分类号： A61B5/1455 , A61B5/00 , A61N1/362 , A61N1/365 , A61N1/39
CPC分类号： A61N1/3622 , A61B5/02028 , A61B5/0215 , A61B5/042 , A61B5/1116 , A61B5/14542 , A61B5/1459 , A61N1/36557 , A61N1/3956
摘要： An implantable medical device that includes an optical sensor for providing a signal corresponding to light attenuation by a volume of blood perfused tissue, a control module coupled to the optical sensor controlling the light emitted by the optical sensor, a monitoring module receiving an optical sensor output signal and measuring light attenuation, a tissue electrode for stimulating the volume of blood perfused tissue, a pulse generator coupled to the tissue electrode for delivering electrical stimulation to the volume of blood-perfused tissue, and a processor coupled to the cardiac electrode and the monitoring module and configured to detect an arrhythmia in response to the depolarization signals, compute a tissue oxygenation measurement and control the pulse generator to deliver electrical stimulation to the volume of blood-perfused tissue in response to detecting the arrhythmia, and detect a hemodynamic status of the arrhythmia in response to at least one of a detected rate of tissue oxygenation decline and a detected rate of tissue oxygenation recovery.
摘要翻译：一种可植入医疗装置，其包括：光学传感器，用于通过一定量的血液灌注组织提供对应于光衰减的信号;耦合到所述光学传感器的控制模块，所述控制模块控制由所述光学传感器发射的光;监测模块，其接收光学传感器输出信号和测量光衰减的组织电极，用于刺激血液灌注组织的体积的组织电极，耦合到组织电极的脉冲发生器，用于向血液灌注组织的体积输送电刺激，以及耦合到心脏电极和监测器模块并且被配置为响应于去极化信号检测心律失常，计算组织氧合测量并控制脉冲发生器以响应于检测到心律失常而向血液灌注组织的体积递送电刺激，并且检测血液动力学状态响应于检测到的tis的速率中的至少一种的心律失常检测氧合反应的下降和组织氧合恢复率。

6. 发明申请

WO2011031739A1 METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 审中-公开
标题翻译：使用组织氧化测量法进行后期评估的方法和装置
公开(公告)号：WO2011031739A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048103
申请日：2010-09-08
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , HAVEL, William J.
发明人： KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , HAVEL, William J.
IPC分类号： A61N1/39 , A61B5/00
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the optical sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, and determine whether the delivered therapy restored cardiac hemodynamic function in response to the determined tissue oxygenation trend.
摘要翻译：一种用于递送疗法的方法和装置，其包括用于感测心脏信号并递送治疗的电极;治疗递送模块，其耦合到所述电极，以响应于所感测的心脏信号经由所述电极递送治疗;发射光和检测的传感器发射由邻近光学传感器的组织体积散射的光以产生相应的检测到的光强度输出信号;耦合到传感器的控制模块，用于响应于递送治疗来控制传感器的光发射;以及控制器，耦合到治疗递送模块和传感器，所述控制器被配置为响应于输出信号确定组织氧合测量，响应于组织氧合测量确定组织氧合趋势，并且确定所递送的治疗是否响应于所确定的组织氧合来恢复心脏血液动力学功能趋势。

7. 发明申请

WO2010144665A1 DEVICE AND METHOD FOR MONITORING OF ABSOLUTE OXYGEN SATURATION AND TOTAL HEMOGLOBIN CONCENTRATION 审中-公开
标题翻译：用于监测绝对氧化饱和度和总HEMOGLOBIN浓度的装置和方法
公开(公告)号：WO2010144665A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038114
申请日：2010-06-10
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , CARNEY, James K. , ANDERSON, David A.
发明人： KUHN, Jonathan L. , CINBIS, Can , CARNEY, James K. , ANDERSON, David A.
IPC分类号： A61B5/00
CPC分类号： A61B5/14552 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/7239 , A61N1/36557
摘要： A medical device for monitoring of oxygen saturation includes an optical sensor adapted for positioning adjacent to a tissue volume. The optical sensor has a light emitting portion capable of emitting light at a plurality of wavelengths and a light detecting portion capable of generating an electrical output signal corresponding to light incident on the detecting portion. A control module coupled to the optical sensor controls the light emitted by the light emitting portion. A monitoring module receives the output signal from the light detecting portion and computes a volume-independent measure of oxygen saturation in the volume of tissue using the output signal.
摘要翻译：用于监测氧饱和度的医疗装置包括适于邻近组织体积定位的光学传感器。光学传感器具有能够发射多个波长的光的发光部和能够产生与入射到检测部上的光对应的电输出信号的光检测部。耦合到光学传感器的控制模块控制由发光部分发射的光。监测模块接收来自光检测部分的输出信号，并使用输出信号计算组织体积中的氧饱和度的体积无关测量。

