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1. 发明申请

WO2008094879A1 CONDUCTOR JUNCTIONS FOR MEDICAL ELECTRICAL LEADS 审中-公开
标题翻译：医用导线导体接头
公开(公告)号：WO2008094879A1
公开(公告)日：2008-08-07
申请号：PCT/US2008/052255
申请日：2008-01-29
申请人： MEDTRONIC, INC. , HUOTARI, Craig, T. , LESSAR, Joseph, F. , BREYEN, Mark, D. , BAUER, Ryan, T.
发明人： HUOTARI, Craig, T. , LESSAR, Joseph, F. , BREYEN, Mark, D. , BAUER, Ryan, T.
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , H01R4/50 , H01R2201/12 , Y10T29/5193 , Y10T29/53183
摘要： A core component of a medical electrical lead extends within an inner conductive surface of a conductive ring such that an outer surface of the core holds a portion of a conductor against the inner conductive surface for electrical contact therewith. The outer surface of the core may be deformed by a compressive force of the conductor portion having been forced against the inner surface of the ring. Such a conductor junction may be formed by pushing the ring over the core to capture the conductor portion between the ring and the core and thereby displace a layer of insulation surrounding the conductor portion. The inner surface of the ring preferably has a diameter at one, or both terminal ends that is greater than a diameter of the inner surface between the ends.
摘要翻译：医疗电引线的核心部件在导电环的内部导电表面内延伸，使得芯的外表面将导体的一部分保持抵靠内部导电表面以与其电接触。芯体的外表面可能由于已经被迫抵靠环的内表面的导体部分的压缩力而变形。可以通过将环推到芯上以捕获环和芯之间的导体部分，从而置换导体部分周围的绝缘层来形成这样的导体接合部。环的内表面优选在一个或两个末端处的直径大于端部之间的内表面的直径。

2. 发明申请

WO2007101083A2 SEPARATOR SYSTEMS FOR ELECTROCHEMICAL CELLS 审中-公开
标题翻译：电化学细胞分离系统
公开(公告)号：WO2007101083A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/062645
申请日：2007-02-23
申请人： MEDTRONIC, INC , NORTON, John, D. , MILTICH, Thomas, P. , RORVICK, Anthony, W. , NIELSEN, Christian, S. , BREYEN, Mark, D. , LESSAR, Joseph, F. , PIGNATO, Paul, A.
发明人： NORTON, John, D. , MILTICH, Thomas, P. , RORVICK, Anthony, W. , NIELSEN, Christian, S. , BREYEN, Mark, D. , LESSAR, Joseph, F. , PIGNATO, Paul, A.
IPC分类号： H01G9/02
CPC分类号： H01G9/02
摘要： A capacitor cell is presented. The capacitor cell includes an anode, a cathode spaced from and operatively associated with the anode, an electrolyte operatively associated with the anode and the cathode. A layered separator includes a plurality of separator material layers disposed between the anode and cathode. The plurality of separator material layers includes a first layer and a second layer. The first layer is characterized by a first value of a physical property and the second layer is characterized by a second value of the physical property.
摘要翻译：提出了一个电容器单元。电容器单元包括阳极，与阳极间隔开并且与阳极可操作地相关联的电解质，与阳极和阴极可操作地连接的电解质。分层分离器包括设置在阳极和阴极之间的多个隔板材料层。多个隔板材料层包括第一层和第二层。第一层的特征在于物理性质的第一值，第二层的特征在于物理性质的第二值。

