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1. 发明申请

WO2012151364A1 ASSESSING INTRA-CARDIAC ACTIVATION PATTERNS AND ELECTRICAL DYSSYNCHRONY 审中-公开
标题翻译：评估心脏起搏模式和电除颤
公开(公告)号：WO2012151364A1
公开(公告)日：2012-11-08
申请号：PCT/US2012/036262
申请日：2012-05-03
申请人： MEDTRONIC, INC. , GHOSH, Subham , GILLBERG, Jeffrey M. , STADLER, Robert W.
发明人： GHOSH, Subham , GILLBERG, Jeffrey M. , STADLER, Robert W.
IPC分类号： A61B5/0402 , A61B5/0408 , A61N1/362 , A61N1/368
CPC分类号： A61B5/04012 , A61B5/02 , A61B5/0402 , A61B5/04085 , A61B5/044 , A61B5/0452 , A61B5/05 , A61B5/742 , A61N1/0476 , A61N1/0484 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.
摘要翻译：描述了评估心脏电气不同步的技术。在一些示例中，为多个躯干表面电位信号中的每一个确定激活时间。可以分析或呈现这些激活时间的分散或序列以提供患者心脏的电不同步的各种指示。在一些示例中，电极组的电极的位置以及因此感测躯干表面电位信号的位置可以投影在包括模型心脏的模型躯干的表面上。可以解决心电图的逆问题，以基于从患者感测的躯干表面电位信号来确定模型心脏区域的电激活时间。

2. 发明申请

WO2012154489A1 TECHNIQUES FOR DETERMINING MORPHOLOGICAL STABILITY OF CARDIAC CYCLES 审中-公开
标题翻译：用于确定心脏循环的形态稳定性的技术
公开(公告)号：WO2012154489A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/036285
申请日：2012-05-03
申请人： MEDTRONIC, INC. , GHOSH, Subham , GILLBERG, Jeffrey M.
发明人： GHOSH, Subham , GILLBERG, Jeffrey M.
IPC分类号： A61B5/04 , A61B5/0452 , A61N1/362
CPC分类号： A61B5/686 , A61B5/04012 , A61B5/0452 , A61N1/3621
摘要： A medical device, comprising: a memory; and a processing module configured to retrieve electrogram (EGM) data for N cardiac cycles from the memory, wherein N is an integer greater than 1, categorize each of the N cardiac cycles into one of a plurality of categories based on a morphology of the N cardiac cycles, perform comparisons be¬ tween pairs of the N cardiac cycles, each of the comparisons between two cardiac cycles comprising: detecting a mismatch between the two cardiac cycles when the two cardiac cycles are in different categories; and detecting a match between the two cardiac cycles when the two cardiac cycles are in the same category, wherein the processing module is further configured to classify the rhythm of the N cardiac cycles based on a number of detected matches and detected mismatches.
摘要翻译：一种医疗装置，包括：存储器; 以及处理模块，被配置为从存储器中检索N个心动周期的电描记图（EGM）数据，其中N是大于1的整数，基于N的形态将N个心动周期中的每一个分类为多个类别心动周期，执行N个心动周期对之间的比较，两个心动周期之间的每个比较包括：当两个心动周期处于不同类别时，检测两个心动周期之间的失配; 以及当所述两个心动周期处于相同类别时，检测所述两个心动周期之间的匹配，其中所述处理模块还被配置为基于检测到的匹配的数量和检测到的错配来对所述N个心动周期的节律进行分类。

