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1. 发明申请

WO2010144668A1 TISSUE OXYGENATION MONITORING IN HEART FAILURE 审中-公开
标题翻译：心脏失效组织氧化监测
公开(公告)号：WO2010144668A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038117
申请日：2010-06-10
申请人： MEDTRONIC, INC. , CINBIS, Can , CARNEY, James K. , KUHN, Jonathan L. , ANDERSON, David A.
发明人： CINBIS, Can , CARNEY, James K. , KUHN, Jonathan L. , ANDERSON, David A.
IPC分类号： A61N1/365
CPC分类号： A61N1/36557
摘要： A medical device for monitoring delivery of a therapy that includes a therapy delivery module to deliver a therapy, a controller to set a therapy delivery control parameter, an optical sensor to produce a signal corresponding to tissue light attenuation, and a processor configured to compute a tissue oxygenation measurement from the optical sensor signal, wherein the controller, the optical sensor, and the processor operate cooperatively to determine a setting of the therapy delivery control parameter corresponding to a maximum tissue oxygenation.
摘要翻译：一种用于监测治疗递送的医疗装置，其包括用于递送疗法的治疗递送模块，用于设置治疗递送控制参数的控制器，用于产生对应于组织光衰减的信号的光学传感器，以及被配置为计算来自光学传感器信号的组织氧合测量，其中所述控制器，所述光学传感器和所述处理器协同工作以确定对应于最大组织氧合的所述治疗传递控制参数的设置。

2. 发明申请

WO2010144649A1 SHOCK REDUCTION USING ABSOLUTE CALIBRATED TISSUE OXYGEN SATURATION AND TOTAL HEMOGLOBIN VOLUME FRACTION 审中-公开
标题翻译：使用绝对标准组织氧气饱和和总HEMOGLOBIN体积分数减少减少
公开(公告)号：WO2010144649A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038084
申请日：2010-06-10
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , CARNEY, James K.
发明人： KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , CARNEY, James K.
IPC分类号： A61B5/1455 , A61B5/00 , A61N1/362 , A61N1/365 , A61N1/39
CPC分类号： A61N1/3622 , A61B5/02028 , A61B5/0215 , A61B5/042 , A61B5/1116 , A61B5/14542 , A61B5/1459 , A61N1/36557 , A61N1/3956
摘要： An implantable medical device that includes an optical sensor for providing a signal corresponding to light attenuation by a volume of blood perfused tissue, a control module coupled to the optical sensor controlling the light emitted by the optical sensor, a monitoring module receiving an optical sensor output signal and measuring light attenuation, a tissue electrode for stimulating the volume of blood perfused tissue, a pulse generator coupled to the tissue electrode for delivering electrical stimulation to the volume of blood-perfused tissue, and a processor coupled to the cardiac electrode and the monitoring module and configured to detect an arrhythmia in response to the depolarization signals, compute a tissue oxygenation measurement and control the pulse generator to deliver electrical stimulation to the volume of blood-perfused tissue in response to detecting the arrhythmia, and detect a hemodynamic status of the arrhythmia in response to at least one of a detected rate of tissue oxygenation decline and a detected rate of tissue oxygenation recovery.
摘要翻译：一种可植入医疗装置，其包括：光学传感器，用于通过一定量的血液灌注组织提供对应于光衰减的信号;耦合到所述光学传感器的控制模块，所述控制模块控制由所述光学传感器发射的光;监测模块，其接收光学传感器输出信号和测量光衰减的组织电极，用于刺激血液灌注组织的体积的组织电极，耦合到组织电极的脉冲发生器，用于向血液灌注组织的体积输送电刺激，以及耦合到心脏电极和监测器模块并且被配置为响应于去极化信号检测心律失常，计算组织氧合测量并控制脉冲发生器以响应于检测到心律失常而向血液灌注组织的体积递送电刺激，并且检测血液动力学状态响应于检测到的tis的速率中的至少一种的心律失常检测氧合反应的下降和组织氧合恢复率。