3. 发明申请

WO2011002546A1 IMPLANTABLE MEDICAL DEVICE INCLUDING MECHANICAL STRESS SENSOR 审中-公开
标题翻译：包括机械应力传感器的可植入医疗装置
公开(公告)号：WO2011002546A1
公开(公告)日：2011-01-06
申请号：PCT/US2010/032415
申请日：2010-04-26
申请人： MEDTRONIC, INC. , LESSAR, Joseph, F. , SCHENDEL, Michael, J. , NEVILLE, James, D. , LITOW, Micah, A.
发明人： LESSAR, Joseph, F. , SCHENDEL, Michael, J. , NEVILLE, James, D. , LITOW, Micah, A.
IPC分类号： A61N1/375 , A61N1/36 , A61N1/08 , A61N1/372 , A61B5/0488 , A61B5/11 , A61B5/22
CPC分类号： A61N1/025 , A61N1/08 , A61N1/3605 , A61N1/3752 , A61N1/3758 , A61N2001/37294
摘要： Systems and techniques for determining in vivo mechanical load exerted on an implanted medical device (IMD) are described. The IMD or a device that has a substantially similar form factor as the IMD includes at least one mechanical stress sensor mechanically coupled to a housing or a component within the housing. In some examples, a patient parameter is determined based on a signal indicative of the in vivo mechanical load exerted on the IMD. In addition, in some examples, a processor determines whether a transient or cumulative mechanical load exerted on an IMD exceeded a predetermined threshold. A processor may additionally or alternatively determine whether a pattern in the mechanical loading of the IMD indicates a diversion from a manufacturing, shipping, storage or other handling process.
摘要翻译：描述用于确定施加在植入医疗装置（IMD）上的体内机械载荷的系统和技术。具有与IMD基本相似的形状因子的IMD或装置包括机械耦合到壳体或壳体内的部件的至少一个机械应力传感器。在一些示例中，基于指示施加在IMD上的体内机械负荷的信号来确定患者参数。此外，在一些示例中，处理器确定施加在IMD上的瞬时或累积机械负载是否超过预定阈值。处理器可以附加地或可选地确定IMD的机械加载中的图案是否表示从制造，运输，存储或其他处理过程转移。

4. 发明申请

WO2004108021A2 IMPLANTS BASED ON ENGINEERED METAL MATRIX COMPOSITE MATERIALS HAVING ENHANCED IMAGING AND WEAR RESISTANCE 审中-公开
标题翻译：基于具有增强成像和耐磨性的工程金属基复合材料的植入
公开(公告)号：WO2004108021A2
公开(公告)日：2004-12-16
申请号：PCT/US2004/016772
申请日：2004-05-25
申请人： SDGI HOLDINGS, INC. , ISTEPHANOUS, Naim , MARIK, Greg, C. , LESSAR, Joseph, F. , UNTEREKER, Darrel, F.
发明人： ISTEPHANOUS, Naim , MARIK, Greg, C. , LESSAR, Joseph, F. , UNTEREKER, Darrel, F.
IPC分类号： A61F2/44
CPC分类号： A61B17/7052 , A61B17/7001 , A61B17/7049 , A61B17/7059 , A61B17/80 , A61F2/30965 , A61F2/32 , A61F2/38 , A61F2/442 , A61F2/4425 , A61F2002/30062 , A61F2002/3008 , A61F2002/30677 , A61F2002/30968 , A61F2002/30971 , A61F2002/443 , A61F2210/0004 , A61F2240/001 , A61F2250/0098 , A61F2310/00023 , A61F2310/00089 , A61F2310/00095 , A61F2310/00167 , A61F2310/00203 , A61F2310/00239 , A61F2310/00263 , A61F2310/00269 , A61F2310/00305 , A61F2310/00323 , A61L27/427 , A61L27/56 , A61L31/124 , A61L31/146 , A61N1/05 , B33Y80/00
摘要： This invention relates to an implantable medical device to treat a patient. The implantable device can be an orthopedic device such as a spinal implant including, but not restricted to, a disc or nucleus pulposus prosthesis, a spinal rod assembly, or a bone fixation plate. The orthopedic device can be formed to include a metal matrix composite that provides enhanced wear and diagnostic imaging techniques. In other forms, the present invention provides an implantable medical device that includes a porous metal matrix composite that can deliver a therapeutic composition to a patient. In still other forms, the present invention provides an implantable electrical device or lead formed to include a metal matrix composite that provides lower polarization and interfacial impedance and allows enhanced sensing of the physiological signals.
摘要翻译：本发明涉及一种用于治疗患者的可植入医疗装置。可植入装置可以是诸如脊椎植入物的矫形装置，包括但不限于圆盘或髓核假体，脊柱杆组件或骨固定板。矫形装置可以形成为包括提供增强的磨损和诊断成像技术的金属基质复合材料。在其他形式中，本发明提供了一种植入式医疗装置，其包括能将治疗组合物递送至患者的多孔金属基质复合物。在其它形式中，本发明提供一种可植入电气装置或导线，其形成为包括提供较低极化和界面阻抗并允许对生理信号的增强感测的金属基质复合材料。