3. 发明申请

WO2011136926A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 审中-公开
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：WO2011136926A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/032265
申请日：2011-04-13
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
发明人： ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
IPC分类号： A61B5/0464 , A61N1/362
CPC分类号： A61B5/0464 , A61B5/7203 , A61N1/3622 , A61N1/36507 , A61N1/37264
摘要： A medical device and associated method for discriminating cardiac events includes determining whether a first match score is within a first match zone having a first correlation with a non-treatable cardiac event, a second match zone having a second correlation with the non-treatable cardiac event less than the first correlation with the non-treatable event, a third match zone having a first correlation with a treatable cardiac event, and a fourth match zone having a second correlation with the treatable cardiac event greater than the first correlation with the treatable cardiac event. A determination is made as to whether a second match score and a third match score are within the first match zone, the second match zone, the third match zone and the fourth match zone to generate a first adjusting factor, and cardiac event evidence is accumulated in response to the first adjusting factor for discriminating cardiac events.
摘要翻译：用于鉴别心脏事件的医疗装置和相关联的方法包括确定第一匹配得分是否在与不可治疗心脏事件具有第一相关性的第一匹配区域内，与不可治疗心脏事件具有第二相关性的第二匹配区域小于与不可治疗事件的第一相关性，具有与可治疗心脏事件的第一相关性的第三匹配区，以及与可治疗心脏事件具有大于与可治疗心脏事件的第一相关性的第二相关性的第四匹配区。确定第二匹配分数和第三匹配分数是否在第一匹配区域，第二匹配区域，第三匹配区域和第四匹配区域内，以产生第一调整因子，并且累积心脏事件证据响应于用于区分心脏事件的第一调整因子。

4. 发明申请

WO2012051163A1 A SEQUENTIAL DISCRIMINATION APPROACH FOR DETECTING TREATABLE CARDIAC RHYTHMS 审中-公开
标题翻译：用于检测可治疗心脏病的顺序分析方法
公开(公告)号：WO2012051163A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/055732
申请日：2011-10-11
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , STADLER, Robert, W. , GILLBERG, Jeffrey M.
发明人： ZHANG, Xusheng , STADLER, Robert, W. , GILLBERG, Jeffrey M.
IPC分类号： A61B5/0464 , A61N1/39
CPC分类号： A61B5/7267 , A61B5/0422 , A61B5/046 , A61B5/0464 , A61B5/686 , A61B5/7239 , A61N1/3624 , A61N1/3962
摘要： A system and method for use in a medical device for discriminating cardiac events establishes population-based thresholds corresponding to cardiac signal morphology metrics for discriminating between a first cardiac event and a second cardiac event. A population-based threshold criterion for discriminating cardiac events is established. The population-based threshold criterion is applied to a cardiac signal segment and the segment is classified if the criterion is satisfied. A patient-specific threshold is established in response to the sensed cardiac signal segment not being classified after applying the population-based threshold criterion. The sensed signal segment is classified in response to the patient-specific threshold comparison.
摘要翻译：用于辨别心脏事件的医疗装置中的系统和方法建立了对应于心脏信号形态度量的基于群体的阈值，用于区分第一心脏事件和第二心脏事件。建立了基于人群的阈值判别标准，用于辨别心脏事件。基于人群的阈值标准被应用于心脏信号段，并且如果满足标准，则对该段进行分类。响应于在应用基于群体的阈值标准之后未被分类的感测到的心脏信号段建立患者特异性阈值。感测的信号段根据患者特异性阈值比较进行分类。

5. 发明申请

WO2011136916A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 审中-公开
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：WO2011136916A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/032004
申请日：2011-04-12
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
发明人： ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
IPC分类号： A61N1/39 , A61B5/0452
CPC分类号： A61B5/04525 , A61B5/02405 , A61B5/7203 , A61N1/3962
摘要： A medical device and associated method for discriminating cardiac events includes sensing a cardiac signal spatially located across approximately a full duration of a predetermined sensing window. A match score is determined corresponding to the sensed cardiac signal. A beat feature of multiple beat features across less than the full duration of the sensing window is determined, the beat feature being selected from the multiple beat features in response to the match score. Cardiac event evidence is accumulated in response to the match score and the determined beat feature, and cardiac events are discriminated in response to the accumulated cardiac evidence.
摘要翻译：用于鉴别心脏事件的医疗装置和相关联的方法包括感测在预定感测窗口的大约整个持续时间上空间定位的心脏信号。根据感测的心脏信号确定匹配分数。确定在小于感测窗口的整个持续时间的多个拍子特征的拍子特征，响应于匹配分数，从多拍特征中选择节拍特征。响应于匹配得分和确定的搏动特征累积心脏事件证据，并且响应于累积的心脏证据来区分心脏事件。