3. 发明申请

WO2010144665A1 DEVICE AND METHOD FOR MONITORING OF ABSOLUTE OXYGEN SATURATION AND TOTAL HEMOGLOBIN CONCENTRATION 审中-公开
标题翻译：用于监测绝对氧化饱和度和总HEMOGLOBIN浓度的装置和方法
公开(公告)号：WO2010144665A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038114
申请日：2010-06-10
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , CARNEY, James K. , ANDERSON, David A.
发明人： KUHN, Jonathan L. , CINBIS, Can , CARNEY, James K. , ANDERSON, David A.
IPC分类号： A61B5/00
CPC分类号： A61B5/14552 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/7239 , A61N1/36557
摘要： A medical device for monitoring of oxygen saturation includes an optical sensor adapted for positioning adjacent to a tissue volume. The optical sensor has a light emitting portion capable of emitting light at a plurality of wavelengths and a light detecting portion capable of generating an electrical output signal corresponding to light incident on the detecting portion. A control module coupled to the optical sensor controls the light emitted by the light emitting portion. A monitoring module receives the output signal from the light detecting portion and computes a volume-independent measure of oxygen saturation in the volume of tissue using the output signal.
摘要翻译：用于监测氧饱和度的医疗装置包括适于邻近组织体积定位的光学传感器。光学传感器具有能够发射多个波长的光的发光部和能够产生与入射到检测部上的光对应的电输出信号的光检测部。耦合到光学传感器的控制模块控制由发光部分发射的光。监测模块接收来自光检测部分的输出信号，并使用输出信号计算组织体积中的氧饱和度的体积无关测量。

4. 发明申请

WO2010144652A1 TISSUE OXYGENATION MONITORING IN HEART FAILURE 审中-公开
标题翻译：心脏失效组织氧化监测
公开(公告)号：WO2010144652A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038087
申请日：2010-06-10
申请人： MEDTRONIC, INC. , CINBIS, Can , CARNEY, James, K. , KUHN, Jonathan, L. , ANDERSON, David, A.
发明人： CINBIS, Can , CARNEY, James, K. , KUHN, Jonathan, L. , ANDERSON, David, A.
IPC分类号： A61N1/365
CPC分类号： A61N1/36557
摘要： A medical device system and associated method are used for monitoring a heart failure patient. A medical device for monitoring delivery of a therapy includes a sensor sensing an optical sensor signal corresponding to light attenuation by a volume of body tissue of a patient, a therapy delivery module to deliver a therapy, and a processor configured to compute a first tissue oxygenation measurement from the optical sensor signal prior to initiating delivery of the therapy, compute a second tissue oxygenation measurement from the optical sensor signal subsequent to initiating delivery of the therapy, compare the first and the second tissue oxygenation measurements, and determine whether the delivered therapy was successful in response to the first tissue oxygenation measurement and the second tissue oxygenation measurement.
摘要翻译：医疗器械系统和相关方法用于监测心力衰竭患者。用于监测治疗递送的医疗装置包括传感器，其感测对应于患者的身体组织的体积的光衰减的光学传感器信号，用于递送治疗的治疗递送模块，以及被配置为计算第一组织氧合在开始递送治疗之前从光学传感器信号测量，在开始递送治疗之后，从光学传感器信号计算第二组织氧合测量，比较第一和第二组织氧合测量，并确定递送的治疗是否为成功地响应于第一次组织氧合测量和第二次组织氧合测量。

5. 发明申请

WO2010144648A1 SHOCK REDUCTION USING ABSOLUTE CALIBRATED TISSUE OXYGEN SATURATION AND TOTAL HEMOGLOBIN VOLUME FRACTION 审中-公开
标题翻译：使用绝对标准组织氧气饱和和总HEMOGLOBIN体积分数减少减少
公开(公告)号：WO2010144648A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038082
申请日：2010-06-10
申请人： MEDTRONIC, INC. , KUHN, Jonathan, L. , CINBIS, Can , ANDERSON, David, A. , CARNEY, James, K.
发明人： KUHN, Jonathan, L. , CINBIS, Can , ANDERSON, David, A. , CARNEY, James, K.
IPC分类号： A61B5/1455 , A61B5/00 , A61N1/362 , A61N1/365 , A61N1/39
CPC分类号： A61N1/3622 , A61B5/02028 , A61B5/0215 , A61B5/042 , A61B5/1116 , A61B5/14542 , A61B5/1459 , A61N1/36557 , A61N1/3956
摘要： An implantable medical device for detecting and treating an arrhythmia includes an optical sensor adapted for positioning adjacent to a blood-perfused tissue volume. In one embodiment for controlling arrhythmia therapies delivered by the device, the optical sensor is controlled to emit light in response to detecting an arrhythmia, detect light scattered by the volume of blood perfused tissue including measuring an optical sensor output signal corresponding to the intensity of scattered light for at least four spaced-apart wavelengths, and compute a volume-independent measure of tissue oxygen saturation from the detected light. The hemodynamic status of the arrhythmia is detected in response to the measure of tissue oxygen saturation.
摘要翻译：用于检测和治疗心律失常的可植入医疗装置包括适于邻近于血液灌注的组织体积定位的光学传感器。在用于控制由装置传送的心律失常治疗的一个实施例中，响应于检测到心律失常，控制光学传感器发光，检测由血液灌注组织的体积散射的光，包括测量对应于散射强度的光学传感器输出信号用于至少四个间隔波长的光，并且从检测到的光计算组织氧饱和度的体积独立测量。响应于组织氧饱和度的测量，检测心律失常的血液动力学状态。