5. 发明申请

WO2006079063A1 ARTICULATING SPINAL DISC IMPLANTS WITH AMORPHOUS METAL ELEMENTS 审中-公开
标题翻译：用非晶金属元素描述脊椎椎间盘植入物
公开(公告)号：WO2006079063A1
公开(公告)日：2006-07-27
申请号：PCT/US2006/002427
申请日：2006-01-23
申请人： SDGI HOLDINGS, INC. , ISTEPHANOUS, Naim, S. , MARIK, Greg, C. , EISERMANN, Lukas, G. , LESSAR, Joseph, F. , UNTEREKER, Daniel, F.
发明人： ISTEPHANOUS, Naim, S. , MARIK, Greg, C. , EISERMANN, Lukas, G. , LESSAR, Joseph, F. , UNTEREKER, Daniel, F.
CPC分类号： A61F2/442 , A61F2/4611 , A61F2002/30387 , A61F2002/30448 , A61F2002/30451 , A61F2002/30507 , A61F2002/30578 , A61F2002/30589 , A61F2002/30652 , A61F2002/30655 , A61F2002/30662 , A61F2002/30682 , A61F2002/30683 , A61F2002/30685 , A61F2002/30785 , A61F2002/30828 , A61F2002/30836 , A61F2002/30884 , A61F2002/30906 , A61F2002/30925 , A61F2002/3093 , A61F2220/0025 , A61F2220/005 , A61F2220/0058 , A61F2310/00023 , A61F2310/00071 , A61F2310/00077 , A61F2310/00089 , A61F2310/00796
摘要： Described are artificial disc implants for insertion between first and second adjacent vertebrae in a patient. The implants have a first member and a second member in articulating relationship. At least one member of the implant includes an amorphous metal element. Also described are related methods of making and using artificial disc implants.
摘要翻译：描述了用于在患者中插入第一和第二相邻椎骨之间的人造椎间盘植入物。植入物具有第一个成员和第二个成员的关系。植入物的至少一个构件包括非晶金属元素。还描述了制造和使用人造椎间盘植入物的相关方法。

6. 发明申请

WO2006063354A1 IMPLANTS BASED ON ENGINEERED COMPOSITE MATERIALS HAVING ENHANCED IMAGING AND WEAR RESISTANCE 审中-公开
标题翻译：基于具有增强成像和耐磨性的工程复合材料的植入物
公开(公告)号：WO2006063354A1
公开(公告)日：2006-06-15
申请号：PCT/US2005/045027
申请日：2005-12-12
申请人： SDGI HOLDINGS, INC. , LESSAR, Joseph, F. , MARIK, Greg, C. , UNTERKER, Darrel. F. , ISTEPHANOUS, Naim, S. , GIL, Carlos, E. , ROULEAU, Jeffrey, P. , CONTA, Robert, L.
发明人： LESSAR, Joseph, F. , MARIK, Greg, C. , UNTERKER, Darrel. F. , ISTEPHANOUS, Naim, S. , GIL, Carlos, E. , ROULEAU, Jeffrey, P. , CONTA, Robert, L.
IPC分类号： A61F2/44 , A61F2/00 , A61F2/30
CPC分类号： A61L27/427 , A61F2/30767 , A61F2/4425 , A61F2002/30011 , A61F2002/30563 , A61F2002/30677 , A61F2002/30971 , A61F2002/443 , A61F2250/0023 , A61F2310/00023 , A61F2310/00089 , A61F2310/00095 , A61F2310/00179 , A61F2310/00401 , A61F2310/00407 , A61F2310/00413 , A61L27/30 , A61L2430/38 , B22F7/06 , B22F2999/00 , Y02P10/295 , B22F3/1055 , B22F3/225 , B22F3/115 , B22F3/17 , B22F3/18
摘要： This invention relates to a metal composite orthopedic device such as an articulating spinal spacer (60, 90). The device can comprise a metallic substrate (62, 96) cladded or joined to one or more metallic layer(s) (68, 98). The substrate and metallic layer(s) can be selected of different metals and metal alloys to provide desired wear performance, imaging characteristics and optionally to serve as a reservoir for therapeutic agents.
摘要翻译：本发明涉及一种金属复合矫形装置，例如关节式脊椎间隔器（60,90）。该装置可以包括被包覆或连接到一个或多个金属层（68,98）的金属基底（62,96）。基底和金属层可以选自不同的金属和金属合金，以提供期望的磨损性能，成像特性，并且任选地用作治疗剂的贮存器。