6. 发明申请

WO2010126703A1 IMPLANTABLE MEDICAL DEVICE WITH MEANS FOR DISTINGUISHING BETWEEN TREATABLE AND NON-TREATABLE HEART RHYTHMS 审中-公开
标题翻译：具有可治疗和不可治疗心脏疾病之间差异的手段的可植入医疗器械
公开(公告)号：WO2010126703A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/030711
申请日：2010-04-12
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
发明人： ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
IPC分类号： A61N1/362
CPC分类号： A61N1/3621 , A61B5/04525 , A61B5/046 , A61B5/0464 , A61B5/726 , A61B5/7264 , A61N1/36507 , A61N1/3962 , G06F19/00
摘要： Techniques are described for distinguishing between treatable and non-treatable heart rhythms. A medical device that operates in accordance with the techniques analyzes characteristics over several cardiac event intervals to detect initiation of a sudden rate onset. After detection of the initiation of the sudden rate onset, the IMD analyzes a morphology of an EGM associated with a selected cardiac event within the first several beats after the initiation of sudden rate onset. In one example, the IMD analyzes the morphology of the EGM associated with the first cardiac event immediately subsequent to the initiation of the sudden rate onset. If the morphology of the EGM of the selected cardiac event is abnormal compared to template EGM, the rhythm is classified as treatable. Otherwise, the rhythm is classified as non-treatable.
摘要翻译：描述了用于区分可治疗和不可治疗的心脏节律的技术。根据该技术操作的医疗装置分析几个心脏事件间隔的特征，以检测突然发生率的起始。在检测到突发性发作起始之后，IMD分析在突然发病起始之后的前几次心跳中与所选心脏事件相关的EGM的形态。在一个实例中，IMD分析与突然发病起始之后紧接着的第一次心脏事件相关的EGM的形态。如果所选心脏事件的EGM的形态与模板EGM相比异常，则将节律分类为可治疗的。否则，节奏被分类为不可治疗。

7. 发明申请

WO2011136923A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 审中-公开
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：WO2011136923A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/032208
申请日：2011-04-13
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
发明人： ZHANG, Xusheng , STADLER, Robert W. , GILLBERG, Jeffrey M.
IPC分类号： A61B5/0464 , A61N1/362
CPC分类号： A61B5/0464 , A61B5/04525 , A61B5/686 , A61B5/6869 , A61B5/7203 , A61N1/3621 , A61N1/3624 , A61N1/3962
摘要： A medical device and associated method for discriminating cardiac events includes determining whether a first match score is within a first match zone having a first correlation with a non-treatable cardiac event, a second match zone having a second correlation with the non-treatable cardiac event less than the first correlation, a third match zone having a first correlation with a treatable cardiac event, and a fourth match zone having a second correlation with the treatable cardiac event greater than the first correlation with the treatable cardiac event. In response to the first match score being within one of the first and second match zones, a determination is made whether consecutive match scores are within the first match zone and whether a break in the treatable cardiac event has occurred. Cardiac evidence is accumulated in response to determining whether a break has occurred and utilized to discriminate cardiac events.
摘要翻译：用于识别心脏事件的医疗装置和相关联的方法包括确定第一匹配得分是否在与不可治疗心脏事件具有第一相关性的第一匹配区域内，与不可治疗心脏事件具有第二相关性的第二匹配区域小于第一相关性，具有与可治疗心脏事件的第一相关性的第三匹配区，以及与可治疗心脏事件具有大于与可治疗心脏事件的第一相关性的第二相关性的第四匹配区。响应于第一匹配分数在第一和第二匹配区域之一内，确定连续匹配分数是否在第一匹配区域内，以及是否发生可治疗心脏事件的中断。响应于确定是否发生休息并利用心脏事件来积累心脏证据。