6. 发明申请

WO2012067906A1 COEFFICENT DETERMINATION FOR BLOOD OXYGEN SATURATION AND TOTAL HEMOGLOBIN CONCENTRATION INDICES 审中-公开
标题翻译：血氧饱和度和总HEMOGLOBIN浓度指标的系数测定
公开(公告)号：WO2012067906A1
公开(公告)日：2012-05-24
申请号：PCT/US2011/059875
申请日：2011-11-09
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , CARNEY, James K.
发明人： KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , CARNEY, James K.
IPC分类号： A61B5/1455 , A61B5/1459
CPC分类号： A61B5/1459 , A61B5/0075 , A61B5/14535 , A61B5/14542 , A61B5/14551 , A61B5/1495 , A61B5/4836
摘要： A first concentration of a chromophore corresponding to a measurement volume of an optical sensor is determined. A second concentration of the chromophore is obtained in the vicinity of the measurement volume corresponding to a change in at least one of a total concentration of the chromophore and a relative concentration of a first form of the chromophore to the total concentration of the chromophore in the measurement volume. Light remittance measurements including a first light wavelength and a second light wavelength are obtained corresponding to the first chromophore concentration and the second chromophore concentration. A coefficient for computing an index of a change in the chromophore concentration is computed using the difference between the first and second chromophore concentrations and the first and second light remittance measurements.
摘要翻译：确定对应于光学传感器的测量体积的发色团的第一浓度。在测量体积附近获得发色团的第二浓度，其对应于发色团的总浓度和发色团的第一形式的相对浓度与发色团的总浓度中的至少一个的变化相关测量体积。对应于第一发色团浓度和第二发色团浓度获得包括第一光波长和第二光波长的光汇率测量。使用第一和第二生色团浓度与第一和第二光汇率测量之间的差来计算计算发色团浓度变化指数的系数。

7. 发明申请

WO2010144667A1 TISSUE OXYGENATION MONITORING IN HEART FAILURE 审中-公开
标题翻译：心脏失效组织氧化监测
公开(公告)号：WO2010144667A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038116
申请日：2010-06-10
申请人： MEDTRONIC, INC. , CINBIS, Can , CARNEY, James K. , KUHN, Jonathan L. , ANDERSON, David A.
发明人： CINBIS, Can , CARNEY, James K. , KUHN, Jonathan L. , ANDERSON, David A.
IPC分类号： A61N1/365
CPC分类号： A61N1/36557
摘要： A medical device system and associated method control the delivery of a heart failure therapy to a patient. The system includes an activity sensor and detects a change in activity level of the patient. The system further include an optical sensor to sense signal corresponding to tissue light attenuation. The system computes a tissue oxygenation measurement in response to detecting a change in activity level. A parameter controlling delivery of the heart failure therapy is adjusted in response to detecting the decreased tissue oxygenation.
摘要翻译：医疗装置系统和相关联的方法控制对患者的心力衰竭治疗的递送。该系统包括活动传感器并检测患者的活动水平的变化。该系统还包括用于感测对应于组织光衰减的信号的光学传感器。响应于检测到活动水平的变化，系统计算组织氧合测量。响应于检测到减少的组织氧合而调整控制心力衰竭治疗递送的参数。

8. 发明申请

WO2011093913A1 OPTICAL SENSOR FOR MEDICAL DEVICE 审中-公开
标题翻译：光学传感器医疗器械
公开(公告)号：WO2011093913A1
公开(公告)日：2011-08-04
申请号：PCT/US2010/032091
申请日：2010-04-22
申请人： MEDTRONIC, INC. , KUHN, Jonathan, L. , ANDERSON, Thomas, A. , CINBIS, Can , JELEN, Jeffrey, M. , DAVIS, Timothy , CARNEY, James, K.
发明人： KUHN, Jonathan, L. , ANDERSON, Thomas, A. , CINBIS, Can , JELEN, Jeffrey, M. , DAVIS, Timothy , CARNEY, James, K.
IPC分类号： A61B5/145 , A61B5/1455 , A61B5/00 , A61N1/36
CPC分类号： A61N1/3702 , A61B5/14503 , A61B5/14532 , A61B5/1455 , A61B5/6846 , A61N1/36557 , Y10T29/49002
摘要： An optical sensor for a medical device includes a fixed lens spacing between emit and receive modules to achieve target sensor sensitivity, while varying other sensor parameters in order to increase signal amplitude without increasing power demand. The size of at least one of emit and receive module lenses of an optical sensor, and the offset between the opto-electronic component and the respective lens of at least one of emit and receive modules is decreased to increase amplitude of the signal received by the receive module from the emit module.
摘要翻译：用于医疗装置的光学传感器包括发射和接收模块之间的固定透镜间隔，以实现目标传感器灵敏度，同时改变其它传感器参数，以便增加信号幅度而不增加功率需求。光传感器的发射和接收模块透镜中的至少一个的尺寸以及光电元件与发射模块和接收模块中的至少一个的相应透镜之间的偏移被减小以增加由从发射模块接收模块。