7. 发明申请

WO1995024941A1 MEDICAL ELECTRICAL LEAD 审中-公开
标题翻译：医用电线
公开(公告)号：WO1995024941A1
公开(公告)日：1995-09-21
申请号：PCT/US1995002817
申请日：1995-03-06
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , BREYEN, Mark, D. , LESSAR, Joseph, F. , STOKES, Kenneth, B. , UPTON, James, E. , ISTEPHANOUS, Naim, S. , MILLER, Jennifer, P.
IPC分类号： A61N01/05
CPC分类号： A61N1/056
摘要： A medical electrical lead of the type which includes an electrode at a distal end of the lead, a connector at a proximal end of the lead and an elongated electrical conductor extending between the electrode and the connector. The conductor is comprised of a wire wound in a coil configuration with the wire comprised of a duplex titanium alloy. Materials of such composition have been found to have suitable conductivity for use with implantable pulse generators and suitable fatigue strength when used in endocardial lead placement. Moreover, such materials have been found to pass tests intended to detect metal ion oxidation (MIO) in susceptible polymeric materials.
摘要翻译：一种医用电引线，其包括在引线的远端处的电极，在引线的近端处的连接器和在电极和连接器之间延伸的细长电导体。导线由线圈构造的线组成，线由双相钛合金组成。已经发现这种组合物的材料具有适合的导电性，用于可植入的脉冲发生器，并且当用于心内膜引导放置时具有合适的疲劳强度。此外，已经发现这些材料通过旨在检测敏感聚合材料中的金属离子氧化（MIO）的测试。

8. 发明申请

WO1997049449A1 MEDICAL ELECTRICAL LEAD HAVING A CRUSH RESISTANT LEAD BODY 审中-公开
标题翻译：具有耐冲击导体身体的医用电线
公开(公告)号：WO1997049449A1
公开(公告)日：1997-12-31
申请号：PCT/US1997010548
申请日：1997-06-16
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , SWOYER, John, M. , McINTYRE, Peter, B. , UPTON, James, E. , HEBZYNSKI, Annette, M. , LESSAR, Joseph, F.
IPC分类号： A61N01/05
CPC分类号： A61N1/056
摘要： A medical lead which has a connector assembly coupled to an electrode by a lead body, the lead body is designed so as to have greater resistance to crush fatigue in the area which is located between the rib and clavicle when implanted. In particular the lead body of the present invention features an insulative sheath (109) covering a coiled conductor. The coiled conductor has three sections, viz., proximal (120), intermediate (122) and distal (121) sections. The intermediate section has a different pitch as compared to proximal section (120) and distal section (121). In the preferred embodiment, intermediate section has a pitch of approximately 0.100 while proximal section has a pitch of approximately 0.025 and distal section has a pitch of approximately 0.025. Moreover, intermediate section has a length of approximately 10.4 inches while proximal section has a length of approximately 5.1 inches and distal section has a length of approximately 7.2 inches. In such a manner the lead of the present invention presents a coiled conductor having a greater pitch in the area in which crush fatigue between the clavicle and rib is likely to occur.
摘要翻译：一种医用引线，其具有通过引线体与电极耦合的连接器组件，所述引线体被设计成在植入时位于肋和锁骨之间的区域中具有较大的抗挤压疲劳性。特别地，本发明的引线体具有覆盖线圈导体的绝缘护套（109）。线圈导体具有三个部分，即近端（120），中间（122）和远端（121）部分。中间部分与近端部分（120）和远端部分（121）相比具有不同的间距。在优选实施例中，中间部分具有大约0.100的间距，而近侧部分具有大约0.025的间距，并且远侧部分具有大约0.025的节距。此外，中间部分具有大约10.4英寸的长度，而近端部分具有大约5.1英寸的长度，并且远端部分具有大约7.2英寸的长度。以这种方式，本发明的引线呈现在可能发生锁骨和肋骨之间的挤压疲劳的区域中具有较大间距的螺旋导体。