8. 发明申请

WO2011041147A1 PACE DISCRIMINATION OF TACHYCARDIA USING ATRIAL-VENTRICULAR PACING 审中-公开
标题翻译：使用心房透明膜的斑马鱼的鉴别
公开(公告)号：WO2011041147A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/049448
申请日：2010-09-20
申请人： MEDTRONIC, INC. , BROWN, Mark L. , JACKSON, Troy E. , GILLBERG, Jeffrey M.
发明人： BROWN, Mark L. , JACKSON, Troy E. , GILLBERG, Jeffrey M.
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3716 , A61N1/3962
摘要： A cardiac medical device and associated method control delivery of dual chamber burst pacing pulses in response to detecting tachycardia. In one embodiment, a single chamber pacing pulse is delivered in response to detecting a tachycardia. Dual chamber pacing pulses are delivered subsequent to the single chamber pacing pulse. An intrinsic depolarization is sensed subsequent to delivering the dual chamber pacing pulses. The tachycardia episode is classified in response to the sensed intrinsic depolarization.
摘要翻译：响应于检测到心动过速，心脏医疗装置和相关联的方法控制双室脉冲起搏脉冲的传递。在一个实施例中，响应于检测到心动过速而递送单室起搏脉冲。双室起搏脉冲在单室起搏脉冲之后传递。在递送双室起搏脉冲之后感测到固有去极化。心动过速发作根据感觉到的内在去极化进行分类。

9. 发明申请

WO2008079797A1 GRADUALLY SYNCHRONIZED SIMULTANEOUS ATRIAL AND VENTRICULAR PACING FOR CARDIAC RHYTHM DISCRIMINATION 审中-公开
标题翻译：同时同步同步心律失常和心血管疾病
公开(公告)号：WO2008079797A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/087848
申请日：2007-12-18
申请人： MEDTRONIC, INC , JACKSON, Troy Edward , BROWN, Mark L. , GILLBERG, Jeffrey M.
发明人： JACKSON, Troy Edward , BROWN, Mark L. , GILLBERG, Jeffrey M.
IPC分类号： A61N1/368
CPC分类号： A61N1/3622
摘要： A cardiac medical device used for delivering anti-tachycardia pacing in both the atrial and ventricular regions in a simultaneous manner, while preventing potential of inducing atrial arrhythmia. The pacing pulses may be synchronized in a gradual manner so that simultaneous delivery of the pulses is ultimately achieved at reduced risk of inducing atrial arrhythmia. The pacing pulses may also be synchronized immediately after a determination is made whether simultaneous pacing pulses will be delivered in the vulnerable regions of the cardiac cycle.
摘要翻译：一种用于以同时方式在心房和心室区域递送抗心动过速起搏的心脏医疗装置，同时防止引起心房心律失常的可能性。起搏脉冲可以以逐步的方式同步，从而最终以减少诱导心房心律失常的风险实现脉冲的同时传递。在确定是否在心动周期的脆弱区域中是否同时起搏脉冲将被递送之后，起搏脉冲也可以立即同步。

10. 发明申请

WO2011041117A1 PACE DISCRIMINATION OF TACHYCARDIA USING ATRIAL-VENTRICULAR PACING 审中-公开
标题翻译：心房扑动心动过速对心动过速的辨别
公开(公告)号：WO2011041117A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/049026
申请日：2010-09-16
申请人： MEDTRONIC, INC. , BROWN, Mark L. , JACKSON, Troy E. , GILLBERG, Jeffrey M.
发明人： BROWN, Mark L. , JACKSON, Troy E. , GILLBERG, Jeffrey M.
IPC分类号： A61N1/362 , A61N1/37 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/3702 , A61N1/3962
摘要： A cardiac medical device and associated method control delivery of dual chamber burst pacing pulses in response to detecting tachycardia. In one embodiment, a single chamber pacing pulse is delivered in response to detecting a tachycardia. Dual chamber pacing pulses are delivered subsequent to the single chamber pacing pulse. An intrinsic depolarization is sensed subsequent to delivering the dual chamber pacing pulses. The tachycardia episode is classified in response to the sensed intrinsic depolarization.
摘要翻译：心脏医疗装置和相关方法响应于检测到心动过速而控制双腔脉冲起搏脉冲的输送。在一个实施例中，响应于检测到心动过速而输送单腔起搏脉冲。双腔起搏脉冲在单腔起搏脉冲之后递送。在递送双腔起搏脉冲之后感测内在的去极化。心动过速发作是根据感觉到的内在去极化进行分类的。

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