9. 发明申请

WO2011093914A1 OPTICAL SENSOR FOR MEDICAL DEVICE 审中-公开
标题翻译：光学传感器医疗器械
公开(公告)号：WO2011093914A1
公开(公告)日：2011-08-04
申请号：PCT/US2010/032096
申请日：2010-04-22
申请人： MEDTRONIC, INC. , KUHN, Jonathan, L. , ANDERSON, Thomas, A. , CINBIS, Can , JELEN, Jeffrey, M. , DAVIS, Timothy , CARNEY, James, K.
发明人： KUHN, Jonathan, L. , ANDERSON, Thomas, A. , CINBIS, Can , JELEN, Jeffrey, M. , DAVIS, Timothy , CARNEY, James, K.
IPC分类号： A61B5/145 , A61N1/36
CPC分类号： A61N1/3702 , A61B5/14503 , A61B5/14532 , A61B5/1455 , A61B5/6846 , A61N1/36557 , Y10T29/49002
摘要： An optical sensor for a medical device includes a fixed lens spacing between emit and receive modules to achieve target sensor sensitivity, while varying other sensor parameters in order to increase signal amplitude without increasing power demand. The arrangement of an opto-electronic component within an optical sensor receive module is improved by masking the receive module lens with an opaque member to create a masked lens leading edge that is aligned with a leading edge of the opto-electronic component.
摘要翻译：用于医疗装置的光学传感器包括发射和接收模块之间的固定透镜间隔，以实现目标传感器灵敏度，同时改变其它传感器参数，以便增加信号幅度而不增加功率需求。通过用不透明部件掩蔽接收模块透镜来改善光学传感器接收模块内的光电子部件的布置，以产生与光电子部件的前沿对准的掩蔽透镜前缘。

10. 发明申请

WO2011093912A1 OPTICAL SENSOR FOR MEDICAL DEVICE 审中-公开
标题翻译：光学传感器医疗器械
公开(公告)号：WO2011093912A1
公开(公告)日：2011-08-04
申请号：PCT/US2010/032080
申请日：2010-04-22
申请人： MEDTRONIC, INC. , KUHN, Jonathan, L. , ANDERSON, Thomas, A. , CINBIS, Can , JELEN, Jeffrey, M. , DAVIS, Timothy , CARNEY, James, K.
发明人： KUHN, Jonathan, L. , ANDERSON, Thomas, A. , CINBIS, Can , JELEN, Jeffrey, M. , DAVIS, Timothy , CARNEY, James, K.
IPC分类号： A61B5/145 , A61N1/36
CPC分类号： A61N1/3702 , A61B5/14503 , A61B5/14532 , A61B5/1455 , A61B5/6846 , A61N1/36557 , Y10T29/49002
摘要： An optical sensor for a medical device includes a fixed lens spacing between emit and receive modules to achieve target sensor sensitivity, while varying other sensor parameters in order to increase signal amplitude without increasing power demand. An optical sensor connected to a housing of a medical device includes a circuit board, an opto-electronic component, a wall, a lens, and a ferrule. The circuit board is arranged within the housing. The opto-electronic component is mounted on a surface of the circuit board. The wall protrudes from the surface of the circuit board and surrounds the opto-electronic component. The lens is offset from the surface of the circuit board. The ferrule is connected to the housing, the lens and the wall. An inner surface of the wall mates with an outer surface of the ferrule.
摘要翻译：用于医疗装置的光学传感器包括发射和接收模块之间的固定透镜间隔，以实现目标传感器灵敏度，同时改变其它传感器参数，以便增加信号幅度而不增加功率需求。连接到医疗装置的壳体的光学传感器包括电路板，光电子部件，壁，透镜和套圈。电路板布置在外壳内。光电子部件安装在电路板的表面上。壁从电路板的表面突出并围绕光电子部件。透镜偏离电路板的表面。套圈连接到外壳，透镜和墙壁。壁的内表面与套圈的外表面配合。

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