9. 发明申请

WO1995024942A1 MEDICAL ELECTRICAL LEAD 审中-公开
标题翻译：医用电线
公开(公告)号：WO1995024942A1
公开(公告)日：1995-09-21
申请号：PCT/US1995002824
申请日：1995-03-06
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , BREYEN, Mark, D. , ISTEPHANOUS, Naim, S. , KRASKA, Robert, E. , LESSAR, Joseph, F. , MILLER, Jennifer, P.
IPC分类号： A61N01/05
CPC分类号： A61N1/056
摘要： A medical electrical lead of the type which includes an electrode at a distal end of the lead, a connector at a proximal end of the lead and an elongated electrical conductor extending between the electrode and the connector. The conductor is comprised of a wire wound in a coil configuration with the wire comprised of a duplex stainless steel having a composition of at least 22 % chromium, 3 % molybdenum and 5 % nickel. Material of such composition has been found to have suitable conductivity for use with implantable pulse generators and suitable fatigue strength when used in endocardial lead placement. Moreover, such material has been found to pass tests intended to detect metal ion oxidation (MIO) in polymeric materials.
摘要翻译：一种医用电引线，其包括在引线的远端处的电极，在引线的近端处的连接器和在电极和连接器之间延伸的细长电导体。该导体由卷绕成线圈构造的线组成，线由具有至少22％铬，3％钼和5％镍组成的双相不锈钢组成。已经发现，这种组合物的材料具有适合的导电性，用于可植入的脉冲发生器，并且当用于心内膜引导放置时具有合适的疲劳强度。此外，已经发现这种材料通过用于检测聚合物材料中的金属离子氧化（MIO）的测试。

10. 发明申请

WO2004030751A1 IMPLANTABLE MEDICAL DEVICE LEAD CONDUCTOR AND PROCESS FOR FORMING 审中-公开
标题翻译：可植入医疗装置导线器及其形成工艺
公开(公告)号：WO2004030751A1
公开(公告)日：2004-04-15
申请号：PCT/US2003/030375
申请日：2003-09-25
申请人： MEDTRONIC, INC.
发明人： LESSAR, Joseph, F. , MARTINEZ, Gonzalo , BOSER, Gregory, A. , WISER, Jeff, A. , MCINTYRE, Peter, B. , MAYER, David, W. , BAKER, Paul, D.
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/05
摘要： An implantable medical device lead having an integral biostable in-sutu grown oxide insulation and process for forming that includes a lead body extending from a proximal end to a distal end, and a plurality of conductor wires electrically coupling the proximal end and the distal end of the lead body, with one or more of the plurality of conductor wires being formed of a material having a chemically modifiable surface for producing an insulating oxide layer thereon. An insulation layer corresponding to the native oxide layer is formed about the one or more of the plurality of conductor wires.
摘要翻译：一种可植入医疗器械引线，其具有整体的生物稳定的Sutu生长的氧化物绝缘体和用于形成的工艺，其包括从近端延伸到远端的引线主体，以及多个导线，其电连接近端和远端所述引线体，所述多根导线中的一个或多个由具有化学修饰表面的材料形成，以在其上产生绝缘氧化物层。围绕多条导线中的一条或多条形成与天然氧化物层相对应的绝缘层。

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