8. 发明申请

WO2009076063A1 IMPLANTABLE OPTICAL SENSOR AND METHOD FOR MANUFACTURE 审中-公开
标题翻译：可植入的光学传感器及其制造方法
公开(公告)号：WO2009076063A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/084675
申请日：2008-11-25
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ECKER, Robert M. , DAVIS, Timothy J. , KNOWLES, Shawn D.
发明人： KUHN, Jonathan L. , CINBIS, Can , ECKER, Robert M. , DAVIS, Timothy J. , KNOWLES, Shawn D.
IPC分类号： A61B5/00
CPC分类号： A61B5/14542 , A61B5/0084 , A61B5/0086 , A61B5/14532 , A61B5/14552 , A61B5/1459 , A61B5/6846 , A61B2562/02 , A61B2562/043 , A61B2562/146
摘要： An implantable optical sensor and associated manufacturing method include a sensor housing having an inner surface and an outer surface and a window formed in the housing extending between the housing inner surface and the housing outer surface. An opto-electronic device enclosed within the housing and having a photonic surface is operatively positioned proximate the window for emitting light through the window or detecting light through the window. An optical coupling member is positioned between the opto-electronic device and the window for reducing light reflection at a surface within the implantable optical sensor.
摘要翻译：可植入光学传感器和相关联的制造方法包括具有内表面和外表面的传感器外壳和形成在壳体中的窗口，该壳体在壳体内表面和壳体外表面之间延伸。封闭在壳体内并具有光子表面的光电器件可操作地定位在窗口附近，用于通过窗口发射光或通过窗口检测光。光耦合构件位于光电器件和窗口之间，用于减少可植入光学传感器内的表面处的光反射。

9. 发明申请

WO2013062653A1 METHOD AND APPARATUS FOR CALIBRATING AN ABSOLUTE OXYGEN SATURATION SENSOR 审中-公开
标题翻译：用于校准绝对氧气饱和传感器的方法和装置
公开(公告)号：WO2013062653A1
公开(公告)日：2013-05-02
申请号：PCT/US2012/049817
申请日：2012-08-07
申请人： MEDTRONIC, INC. , KUHN, Jonathan L.
发明人： KUHN, Jonathan L.
IPC分类号： A61B5/1455 , A61B5/1495
CPC分类号： A61B5/14551 , A61B5/1495
摘要： A method for using a medical device comprising an optical sensor to measure calibrated oxygen saturation in a body tissue uses a standard spectral response of blood established for multiple of oxygen saturations and a standard spectral response of a reference material. The standard responses are established using a spectrometer. The spectral power output of the optical sensor is measured using a spectrometer. The optical sensor output signal response to the reference material is obtained. A processor computes a device-specific calibration curve for the medical device using the measured spectral power output and the standard spectral response of blood and computes an optical gain using the standard spectral response of the reference material and the measured spectral power output of the optical sensor. The device-specific calibration curve and optical gain of the optical sensor are stored in a memory of the medical device.
摘要翻译：使用包括光学传感器来测量身体组织中的校准氧饱和度的医疗装置的方法使用针对多个氧饱和度建立的血液的标准光谱响应和参考材料的标准光谱响应。使用光谱仪建立标准响应。使用光谱仪测量光学传感器的光谱功率输出。获得对参考材料的光学传感器输出信号响应。处理器使用测量的光谱功率输出和血液的标准光谱响应来计算医疗设备的设备特定校准曲线，并使用参考材料的标准光谱响应和光学传感器的测量光谱功率输出来计算光学增益。光学传感器的特定于设备的校准曲线和光学增益被存储在医疗设备的存储器中。

10. 发明申请

WO2011031597A1 METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 审中-公开
标题翻译：使用组织氧化测量法进行后期评估的方法和装置
公开(公告)号：WO2011031597A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/047450
申请日：2010-09-01
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , HAVEL, William J.
发明人： KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , HAVEL, William J.
IPC分类号： A61N1/39 , A61B5/00
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy; and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine a tissue oxygenation measurement in response to the output signal, and determine whether the delivered therapy was successful in restoring cardiac hemodynamic function in response to the tissue oxygenation measurement.
摘要翻译：一种用于递送治疗的方法和装置，其包括用于感测心脏信号并递送治疗的电极，治疗递送模块，其耦合到所述电极，以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器发射由邻近传感器的组织体积散射的光，以产生相应的检测到的光强度输出信号;控制模块，其耦合到所述传感器以响应于递送所述治疗来控制所述传感器的光发射; 以及耦合到所述治疗递送模块和所述传感器的控制器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，并且确定所递送的治疗是否成功响应于所述组织氧合测量来恢复心脏血液动力学功能。

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